Long-term outcomes of patients with papillary thyroid cancer who did not undergo prophylactic central neck dissection.

Abstract:

Aims:The role of prophylactic central neck dissection (CND) in the management of papillary thyroid carcinoma (PTC) is controversial. This study reports outcomes of an observational approach in PTC patients without clinical evidence of lymph node metastasis. Materials and Methods:Patients with PTC who had surgery (without prophylactic CND) between January 2000 and December 2008 were included in this study. Recurrence-free survival (RFS) and disease-specific survival (DSS) were calculated using the Kaplan-Meier method. Cox regression was used in multivariable models. Results:Out of 625 patients, 486 (77.8%) were female, 144 (23%) were aged 55 years or more, 73 (11.7%) had macroscopic extrathyroidal extension, and 79 (12.7%) had pT3 or pT4 disease. Samples were collected from 12 (1.9%) patients with lymph node metastasis in the perithyroidal tissue and 2 (0.3%) patients with lymph node metastasis in the lateral neck lymph tissue for frozen section examination. After a median follow-up of 104 months, the 10-year DSS and RFS rates were 99.7% and 90.2%, respectively. The 10-year lymph node recurrence rate in the central compartment was 2.7%. pT3/4 stage was an independent predictive factor for RFS (P < 0.001, hazard ratio 1.966, 95% confidence interval 1.446-2.673). Conclusion:The outcomes of patients with clinically negative lymph nodes in the central compartment were favorable without prophylactic CND.

journal_name

J Cancer Res Ther

authors

Huang H,Wu L,Liu W,Liu J,Liu Y,Xu Z

doi

10.4103/jcrt.JCRT_620_19

subject

Has Abstract

pub_date

2020-09-01 00:00:00

pages

1077-1081

issue

5

eissn

0973-1482

issn

1998-4138

pii

JCanResTher_2020_16_5_1077_296441

journal_volume

16

pub_type

杂志文章
  • Search of an ideal location of isocenter in intensity-modulated radiotherapy treatment plans: A dosimetrical approach.

    abstract:Aim:The aim of this study is to identify an ideal location of isocenter in intensity-modulated radiotherapy (IMRT) treatment plans. Materials and Methods:A total of 28 clinical target volumes and 4 English capital letters (C, L, T, and H) target volumes were considered in this study. Two IMRT treatment plans were gene...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/jcrt.JCRT_985_16

    authors: Mandal A,Asthana AK,Pradhan S,Shahi UP,Choudhary S

    更新日期:2019-01-01 00:00:00

  • Immunological subtypes analysis of Uygur diffuse large B-cell lymphoma in Xinjiang and their prognostic significance.

    abstract:OBJECTIVE:This study aims to explore the application of Choi's typing method in the immunological typing of diffuse large B-cell lymphoma (DLBCL) in Xinjiang Autonomous Region and its prognostic significance. MATERIALS AND METHODS:Seventy-eight cases of DLBCL tumor tissues from Xinjiang were collected to detect the ex...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/0973-1482.144357

    authors: Jia CD,Liang LP,Yang LL,Yue N,Zhao F,Bai JP

    更新日期:2015-10-01 00:00:00

  • Protective effect of ayurvedic formulations against doxorubicin-induced cardiotoxicity: Preliminary studies on Brahma Rasayana and Chyavanaprash.

    abstract:AIM OF STUDY:The present work aimed to examine the efficacy of two ayurvedic formulations, Brahma Rasayana (BRM) and Chyavanaprash (CHM) to alleviate doxorubicin (DOX) induced acute cardiotoxicity. MATERIALS AND METHODS:Swiss albino mice were administered with DOX (25 mg/kg, i.p.) and two doses of BRM or CHM (1 and 2 ...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/0973-1482.151931

    authors: AlSuhailbani E,Menon A,Nair CK

    更新日期:2016-04-01 00:00:00

  • Evaluation of the organs at risk doses for lung tumors in gated and conventional radiotherapy.

    abstract:Purpose:The purpose of this study was to evaluate the organs at risk (OARs) doses for lung tumors in gated radiotherapy (RT) compared to conventional RT using the four-dimensional extended cardiac-torso (4D-XCAT) digital phantom in a simulation study. Materials and Methods:4D-XCAT digital phantom was used to create 32...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/jcrt.JCRT_735_18

    authors: Shahzadeh S,Gholami S,Aghamiri SMR,Mahani H,Nabavi M

    更新日期:2020-07-01 00:00:00

  • Cutaneous metastasis of transitional cell bladder carcinoma: a rare presentation and literature review.

    abstract::Cutaneous metastasis from transitional cell bladder carcinoma is a rare clinical entity associated with poor prognosis. We present a case of cutaneous metastasis arising from a transitional cell bladder carcinoma in a male patient who had undergone a radical cystectomy and bilateral ureterostomy 17 months previously. ...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章,评审

    doi:10.4103/0973-1482.82940

    authors: Salemis NS,Gakis C,Zografidis A,Gourgiotis S

    更新日期:2011-04-01 00:00:00

  • Renal cell carcinoma presenting with heart metastasis without inferior vena caval and right atrial involvement.

    abstract::Heart metastasis of renal cell carcinoma (RCC) without vena cava inferior involvement is exceptionally rare. Here, we presented a case of RCC presenting with the right ventricle metastasis without inferior vena caval and right atrial involvement. ...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 信件

    doi:10.4103/0973-1482.193111

    authors: Sahin S,Karatas F,Hacioglu MB,Aytekin A,Cilbir E,Conkbayir I

    更新日期:2018-01-01 00:00:00

  • MRI diagnosis of intradural extramedullary tumors.

    abstract:OBJECTIVE:This study evaluates the magnetic resonance imaging (MRI) manifestation of intradural extramedullary (IDEM) tumors to improve the imaging diagnostic level. MATERIALS AND METHODS:From January 2005 to December 2012, a retrospective analysis of the MRI examination was performed on 108 patients with IDEM tumors ...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/0973-1482.137993

    authors: Gu R,Liu JB,Zhang Q,Liu GY,Zhu QS

    更新日期:2014-10-01 00:00:00

  • Good prognostic factor in patients with nonmetastatic nasopharyngeal carcinoma: Programmed death ligand-1 expression in tumor cells.

    abstract:Purpose:Programmed death ligand-1 (PD-L1) is the main ligand for programmed death-1 (PD-1), and is one of the major targets for cancer immunotherapy. Only a few studies are available for the clinical significance of PD-1/PD-L1 in nasopharyngeal carcinoma (NPC). There is a controversial association between PD-L1 express...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/jcrt.JCRT_759_19

    authors: Sahinli H,Akyürek N,Yılmaz M,Kandemir O,Duran AO,Kulaçoǧlu S,Uçar G,Acar E,Özet A,Öksüzoǧlu OBÇ,Özdemir NY

    更新日期:2020-12-01 00:00:00

  • What is the role of florine-18 fluorodeoxyglucose/positron emission tomography/computed tomography imaging in well-differentiated thyroid cancers with negative iodine-131 scan high thyroglobulin and normal anti-thyroglobulin levels.

    abstract:PURPOSE:This retrospective study aims to assess the cut-off value of thyroglobulin (Tg) levels in nux or metastatic well-differentiated thyroid cancers (DTCs) with normal anti-Tg levels using with fluorodeoxyglucose/positron emission tomography/computed tomography (FDG PET/CT). MATERIALS AND METHODS:We reviewed FDG PE...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/0973-1482.176412

    authors: Döner RK,Sager S,Görtan FA,Topuz ÖV,Akyel R,Vatankulu B,Baran A,Teksoz S,Sönmezoglu K

    更新日期:2016-04-01 00:00:00

  • Care givers' depression, anxiety, distress, and somatization as predictors of identical symptoms in cancer patients.

    abstract:CONTEXT:The critical condition of the cancer patient and the stringent medical procedures do not often warrant the accessibility of the patient for psychological evaluation. Therefore, the study is conceptualized to assess the psychological problems of caregivers, which in turn have their impact upon cancer patients. ...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/0973-1482.146088

    authors: Padmaja G,Vanlalhruaii C,Rana S,Nandinee D,Hariharan M

    更新日期:2016-01-01 00:00:00

  • Efficacy of tyrosine kinase inhibitors in routine clinical practice: epidermal growth factor mutations and their implications.

    abstract:BACKGROUND:Activating mutations in the epidermal growth factor (EGFR) gene confer sensitivity to the tyrosine kinase inhibitors (TKIs) in patients with advanced non-small cell lung cancer (NSCLC). TKI treatment efficacy and EGFR mutation implications were evaluated in clinically selected advanced NSCLC patients treated...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/0973-1482.113379

    authors: Ovcaricek T,Cufer T,Kern I,Sodja E,Sadikov A

    更新日期:2013-04-01 00:00:00

  • Multiple subcutaneous metastases as the solitary presenting site of colorectal cancer.

    abstract::Skin metastases, as a presenting symptom of gastrointestinal malignancies, are very rare and signify aggressive disease. They usually occur after a long period of diagnosis and along with other visceral metastases. We present the case of an 18-year-old male with diffuse subcutaneous metastases as a presenting feature ...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 信件

    doi:10.4103/0973-1482.172586

    authors: Nallathambi C,Singh IY,Patton Z

    更新日期:2018-04-01 00:00:00

  • Efficacy of apatinib on multiple advanced-stage nongastric cancers.

    abstract:Background:Apatinib has been approved for the treatment of advanced gastric adenocarcinoma and gastric-esophageal junctional adenocarcinoma, but its efficacy is unknown for other advanced solid tumors. Aims and Objectives:We retrospectively reviewed the use of apatinib for multiple advanced-stage non-gastric cancers. ...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/jcrt.JCRT_24_19

    authors: Wu X,Wang H,Wu Y,Jin J,Zhan Y,Zhu G,Zhang F,Zhang C,Gan J,Li W

    更新日期:2019-01-01 00:00:00

  • Primary synchronous mesenteric neuroendocrine tumors: Report of a rare case with review of literature.

    abstract::Most neuroendocrine tumors of the gastrointestinal tract are traditionally termed "carcinoid tumors." More than 90% of all gastrointestinal carcinoids are located in the appendix, small intestine, rectum, and mesenteric carcinoids are rare. Even when invasive, most carcinoids are relatively indolent and display minima...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 信件,评审

    doi:10.4103/0973-1482.138108

    authors: Kamath SM,Pingali S,Girish G,Harish K

    更新日期:2015-07-01 00:00:00

  • Metastatic brain tumors from small-cell esophageal cancer: clinical characteristics and outcome.

    abstract:AIMS:Few studies have examined the clinical characteristics of patients with brain metastases from small-cell esophageal cancer. In this study, we review the clinical characteristics and outcomes in patients with brain metastases from small-cell esophageal cancer. PATIENTS AND METHODS:From August 2002 to August 2012, ...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/0973-1482.151469

    authors: Feng W,Harada H,Zhang P,Mitsuya K,Zheng X,Yasui H,Nakasu Y,Chen M,Nishimura T

    更新日期:2014-12-01 00:00:00

  • Tooth agenesis: A susceptible indicator for colorectal cancer?

    abstract:Context/Background:Tooth agenesis (excluding third molars) is a common congenital disorder that affects 2.2-10% of the general population. A number of different genes have been shown to be associated with cases of tooth agenesis including AXIN2, IRF6, FGFR1, MSX1, PAX9, and TGFA. Wingless/integration signaling gene, AX...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/0973-1482.168997

    authors: Paranjyothi MV,Kumaraswamy KL,Begum LF,Manjunath K,Litha.,Basheer S

    更新日期:2018-04-01 00:00:00

  • Morphometric computer-assisted image analysis of epithelial cells in different grades of oral squamous cell carcinoma.

    abstract:Introduction:Oral squamous cell carcinoma (OSCC) accounts 94% of all malignant lesions in the oral cavity. In the assessment of OSCC, nowadays the WHO grading system has been followed widely but due to its subjectivity, investigators applied the sophisticated technique of computer-assisted image analysis in the grading...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/0973-1482.189423

    authors: Ananjan C,Jyothi M,Laxmidevi BL,Gopinathan PA,Nazir SH,Pradeep L

    更新日期:2018-01-01 00:00:00

  • Efficacy of alpha lipoic acid in adjunct with intralesional steroids and hyaluronidase in the management of oral submucous fibrosis.

    abstract:BACKGROUND AND OBJECTIVES:Oral submucous fibrosis (OSF) is a chronic irreversible condition of the oral mucosa with proven malignant potential. However, till date, there has been a dearth of effective management strategies. This study used alpha lipoic acid, an antioxidant, in oral form to determine if it could be usef...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/0973-1482.77087

    authors: Rao PK

    更新日期:2010-10-01 00:00:00

  • The expression and prognostic significance of Mucin 13 and Mucin 20 in esophageal squamous cell carcinoma.

    abstract:BACKGROUND:Mucin 13 (MUC13) and Mucin 20 (MUC20) are high molecular weight transmembrane O-linked glycoprotein secreted by epithelium and are widely overexpressed in epithelial tumor cells. Previously, it has been reported that MUC13 and MUC20 were prognostic molecular biomarkers of some epithelial tumors, but few has ...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/0973-1482.163846

    authors: Wang H,Shen L,Lin Y,Shi Q,Yang Y,Chen K

    更新日期:2015-08-01 00:00:00

  • Systemic lupus erythematous increased lung cancer risk: Evidence from a meta-analysis.

    abstract:AIMS:Several studies suggested that systemic lupus erythematosus (SLE) were associated with the risk of lung cancer. However, other studies did not confirm the result. Therefore, we conducted a meta-analysis to investigate this association. MATERIALS AND METHODS:A systematic literature search was conducted using the P...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章,meta分析

    doi:10.4103/0973-1482.172115

    authors: Wu Y,Hou Q

    更新日期:2016-04-01 00:00:00

  • Radiotherapy for management of skin cancers in fibrodysplasia ossificans progressiva: a case report and review of the literature.

    abstract::Fibrodysplasia ossificans progressiva (FOP) is a rare condition of ectopic calcification leading to increasing disability throughout life, with most patients being wheelchair bound by the age of 30. Ectopic calcification can be triggered by trauma and it is therefore important to minimize biopsies and operative proced...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/0973-1482.39603

    authors: Frew JA,Kelly CG

    更新日期:2008-01-01 00:00:00

  • An overview on small-field dosimetry in photon beam radiotherapy: Developments and challenges.

    abstract::Small fields are more repeatedly used for radiation therapy as small segments in intensity-modulated radiotherapy or as in the form of independent fields in stereotactic radiosurgery and other novel equipment such as cyberknife and tomotherapy. Nevertheless, the application of small fields for radiotherapy of lung mak...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章,评审

    doi:10.4103/0973-1482.199444

    authors: Bagheri H,Soleimani A,Gharehaghaji N,Mesbahi A,Manouchehri F,Shekarchi B,Dormanesh B,Dadgar HA

    更新日期:2017-04-01 00:00:00

  • Ezrin expression in the primary hepatocellular carcinoma patients and associated with clinical, pathological characteristics.

    abstract:OBJECTIVE:The aim of this study was to assess Ezrin expression in the primary hepatic carcinoma patients and associated with clinical, pathological characteristics. MATERIALS AND METHODS:Fifty-one patients with primary hepatocellular carcinoma (PHC) with completed clinical data were retrospectively analyzed in this st...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/0973-1482.200761

    authors: Pan D,Wang S,Ye H,Xu S,Ye G

    更新日期:2016-12-01 00:00:00

  • The clinical significance of ultrasound grayscale ratio in differentiating markedly hypoechoic and anechoic minimal thyroid nodules.

    abstract:Purpose:This study explored ultrasound grayscale ratios (USGRs) for differentiating markedly hypoechoic and anechoic minimal thyroid nodules. Materials and Methods:Longitudinal scan images of 193 markedly hypoechoic papillary thyroid microcarcinoma (PTMC) lesions from 184 patients were retrospectively reviewed using R...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/jcrt.JCRT_1031_17

    authors: Lei ZK,Li MK,Luo DC,Han ZJ

    更新日期:2018-01-01 00:00:00

  • Antiproliferative activity of Camellia sinensis mediated silver nanoparticles on three different human cancer cell lines.

    abstract:Introduction:Cancer is one of the leading causes of mortality in the world and there are many types of cancer. The current treatments against cancer are surgery, chemotherapy, and radiation therapy, but these come with varied side effects as they harm noncancer cells too. Therefore, search for new treatments is one of ...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/jcrt.JCRT_575_16

    authors: Yadav A,Mendhulkar VD

    更新日期:2018-10-01 00:00:00

  • Antitumoral potential of microvesicles extracted from human adipose-derived mesenchymal stem cells on human breast cancer cells.

    abstract:Aim of Study:One of the new methods that have promising results is the use of cell-derived microvesicles (MVs) to kill tumor cells. Given that MVs contain apoptotic materials, genes, and proteins, they can interfere with the fate of adjacent cells. Materials and Methods:In the present study, after adipose tissue-deriv...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/jcrt.JCRT_147_18

    authors: Rezaie Z,Ardeshirylajimi A,Ashkezari MD,Seifati SM

    更新日期:2019-07-01 00:00:00

  • The effect of metabolic syndrome on prostate cancer final pathology.

    abstract:Aim of Study:Metabolic syndrome (MetS) is an abnormality that increases the risk of cardiovascular disease and diabetes. In the recent years, studies showed that MetS is associated with increased risk of incidence, aggressiveness, and mortality of prostate cancer (PCa). We examined the influence of MetS at final pathol...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/0973-1482.187290

    authors: Caliskan S,Kaba S,Özsoy E,Keleş MO,Koca O,Akyüz M,Karaman MI

    更新日期:2019-03-01 00:00:00

  • Primary extraneural ependymoma of the broad ligament: A rare entity.

    abstract::Extraneural broad ligament ependymoma is a rare entity. Herein, we present a case of unusually large broad ligament ependymoma in a 32-year-old female with pain and lump in the lower abdomen. Contrast-enhanced computed tomography abdomen revealed multiple heterogeneously enhancing pelvic masses with lobulated surface ...

    journal_title:Journal of cancer research and therapeutics

    pub_type:

    doi:10.4103/jcrt.JCRT_672_17

    authors: Kumari A,Diwaker P,Gogoi P,Arora VK,Garg PK,Pandey R

    更新日期:2019-10-01 00:00:00

  • Clinical significance of Twist, E-cadherin, and N-cadherin protein expression in endometrioid adenocarcinoma.

    abstract:OBJECTIVE:The aim of the study was to investigate the expression of Twist, E-cadherin, and N-cadherin both in normal endometrium and in endometrioid adenocarcinoma tissues (NET and EAT), and further discuss the relationship between the proteins expression and the clinical parameters. METHODS:Seventy-six EAT and 50 NET...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/jcrt.JCRT_405_17

    authors: Xie X,Zheng X,Wang J,Chen L

    更新日期:2017-01-01 00:00:00

  • Primary spinal glioblastoma treated with adjuvant radiation and temozolomide: Report of two cases.

    abstract::Primary spinal glioblastoma multiforme (GBM) is a rare entity, which is invariably associated with poor outcome. Standard treatment is surgery followed by post-operative radiotherapy. Due to paucity of cases role of chemotherapy is investigational. We intend to report two cases of primary spinal GBM treated with radia...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 信件

    doi:10.4103/0973-1482.137998

    authors: Mallick S,Madan R,Julka PK

    更新日期:2015-07-01 00:00:00