当前位置： SCI文献检索 > Journal of Cancer Research and Therapeutics期刊下所有文献 > Oral rinse-based cytology and conventional exfoliative cytology: a comparative study.

Oral rinse-based cytology and conventional exfoliative cytology: a comparative study.

Abstract：

CONTEXT:Simple screening test for resource-challenged areas. AIMS:To compare specimen adequacy and diagnostic agreement between oral rinse-based smears and conventional smears in oral cancer, oral leukoplakia, and normal controls. SETTINGS AND DESIGN:Twenty-five histologically confirmed cases of oral cancer, 29 clinically diagnosed cases of oral leukoplakia, and 54 normal controls were subjected to the oral rub-and-rinse technique and the conventional exfoliative cytology. PATIENTS AND METHODS:Smears were consequently stained with the Papanicolaou (PAP) stain and were examined independently by two different cytopathologists in a double-blind fashion. The results were classified as: Negative, atypical, positive, and unsatisfactory. Furthermore, they were compared, to assess the sample adequacy, cellular distribution, staining, leucocytes/inflammation and cellular clarity in both the smears. STATISTICAL ANALYSIS USED:Chi square test and Wilcoxon-matched pairs signed rank test (P ≤ 0.05). RESULTS:Among the cancer cases, 84% showed positive, 8% atypical, and 8% unsatisfactory, after using the conventional technique, whereas, the oral rinse technique showed 80% positive, 16% atypical, and 4% unsatisfactory cases. The conventional technique showed 44.82, 37.93, and 6.89% and the oral rinse technique showed 48.27, 31.03, and 20.68% negative, positive, and atypical cases, respectively, among the leukoplakia cases. Among the normal controls, 9.26 and 90.74% and with the oral rinse technique 3.70 and 96.29% showed atypical and negative cases with the conventional technique. Sample adequacy and cellular clarity showed a statistically significant difference between both techniques. CONCLUSIONS:Both smears were diagnostically reliable, however, the oral rinse-based method showed an overall improvement in sample adequacy and cellular clarity.

journal_name

J Cancer Res Ther

journal_title

Journal of cancer research and therapeutics

authors

Mulki S,Shetty P,Pai P

doi

10.4103/0973-1482.137910

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

129-35

issue

eissn

0973-1482

issn

1998-4138

pii

JCanResTher_2015_11_1_129_137910

journal_volume

pub_type

杂志文章

在线工具

Oral rinse-based cytology and conventional exfoliative cytology: a comparative study.