Abstract：
AIMS:Few studies have examined the clinical characteristics of patients with brain metastases from small-cell esophageal cancer. In this study, we review the clinical characteristics and outcomes in patients with brain metastases from small-cell esophageal cancer. PATIENTS AND METHODS:From August 2002 to August 2012, consecutive patients diagnosed with brain metastases from small-cell esophageal cancer and treated with radiotherapy were enrolled. Clinical features, diagnostic findings, and survival were analyzed. RESULTS:Six patients treated with brain radiotherapy were identified. The median age was 64 (range 61-74) years. All patients had neurological impairments. Three patients had supra- and infra-tentorial metastases, and three patients had cerebrum metastases. Brain metastases were detected when esophageal cancer was initially diagnosed in two patients. In three patients, magnetic resonance imaging findings after radiotherapy confirmed a significant response to treatment. The median overall survival was 6.0 months. During the same period, 43 patients with squamous cell carcinoma and seven patients with adenocarcinoma who had brain metastases were identified. Survival periods for squamous cell carcinoma and adenocarcinoma patients who had brain metastases were 5.5 months and 4.2 months, respectively. There was no significant difference in overall survival according to the histological type. CONCLUSIONS:Brain metastases from small-cell esophageal cancer tend to spread to the cerebellum and impair patients' quality-of-life. Brain radiotherapy had a positive effect in this case series; however, overall survival remains short.
journal_name
J Cancer Res Therjournal_title
Journal of cancer research and therapeuticsauthors
Feng W,Harada H,Zhang P,Mitsuya K,Zheng X,Yasui H,Nakasu Y,Chen M,Nishimura Tdoi
10.4103/0973-1482.151469subject
Has Abstractpub_date
2014-12-01 00:00:00pages
256-8eissn
0973-1482issn
1998-4138pii
JCanResTher_2014_10_8_256_151469journal_volume
10 Supplpub_type
杂志文章abstract：:Dermatofibrosarcoma protuberans (DFSP) is a low-grade tumor with rare metastasis. A 26-year-old male presented with multiple cutaneous nodular lesions of DFSP since 3 months along with distant metastasis to the brain, pleura, and muscles that were detected on investigations. The case is being reported due to its rare ...
journal_title：Journal of cancer research and therapeutics
pub_type： 信件
doi：10.4103/0973-1482.146099
更新日期：2015-07-01 00:00:00
abstract：:Most neuroendocrine tumors of the gastrointestinal tract are traditionally termed "carcinoid tumors." More than 90% of all gastrointestinal carcinoids are located in the appendix, small intestine, rectum, and mesenteric carcinoids are rare. Even when invasive, most carcinoids are relatively indolent and display minima...
journal_title：Journal of cancer research and therapeutics
pub_type： 信件,评审
doi：10.4103/0973-1482.138108
更新日期：2015-07-01 00:00:00
abstract：Background:Ghrelin plays a role in mechanisms related to cancer progression - including cell proliferation, invasion and migration, and resistance to apoptosis in the cell lines from several cancers. We investigated the role of ghrelin levels in cancer cachexia-anorexia in patients with locally advanced nonsmall-cell l...
journal_title：Journal of cancer research and therapeutics
pub_type： 杂志文章
doi：110.4103/jcrt.JCRT_10_19
更新日期：2020-07-01 00:00:00
abstract：:Extraneural broad ligament ependymoma is a rare entity. Herein, we present a case of unusually large broad ligament ependymoma in a 32-year-old female with pain and lump in the lower abdomen. Contrast-enhanced computed tomography abdomen revealed multiple heterogeneously enhancing pelvic masses with lobulated surface ...
journal_title：Journal of cancer research and therapeutics
pub_type：
doi：10.4103/jcrt.JCRT_672_17
更新日期：2019-10-01 00:00:00
abstract：AIMS:Circulating extracellular micro ribonucleic acids (miRNAs) are considered as potential biomarkers for malignancy detection and diagnosis. The aim of this study was to determine whether circulating miRNA-148/152 family (miR-148a, miR-148b, and miR-152) expression in plasma could be used as potential biomarkers for ...
journal_title：Journal of cancer research and therapeutics
pub_type： 杂志文章
doi：10.4103/0973-1482.150420
更新日期：2016-04-01 00:00:00
abstract：Objective:This study aimed to explore the risk factors of hepatocellular carcinoma (HCC) and survival analysis for cirrhosis after transjugular intrahepatic portosystemic shunt (TIPS) in treating portal hypertension. Materials and Methods:A retrospective database review was performed, including 106 patients (33 female...
journal_title：Journal of cancer research and therapeutics
pub_type： 杂志文章
doi：10.4103/jcrt.JCRT_930_17
更新日期：2018-01-01 00:00:00
abstract：PURPOSE:To assess the efficacy of radiation in the treatment of juvenile nasopharyngeal angiofibroma (JNA). MATERIALS AND METHODS:Data were retrieved for JNA treated with radiotherapy from 1987-2012. The demographics, treatment and outcome data were recorded in predesigned proforma. RESULTS:Data of 32 patients were r...
journal_title：Journal of cancer research and therapeutics
pub_type： 杂志文章
doi：10.4103/0973-1482.150349
更新日期：2015-01-01 00:00:00
abstract：OBJECTIVE:The aim of the study was to investigate the expression of Twist, E-cadherin, and N-cadherin both in normal endometrium and in endometrioid adenocarcinoma tissues (NET and EAT), and further discuss the relationship between the proteins expression and the clinical parameters. METHODS:Seventy-six EAT and 50 NET...
journal_title：Journal of cancer research and therapeutics
pub_type： 杂志文章
doi：10.4103/jcrt.JCRT_405_17
更新日期：2017-01-01 00:00:00
abstract：:Healthy breast tissue is sensitive to radiation fraction size, such that small changes in fraction size can lead to larger changes in radiation effects on these tissues. Conventional breast and/or chest wall irradiation uses 2 Gy daily fractions, for 5-6 weeks. Such a long treatment schedule has major implications on ...
journal_title：Journal of cancer research and therapeutics
pub_type： 杂志文章,评审
doi：10.4103/0973-1482.157342
更新日期：2015-04-01 00:00:00
abstract：Aim of Study:One of the new methods that have promising results is the use of cell-derived microvesicles (MVs) to kill tumor cells. Given that MVs contain apoptotic materials, genes, and proteins, they can interfere with the fate of adjacent cells. Materials and Methods:In the present study, after adipose tissue-deriv...
journal_title：Journal of cancer research and therapeutics
pub_type： 杂志文章
doi：10.4103/jcrt.JCRT_147_18
更新日期：2019-07-01 00:00:00
abstract：:Papillary carcinoma is a well-differentiated type of thyroid carcinoma with very good overall prognosis. The commonest site of metastases is the lymph node, distant metastases being rare. We present a case of a 52-year-old male who presented with a solitary metastasis in the left para-sellar region and cavernous sinus...
journal_title：Journal of cancer research and therapeutics
pub_type： 杂志文章,评审
doi：10.4103/0973-1482.103528
更新日期：2012-07-01 00:00:00
abstract：Introduction:Human papillomavirus (HPV) is emerging as a risk factor for esophageal squamous carcinoma. The prognostic value of the HPV status has been investigated. However, the results are much controversial. Aim:This study aims to document the association of HPV infection and mutation of p53 gene in esophageal squa...
journal_title：Journal of cancer research and therapeutics
pub_type： 杂志文章
doi：10.4103/jcrt.JCRT_296_17
更新日期：2020-12-01 00:00:00
abstract：:Many oral lesions may need to be diagnosed by removing a sample of tissue from the oral cavity. Biopsy is widely used in the medical field, but the practice is not quite widespread in dental practice. As oral pathologists, we have found many artifacts in the tissue specimen because of poor biopsy technique or handling...
journal_title：Journal of cancer research and therapeutics
pub_type： 杂志文章,评审
doi：10.4103/0973-1482.98969
更新日期：2012-04-01 00:00:00
abstract：OBJECTIVE:The aim of this retrospective study was to evaluate the clinical efficacy and prognosis of breast-conserving surgery versus modified radical mastectomy in the treatment of early stage breast cancer. PATIENTS AND METHODS:Two hundred and nineteen cases of early stage breast cancer were reviewed and retrospecti...
journal_title：Journal of cancer research and therapeutics
pub_type： 杂志文章
doi：10.4103/0973-1482.163835
更新日期：2015-08-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to assess Ezrin expression in the primary hepatic carcinoma patients and associated with clinical, pathological characteristics. MATERIALS AND METHODS:Fifty-one patients with primary hepatocellular carcinoma (PHC) with completed clinical data were retrospectively analyzed in this st...
journal_title：Journal of cancer research and therapeutics
pub_type： 杂志文章
doi：10.4103/0973-1482.200761
更新日期：2016-12-01 00:00:00
abstract：AIM OF STUDY:To explore sanazole (AK) directed targeting of the antineoplastic drug doxorubicin (DOX) complexed with silver nanoparticles (SNs) to tumor growth in a murine model. MATERIALS AND METHODS:Sanazole (AK) and DOX were complexed with SNs, individually and in combination to obtain SN-AK, SN-DOX, and SN-AK-DOX....
journal_title：Journal of cancer research and therapeutics
pub_type： 杂志文章
doi：10.4103/0973-1482.148705
更新日期：2014-10-01 00:00:00
abstract：:[This corrects the article DOI: 10.4103/0973-1482.163868.]. ...
journal_title：Journal of cancer research and therapeutics
pub_type： 已发布勘误
doi：10.4103/0973-1482.197539
更新日期：2016-07-01 00:00:00
abstract：AIM:To evolve a fast dose verification method for high-dose-rate (HDR) brachytherapy treatment plans and to demonstrate its applicability in different clinical cases. MATERIALS AND METHODS:We developed a software tool in VC++ for the Varisource HDR unit for HDR dosimetry plan verification using TG-43 parameters. HDR t...
journal_title：Journal of cancer research and therapeutics
pub_type： 杂志文章
doi：10.4103/0973-1482.44288
更新日期：2008-10-01 00:00:00
abstract：AIM:Concurrent chemoradiotherapy (CRT) is the standard therapy for patients with unresectable Stage III nonsmall cell lung cancer (NSCLC). The aim of this study was to assess the efficacy and safety of concurrent CRT in unresectable Stage III NSCLC in Turkey. PATIENTS AND METHODS:The study included 82 patients with hi...
journal_title：Journal of cancer research and therapeutics
pub_type： 杂志文章
doi：10.4103/0973-1482.163682
更新日期：2016-01-01 00:00:00
abstract：Objective:Undesired neutron contamination imposed to patients during treatment is among the main factors increasing the risk of secondary cancer in radiotherapy. This additional undesirable dose is due to neutron contamination production in high-energy accelerators. In this study, neutron contamination is investigated ...
journal_title：Journal of cancer research and therapeutics
pub_type： 杂志文章
doi：10.4103/jcrt.JCRT_1257_16
更新日期：2019-03-01 00:00:00
abstract：AIM:This study was aimed to assess the in vivo anti-tumoral potency of the novel 6-nitro-2-(3-chloropropyl)-1H-benz[de]isoquinoline-1,3-dione [Compound 1] that has earlier demonstrated excellent cytotoxicity in 15 out of 17 human tumor cell lines tested. MATERIALS AND METHODS:Two murine tumors namely Sarcoma-180 (S-18...
journal_title：Journal of cancer research and therapeutics
pub_type： 杂志文章
doi：10.4103/0973-1482.119332
更新日期：2013-07-01 00:00:00
abstract：:Basal cell adenoma (BCA) of the salivary glands is an uncommon type of monomorphic adenoma which constitutes 1% of all salivary gland tumors. It most commonly involves parotid gland, while it rarely occurs in minor salivary glands. Upper lip, buccal mucosa, and lower lip are the common intraoral sites; whereas, palate...
journal_title：Journal of cancer research and therapeutics
pub_type： 信件
doi：10.4103/0973-1482.147391
更新日期：2015-10-01 00:00:00
abstract：Aim of the Study:Both matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) is involved in degradation of extracellular matrix and found to stimulate invasion and metastasis in cancer patients. However, studies on the stage-specific expression of MMPs at different stages of larynx carcinoma are stil...
journal_title：Journal of cancer research and therapeutics
pub_type： 杂志文章
doi：10.4103/jcrt.JCRT_360_18
更新日期：2020-04-01 00:00:00
abstract：Background:Squamous cell carcinoma (SCC) of the breast is an extremely rare tumor with vague natural behavior and treatment. The purpose of this study was to identify the clinicopathological features and treatment results of this rare type of breast cancer. Materials and Methods:The medical files of patients with SCC ...
journal_title：Journal of cancer research and therapeutics
pub_type： 杂志文章
doi：10.4103/jcrt.JCRT_303_17
更新日期：2019-07-01 00:00:00
abstract：:Renal cell carcinoma, unclassified constitute about 3-4% of all renal carcinomas. It essentially is a tumor where more than morphological variants or subtypes are seen in a single tumor. Usually there is a mixture of 2-3 different types. However, in this particular case there were at least 5 different types of morphol...
journal_title：Journal of cancer research and therapeutics
pub_type： 信件
doi：10.4103/0973-1482.151420
更新日期：2015-10-01 00:00:00
abstract：:Camrelizumab is a programmed death receptor-1 inhibitor originally developed in China for the treatment of refractory lymphoma. It has also been effective in non-small-cell lung cancer patients. However, the rechallenge of camrelizumab was not reported previously. We report the rechallenge of camrelizumab therapy in t...
journal_title：Journal of cancer research and therapeutics
pub_type：
doi：10.4103/jcrt.JCRT_798_20
更新日期：2020-09-01 00:00:00
abstract：:Lymphoproliferative malignancies can involve both nodal- and extra-nodal tissues. The most common extranodal site involved is the gastrointestinal (GI) tract, and it is secondary to the widespread primary nodal disease. However, about 33% of non-Hodgkin's lymphoma primarily arise from tissues other than lymph nodes, s...
journal_title：Journal of cancer research and therapeutics
pub_type：
doi：10.4103/jcrt.JCRT_239_17
更新日期：2020-01-01 00:00:00
abstract：:Despite recent advances in treatment with multidrug chemotherapy regimens, outcomes of patients with advanced pancreatic ductal adenocarcinoma (PDAC) remain very poor. Treatment with targeted therapies has shown marginal benefits due to intrinsic or acquired resistance. Actionable mutations, while detected infrequentl...
journal_title：Journal of cancer research and therapeutics
pub_type： 杂志文章,评审
doi：10.4103/jcrt.JCRT_729_18
更新日期：2020-07-01 00:00:00
abstract：OBJECTIVE:The objective of the study is to investigate whether hospital-based transitional care can reduce the postoperative complication in patients who received enterostomy or not by pooling the published prospective clinical studies. MATERIALS AND METHODS:Prospective clinical studies related to hospital-based trans...
journal_title：Journal of cancer research and therapeutics
pub_type： 杂志文章,meta分析
doi：10.4103/0973-1482.191637
更新日期：2016-10-01 00:00:00
abstract：BACKGROUND:Prostate-specific membrane antigen (PSMA) is a widely used targeted molecule in prostate patients. The present research, attempts to support the hypothesis that PSMA expression in prostate cancer stem cell-like (CSC) cell populations may be correlated with nanog and other transcription factors in different s...
journal_title：Journal of cancer research and therapeutics
pub_type： 杂志文章
doi：10.4103/0973-1482.131461
更新日期：2014-01-01 00:00:00
