An updated meta-analysis for association of glutathione S-transferase P1 gene polymorphism with the susceptibility of lung cancer.

Abstract:

Aim of Study:The conclusions on the association between glutathione S-transferase P1 (GSTP1) gene polymorphism and lung cancer risk are still debated. This meta-analysis was performed to update the association between GSTP1 and the risk of lung cancer. Materials and Methods:The association investigations were identified from PubMed and Cochrane Library, and eligible studies were included and synthesized using meta-analysis method. Results:Fifty reports were included into this meta-analysis for the association of GSTP1 A/G gene polymorphism and lung cancer susceptibility. The association between GSTPI G allele/GG genotype and lung cancer risk was found in this meta-analysis (G allele: odds ratio [OR] = 1.08, 95% confidence interval [CI]: 1.02-1.14, P = 0.006; GG genotype: OR = 1.09, 95% CI: 1.00-1.18, P = 0.04). However, the AA genotype was not associated with the susceptibility of lung cancer. Conclusion:GSTP1 G allele/GG genotype is associated with the lung cancer susceptibility.

journal_name

J Cancer Res Ther

authors

Liu WZ,Sun Y,Feng X,Bi XH,Liu T,Zhou HF

doi

10.4103/0973-1482.199455

subject

Has Abstract

pub_date

2018-12-01 00:00:00

pages

S1084-S1090

issue

Supplement

eissn

0973-1482

issn

1998-4138

pii

JCanResTher_2018_14_12_1084_199455

journal_volume

14

pub_type

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