Abstract:
Background:Squamous cell carcinoma (SCC) of the breast is an extremely rare tumor with vague natural behavior and treatment. The purpose of this study was to identify the clinicopathological features and treatment results of this rare type of breast cancer. Materials and Methods:The medical files of patients with SCC of the breast presented to Alexandria Main University Hospital during the period from January 1990 to January 2010 were retrospectively reviewed, regarding clinicopathological characteristics and treatment outcome and analyzed. Results:A total of 17 patients were included in this analysis. The median age was 50 years. All patients presented with breast mass. The majority of tumors (88.2%) was negative for hormone receptors. Two-thirds of patients had early T-stage. All patients underwent surgery in our center. Adjuvant tamoxifen was given for two patients. Twelve patients (70.6%) received different adjuvant chemotherapy protocols, and eight patients received radiotherapy. The median disease-free survival was 24 months, and the median overall survival was 40 months. Patients received adjuvant chemotherapy had a statistically significant better disease-free survival (P = 0.014) and overall survival (P = 0.019) compared to patients treated without chemotherapy. Radiotherapy had no significant impact on either disease-free survival or overall survival. Conclusions:SCC of the breast is a very aggressive tumor, and adjuvant chemotherapy should be strongly considered.
journal_name
J Cancer Res Therjournal_title
Journal of cancer research and therapeuticsauthors
Soliman Mdoi
10.4103/jcrt.JCRT_303_17subject
Has Abstractpub_date
2019-07-01 00:00:00pages
1057-1061issue
5eissn
0973-1482issn
1998-4138pii
JCanResTher_2019_15_5_1057_229635journal_volume
15pub_type
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journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
doi:10.4103/0973-1482.137993
更新日期:2014-10-01 00:00:00
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journal_title:Journal of cancer research and therapeutics
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更新日期:2017-04-01 00:00:00
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journal_title:Journal of cancer research and therapeutics
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journal_title:Journal of cancer research and therapeutics
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journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
doi:10.4103/jcrt.JCRT_1066_19
更新日期:2020-09-01 00:00:00
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journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章,评审
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更新日期:2012-07-01 00:00:00
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journal_title:Journal of cancer research and therapeutics
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journal_title:Journal of cancer research and therapeutics
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journal_title:Journal of cancer research and therapeutics
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journal_title:Journal of cancer research and therapeutics
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更新日期:2017-07-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2010-04-01 00:00:00
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journal_title:Journal of cancer research and therapeutics
pub_type: 信件
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更新日期:2014-04-01 00:00:00
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journal_title:Journal of cancer research and therapeutics
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journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
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更新日期:2017-04-01 00:00:00
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journal_title:Journal of cancer research and therapeutics
pub_type: 信件
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journal_title:Journal of cancer research and therapeutics
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journal_title:Journal of cancer research and therapeutics
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