Abstract:
Introduction:Cancer is one of the leading causes of mortality in the world and there are many types of cancer. The current treatments against cancer are surgery, chemotherapy, and radiation therapy, but these come with varied side effects as they harm noncancer cells too. Therefore, search for new treatments is one of the important research areas nowadays and nanoparticles are one such potential anticancer agent. Aim of the Study:We hypothesized that silver nanoparticles and tea extract may have anticancer activities along with their synergistic counterparts with adriamycin (ADR) on HT-29 human colon cancer cell line, MCF-7 human breast cancer cell line, and MOLT-4 human leukemia cancer cell line. Materials and Methods:The biosynthesized silver nanoparticles were characterized by ultraviolet-visible spectroscopy, nanoparticle tracking analyzer (NTA), X-ray diffraction, scanning electron microscopy, transmission electron microscopy (TEM), and Fourier transform infrared analysis. The cytotoxic activity was measured using the sulforhodamine B assay protocol on the HT-29, MCF-7, and MOLT-4 cell lines. Results:The synthesized AgNPs gave absorption maxima at 415 nm, with four different diffraction peaks (°2θ values) corresponding to the face centered cubic silver lines. Our results showed that AgNPs exhibited the highest cytotoxic activity at 20 μg/mL concentration against all the three cell lines followed by the combination of AgNPs+ADR. Conclusion:The superior activity of the silver nanoparticles may be due to its spherical shape and smaller particle size 10-30 nm as confirmed from NTA and TEM analysis. The data obtained in the study reveal the potent therapeutic value of biogenic silver nanoparticles.
journal_name
J Cancer Res Therjournal_title
Journal of cancer research and therapeuticsauthors
Yadav A,Mendhulkar VDdoi
10.4103/jcrt.JCRT_575_16subject
Has Abstractpub_date
2018-10-01 00:00:00pages
1316-1324issue
6eissn
0973-1482issn
1998-4138pii
JCanResTher_2018_14_6_1316_231357journal_volume
14pub_type
杂志文章abstract:AIMS:Circulating extracellular micro ribonucleic acids (miRNAs) are considered as potential biomarkers for malignancy detection and diagnosis. The aim of this study was to determine whether circulating miRNA-148/152 family (miR-148a, miR-148b, and miR-152) expression in plasma could be used as potential biomarkers for ...
journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
doi:10.4103/0973-1482.150420
更新日期:2016-04-01 00:00:00
abstract::Complementary and alternative medicine (CAM) use among cancer patients is widely prevalent and often underreported. Advanced stage of disease is significantly associated with CAM use. The concurrent use of alternative medicines and chemotherapy drugs has the potential to lead to toxicities as well as altered therapeut...
journal_title:Journal of cancer research and therapeutics
pub_type: 信件
doi:10.4103/0973-1482.171362
更新日期:2015-10-01 00:00:00
abstract::Camrelizumab is a programmed death receptor-1 inhibitor originally developed in China for the treatment of refractory lymphoma. It has also been effective in non-small-cell lung cancer patients. However, the rechallenge of camrelizumab was not reported previously. We report the rechallenge of camrelizumab therapy in t...
journal_title:Journal of cancer research and therapeutics
pub_type:
doi:10.4103/jcrt.JCRT_798_20
更新日期:2020-09-01 00:00:00
abstract:Purpose:The purpose of this study was to evaluate the organs at risk (OARs) doses for lung tumors in gated radiotherapy (RT) compared to conventional RT using the four-dimensional extended cardiac-torso (4D-XCAT) digital phantom in a simulation study. Materials and Methods:4D-XCAT digital phantom was used to create 32...
journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
doi:10.4103/jcrt.JCRT_735_18
更新日期:2020-07-01 00:00:00
abstract:AIM OF STUDY:Embelin and celastrol, inhibitors of XIAP and NF-κB proteins respectively, have been derived from natural sources and shown anti-tumor activities against different cancer cell lines. Some interactions have recently been discovered between XIAP and NF-κB pathways, but the effects of these inhibitors in comb...
journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
doi:10.4103/0973-1482.150407
更新日期:2016-01-01 00:00:00
abstract:Purpose:The aim of the study is to study the feasibility of gamma-ray-detection-based precision dose measurement of 125I seed brachytherapy in solid water. Materials and Methods:Seven group 125I seeds with different activities were put into a hole in the center of solid water individually. Each group had ten seeds, an...
journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
doi:10.4103/jcrt.JCRT_522_18
更新日期:2019-01-01 00:00:00
abstract::Cutaneous metastasis from transitional cell bladder carcinoma is a rare clinical entity associated with poor prognosis. We present a case of cutaneous metastasis arising from a transitional cell bladder carcinoma in a male patient who had undergone a radical cystectomy and bilateral ureterostomy 17 months previously. ...
journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章,评审
doi:10.4103/0973-1482.82940
更新日期:2011-04-01 00:00:00
abstract:OBJECTIVE:To explore the outcome and prognostic factors of recursive partitioning analysis (RPA) Class III brain metastatic patients treated with stereotactic radiotherapy (SRT). MATERIALS AND METHODS:Fifty-six consecutive patients with metastatic brain tumors and Karnofsky performance scale (KPS) scores <70 treated w...
journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
doi:10.4103/0973-1482.160925
更新日期:2016-01-01 00:00:00
abstract:Aim of Study:One of the new methods that have promising results is the use of cell-derived microvesicles (MVs) to kill tumor cells. Given that MVs contain apoptotic materials, genes, and proteins, they can interfere with the fate of adjacent cells. Materials and Methods:In the present study, after adipose tissue-deriv...
journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
doi:10.4103/jcrt.JCRT_147_18
更新日期:2019-07-01 00:00:00
abstract:Objective:The aim of this study is to investigate the application and the feasibility of microwave ablation in laparoscopic partial splenectomy. Materials and Methods:From January 2018 to June 2019, four patients with benign spleen lesions in our hospital underwent laparoscopic partial splenectomy assisted by microwav...
journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
doi:10.4103/jcrt.JCRT_816_19
更新日期:2020-09-01 00:00:00
abstract::Retroperitoneal leiomyosarcoma is relatively uncommon. Leiomyosarcoma has accounted for about 5%-10% of soft-tissue sarcoma, and 1/2-2/3 of the primary lesions were retroperitoneal, with a cumulative 5-year survival rate of only 35%.Leiomyosarcoma is one kind of soft-tissue sarcoma with the lowest survival rates due t...
journal_title:Journal of cancer research and therapeutics
pub_type:
doi:10.4103/jcrt.JCRT_66_18
更新日期:2020-01-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) is one of the most common malignant tumors. Currently, the main effective treatment options for HCC include resection, liver transplantation, various percutaneous modalities (such as transarterial chemoembolization [TACE] and thermal ablation), and tyrosine kinase inhibitors (TKIs). Here...
journal_title:Journal of cancer research and therapeutics
pub_type:
doi:10.4103/jcrt.JCRT_101_20
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to investigate the value of two quantitative indicators, the apparent diffusion coefficient (ADC) and the exponent apparent diffusion coefficient (EADC), of magnetic resonance imaging (MRI) diffusion-weighted imaging (DWI) in the differential diagnosis of ovarian epithelial tumors. ...
journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
doi:10.4103/0973-1482.163667
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:The profiles of lipids in normal and cancerous tissues may differ revealing information about cancer development and progression. Lipids being surface active, changes in lipid profiles can manifest as altered surface activity profiles. Langmuir monolayers offer a convenient model for evaluating surface activ...
journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
doi:10.4103/0973-1482.19600
更新日期:2005-07-01 00:00:00
abstract::Hematological disorders, especially single lineage abnormalities, have been described in hyperthyroidism. Pancytopenia has been reported, without myelodysplastic syndrome or megaloblastic anemia. We studied the peripheral blood smear and the bone marrow aspiration and biopsy of a 65-year-old lady, who presented with p...
journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
doi:10.4103/0973-1482.31972
更新日期:2007-01-01 00:00:00
abstract:Background and Objectives:Human chorionic gonadotropin-β (hCGβ) is a hormone glycoprotein usually secreted by trophoblastic cells in early pregnancy and helps in growth and development of the embryo. While many trophoblastic and nontrophoblastic malignancies express elevated levels of hCGβ in serum, increased immunohis...
journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
doi:10.4103/0973-1482.184523
更新日期:2018-07-01 00:00:00
abstract:INTRODUCTION:Using physical wedges (PWs) to modify dose distribution and more homogeneous target coverage is a well-established technique. However, there are many problems with PWs known as beam hardening, which made them problematic. This can be overcome by dynamic wedges which do not filter beam. Comparison of physic...
journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
doi:10.4103/0973-1482.206244
更新日期:2017-01-01 00:00:00
abstract:Aim:The aims of this study are to evaluate the serum levels of paraoxonase (PON) and arylesterase (ARE) in breast cancer (BC) patients; to determine their relationship with chemotherapy requirements in BC; and to find a cut-off value to assess subjects with a higher risk of BC. Subjects and Methods:A total of 40 BC pa...
journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
doi:10.4103/0973-1482.235355
更新日期:2018-06-01 00:00:00
abstract::Tailgut cysts (TGCs) are rare congenital lesions derived from the remnants of primitive hindgut and are usually lined by squamous, transitional, or glandular epithelium. Malignant transformation in TGC may occur which is still rarer. Most common malignancies that arise from these cysts are adenocarcinomas. Preoperativ...
journal_title:Journal of cancer research and therapeutics
pub_type: 信件
doi:10.4103/jcrt.JCRT_212_17
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Somatic mutations of the epidermal growth factor receptor (EGFR) gene have been associated with tumor response to tyrosine kinase inhibitors (TKIs) and favorable outcome in patients with non-small-cell lung cancer (NSCLC). The activating mutations that confer sensitivity to EGFR TKIs are present in the TK do...
journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
doi:10.4103/0973-1482.147711
更新日期:2016-04-01 00:00:00
abstract:Aims:The goal of this study was to analyze the puncture routes of imaging-guided thermal ablation for tumors of the hepatic caudate lobe. Materials and Methods:The imaging-guided thermal ablation puncture routes of 12 cases of hepatic caudate lobe tumors were collected in our hospital from January 2013 to February 201...
journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
doi:10.4103/jcrt.JCRT_341_19
更新日期:2020-01-01 00:00:00
abstract::Acinic cell carcinoma (ACC) is a low-grade malignant salivary gland neoplasm that comprises approximately 17% of primary salivary gland malignancies or about 6% of all salivary gland neoplasms. The most common intraoral sites are the buccal mucosa, lips, and palate. The diagnosis of ACC frequently presents difficultie...
journal_title:Journal of cancer research and therapeutics
pub_type:
doi:10.4103/jcrt.JCRT_399_18
更新日期:2020-04-01 00:00:00
abstract::The present case report defines a rare case of a liposarcoma with bone metastasis resulting in a complete remission (CR) following trabectedin treatment. The patient was referred with abdominal swelling and pain. A retroperitoneal mass was detected and described as dedifferentiated liposarcoma (DDLS). The mass was sur...
journal_title:Journal of cancer research and therapeutics
pub_type: 信件,评审
doi:10.4103/0973-1482.158032
更新日期:2015-10-01 00:00:00
abstract::Melanoma is rare in children, but its incidence appears to be increasing. Melanoma accounts for the highest mortality among all skin cancer types. This disease is characterized by high-grade malignancy, easy metastasis, poor prognosis, and high death rate. Melanoma in children may be biologically different from that i...
journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章,评审
doi:10.4103/0973-1482.145788
更新日期:2014-11-01 00:00:00
abstract:AIM:To evolve a fast dose verification method for high-dose-rate (HDR) brachytherapy treatment plans and to demonstrate its applicability in different clinical cases. MATERIALS AND METHODS:We developed a software tool in VC++ for the Varisource HDR unit for HDR dosimetry plan verification using TG-43 parameters. HDR t...
journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
doi:10.4103/0973-1482.44288
更新日期:2008-10-01 00:00:00
abstract:Background:Apatinib has been approved for the treatment of advanced gastric adenocarcinoma and gastric-esophageal junctional adenocarcinoma, but its efficacy is unknown for other advanced solid tumors. Aims and Objectives:We retrospectively reviewed the use of apatinib for multiple advanced-stage non-gastric cancers. ...
journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
doi:10.4103/jcrt.JCRT_24_19
更新日期:2019-01-01 00:00:00
abstract::[This corrects the article DOI: 10.4103/0973-1482.180685]. ...
journal_title:Journal of cancer research and therapeutics
pub_type: 已发布勘误
doi:10.4103/0973-1482.274082
更新日期:2019-10-01 00:00:00
abstract::Ectopic extrarenal renin-producing tumor is a rare disease with approximately 30 case reports in English literature. We herein present the first case of renin-producing germ cell tumors in the pineal apparatus and mediastinum. A 26-year-old man who had undergone craniotomy for the treatment of pineal tumor was found t...
journal_title:Journal of cancer research and therapeutics
pub_type: 信件
doi:10.4103/0973-1482.180682
更新日期:2018-09-01 00:00:00
abstract:BACKGROUND:The overall goal of this study is to use a bacterial toxin as drug delivery agents for chemotherapy drugs and overcome the development of resistance to these medicines. COR-L105 and MDA-MB 231 which are epithelial-like were used in this study. Cytotoxicity assays were performed by 3-(4, 5-dimethyl-2-thiazoly...
journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
doi:10.4103/0973-1482.131338
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Oral cancer (OC) mortality is very high in Sudan, particularly among men due to the habit of Toombak use (tobacco specific nitrose amine (TSN)) rich tobacco. AIMS:Our aim was to determine whether OC is gender-specific due to increased Toombak use among males as suggested a risk for subsequent development of...
journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
doi:10.4103/0973-1482.34696
更新日期:2007-04-01 00:00:00