Abstract:
:Malignant melanoma has been reported to affect all organs of the human body with the metastasis. Stomach metastases are quite rare in cases of the most commonly reported primaries including, melanoma and breast, and lung carcinomas. This report involves, a 56-year-old man suffering from melanoma of the lower extremity that developed into gastric, pulmonary, and brain metastases. The patient who experienced epigastric pain with suspicious melanoma was referred to undergo endoscopy. A black and white ulcer with dimensions of 1 × 1.5 cm and a mass of 1 × 2 cm mass were found at D1 and lesser curvature. Physical examination revealed a 2 × 3 cm black lesion at his right heel. Pathologic examination provided multiple pieces of creamy soft-tissue measuring 0.3 × 0.2 × 0.1 cm showing pigmented tumor cells in lamina propria. Staining biopsy samples with anti-HMB-45 and Fontana demonstrated a higher degree of positivity in tumor cells. The patient was admitted to the hospital, but unfortunately his general conditions were deteriorated and he developed convulsion and deceased four days after admission.
journal_name
J Cancer Res Therjournal_title
Journal of cancer research and therapeuticsauthors
Eivazi-Ziaei J,Esmaili Hdoi
10.4103/0973-1482.136029subject
Has Abstractpub_date
2014-07-01 00:00:00pages
733-6issue
3eissn
0973-1482issn
1998-4138pii
JCanResTher_2014_10_3_733_136029journal_volume
10pub_type
信件abstract:OBJECTIVE:The aim of this study was to determine age-specific incidence ratios, gastric cancer localization trend, histologic subtype and cancer related survival that whether have changed during the period from 1999 to 2010. MATERIALS AND METHODS:A total of 866 gastric cancer patients treated at the hospital were retr...
journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
doi:10.4103/0973-1482.126466
更新日期:2013-10-01 00:00:00
abstract:Purpose:Glioblastoma (GBM) is characterized by early relapse and mortality. Treatment resistance could be a characteristic exhibited by pro-genitor neoplastic cells that reside in the subventricular zone (SVZ). This retrospective study was conducted to assess the correlation of SVZ doses and survival in patients with G...
journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
doi:10.4103/jcrt.JCRT_295_17
更新日期:2018-10-01 00:00:00
abstract:Aim:The aims of this study are to evaluate the serum levels of paraoxonase (PON) and arylesterase (ARE) in breast cancer (BC) patients; to determine their relationship with chemotherapy requirements in BC; and to find a cut-off value to assess subjects with a higher risk of BC. Subjects and Methods:A total of 40 BC pa...
journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
doi:10.4103/0973-1482.235355
更新日期:2018-06-01 00:00:00
abstract:AIM OF STUDY:Embelin and celastrol, inhibitors of XIAP and NF-κB proteins respectively, have been derived from natural sources and shown anti-tumor activities against different cancer cell lines. Some interactions have recently been discovered between XIAP and NF-κB pathways, but the effects of these inhibitors in comb...
journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
doi:10.4103/0973-1482.150407
更新日期:2016-01-01 00:00:00
abstract:Introduction:Screening and diagnostic efforts for breast cancer are critical because the disease has a high rate of successful outcomes with early identification and treatment. The mammography (MG) and Ultrasonography/ ultrasound (USG) are individually effective diagnostic modalities for detection of breast pathologies...
journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
doi:10.4103/0973-1482.191053
更新日期:2018-07-01 00:00:00
abstract:Aim of Study:Metabolic syndrome (MetS) is an abnormality that increases the risk of cardiovascular disease and diabetes. In the recent years, studies showed that MetS is associated with increased risk of incidence, aggressiveness, and mortality of prostate cancer (PCa). We examined the influence of MetS at final pathol...
journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
doi:10.4103/0973-1482.187290
更新日期:2019-03-01 00:00:00
abstract:OBJECTIVE:The epidural anesthesia and general anesthesia are the most commonly used in lung surgery through video-assisted thoracic surgery (VATS). Each of these methods has their advantages and disadvantages, so the aim of this meta-analysis is to identify which anesthesia is more conducive to lung surgery under VATS ...
journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章,meta分析
doi:10.4103/0973-1482.170534
更新日期:2015-11-01 00:00:00
abstract:BACKGROUND:Synovial sarcoma (SS) is a rare disease and compared with other soft-tissue sarcomas has a relatively high mortality rate. The optimal management of this disease and prognostic factors associated with patient outcome remains controversial. AIMS:We aimed to evaluate the factors affecting the outcomes of SS p...
journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章,多中心研究
doi:10.4103/0973-1482.131381
更新日期:2014-01-01 00:00:00
abstract:AIMS:Circulating extracellular micro ribonucleic acids (miRNAs) are considered as potential biomarkers for malignancy detection and diagnosis. The aim of this study was to determine whether circulating miRNA-148/152 family (miR-148a, miR-148b, and miR-152) expression in plasma could be used as potential biomarkers for ...
journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
doi:10.4103/0973-1482.150420
更新日期:2016-04-01 00:00:00
abstract::Acinic cell carcinoma (ACC) is a low-grade malignant salivary gland neoplasm that comprises approximately 17% of primary salivary gland malignancies or about 6% of all salivary gland neoplasms. The most common intraoral sites are the buccal mucosa, lips, and palate. The diagnosis of ACC frequently presents difficultie...
journal_title:Journal of cancer research and therapeutics
pub_type:
doi:10.4103/jcrt.JCRT_399_18
更新日期:2020-04-01 00:00:00
abstract::Dermatofibrosarcoma protuberans (DFSP) is an uncommon, locally aggressive, soft tissue tumor. Its occurrence over face is very rare. We are presenting a case of giant DFSP over left cheek, which produces oncological, functional and esthetic challenges and deals by multidisciplinary team. We also reviewed the relevant ...
journal_title:Journal of cancer research and therapeutics
pub_type: 信件
doi:10.4103/0973-1482.139386
更新日期:2015-10-01 00:00:00
abstract::Multiple enlarged lymph nodes in an elderly female patient can have varied etiologies as well as histologic pictures. We are presenting the case of a 53-year-old female who presented with inguinal lymphadenopathy with fever, which was clinically misconstrued as lymphoma. Cytology could not exclude a lymphoma. Histolog...
journal_title:Journal of cancer research and therapeutics
pub_type: 信件
doi:10.4103/0973-1482.147714
更新日期:2015-07-01 00:00:00
abstract:INTRODUCTION:Using physical wedges (PWs) to modify dose distribution and more homogeneous target coverage is a well-established technique. However, there are many problems with PWs known as beam hardening, which made them problematic. This can be overcome by dynamic wedges which do not filter beam. Comparison of physic...
journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
doi:10.4103/0973-1482.206244
更新日期:2017-01-01 00:00:00
abstract:Introduction:Oral squamous cell carcinoma (OSCC) accounts 94% of all malignant lesions in the oral cavity. In the assessment of OSCC, nowadays the WHO grading system has been followed widely but due to its subjectivity, investigators applied the sophisticated technique of computer-assisted image analysis in the grading...
journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
doi:10.4103/0973-1482.189423
更新日期:2018-01-01 00:00:00
abstract:AIMS:To compare three-dimensional conformal radiation therapy (3DCRT) and intensity-modulated radiation therapy (IMRT) in posterior fossa (PF) boost in children with medulloblastoma (MB); dosimetrically evaluating and comparing both techniques with regard to target coverage and doses to organs at risk. SETTINGS AND DE...
journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
doi:10.4103/0973-1482.220416
更新日期:2017-10-01 00:00:00
abstract:Purpose:The aim of the study is to study the feasibility of gamma-ray-detection-based precision dose measurement of 125I seed brachytherapy in solid water. Materials and Methods:Seven group 125I seeds with different activities were put into a hole in the center of solid water individually. Each group had ten seeds, an...
journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
doi:10.4103/jcrt.JCRT_522_18
更新日期:2019-01-01 00:00:00
abstract:Objective:The aim of this study was to explore the clinical value of capsule endoscopy in the diagnosis of small intestine neoplastic lesions. Materials and Methods:A retrospective analysis was conducted on the clinical data of 108 patients who underwent capsule endoscopic examination in the Endoscopy Center of Xinxia...
journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
doi:10.4103/jcrt.JCRT_584_17
更新日期:2018-01-01 00:00:00
abstract:Aims:The role of prophylactic central neck dissection (CND) in the management of papillary thyroid carcinoma (PTC) is controversial. This study reports outcomes of an observational approach in PTC patients without clinical evidence of lymph node metastasis. Materials and Methods:Patients with PTC who had surgery (with...
journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
doi:10.4103/jcrt.JCRT_620_19
更新日期:2020-09-01 00:00:00
abstract:Aim of Study:To examine the function of lenalidomide (LEN) on the human multidrug resistance (MDR)-type gastric cancer line SGC7901/vincristine (VCR) via regulating Notch signaling. Materials and Methods:Quantitative polymerase chain reaction was used for checking the genes of Notch, DNA methyltransferase (DNMT), RBP-...
journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
doi:10.4103/0973-1482.183181
更新日期:2018-01-01 00:00:00
abstract:Background:Ghrelin plays a role in mechanisms related to cancer progression - including cell proliferation, invasion and migration, and resistance to apoptosis in the cell lines from several cancers. We investigated the role of ghrelin levels in cancer cachexia-anorexia in patients with locally advanced nonsmall-cell l...
journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
doi:110.4103/jcrt.JCRT_10_19
更新日期:2020-07-01 00:00:00
abstract:CONTEXT:The diagnosis of malignant and potentially malignant epithelial lesions of oral mucosa cannot be based solely on clinical findings. The histologic evaluation of a representative biopsy specimen thus becomes necessary. The site for biopsy, however, is always a subjective choice that sometimes raises doubts about...
journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章,收录出版
doi:10.4103/0973-1482.137957
更新日期:2014-07-01 00:00:00
abstract::Primary mediastinal synovial sarcomas are exceedingly uncommon tumors. Herein, we present the case of primary mediastinal synovial sarcoma (monophasic spindle cell-shaped variant) fully occupying the right hemithorax in a 37-year-old woman who presented to clinic with a 2-month history of right-sided chest pain and sh...
journal_title:Journal of cancer research and therapeutics
pub_type: 信件
doi:10.4103/0973-1482.172137
更新日期:2018-04-01 00:00:00
abstract::We herein describe a case of drug-induced interstitial lung disease (ILD) following treatment with erlotinib. The plasma trough concentration of erlotinib at the time of the ILD diagnosis was extremely elevated compared with the plasma maximum concentration on day 1. We hypothesized that this phenomenon was associated...
journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
doi:10.4103/0973-1482.95201
更新日期:2012-01-01 00:00:00
abstract:Aim:Tumor-associated macrophages (TAMs) play a decisive role in the regulation of tumor progression by manipulating tumor oncogenesis, angiogenesis, and immune functions within tumor microenvironments. Tumor progression is frequently associated with a phenotypic switch from M1 to M2 in TAM. Activation of signal transdu...
journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
doi:10.4103/0973-1482.187298
更新日期:2018-07-01 00:00:00
abstract:Aim:This study was carried out to determine the fungal profile and antifungal susceptibility pattern in the brushing samples of candidiasis in patients with carcinoma of esophagus. Materials and Methods:The study was carried out in the Departments of Microbiology and Surgical Oncology of a regional cancer center from ...
journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
doi:10.4103/jcrt.JCRT_581_18
更新日期:2020-12-01 00:00:00
abstract::[This corrects the article DOI: 10.4103/0973-1482.180080.]. ...
journal_title:Journal of cancer research and therapeutics
pub_type: 已发布勘误
doi:10.4103/0973-1482.186738
更新日期:2016-04-01 00:00:00
abstract:PURPOSE:To report our experience of stereotactic radiosurgery (SRS) in consecutively treated patients with arteriovenous malformations (AVMs). MATERIALS AND METHODS:Of the 87 patients, 23 patients qualified and were treated with SRS as per predefined protocol according to AVM size, location, neurological status, prior...
journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
doi:10.4103/0973-1482.57124
更新日期:2009-07-01 00:00:00
abstract::Heat shock protein 90 (Hsp90) a member of the heat shock proteins (HSPs) family, is an adenosine triphosphate dependent molecular chaperone protein, which integrates multiple oncogenic pathways. Clinically, encouraging results have been demonstrated in melanoma, acute myeloid leukemia, castrate refractory prostate can...
journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章,评审
doi:10.4103/0973-1482.126451
更新日期:2013-10-01 00:00:00
abstract:Purpose:The purpose of this study was to evaluate the organs at risk (OARs) doses for lung tumors in gated radiotherapy (RT) compared to conventional RT using the four-dimensional extended cardiac-torso (4D-XCAT) digital phantom in a simulation study. Materials and Methods:4D-XCAT digital phantom was used to create 32...
journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
doi:10.4103/jcrt.JCRT_735_18
更新日期:2020-07-01 00:00:00
abstract::Radiofrequency ablation (RFA) recently has been applied to benign thyroid nodules, mainly for the cosmetic reasons, and limited cases of local recurrences or focal distant metastases of well-differentiated thyroid cancer, in the high-risk reoperative condition or for the palliative purpose. But no report has been made...
journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
doi:10.4103/0973-1482.73328
更新日期:2010-07-01 00:00:00