Evaluation of the relationship between serum ghrelin levels and cancer cachexia in patients with locally advanced nonsmall-cell lung cancer treated with chemoradiotherapy.

Abstract:

Background:Ghrelin plays a role in mechanisms related to cancer progression - including cell proliferation, invasion and migration, and resistance to apoptosis in the cell lines from several cancers. We investigated the role of ghrelin levels in cancer cachexia-anorexia in patients with locally advanced nonsmall-cell lung cancer (NSCLC) treated with chemoradiotherapy (CRT). Materials and Methods:This study involved 84 NSCLC patients who had received concomitant CRT. Blood ghrelin levels were compared before and 3 months after CRT. Meanwhile, changes in body weight of the patients were also investigated with changes in ghrelin levels before and after CRT. Results:Ghrelin levels were significantly decreased in line with changes in patients' weights in patients receiving CRT (P < 0.001). Serum albumin levels and inflammatory-nutritional index were significantly decreased after radiotherapy (RT) (3.01 ± 0.40 g/dL, 0.38 ± 0.20) when compared with its baseline levels (3.40 ± 0.55 g/dL,P < 0.001; 0.86 ± 0.71,P < 0.001, respectively). Serum C-reactive protein levels were significantly increased after CRT (7.49 ± 6.53 mg/L) when compared with its baseline levels (9.54 ± 3.80 mg/L,P = 0.038). After RT, ghrelin levels in patients were positively correlated with body mass index (r = 0.830,P < 0.001) and albumin (r = 0.758,P < 0.001). Conclusion:Ghrelin may play a role in the pathogenesis of weight loss in NSCLC patients. Ghrelin seems to be implicated in cancer-related weight loss. Ghrelin, cancer, and RT all together have a role in tumor-related anorexia-cachexia in patients with NSCLC. Results of this study need further evaluation as regards to its potential role as an adjuvant diagnostic or prognostic marker.

journal_name

J Cancer Res Ther

authors

Uysal P,Afsar CU,Sozer V,Inanc B,Agaoglu F,Gural Z,Fazlıoglu NY,Cuhadaroglu C,Uzun H

doi

110.4103/jcrt.JCRT_10_19

subject

Has Abstract

pub_date

2020-07-01 00:00:00

pages

855-859

issue

4

eissn

0973-1482

issn

1998-4138

pii

JCanResTher_2020_16_4_855_284487

journal_volume

16

pub_type

杂志文章
  • MicoRNA-451 is a novel tumor suppressor via targeting c-myc in head and neck squamous cell carcinomas.

    abstract:OBJECTIVE:Head and neck squamous cell carcinoma (HNSCC) represents as a common malignancy with increasing incidence in the worldwide. The fact of its poor survival rate urgently requires developing efficient predictive biomarkers for clinical use. MicroRNAs (miRNAs) recently represent as a novel direction for early dia...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/0973-1482.168189

    authors: Wang H,Zhang G,Wu Z,Lu B,Yuan D,Li X,Lu Z

    更新日期:2015-10-01 00:00:00

  • Good prognostic factor in patients with nonmetastatic nasopharyngeal carcinoma: Programmed death ligand-1 expression in tumor cells.

    abstract:Purpose:Programmed death ligand-1 (PD-L1) is the main ligand for programmed death-1 (PD-1), and is one of the major targets for cancer immunotherapy. Only a few studies are available for the clinical significance of PD-1/PD-L1 in nasopharyngeal carcinoma (NPC). There is a controversial association between PD-L1 express...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/jcrt.JCRT_759_19

    authors: Sahinli H,Akyürek N,Yılmaz M,Kandemir O,Duran AO,Kulaçoǧlu S,Uçar G,Acar E,Özet A,Öksüzoǧlu OBÇ,Özdemir NY

    更新日期:2020-12-01 00:00:00

  • The clinical significance of ultrasound grayscale ratio in differentiating markedly hypoechoic and anechoic minimal thyroid nodules.

    abstract:Purpose:This study explored ultrasound grayscale ratios (USGRs) for differentiating markedly hypoechoic and anechoic minimal thyroid nodules. Materials and Methods:Longitudinal scan images of 193 markedly hypoechoic papillary thyroid microcarcinoma (PTMC) lesions from 184 patients were retrospectively reviewed using R...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/jcrt.JCRT_1031_17

    authors: Lei ZK,Li MK,Luo DC,Han ZJ

    更新日期:2018-01-01 00:00:00

  • Search of an ideal location of isocenter in intensity-modulated radiotherapy treatment plans: A dosimetrical approach.

    abstract:Aim:The aim of this study is to identify an ideal location of isocenter in intensity-modulated radiotherapy (IMRT) treatment plans. Materials and Methods:A total of 28 clinical target volumes and 4 English capital letters (C, L, T, and H) target volumes were considered in this study. Two IMRT treatment plans were gene...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/jcrt.JCRT_985_16

    authors: Mandal A,Asthana AK,Pradhan S,Shahi UP,Choudhary S

    更新日期:2019-01-01 00:00:00

  • Percutaneous thermal ablation combined with simultaneous transarterial chemoembolization for hepatocellular carcinoma ≤5 cm.

    abstract:Background/Aim:Percutaneous thermal ablation combined with transarterial chemoembolization (TACE) becomes a treatment option for unresectable hepatocellular carcinoma (HCC). This study aims to investigate the safety and feasibility of percutaneous thermal ablation combined with simultaneous TACE for patients with HCC ≤...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/jcrt.JCRT_250_19

    authors: Wu M,Gao S,Song H,Zhang Z,Wang J,Liu R,Wang X,Cheng J,Luo J,Liu Q,Chen Y,Yan Z,Liu L

    更新日期:2019-01-01 00:00:00

  • The expression and prognostic significance of Mucin 13 and Mucin 20 in esophageal squamous cell carcinoma.

    abstract:BACKGROUND:Mucin 13 (MUC13) and Mucin 20 (MUC20) are high molecular weight transmembrane O-linked glycoprotein secreted by epithelium and are widely overexpressed in epithelial tumor cells. Previously, it has been reported that MUC13 and MUC20 were prognostic molecular biomarkers of some epithelial tumors, but few has ...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/0973-1482.163846

    authors: Wang H,Shen L,Lin Y,Shi Q,Yang Y,Chen K

    更新日期:2015-08-01 00:00:00

  • Transcriptome network analysis reveals candidate genes for renal cell carcinoma.

    abstract:CONTEXT:Renal cell carcinoma (RCC) is a kidney cancer that originates in renal parenchyma and it is the most common type of kidney cancer with approximately 80% lethal cases. AIMS:To interpret the mechanism, explore the regulation of TF-target genes and TF-pathway, and identify the potential key genes of renal cell ca...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/0973-1482.95170

    authors: Zhai W,Xu YF,Liu M,Zheng JH

    更新日期:2012-01-01 00:00:00

  • Orientin mitigates 1, 2-dimethylhydrazine induced lipid peroxidation, antioxidant and biotransforming bacterial enzyme alterations in experimental rats.

    abstract:Background:Colorectal cancer (CRC) is the second most diagnosed cancer often identified during the later stages of carcinogenesis. Orientin, a C-glycoside of luteolin, is well known for its versatile therapeutic action toward oxidative stress-induced cellular response may exert chemoprevention against CRC. Materials a...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/jcrt.JCRT_1363_16

    authors: Thangaraj K,Natesan K,Settu K,Palani M,Govindarasu M,Subborayan V,Vaiyapuri M

    更新日期:2018-10-01 00:00:00

  • In vivo dose estimations through transit signal measured with thimble chamber positioned along the central axis at electronic portal imaging device level in medical linear accelerator in carcinoma of the middle-third esophagus patients undergoing three-di

    abstract:Objective:This study presents a method to estimate midplane dose (Diso, transit) in vivo from transit signal (St) measured with thimble ionization chamber in cancer of the middle-third esophagus patients treated with three-dimensional radiotherapy (RT). This detector is positioned at the level of electronic portal imag...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/jcrt.JCRT_278_17

    authors: Kumar PS,Banerjee S,Arun Kumar ES,Srinivas C,Vadhiraja BM,Saxena PU,Ravichandran R,Kasturi DP

    更新日期:2018-01-01 00:00:00

  • Stereotactic body radiotherapy for the treatment of presacral recurrences from rectal cancers.

    abstract:PURPOSE:Management of recurrent presacral rectal cancer is often not amenable to curative surgery. The goal of this study is to evaluate the safety and efficacy of cyberknife stereotactic body radiotherapy (SBRT) in the management of presacral recurrences. MATERIALS AND METHODS:Between April 2003 and October 2008, 14 ...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/0973-1482.92000

    authors: Defoe SG,Bernard ME,Rwigema JC,Heron DE,Ozhasoglu C,Burton S

    更新日期:2011-10-01 00:00:00

  • A 36-year-old female with Krukenberg tumor from a colonic carcinoma.

    abstract::Krukenberg tumor is bilateral ovarian carcinoma's metastasizing most commonly from a gastric primary followed by a colon. We report a case of 36-year-old female with bilateral ovarian mass diagnosed as Krukenberg with a work up for locating the primary site. In this case, we discuss widely the clinical aspects with hi...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 信件

    doi:10.4103/0973-1482.167615

    authors: Umakanthan S,Bukelo MM,Hardik K

    更新日期:2015-10-01 00:00:00

  • Evaluation of breast lesions by digital mammography and ultrasound along with fine-needle aspiration cytology correlation.

    abstract:Introduction:Screening and diagnostic efforts for breast cancer are critical because the disease has a high rate of successful outcomes with early identification and treatment. The mammography (MG) and Ultrasonography/ ultrasound (USG) are individually effective diagnostic modalities for detection of breast pathologies...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/0973-1482.191053

    authors: Tiwari P,Ghosh S,Agrawal VK

    更新日期:2018-07-01 00:00:00

  • Comparison of primary radiation versus robotic surgery plus adjuvant radiation in high-risk prostate cancer: a single center experience.

    abstract:OBJECTIVE:The objective of this study was to compare robotic-prostatectomy plus adjuvant radiation therapy (RPRAT) versus primary RT for high-risk prostate cancer (HRPCa). MATERIALS AND METHODS:A retrospective chart review was performed for the HRPCa patients treated in our institution between 2000 and 2010. One hundr...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/0973-1482.139601

    authors: Singh P,Desai P,Arora S,Pham AH,Wernicke AG,Smith M,Nori D,Clifford Chao KS,Parashar B

    更新日期:2015-01-01 00:00:00

  • Villous adenoma of the urinary bladder.

    abstract::Villous adenoma is a known entity in the gastrointestinal tract, but very rare in the urinary tract. It is a benign tumor with excellent prognosis, but its progression to adenocarcinoma is not established. Here, we report an additional case of villous adenoma of the urinary bladder. ...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 信件

    doi:10.4103/0973-1482.144360

    authors: Pal DK

    更新日期:2015-07-01 00:00:00

  • Polyclonal antibody-mediated mitotic inhibition in Chinese hamster ovary cells.

    abstract::The nucleus of a mammalian cell undergoes profound reorganization when the cell enters mitosis and a number of proteins involved at various levels of the cell cycle have been characterized. The presence of mitotic-specific proteins has been reported and their roles are important in understanding the mechanics of cell ...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/0973-1482.27587

    authors: Maddaly R,Deepa PV,Pai GM,Preetha B,Ghosh S,Paul SF

    更新日期:2006-07-01 00:00:00

  • Endoscopic ultrasonography-guided poly (lactic acid-co-glycolic acid)-poly (ethylene glycol)-poly (lactic acid-co-glycolic acid) thermogel tunnel creation for natural orifice transluminal endoscopic surgery in porcine model.

    abstract:Background:Natural orifice transluminal endoscopic surgery (NOTES) is a minimal invasive treatment. However, tissue dissection under endoscopy is still challenging due to the flexibility of endoscopy body and there is still no effective method for establishing a tunnel towards the targeted area. We previously showed th...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/jcrt.JCRT_400_18

    authors: Sun X,Yu L,Zhu J,Zu S,Ding J,Liu Y

    更新日期:2019-01-01 00:00:00

  • Fungal profile and antifungal susceptibility pattern of candidiasis in esophageal cancer patients.

    abstract:Aim:This study was carried out to determine the fungal profile and antifungal susceptibility pattern in the brushing samples of candidiasis in patients with carcinoma of esophagus. Materials and Methods:The study was carried out in the Departments of Microbiology and Surgical Oncology of a regional cancer center from ...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/jcrt.JCRT_581_18

    authors: Talukdar A,Barman R,Sarma A,Krishnatreya M,Sharma JD,Kataki AC

    更新日期:2020-12-01 00:00:00

  • Up-regulation of Wnt5a inhibits proliferation and migration of hepatocellular carcinoma cells.

    abstract:Objectives:Increasing evidence suggests that Wnt5a plays an important role in tumorigenesis. In particular, its expression is downregulated in hepatocellular carcinoma (HCC). The aim of this study was to explore the effect of Wnt5a overexpression on HCC cells. Materials and Methods:We transfected the human HCC cell li...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/jcrt.JCRT_886_18

    authors: Wang T,Liu X,Wang J

    更新日期:2019-01-01 00:00:00

  • Serum ferritin is elevated in advanced non-small cell lung cancer patients and is associated with efficacy of platinum-based chemotherapy.

    abstract:AIM:The aim of this study was to determine the expression levels of serum ferritin (SF) and investigate the correlation between SF expression levels and clinical characteristics as well as the efficacy to platinum-based chemotherapy for advanced non-small cell lung cancer (NSCLC) patients. MATERIALS AND METHODS:Electr...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/0973-1482.139156

    authors: Shi HB,Li XD,Jiang JT,Zhao WQ,Ji M,Wu CP

    更新日期:2014-07-01 00:00:00

  • Investigating the risk factors of hepatocellular carcinoma and survival analysis for cirrhosis after transjugular intrahepatic portosystemic shunt in treating portal hypertension.

    abstract:Objective:This study aimed to explore the risk factors of hepatocellular carcinoma (HCC) and survival analysis for cirrhosis after transjugular intrahepatic portosystemic shunt (TIPS) in treating portal hypertension. Materials and Methods:A retrospective database review was performed, including 106 patients (33 female...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/jcrt.JCRT_930_17

    authors: Wei J,Li H,Li C

    更新日期:2018-01-01 00:00:00

  • A dosimetric comparison between three-dimensional conformal radiation therapy and intensity-modulated radiation therapy in the treatment of posterior fossa boost in medulloblastoma.

    abstract:AIMS:To compare three-dimensional conformal radiation therapy (3DCRT) and intensity-modulated radiation therapy (IMRT) in posterior fossa (PF) boost in children with medulloblastoma (MB); dosimetrically evaluating and comparing both techniques with regard to target coverage and doses to organs at risk. SETTINGS AND DE...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/0973-1482.220416

    authors: Gupta M,Kant R,Nautiyal V,Bisht J,Raghuvanshi S,Saini M,Kalra BP,Ahmad M

    更新日期:2017-10-01 00:00:00

  • Apatinib for advanced nonsmall-cell lung cancer: A retrospective case series analysis.

    abstract:Objectives:Apatinib, a tyrosine kinase inhibitor which selectively inhibits vascular endothelial growth factor receptor-2, has been shown to be beneficial to patients with a variety of cancers, including advanced nonsmall-cell lung cancer (NSCLC). Thus, this study was aimed to retrospectively assess the efficacy and sa...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/jcrt.JCRT_258_17

    authors: Yang C,Feng W,Wu D

    更新日期:2018-01-01 00:00:00

  • Asthma and the risk of prostate cancer.

    abstract:Objective:The association between asthma and the risk of prostate cancer remains elusive. We aimed to evaluate the relationship between asthma and the onset of prostate cancer. Methods:We searched PubMed, Embase, and Cochrane databases for articles that assessed the association of asthma with the risk of prostate canc...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章,meta分析

    doi:10.4103/0973-1482.176422

    authors: Li W,Mao S,Tu M,Ge X,Li K,Xie F,Song Y,Miao Y

    更新日期:2018-09-01 00:00:00

  • Ezrin expression in the primary hepatocellular carcinoma patients and associated with clinical, pathological characteristics.

    abstract:OBJECTIVE:The aim of this study was to assess Ezrin expression in the primary hepatic carcinoma patients and associated with clinical, pathological characteristics. MATERIALS AND METHODS:Fifty-one patients with primary hepatocellular carcinoma (PHC) with completed clinical data were retrospectively analyzed in this st...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/0973-1482.200761

    authors: Pan D,Wang S,Ye H,Xu S,Ye G

    更新日期:2016-12-01 00:00:00

  • The impact of patient positioning and use of belly board on small bowel toxicity in patients receiving pelvic radiotherapy for gynecological malignancies.

    abstract:AIM:To determine the efficacy of belly board device in patients receiving postoperative radiation for gynecological malignancies in terms of setup error and acute small bowel toxicity. MATERIALS AND METHODS:Patients requiring postoperative radiation for gynecological malignancies were prospectively randomized to eithe...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/0973-1482.179519

    authors: Anjanappa M,Raghavan RK,James FV,Kumar A,Mathews S,Bhaskaran S,Sreedevi SV,Jayaprakash PG

    更新日期:2017-07-01 00:00:00

  • Development of plasma cell leukemia in a patient with chronic myeloid leukemia while on treatment with imatinib mesylate.

    abstract::Plasma cell leukemia (PCL) is a rare and an aggressive form of plasma cell dyscrasias. We report a 67-year-old male with PCL which developed while on imatinib mesylate (IM) therapy 38 months after diagnosis of chronic myeloid leukemia (CML). The patient has been treated successfully with bortezomib, melphalan and pred...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 信件

    doi:10.4103/0973-1482.192762

    authors: Maral S,Bakanay SM,Yikilmaz AS,Dilek I

    更新日期:2018-10-01 00:00:00

  • Quantitative evaluation of serum fucose in oral squamous cell carcinoma patients.

    abstract:BACKGROUND:Cancer, a disorder of cellular behavior is characterized by the alteration of serum glycoproteins, which are composed of different monosaccharides. One of the monosaccharides is l-fucose, a methyl pentose, which is the terminal sugar in most of the plasma glycoproteins. Elevated levels of protein-bound fucos...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/0973-1482.82928

    authors: Parwani RN,Parwani SR

    更新日期:2011-04-01 00:00:00

  • Preoperative assessment of malignant potential of gastrointestinal stromal tumor by dual-time-point 18F-fluorodeoxyglucose positron emission tomography imaging: Usefulness of standardized uptake value and retention index.

    abstract:Background:To evaluate the usefulness of preoperative imaging with F-18 fluorodeoxyglucose positron emission tomography (FDG-PET) for noninvasive risk assessment of gastrointestinal stromal tumor (GIST). Materials and Methods:A retrospective review including 32 patients with pathologically proven GIST. Preoperative FD...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/jcrt.JCRT_1093_16

    authors: Kwon Y,Park E,Pahk K,Kim S,Kim MJ,Graf D,Park S

    更新日期:2019-01-01 00:00:00

  • Renal cell carcinoma, unclassified with unique features.

    abstract::Renal cell carcinoma, unclassified constitute about 3-4% of all renal carcinomas. It essentially is a tumor where more than morphological variants or subtypes are seen in a single tumor. Usually there is a mixture of 2-3 different types. However, in this particular case there were at least 5 different types of morphol...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 信件

    doi:10.4103/0973-1482.151420

    authors: Chander B,Preet K,Bharti R,Deb P

    更新日期:2015-10-01 00:00:00

  • COVID-19 pandemic: Radiotherapy precautions and preparedness.

    abstract::The novel coronavirus (COVID-19) pandemic has disrupted healthcare delivery across the globe. Cancer patients are at a higher risk of acquiring this infection due to their immunosuppressed state. Timely care of patients while ensuring safety of healthcare workers is need of the hour. We list few precautionary measures...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/jcrt.JCRT_405_20

    authors: Mummudi N,Tibdewal A,Ghosh-Laskar S,Agarwal JP

    更新日期:2020-04-01 00:00:00