Analysis of induced error by susceptibility effect in low-density gel dosimeters.

Abstract:

Purpose:In low-density (LD) gel dosimeter, diffusive spin-spin relaxation rate (R2)-dispersion caused by susceptibility-induced internal gradient leads to a significant deviation in the measured R2 from the real value. In this study, the effect of induced internal gradient on R2 was visualized and quantified algebraically as an important cause of inaccuracy in LD gel dosimeters. Materials and Methods:In this method, two sets of LD and unit-density (UD) gel dosimeters were prepared. The LD gel was made by mixing the UD gel with expanded polystyrene spheres. The R2 was used to determine the spatially resolved decay rates due to diffusion in internal magnetic field. The internal gradient was calculated for a multiple spin-echo sequence. Results:It is shown that in a LD gel, the internal gradient leads to overestimation of mean R2 value (R2mean). Pixel-by-pixel R2 measurements inside a LD gel showed significant deviation from R2 mapping in UD gel. Conclusion:It appears that significant differences between R2mean in a selected region of interest and pixel-by-pixel R2 values are the main source of inaccuracy in dose mapping of a LD gel.

journal_name

J Cancer Res Ther

authors

Pak F,Vaezzadeh V,Eqlimi E,Mirheydari M

doi

10.4103/jcrt.JCRT_407_17

subject

Has Abstract

pub_date

2019-07-01 00:00:00

pages

498-503

issue

3

eissn

0973-1482

issn

1998-4138

pii

JCanResTher_2019_15_3_498_244214

journal_volume

15

pub_type

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