Stage-specific expression analysis ofMMP-2 & MMP-9 in laryngeal carcinoma.

Abstract:

Aim of the Study:Both matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) is involved in degradation of extracellular matrix and found to stimulate invasion and metastasis in cancer patients. However, studies on the stage-specific expression of MMPs at different stages of larynx carcinoma are still lacking. In the present study, we compare the expression level of MMP-2 and MMP-9 at different stages of laryngeal carcinoma. Material and Methods:Tumor tissues samples were taken from larynx cancer patients by deep biopsy during direct laryngoscopy. Gene expression for MMP-2 and MMP-9 was analyzed using RT-PCR. Results:Significantly high expression of MMP-2 was observed compared to the MMP-9 at stage IV compared to the less advanced stages of the disease. Conclusion:Present study concluded that the MMP-2 expressed with a greater magnitude as compared to the MMP-9 in advance stages of laryngeal carcinoma.

journal_name

J Cancer Res Ther

authors

Bakshi J,Goyal AK,Singh V,Sannigrahi M,Khullar M

doi

10.4103/jcrt.JCRT_360_18

subject

Has Abstract

pub_date

2020-04-01 00:00:00

pages

517-520

issue

3

eissn

0973-1482

issn

1998-4138

pii

JCanResTher_2020_16_3_517_263623

journal_volume

16

pub_type

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