Clinical study on thalidomide combined with cinobufagin to treat lung cancer cachexia.

Abstract:

Objective:To discuss and assess the clinical value of treating lung cancer cachexia with thalidomide combined with cinobufagin.s. Methods:A cohort of 54 patients, who were diagnosed with lung carcinoma, was randomly divided into two groups, a trial group and a control group, respectively. The trial group was given 150 mg/day thalidomide and 2700 mg/day cinobufagin; the control group only received 2,700 mg/day cinobufagin. The therapy lasted for 12 weeks, and the nutritional status, quality of life, survival, and side effects in patients in the two groups were recorded. Results:The nutritional status, quality of life, and survival of patients with lung cancer cachexia in the trial group were significantly improved compared to the control group. The trial group received 150 mg thalidomide, which by contrast reduced the incidence of side effect and increased tolerance. Conclusion:Using thalidomide combined with cinobufagin to treat patients with lung cancer cachexia will significantly improve their nutritional status and quality of life. This therapy is better than that using cinobufagin alone and is well tolerated.

journal_name

J Cancer Res Ther

authors

Xie M,Chen X,Qin S,Bao Y,Bu K,Lu Y

doi

10.4103/0973-1482.188436

subject

Has Abstract

pub_date

2018-01-01 00:00:00

pages

226-232

issue

1

eissn

0973-1482

issn

1998-4138

pii

JCanResTher_2018_14_1_226_188436

journal_volume

14

pub_type

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