Abstract:
Aims:The role of prophylactic central neck dissection (CND) in the management of papillary thyroid carcinoma (PTC) is controversial. This study reports outcomes of an observational approach in PTC patients without clinical evidence of lymph node metastasis. Materials and Methods:Patients with PTC who had surgery (without prophylactic CND) between January 2000 and December 2008 were included in this study. Recurrence-free survival (RFS) and disease-specific survival (DSS) were calculated using the Kaplan-Meier method. Cox regression was used in multivariable models. Results:Out of 625 patients, 486 (77.8%) were female, 144 (23%) were aged 55 years or more, 73 (11.7%) had macroscopic extrathyroidal extension, and 79 (12.7%) had pT3 or pT4 disease. Samples were collected from 12 (1.9%) patients with lymph node metastasis in the perithyroidal tissue and 2 (0.3%) patients with lymph node metastasis in the lateral neck lymph tissue for frozen section examination. After a median follow-up of 104 months, the 10-year DSS and RFS rates were 99.7% and 90.2%, respectively. The 10-year lymph node recurrence rate in the central compartment was 2.7%. pT3/4 stage was an independent predictive factor for RFS (P < 0.001, hazard ratio 1.966, 95% confidence interval 1.446-2.673). Conclusion:The outcomes of patients with clinically negative lymph nodes in the central compartment were favorable without prophylactic CND.
journal_name
J Cancer Res Therjournal_title
Journal of cancer research and therapeuticsauthors
Huang H,Wu L,Liu W,Liu J,Liu Y,Xu Zdoi
10.4103/jcrt.JCRT_620_19subject
Has Abstractpub_date
2020-09-01 00:00:00pages
1077-1081issue
5eissn
0973-1482issn
1998-4138pii
JCanResTher_2020_16_5_1077_296441journal_volume
16pub_type
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