Feasibility and safety of GliaSite brachytherapy in treatment of CNS tumors following neurosurgical resection.

Abstract:

PURPOSE:To investigate feasibility and safety of GliaSite brachytherapy for treatment of central nervous system (CNS) tumors following neurosurgical resection. We report mature results of long-term follow-up, outcomes and toxicity. MATERIALS AND METHODS:In the period from 2004 to 2007, 10 consecutive adult patients with recurrent, newly diagnosed, and metastatic brain malignancies underwent GliaSite brachytherapy following maximally safe neurosurgical resection. While 6/10 (60%) patients were treated for recurrence, having previously been treated with external beam radiotherapy (EBRT), 4/10 (40%) received radiotherapy (RT) for the first time. A median dose of 52.0 Gy (range, 45.0 - 60.0 Gy) was prescribed to 0.5 cm - 1.0 cm from the balloon surface. Radiation Therapy Oncology Group (RTOG) criteria were used to assess toxicities associated with this technique. Follow-up was assessed with MRI scans and was available on all enrolled patients. RESULTS:Median follow-up was 38 months (range, 18 - 57 months). Mean size of GliaSite balloon was 3.4 cm (range, 2.0 - 4.0 cm). Median survival was 14.0 months for the entire cohort after the treatment. The 17.6 and 16.0 months average survival for newly diagnosed and recurrent high grade gliomas (HGG), respectively, translated into a three-month improvement in survival in patients with newly diagnosed HGG compared to historical controls (P = 0.033). There were no RTOG grades 3 or 4 acute or late toxicities. Follow-up magnetic resonance imaging (MRI) imaging did not identify radiation necrosis. CONCLUSIONS:Our data indicate that treatment with GliaSite brachytherapy is feasible, safe and renders acceptable local control, acute and long-term toxicities. We are embarking on testing larger numbers of patients with this treatment modality.

journal_name

J Cancer Res Ther

authors

Wernicke AG,Sherr DL,Schwartz TH,Pannullo SC,Stieg PE,Boockvar JA,Ivanidze J,Moliterno JA,Parashar B,Trichter S,Sabbas AM,Nori D

doi

10.4103/0973-1482.63547

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

65-74

issue

1

eissn

0973-1482

issn

1998-4138

pii

JCanResTher_2010_6_1_65_63547

journal_volume

6

pub_type

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