Abstract:
:Hepatocellular carcinoma (HCC) is one of the most common malignant tumors. Currently, the main effective treatment options for HCC include resection, liver transplantation, various percutaneous modalities (such as transarterial chemoembolization [TACE] and thermal ablation), and tyrosine kinase inhibitors (TKIs). Herein, we have proposed a novel therapy which consists of TACE, ablation, tyrosine kinase inhibitors, and immunotherapy (TATI) for patients with advanced HCC). We reported the therapeutic effects of TATI in four patients with advanced HCC. All patients underwent TACE treatment at the beginning of disease diagnosis. During follow-up, all patients were treated with microwave ablation because of a residual tumor or recurrence. For tumor control, apatinib, a TKI, was administered after ablation. If the tumor was resistant to the TKI, we continued to apatinib therapy in combination with immunotherapy (camrelizumab). All the four patients had better survival benefits and no serious adverse effects.
journal_name
J Cancer Res Therjournal_title
Journal of cancer research and therapeuticsauthors
Meng M,Li W,Yang X,Huang G,Wei Z,Ni Y,Han X,Wang J,Ye Xdoi
10.4103/jcrt.JCRT_101_20subject
Has Abstractpub_date
2020-01-01 00:00:00pages
327-334issue
2eissn
0973-1482issn
1998-4138pii
JCanResTher_2020_16_2_327_285177journal_volume
16pub_type
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