Abstract:
Aim:Tumor-associated macrophages (TAMs) play a decisive role in the regulation of tumor progression by manipulating tumor oncogenesis, angiogenesis, and immune functions within tumor microenvironments. Tumor progression is frequently associated with a phenotypic switch from M1 to M2 in TAM. Activation of signal transducer and activator of transcription 3 (STAT3) in TAM lead to tumor-induced immunosuppression. STAT3 is usually constitutively activated in a variety of malignancies. Consequently, STAT3 has emerged as a promising target for cancer immunotherapy. Materials and Methods:In this study, J774A.1 cell line which is an M2 macrophage and overexpress STAT3 was cultured in Dulbecco's Modified Eagle Medium supplemented by fetal bovine serum. Then, the STAT3 silencing was evaluated by semi-quantitative reverse transcription-polymerase chain reaction (RT-PCR) using oligofectamine containing STAT3 short interfering RNA (siRNA). Oligofectamine containing STAT3 siRNA and control siRNA were added at a final concentration of 100 nM siRNA. The untransfected cells were considered as control group. Results:The semi-quantitative RT-PCR studies showed that J774A.1 cells express a high level of STAT3. Incubation of J774A.1 cells with oligofectamine containing STAT3 siRNA knockdown the STAT3 expression significantly both in 48 and 72 h study; however, the effect was more pronounced in 72 h study. Conclusion:The expression of STAT3 in J774A.1 cells confirmed that these cells are M2 macrophage. Moreover, silencing of STAT3 by siRNA delivery using oligofectamine delivery suggests that siRNA delivery using vehicles like nanoliposome could be a useful therapeutic agent in M2 macrophage therapy and its switch to M1 macrophages. This approach could be considered as a novel therapeutic agent for the treatment of all cancers.
journal_name
J Cancer Res Therjournal_title
Journal of cancer research and therapeuticsauthors
Seyedi Z,Hashemzadeh MR,Colagar AH,Jaafari MRdoi
10.4103/0973-1482.187298subject
Has Abstractpub_date
2018-07-01 00:00:00pages
1121-1125issue
5eissn
0973-1482issn
1998-4138pii
JCanResTher_2018_14_5_1121_187298journal_volume
14pub_type
杂志文章abstract:Objective:The aim of this study is to investigate the application and the feasibility of microwave ablation in laparoscopic partial splenectomy. Materials and Methods:From January 2018 to June 2019, four patients with benign spleen lesions in our hospital underwent laparoscopic partial splenectomy assisted by microwav...
journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
doi:10.4103/jcrt.JCRT_816_19
更新日期:2020-09-01 00:00:00
abstract:Aim of Study:Prostate cancer (PCa) is one of the most common cancers among men and has become a significant health problem in developing and developed countries. Prostate-specific antigen (PSA) is a useful marker for screening and monitoring the patients. In this study, the author aimed to detect the prevalence of PCa ...
journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
doi:10.4103/0973-1482.187387
更新日期:2018-10-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to evaluate the postoperative complications for patients with adenocarcinoma of esophagogastric junction. METHODS:Two hundred and eighty subjects with adenocarcinoma of esophagogastric junction who received operation were retrospectively analyzed from June 2006 to December 2010 ...
journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
doi:10.4103/0973-1482.163867
更新日期:2015-08-01 00:00:00
abstract:Objective:The objective of this study is to review the multidetector computed tomography (MDCT) findings of synchronous lymphoma and other solid malignancies. Patients and Methods:This retrospective study included 18 patients confirmed with diagnosis of lymphoma and other solid malignancies. They were 8 women and 10 m...
journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
doi:10.4103/jcrt.JCRT_325_17
更新日期:2020-01-01 00:00:00
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journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
doi:10.4103/0973-1482.126487
更新日期:2013-10-01 00:00:00
abstract::Acinic cell carcinoma (ACC) is a low-grade malignant salivary gland neoplasm that comprises approximately 17% of primary salivary gland malignancies or about 6% of all salivary gland neoplasms. The most common intraoral sites are the buccal mucosa, lips, and palate. The diagnosis of ACC frequently presents difficultie...
journal_title:Journal of cancer research and therapeutics
pub_type:
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更新日期:2020-04-01 00:00:00
abstract::Radiofrequency ablation (RFA) recently has been applied to benign thyroid nodules, mainly for the cosmetic reasons, and limited cases of local recurrences or focal distant metastases of well-differentiated thyroid cancer, in the high-risk reoperative condition or for the palliative purpose. But no report has been made...
journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
doi:10.4103/0973-1482.73328
更新日期:2010-07-01 00:00:00
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journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
doi:10.4103/0973-1482.174533
更新日期:2018-06-01 00:00:00
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journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
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更新日期:2012-01-01 00:00:00
abstract::Heat shock protein 90 (Hsp90) a member of the heat shock proteins (HSPs) family, is an adenosine triphosphate dependent molecular chaperone protein, which integrates multiple oncogenic pathways. Clinically, encouraging results have been demonstrated in melanoma, acute myeloid leukemia, castrate refractory prostate can...
journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章,评审
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更新日期:2013-10-01 00:00:00
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journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
doi:10.4103/0973-1482.77087
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journal_title:Journal of cancer research and therapeutics
pub_type: 信件
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journal_title:Journal of cancer research and therapeutics
pub_type: 信件,评审
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journal_title:Journal of cancer research and therapeutics
pub_type: 信件
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更新日期:2015-10-01 00:00:00
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journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章,评审
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journal_title:Journal of cancer research and therapeutics
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doi:10.4103/jcrt.JCRT_258_17
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journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
doi:10.4103/0973-1482.137910
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journal_title:Journal of cancer research and therapeutics
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doi:10.4103/0973-1482.150349
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journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章,评审
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journal_title:Journal of cancer research and therapeutics
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journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章,评审
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journal_title:Journal of cancer research and therapeutics
pub_type: 信件
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更新日期:2015-07-01 00:00:00
abstract::Chondrosarcoma is the most common malignant tumor of the chest wall. Most patients present with painful progressive swelling in the anterior chest wall arising from the costochondrosternal junction. CT scan with intravenous contrast is the investigation of choice. Wide excision with adequate margins is the standard tr...
journal_title:Journal of cancer research and therapeutics
pub_type: 信件,评审
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journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章,meta分析
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更新日期:2016-12-01 00:00:00
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journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
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更新日期:2009-01-01 00:00:00
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journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
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journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章,收录出版
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更新日期:2014-07-01 00:00:00
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journal_title:Journal of cancer research and therapeutics
pub_type: 信件,评审
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更新日期:2015-10-01 00:00:00
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journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章,meta分析,评审
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更新日期:2016-10-01 00:00:00