Abstract:
BACKGROUND:Wide variations are seen in clinical practice with respect to response to concurrent chemo radiation among cervical cancer patients. Fall in serum glutathione (GSH) level directly correlates with early response to treatment. Whether this early response translates to a better long term outcome is the subject of this prospective study. MATERIALS AND METHODS:Thirty eight women with cervical cancer were treated with concurrent chemo radiation followed by brachytherapy. Serum GSH was measured before and after two fractions of radiation and first chemotherapy. Patients were followed for a median follow up of four years. Fall in GSH was correlated with response at six weeks and disease status at four years. RESULTS:Median fall in serum GSH was 171.16 µg per ml. Fall in GSH was 170.42, 103.54 and 37.25 µg per ml (P value of <0.0001, 0.05 and 0.18) in patients showing complete response, partial response and no response respectively. Among 26 patients who had no disease at six weeks, 22 women remained disease free at four years (P < 0.0001), two recurred (P < 0.05) and two died of other causes respectively. Non bulky tumours and patients more than 50 years of age showed a fall of 190.69, 265.17 µg per ml respectively. CONCLUSION:Greater fall in serum GSH predicts better early response as well as long term disease control.
journal_name
J Cancer Res Therjournal_title
Journal of cancer research and therapeuticsauthors
Narasappa MG,Gururajachar JM,Chokkanna VK,Somashekar Mdoi
10.4103/0973-1482.197562subject
Has Abstractpub_date
2016-07-01 00:00:00pages
1167-1171issue
3eissn
0973-1482issn
1998-4138pii
JCanResTher_2016_12_3_1167_197562journal_volume
12pub_type
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