Abstract:
BACKGROUND:Synovial sarcoma (SS) is a rare disease and compared with other soft-tissue sarcomas has a relatively high mortality rate. The optimal management of this disease and prognostic factors associated with patient outcome remains controversial. AIMS:We aimed to evaluate the factors affecting the outcomes of SS patients in the adjuvant setting. PATIENTS AND METHODS:In this Turkish multicenter study, we assessed the data of 69 SS patients regarding prognostic factors for SS patients retrospectively. RESULTS:Our study included 69 localized SS patients (38 males and 31 females) with a median age of 34.5 years (minimum-maximum: 14-68 years). Overall survival (OS) and disease free survival (DFS) rates for 5 years were 64% and 25%, respectively. All patients under went surgical treatment; 64 patients were treated with a wide excision and 5 patients had an amputation. According to the univariate analysis, adverse prognostic factors for OS were male sex, higher mitotic activity, high Ki-67 levels, trunk localization and inadequate surgical margins. In multivariate analysis, none of these factors had independent significant association with OS. Prognostic factors for DFS; in the univariate analysis were higher mitotic activity, high Ki-67 levels and inadequate surgical margins. Only higher mitotic activity (≥10 high-power field) was significantly associated with worse DFS in the multivariate analysis (hazard ratio: 0.30, % confidence interval: 0.11-0.80, P = 0.017). CONCLUSION:Our study confirms that high mitotic activity is significantly associated with decreased DFS. The question of whether the chemotherapy provides a survival advantage in patients having adverse prognostic factors requires confirmation in randomized trials.
journal_name
J Cancer Res Therjournal_title
Journal of cancer research and therapeuticsauthors
Tarkan Y,Erkan A,Selcuk ES,Mehmet K,Tugba KF,Ozlem US,Suleyman A,Tulay A,Bilge A,Ramazan Y,Yusuf G,Mevlude I,Umut D,Ilhan O,Abdurrahman I,Alper S,Dogan U,Necati A,Berna O,Gok DA,Ugur Y,Mahmut Gdoi
10.4103/0973-1482.131381subject
Has Abstractpub_date
2014-01-01 00:00:00pages
73-8issue
1eissn
0973-1482issn
1998-4138pii
JCanResTher_2014_10_1_73_131381journal_volume
10pub_type
杂志文章,多中心研究abstract::Malignant melanoma has been reported to affect all organs of the human body with the metastasis. Stomach metastases are quite rare in cases of the most commonly reported primaries including, melanoma and breast, and lung carcinomas. This report involves, a 56-year-old man suffering from melanoma of the lower extremity...
journal_title:Journal of cancer research and therapeutics
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journal_title:Journal of cancer research and therapeutics
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journal_title:Journal of cancer research and therapeutics
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journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章,评审
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journal_title:Journal of cancer research and therapeutics
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pub_type: 杂志文章,随机对照试验
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journal_title:Journal of cancer research and therapeutics
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journal_title:Journal of cancer research and therapeutics
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更新日期:2014-12-01 00:00:00
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journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章,meta分析
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journal_title:Journal of cancer research and therapeutics
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journal_title:Journal of cancer research and therapeutics
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pub_type: 杂志文章
doi:10.4103/0973-1482.184512
更新日期:2017-04-01 00:00:00
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journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
doi:10.4103/0973-1482.146056
更新日期:2015-07-01 00:00:00
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journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
doi:10.4103/0973-1482.110384
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journal_title:Journal of cancer research and therapeutics
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journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
doi:10.4103/0973-1482.131338
更新日期:2014-01-01 00:00:00
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journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
doi:10.4103/0973-1482.145866
更新日期:2014-11-01 00:00:00
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journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章,meta分析
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更新日期:2018-12-01 00:00:00