Abstract:
CONTEXT:Renal cell carcinoma (RCC) is a kidney cancer that originates in renal parenchyma and it is the most common type of kidney cancer with approximately 80% lethal cases. AIMS:To interpret the mechanism, explore the regulation of TF-target genes and TF-pathway, and identify the potential key genes of renal cell carcinoma. SETTINGS AND DESIGN:After constructing a regulation network from differently expressed genes and transcription factors, pathway regulation network and gene ontology (GO) enrichment analysis were made. MATERIALS AND METHODS:The gene expression profile set GSE6344, a renal cell carcinoma sample set, was collected from NCBI, pathway data from KEGG, and regulationship data from database TRANSFAC and TRED. STATISTICAL ANALYSIS USED:Besides different expressed genes obtained by limma, impact analysis method and GO enrichment were applied to find the significant expressed pathways. RESULTS:Finally, we constructed a TF-target gene and TF-pathway regulation network of renal cell carcinoma. And some genes proved to be highly related to renal cell carcinoma were identified. CONCLUSIONS:This study illustrated that by incorporating significantly expressed pathway into a regulation network based analysis, one can derive greater insights into the underlying mechanisms of renal cell carcinoma.
journal_name
J Cancer Res Therjournal_title
Journal of cancer research and therapeuticsauthors
Zhai W,Xu YF,Liu M,Zheng JHdoi
10.4103/0973-1482.95170subject
Has Abstractpub_date
2012-01-01 00:00:00pages
28-33issue
1eissn
0973-1482issn
1998-4138pii
JCanResTher_2012_8_1_28_95170journal_volume
8pub_type
杂志文章abstract:OBJECTIVE:The purpose of this study was to evaluate the postoperative complications for patients with adenocarcinoma of esophagogastric junction. METHODS:Two hundred and eighty subjects with adenocarcinoma of esophagogastric junction who received operation were retrospectively analyzed from June 2006 to December 2010 ...
journal_title:Journal of cancer research and therapeutics
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