Multiple subcutaneous metastases as the solitary presenting site of colorectal cancer.

Abstract:

:Skin metastases, as a presenting symptom of gastrointestinal malignancies, are very rare and signify aggressive disease. They usually occur after a long period of diagnosis and along with other visceral metastases. We present the case of an 18-year-old male with diffuse subcutaneous metastases as a presenting feature and as the only site of distant metastases due to rectosigmoid adenocarcinoma. They clinically mimic benign skin lesions and the patient might not present to an oncologist. The diagnosis has to be established by skin biopsy, which will show tumor cell infiltration of the epidermis, dermis, and/or subcutaneous fat. There is no established local treatment for diffuse lesions. Systemic chemotherapy indicated for metastatic colon carcinoma was employed with not much favorable response. Irinotecan based chemotherapy also resulted in posterior reversible encephalopathy syndrome in this patient. Overall, the disease carries a poor prognosis and with no effective treatment available the survival is less than a year.

journal_name

J Cancer Res Ther

authors

Nallathambi C,Singh IY,Patton Z

doi

10.4103/0973-1482.172586

subject

Has Abstract

pub_date

2018-04-01 00:00:00

pages

716-718

issue

3

eissn

0973-1482

issn

1998-4138

pii

JCanResTher_2018_14_3_716_172586

journal_volume

14

pub_type

信件
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