Abstract:
BACKGROUND:Ramucirumab, a fully human immunoglobulin G1 (IgG1) monoclonal antibody targeting vascular endothelial growth factor receptor-2 (VEGFR-2), has been approved for the treatment of advanced gastric cancer or gastroesophageal junction adenocarcinoma. Hypertension has been described as a common adverse event with ramucirumab, but the incidence and risk have not been well determined. We conduct this meta-analysis to investigate the overall incidence and risk of developing hypertension associated with use of ramucirumab. MATERIALS AND METHODS:Databases from PubMed, Web of Science, and abstracts presented at the American Society of Clinical Oncology (ASCO) meeting up to May 31, 2014, were searched to identify relevant studies. Eligible studies included prospective phase II and III trials evaluating ramucirumab in cancer patients with adequate data on hypertension. Statistical analyses were conducted to calculate the summary incidence, relative risk (RR), and 95% confidence intervals (CIs) by using either random--effect or fixed--effect models according to the heterogeneity of included studies. RESULTS:A total of 2,649 patients with a variety of solid tumors from eight prospective clinical trials were included in our analysis. The incidence of all--grade and high-grade hypertension associated with ramucirumab was 16.4% (95%CI: 11.9-22.3%) and 9.8% (95%CI: 7.2-13.0%), respectively. Patients treated with ramucirumab had a significantly increased risk of developing all-grade (RR: 2.28, 95%CI: 1.61-3.24, P < 0.001) and high-grade (RR: 3.59, 95%CI: 2.32-5.53, P < 0.001) hypertension compared with patients treated with control medication. No evidence of publication bias was observed. CONCLUSIONS:The use of ramucirumab is associated with a significantly increased risk of developing hypertension when compared with controls. Close monitoring and appropriate managements are recommended during the therapy.
journal_name
J Cancer Res Therjournal_title
Journal of cancer research and therapeuticsauthors
Qi WX,Fu S,Zhang Q,Guo XMdoi
10.4103/0973-1482.148700subject
Has Abstractpub_date
2016-04-01 00:00:00pages
775-81issue
2eissn
0973-1482issn
1998-4138pii
JCanResTher_2016_12_2_775_148700journal_volume
12pub_type
杂志文章,meta分析,评审abstract:Aims:To explore the biological roles of alpha-fetoprotein (AFP), a tumor-associated antigen in human hepatocellular carcinoma (HCC). Materials and Methods:After knockdown of AFP in HepG2 cells by transfection of specific Stealth™ RNAi, the expression of AFP were detected by reverse transcription polymerase chain react...
journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
doi:10.4103/0973-1482.180681
更新日期:2018-09-01 00:00:00
abstract:Objective:This study presents a method to estimate midplane dose (Diso, transit) in vivo from transit signal (St) measured with thimble ionization chamber in cancer of the middle-third esophagus patients treated with three-dimensional radiotherapy (RT). This detector is positioned at the level of electronic portal imag...
journal_title:Journal of cancer research and therapeutics
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doi:10.4103/jcrt.JCRT_278_17
更新日期:2018-01-01 00:00:00
abstract::Burkitt's lymphoma is an uncommon form of non-Hodgkin's lymphoma (NHL) in adults and represents < 5% of NHL adults. Burkitt's lymphoma involving primarily the appendicular skeleton is rarely described. We present the case of a young man with primary Burkitt's lymphoma involving the humerus as the only site of disease....
journal_title:Journal of cancer research and therapeutics
pub_type: 信件
doi:10.4103/0973-1482.148678
更新日期:2015-10-01 00:00:00
abstract:PURPOSE:This retrospective study aims to assess the cut-off value of thyroglobulin (Tg) levels in nux or metastatic well-differentiated thyroid cancers (DTCs) with normal anti-Tg levels using with fluorodeoxyglucose/positron emission tomography/computed tomography (FDG PET/CT). MATERIALS AND METHODS:We reviewed FDG PE...
journal_title:Journal of cancer research and therapeutics
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更新日期:2016-04-01 00:00:00
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journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
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更新日期:2016-01-01 00:00:00
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journal_title:Journal of cancer research and therapeutics
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doi:10.4103/jcrt.JCRT_269_18
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journal_title:Journal of cancer research and therapeutics
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更新日期:2017-01-01 00:00:00
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journal_title:Journal of cancer research and therapeutics
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doi:10.4103/0973-1482.168189
更新日期:2015-10-01 00:00:00
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journal_title:Journal of cancer research and therapeutics
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更新日期:2007-04-01 00:00:00
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journal_title:Journal of cancer research and therapeutics
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journal_title:Journal of cancer research and therapeutics
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abstract::Squamous cell carcinoma of urinary tract is a rarely encountered tumor. It is more frequently reported in urinary bladder and male urethra than renal pelvis. Squamous cell carcinoma of renal pelvis is usually associated with nephrolithiasis. However, coexistence of keratinizing squamous cell carcinoma with xanthogranu...
journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
doi:10.4103/0973-1482.73351
更新日期:2010-07-01 00:00:00
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journal_title:Journal of cancer research and therapeutics
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doi:10.4103/jcrt.JCRT_77_17
更新日期:2019-01-01 00:00:00
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journal_title:Journal of cancer research and therapeutics
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更新日期:2020-12-01 00:00:00
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journal_title:Journal of cancer research and therapeutics
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doi:10.4103/0973-1482.204887
更新日期:2017-07-01 00:00:00
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journal_title:Journal of cancer research and therapeutics
pub_type: 信件
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更新日期:2014-04-01 00:00:00
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journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章,评审
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abstract::An important approach for describing a region is to quantify its structure content. In this paper the use of functions for computing texture based on statistical measures is prescribed. MPM (Maximizer of the posterior margins) algorithm is employed. The segmentation based on texture feature would classify the breast t...
journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
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更新日期:2005-10-01 00:00:00
abstract::Papillary carcinoma is a well-differentiated type of thyroid carcinoma with very good overall prognosis. The commonest site of metastases is the lymph node, distant metastases being rare. We present a case of a 52-year-old male who presented with a solitary metastasis in the left para-sellar region and cavernous sinus...
journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章,评审
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更新日期:2013-10-01 00:00:00
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journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章,多中心研究
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更新日期:2014-01-01 00:00:00
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journal_title:Journal of cancer research and therapeutics
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更新日期:2018-07-01 00:00:00
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journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章,meta分析
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更新日期:2016-04-01 00:00:00
abstract::A solitary fibrous tumor is a rare spindle cell neoplasm originating from the mesenchyme. This type of tumor of the orbit is very uncommon and can be misdiagnosed as a hemangiopericytoma, fibrous histiocytoma, meningioma, or neurofibroma. We report an orbital solitary fibrous tumor in an 18-year-old male, with slow-gr...
journal_title:Journal of cancer research and therapeutics
pub_type: 信件
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更新日期:2019-07-01 00:00:00
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journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
doi:10.4103/0973-1482.189423
更新日期:2018-01-01 00:00:00
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更新日期:2018-09-01 00:00:00
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journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
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更新日期:2012-01-01 00:00:00
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journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
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更新日期:2013-04-01 00:00:00