Abstract:
Context/Background:Tooth agenesis (excluding third molars) is a common congenital disorder that affects 2.2-10% of the general population. A number of different genes have been shown to be associated with cases of tooth agenesis including AXIN2, IRF6, FGFR1, MSX1, PAX9, and TGFA. Wingless/integration signaling gene, AXIN2, is linked to tooth agenesis and also to colorectal cancer (CRC). Aims:To analyze the correlation between tooth agenesis and CRC. Materials and Methods:The study included 50 individuals, who were divided into two groups. Group A: 25 individuals diagnosed with CRC and Group B: 25 individuals as a control group. The clinical details were recorded using preformed questionnaire, approved by ethical committee. Orthopantomogram was obtained for all the cases and controls. Results:We observed that 16% of cases and 8% of controls reported having tooth agenesis and there was no statistical significance of difference between them (P = 0.384). Among the study group, 4% reported oligodontia and 12% cases reported hypodontia. In the control group 8% reported hypodontia, there was no incidence of oligodontia. Additional finding in the study group was that 24% cases had fissured tongue which was not seen in the control group. Conclusion:Individuals with tooth agenesis might have an increased risk for CRC. A larger epidemiological study along with genetic mapping and gene sequencing is necessary to rule out the risk and relationship between tooth agenesis and CRC.
journal_name
J Cancer Res Therjournal_title
Journal of cancer research and therapeuticsauthors
Paranjyothi MV,Kumaraswamy KL,Begum LF,Manjunath K,Litha.,Basheer Sdoi
10.4103/0973-1482.168997subject
Has Abstractpub_date
2018-04-01 00:00:00pages
527-531issue
3eissn
0973-1482issn
1998-4138pii
JCanResTher_2018_14_3_527_168997journal_volume
14pub_type
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