Immunohistochemical study of the expression of human chorionic gonadotropin-β in salivary gland tumors.

Abstract:

Background and Objectives:Human chorionic gonadotropin-β (hCGβ) is a hormone glycoprotein usually secreted by trophoblastic cells in early pregnancy and helps in growth and development of the embryo. While many trophoblastic and nontrophoblastic malignancies express elevated levels of hCGβ in serum, increased immunohistochemical reactivity has also been reported in malignant and aggressive tumors, thus serving as a marker. As limited studies exist on tumors of the oral- and para-oral region, it prompted us to observe the immunohistochemical expression of hCGβ in salivary gland tumors. Materials and Methods:A total of 21 cases of salivary gland tumors - 16 cases of mucoepidermoid carcinoma (MEC), adenoid cystic carcinoma (ACC), and five cases of pleomorphic adenoma - were included in the study. The sections were subjected to immunohistochemical procedures using hCGβ antigen. The degree of intensity and distribution of hCGβ immunostaining was assessed. Results:One case of each (12.5%) MEC and ACC showed positive staining, and no staining was observed in the pleomorphic adenoma. Conclusion:The presence of hCGβ positive tumor cells appears to potentially reflect the aggressive behavior of MEC and ACC.

journal_name

J Cancer Res Ther

authors

Meda S,Reginald BA,Reddy BS

doi

10.4103/0973-1482.184523

subject

Has Abstract

pub_date

2018-07-01 00:00:00

pages

952-956

issue

5

eissn

0973-1482

issn

1998-4138

pii

JCanResTher_2018_14_5_952_184523

journal_volume

14

pub_type

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