Genetic variants identified by GWAS was associated with colorectal cancer in the Han Chinese population.

Abstract:

AIM OF STUDY:Colorectal cancer (CRC), now the third most common cancer across the world, is known to aggregate in families. Recently, genome-wide association studies have identified two single nucleotide polymorphisms (SNP) associated with CRC in Caucasians. MATERIALS AND METHODS:To validate whether the same variations conferred risk to CRC in the Han Chinese population, we genotyped 760 individuals (380 controls and 380 cases samples) recruited from the Han Chinese origin. RESULTS:We found rs11987193 in 8p12 (P = 0.0472 after correction, OR = 0.751) was significantly associated with CRC but rs12080929 in 1p33 (P = 0.0650 after correction, OR = 0.750) was not. CONCLUSION:Our findings supported that rs11987193 is a susceptibility locus for CRC, and gene DUSP4 was possible to play a role in the pathology of CRC.

journal_name

J Cancer Res Ther

authors

Qiao HP,Zhang CY,Yu ZL,Li QM,Jiao Y,Cao JP

doi

10.4103/0973-1482.150346

subject

Has Abstract

pub_date

2015-04-01 00:00:00

pages

468-70

issue

2

eissn

0973-1482

issn

1998-4138

pii

JCanResTher_2015_11_2_468_150346

journal_volume

11

pub_type

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