The value of serum Cyfra21-1 as a biomarker in the diagnosis of patients with non-small cell lung cancer: a meta-analysis.

Abstract:

OBJECTIVE:The serum level of Cyfra21-1 was always elevated in patients with nonsmall cell lung carcinoma. The aim of this meta-analysis was to evaluate the serum Cyfra21-1 as a biomarker in the diagnosis of nonsmall cell lung cancer (NSCLC). METHODS:All the articles associated with serum Cyfra21-1 in the diagnosis of NSCLC were searched in the PubMed, Medline, and CNKI databases. The number of patients for true positive, false positive, false negative and true negative were extracted from each individual study. The pooled sensitivity, specificity, positive likely hood ratio (+lr), negative likely hood ratio (-lr), diagnosis odds ratio (dor) and summary receiver operating characteristic (sroc) curve were calculated by MetaDiSc 1.4 software. RESULTS:After searching the databases, 17 studies with 4221 subjects were met the inclusion criteria and finally included in this meta-analysis. The pooled diagnosis sensitivity, specificity, +lr, -lr and dor were 0.72 (95% confidence interval [CI]: 0.70-0.73), 0.94 (95%CI: 0.93-0.95), 8.81 (95%CI: 6.36-12.22), 0.42 (95%CI: 0.32-0.55) and 22.57 (95%CI: 13.89-36.68) respectively. The area under the sroc curve was 0.95. And significant publication bias was found in this meta-analysis (P = 0.049). CONCLUSION:With published data, the serum Cyfra21-1 was a useful biomarker for diagnosis of NSCLC. OBJECTIVE:The serum level of Cyfra21-1 was always elevated in patients with nonsmall cell lung carcinoma. The aim of this meta-analysis was to evaluate the serum Cyfra21-1 as a biomarker in the diagnosis of nonsmall cell lung cancer (NSCLC). METHODS:All the articles associated with serum Cyfra21-1 in the diagnosis of NSCLC were searched in the PubMed, Medline, and CNKI databases. The number of patients for true positive, false positive, false negative and true negative were extracted from each individual study. The pooled sensitivity, specificity, positive likely hood ratio (+lr), negative likely hood ratio (-lr), diagnosis odds ratio (dor) and summary receiver operating characteristic (sroc) curve were calculated by MetaDiSc 1.4 software. RESULTS:After searching the databases, 17 studies with 4221 subjects were met the inclusion criteria and finally included in this meta-analysis. The pooled diagnosis sensitivity, specificity, +lr, -lr and dor were 0.72 (95% confidence interval [CI]: 0.70-0.73), 0.94 (95%CI: 0.93-0.95), 8.81 (95%CI: 6.36-12.22), 0.42 (95%CI: 0.32-0.55) and 22.57 (95%CI: 13.89-36.68) respectively. The area under the sroc curve was 0.95. And significant publication bias was found in this meta-analysis (P = 0.049). CONCLUSION:With published data, the serum Cyfra21-1 was a useful biomarker for diagnosis of NSCLC.

journal_name

J Cancer Res Ther

authors

Cui C,Sun X,Zhang J,Han D,Gu J

doi

10.4103/0973-1482.145835

subject

Has Abstract

pub_date

2014-11-01 00:00:00

pages

C131-4

eissn

0973-1482

issn

1998-4138

pii

JCanResTher_2014_10_7_131_145835

journal_volume

10 Suppl

pub_type

杂志文章,meta分析
  • Breast-conserving surgery versus modified radical mastectomy in treatment of early stage breast cancer: A retrospective study of 107 cases.

    abstract:OBJECTIVE:The aim of this retrospective study was to evaluate the clinical efficacy and prognosis of breast-conserving surgery versus modified radical mastectomy in the treatment of early stage breast cancer. PATIENTS AND METHODS:Two hundred and nineteen cases of early stage breast cancer were reviewed and retrospecti...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/0973-1482.163835

    authors: Chen Z,Xu Y,Shu J,Xu N

    更新日期:2015-08-01 00:00:00

  • An overview on small-field dosimetry in photon beam radiotherapy: Developments and challenges.

    abstract::Small fields are more repeatedly used for radiation therapy as small segments in intensity-modulated radiotherapy or as in the form of independent fields in stereotactic radiosurgery and other novel equipment such as cyberknife and tomotherapy. Nevertheless, the application of small fields for radiotherapy of lung mak...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章,评审

    doi:10.4103/0973-1482.199444

    authors: Bagheri H,Soleimani A,Gharehaghaji N,Mesbahi A,Manouchehri F,Shekarchi B,Dormanesh B,Dadgar HA

    更新日期:2017-04-01 00:00:00

  • Measurement of fast neutron contamination caused by the presence of wedge and block using CR-39 detector.

    abstract:Objective:Undesired neutron contamination imposed to patients during treatment is among the main factors increasing the risk of secondary cancer in radiotherapy. This additional undesirable dose is due to neutron contamination production in high-energy accelerators. In this study, neutron contamination is investigated ...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/jcrt.JCRT_1257_16

    authors: Khajetash B,Bahreyni Toossi MT,Ghorbani M,Jahangiri M,Akbari F

    更新日期:2019-03-01 00:00:00

  • Wnt5a/Ca (2+) /calcineurin/nuclear factor of activated T signaling pathway as a potential marker of pediatric melanoma.

    abstract::Melanoma is rare in children, but its incidence appears to be increasing. Melanoma accounts for the highest mortality among all skin cancer types. This disease is characterized by high-grade malignancy, easy metastasis, poor prognosis, and high death rate. Melanoma in children may be biologically different from that i...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章,评审

    doi:10.4103/0973-1482.145788

    authors: Yang Y,Qian Q

    更新日期:2014-11-01 00:00:00

  • Telomere length variation and expression analysis of shelterin complex genes during gallbladder carcinogenesis.

    abstract:BACKGROUND:Telomeres, which are bound with shelterin protein complex, play an important role in maintaining genomic stability and its dysfunction may lead to carcinogenesis. Here, we aimed to analyze whether shelterin complex gene expression and telomere length variation, play any role in gallbladder carcinogenesis. M...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/0973-1482.184512

    authors: Poojary SS,Mishra G,Singh TD,Gupta S,Shrivastav BR,Tiwari PK

    更新日期:2017-04-01 00:00:00

  • Survey of undergraduate medical students on their understanding and attitude towards the discipline of radiotherapy.

    abstract:AIM:The discipline of radiotherapy (RT) in India is considered a low priority subject. Postgraduate (PG) students rarely choose RT as a career option. The possible reasons could be: 1) limited availability of PG course training centers, 2) limited job prospects, etc. We decided to conduct a survey of undergraduate (UG)...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/0973-1482.63556

    authors: Sharma DN,Rath GK,Parashar A,Singh P

    更新日期:2010-01-01 00:00:00

  • Oral biopsy: oral pathologist's perspective.

    abstract::Many oral lesions may need to be diagnosed by removing a sample of tissue from the oral cavity. Biopsy is widely used in the medical field, but the practice is not quite widespread in dental practice. As oral pathologists, we have found many artifacts in the tissue specimen because of poor biopsy technique or handling...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章,评审

    doi:10.4103/0973-1482.98969

    authors: Kumaraswamy KL,Vidhya M,Rao PK,Mukunda A

    更新日期:2012-04-01 00:00:00

  • Clinical and pathological features of patients with resected synovial sarcoma: a multicenter retrospective analysis of the Anatolian Society of Medical Oncology.

    abstract:BACKGROUND:Synovial sarcoma (SS) is a rare disease and compared with other soft-tissue sarcomas has a relatively high mortality rate. The optimal management of this disease and prognostic factors associated with patient outcome remains controversial. AIMS:We aimed to evaluate the factors affecting the outcomes of SS p...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章,多中心研究

    doi:10.4103/0973-1482.131381

    authors: Tarkan Y,Erkan A,Selcuk ES,Mehmet K,Tugba KF,Ozlem US,Suleyman A,Tulay A,Bilge A,Ramazan Y,Yusuf G,Mevlude I,Umut D,Ilhan O,Abdurrahman I,Alper S,Dogan U,Necati A,Berna O,Gok DA,Ugur Y,Mahmut G

    更新日期:2014-01-01 00:00:00

  • Evaluation of clinical process in osteosarcoma patients treated with chemotherapy including cisplatin, adriamycin, ifosfamide, and etoposide and determination of the treatment sequels in a long-term 11-year follow-up.

    abstract:AIM:The aim of this study was to evaluate the effect of adding etoposide and ifosfamide chemotherapy drugs to treatment regimen of patients affected with osteosarcoma and to determine the clinical process and response to treatment during a follow-up period of 11 years. MATERIALS AND METHODS:Forty patients with osteosa...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/0973-1482.199447

    authors: Aznab M,Hematti M

    更新日期:2017-04-01 00:00:00

  • The prognostic factors for clinical N1b patients in thyroid papillary carcinoma.

    abstract:Background:The aim of this study is to determine the prognostic factors which affect both disease-free survival (DFS) and overall survival (OS) in thyroid papillary carcinoma with clinical lateral lymph node metastasis. Methods:One hundred and three papillary thyroid carcinomas diagnosed in adult patients received the...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/jcrt.JCRT_1011_16

    authors: Yuksel UM,Turanli S,Acar Y,Berberoglu U

    更新日期:2019-07-01 00:00:00

  • Development of plasma cell leukemia in a patient with chronic myeloid leukemia while on treatment with imatinib mesylate.

    abstract::Plasma cell leukemia (PCL) is a rare and an aggressive form of plasma cell dyscrasias. We report a 67-year-old male with PCL which developed while on imatinib mesylate (IM) therapy 38 months after diagnosis of chronic myeloid leukemia (CML). The patient has been treated successfully with bortezomib, melphalan and pred...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 信件

    doi:10.4103/0973-1482.192762

    authors: Maral S,Bakanay SM,Yikilmaz AS,Dilek I

    更新日期:2018-10-01 00:00:00

  • COVID-19 pandemic: Radiotherapy precautions and preparedness.

    abstract::The novel coronavirus (COVID-19) pandemic has disrupted healthcare delivery across the globe. Cancer patients are at a higher risk of acquiring this infection due to their immunosuppressed state. Timely care of patients while ensuring safety of healthcare workers is need of the hour. We list few precautionary measures...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/jcrt.JCRT_405_20

    authors: Mummudi N,Tibdewal A,Ghosh-Laskar S,Agarwal JP

    更新日期:2020-04-01 00:00:00

  • Off-label use of anti-cancer drugs in India: to be or not to be!

    abstract:BACKGROUND:Administering drugs outside the terms of their official labeling is called off-label use. In the West, oncologists often use drugs off-label, which offers several advantages especially while treating patients with multiple comorbidities or advanced cancer. The practice of off-label prescribing of anticancer ...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/0973-1482.80455

    authors: Gota V,Patial P

    更新日期:2011-01-01 00:00:00

  • Good prognostic factor in patients with nonmetastatic nasopharyngeal carcinoma: Programmed death ligand-1 expression in tumor cells.

    abstract:Purpose:Programmed death ligand-1 (PD-L1) is the main ligand for programmed death-1 (PD-1), and is one of the major targets for cancer immunotherapy. Only a few studies are available for the clinical significance of PD-1/PD-L1 in nasopharyngeal carcinoma (NPC). There is a controversial association between PD-L1 express...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/jcrt.JCRT_759_19

    authors: Sahinli H,Akyürek N,Yılmaz M,Kandemir O,Duran AO,Kulaçoǧlu S,Uçar G,Acar E,Özet A,Öksüzoǧlu OBÇ,Özdemir NY

    更新日期:2020-12-01 00:00:00

  • Atypical giant chondroblastoma mimicking a chondrosarcoma.

    abstract::Chondroblastoma is a rare, benign tumor derived from chondroblasts, commonly presenting in the second decade of life. It is usually found in the epiphysis or apophysis of long bones; however, it may rarely affect flat bones like scapula. Occasionally a histologically typical chondroblastoma may exhibit an aggressive b...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 信件

    doi:10.4103/0973-1482.139387

    authors: Dhanda S,Menon S,Gulia A

    更新日期:2015-07-01 00:00:00

  • Acinic cell carcinoma of the posterior buccal mucosa: A rare case report.

    abstract::Acinic cell carcinoma (ACC) is a low-grade malignant salivary gland neoplasm that comprises approximately 17% of primary salivary gland malignancies or about 6% of all salivary gland neoplasms. The most common intraoral sites are the buccal mucosa, lips, and palate. The diagnosis of ACC frequently presents difficultie...

    journal_title:Journal of cancer research and therapeutics

    pub_type:

    doi:10.4103/jcrt.JCRT_399_18

    authors: Babu SS,Sunil S,Prathap A,Mathew AL

    更新日期:2020-04-01 00:00:00

  • Role of adjuvant radiotherapy in metaplastic matrix producing breast cancer: a case study with review of literature.

    abstract::A rare and unique variant of breast cancer--metaplastic matrix producing carcinoma, is presented. Surgery has been the mainstay of treatment. The role of adjuvant postoperative radiotherapy, as has been used in this patient, has been reviewed. ...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/0973-1482.25855

    authors: Kumar P,Agarwal T,Krishnani N,Singh S,Datta NR

    更新日期:2006-04-01 00:00:00

  • Hemoglobin, albumin, lymphocyte, and platelet score and neutrophil-to-lymphocyte ratio are novel significant prognostic factors for patients with small-cell lung cancer undergoing chemotherapy.

    abstract:Objective:The hemoglobin, albumin, lymphocyte, and platelet (HALP) score, neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) are the important prognostic markers in some tumor types. This study aimed to evaluate the prognostic impact of pretreatment using HALP, NLR, and PLR for patients with s...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/jcrt.JCRT_1066_19

    authors: Yang N,Han X,Yu J,Shu W,Qiu F,Han J

    更新日期:2020-09-01 00:00:00

  • Potent chemopreventive effect of mangiferin on lung carcinogenesis in experimental Swiss albino mice.

    abstract:AIM OF THE STUDY:In the present study the effects of mangiferin were tested against lung cancer-bearing mice in both the pre-initiation and post-initiation periods. MATERIALS AND METHODS:Healthy male Swiss albino mice (6-8 weeks old) were used throughout the study. The animals were treated with mangiferin (100 mg/kg b...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/0973-1482.137966

    authors: Rajendran P,Rengarajan T,Nishigaki I,Ekambaram G,Sakthisekaran D

    更新日期:2014-10-01 00:00:00

  • Adenocarcinoma in a tailgut cyst: A rare case report.

    abstract::Tailgut cysts (TGCs) are rare congenital lesions derived from the remnants of primitive hindgut and are usually lined by squamous, transitional, or glandular epithelium. Malignant transformation in TGC may occur which is still rarer. Most common malignancies that arise from these cysts are adenocarcinomas. Preoperativ...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 信件

    doi:10.4103/jcrt.JCRT_212_17

    authors: Valecha J,Ojha SS,Sharma A,Nilkanthe R

    更新日期:2019-01-01 00:00:00

  • Massive scapular metastasis as a presenting feature of carcinoma of the lip.

    abstract::Carcinoma of the lip is a slow-growing locally-advanced disease with low metastatic potential. Distant skeletal metastasis is reported very rarely and the vertebral column is the most common site. A 58-year-old male smoker presented with pain and massive swelling of the left scapula for six months. He also noticed a s...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/0973-1482.73338

    authors: Bandyopadhyay R,Nag D,Bandyopadhyay SK

    更新日期:2010-07-01 00:00:00

  • Significance of ovoid separation with various applications of high-dose-rate-intracavitary radiotherapy in carcinoma of uterine cervix: a study from rural centre of Maharashtra, India.

    abstract:AIMS:To analyze the differences in dose distribution, with ovoid separation in various applications, by different radiotherapists in the same patient of carcinoma of the uterine cervix treated by multiple fractions of high-dose-rate (HDR) intracavitary Radio therapy (ICRT). SETTINGS:Pravara Rural Hospital and Rural Me...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章,随机对照试验

    doi:10.4103/0973-1482.65251

    authors: Jain VS,Singh KK,Umberkar RB,Sarje MB,Jain SM

    更新日期:2010-04-01 00:00:00

  • Ultrasonographic diagnosis of benign masseter muscle hypertrophy: A case report.

    abstract::Masseter hypertrophy is a characteristic condition resulting from an increase in the size of the muscle mass. At times, it produces significant facial asymmetry and is an important finding in the differential diagnosis of similar located entities. A proper diagnosis of this condition would avoid more aggressive and un...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 信件

    doi:10.4103/0973-1482.204889

    authors: Naphade VV,Kedia SG,Patil P,Khare S

    更新日期:2018-12-01 00:00:00

  • A 36-year-old female with Krukenberg tumor from a colonic carcinoma.

    abstract::Krukenberg tumor is bilateral ovarian carcinoma's metastasizing most commonly from a gastric primary followed by a colon. We report a case of 36-year-old female with bilateral ovarian mass diagnosed as Krukenberg with a work up for locating the primary site. In this case, we discuss widely the clinical aspects with hi...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 信件

    doi:10.4103/0973-1482.167615

    authors: Umakanthan S,Bukelo MM,Hardik K

    更新日期:2015-10-01 00:00:00

  • Investigating the risk factors of hepatocellular carcinoma and survival analysis for cirrhosis after transjugular intrahepatic portosystemic shunt in treating portal hypertension.

    abstract:Objective:This study aimed to explore the risk factors of hepatocellular carcinoma (HCC) and survival analysis for cirrhosis after transjugular intrahepatic portosystemic shunt (TIPS) in treating portal hypertension. Materials and Methods:A retrospective database review was performed, including 106 patients (33 female...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/jcrt.JCRT_930_17

    authors: Wei J,Li H,Li C

    更新日期:2018-01-01 00:00:00

  • Imbalance of T-helper 1/T-helper 2 cytokines and impaired glucose tolerance among patient with acute coronary syndrome.

    abstract:Purpose:The balance between T helper (Th) cells Th1- and Th2-related cytokines plays a key role in the clinical process of acute coronary syndrome (ACS) and type 2 diabetes mellitus (T2DM) or impaired glucose tolerance (IGT). The objective of this study was to assess the status of Th1/Th2 cytokines in patients with ACS...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/0973-1482.194346

    authors: Zhao SL,Mo ZH,He HH,Zhao LL,Xie YH

    更新日期:2018-06-01 00:00:00

  • To B(iopsy) or not to B(iopsy).

    abstract::Often in metastatic disease, biopsy confirmation of suspicious central nervous system (CNS) lesions is not mandated according to the American College of Radiology, International Radiosurgery Association, and the National Comprehensive Cancer Network. We present a case of an individual who was thought to have metastati...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 信件

    doi:10.4103/0973-1482.220417

    authors: Gestaut MM,Strober ED,Jhavar SG,Patel MK

    更新日期:2017-10-01 00:00:00

  • Evaluation of the organs at risk doses for lung tumors in gated and conventional radiotherapy.

    abstract:Purpose:The purpose of this study was to evaluate the organs at risk (OARs) doses for lung tumors in gated radiotherapy (RT) compared to conventional RT using the four-dimensional extended cardiac-torso (4D-XCAT) digital phantom in a simulation study. Materials and Methods:4D-XCAT digital phantom was used to create 32...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/jcrt.JCRT_735_18

    authors: Shahzadeh S,Gholami S,Aghamiri SMR,Mahani H,Nabavi M

    更新日期:2020-07-01 00:00:00

  • Angiogenesis and mast cell density as predictors of patient survival in squamous cell carcinoma of lung.

    abstract:BACKGROUND:Measuring the microvascular and mast cell density in squamous cell carcinoma of lung and correlating them with the patient survival may be helpful to guide the use of cancer chemotherapeutic agents which target molecular mechanisms of tumour angiogenesis and mast cells. MATERIALS AND METHODS:It was an obser...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/0973-1482.126487

    authors: Ullah E,Nagi AH,Ashraf M

    更新日期:2013-10-01 00:00:00

  • Postoperative treatment of glioblastoma multiforme with radiation therapy plus concomitant and adjuvant temozolomide : A mono-institutional experience of 215 patients.

    abstract:OBJECTIVE:To study the clinical results and prognostic factors of patients with glioblastoma multiforme (GBM) treated by postoperative radiation therapy (PORT) and concomitant temozolomide followed by adjuvant temozolomide. METHODS:From 2005 to 2008, 215 patients (median age 48 years) with GBM were treated with PORT p...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/0973-1482.119310

    authors: Julka PK,Sharma DN,Mallick S,Gandhi AK,Joshi N,Rath GK

    更新日期:2013-07-01 00:00:00