Abstract：
:Aspirin remains one of the most extensively studied cardiovascular medications in the history of medicine. However, despite multiple, well-designed, large randomized controlled trials evaluating the potential of aspirin to prevent cardiovascular events in individuals without known cardiovascular disease (CVD), the role of aspirin in primary prevention is currently unclear. The initial aspirin trials included largely low-risk individuals with primary outcomes mostly focused on myocardial infarction (MI) and stroke, and showed a significant reduction in these CVD outcomes, especially MI. The more recently conducted trials have focused on older, higher CVD risk populations with high rates of lipid-lowering and antihypertensive medications use. These studies have used broader CVD outcomes as their primary end points and have failed to show a significant benefit of aspirin therapy in primary prevention. The exact reasons for the lack of efficacy in these recent trials are unclear but may be related to low rate of atherothrombotic events relative to other CVD events in the populations studied. Four large randomized controlled trials are currently underway which should provide some clarity in determining the optimal use of aspirin in the primary prevention of CVD.
journal_name
Curr Atheroscler Repjournal_title
Current atherosclerosis reportsauthors
Miedema MD,Huguelet J,Virani SSdoi
10.1007/s11883-015-0555-0subject
Has Abstractpub_date
2016-01-01 00:00:00pages
4issue
1eissn
1523-3804issn
1534-6242pii
10.1007/s11883-015-0555-0journal_volume
18pub_type
杂志文章,评审abstract：:Diabetes and its micro- and macrovascular complications represent a worldwide epidemic that will place an enormous financial burden on poorer countries in the years to come. In patients with diabetes and hypertension, the main determinant of the cardiovascular and renal benefits of antihypertensive drugs is the blood ...
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更新日期：2011-04-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2014-10-01 00:00:00
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journal_title：Current atherosclerosis reports
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更新日期：2019-04-12 00:00:00
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journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
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更新日期：2002-11-01 00:00:00
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journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
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更新日期：2001-03-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2019-11-19 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2020-06-18 00:00:00
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journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
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更新日期：2005-02-01 00:00:00
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journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
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更新日期：2002-09-01 00:00:00
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更新日期：2002-07-01 00:00:00
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journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
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更新日期：2000-07-01 00:00:00
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journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
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更新日期：2020-08-09 00:00:00
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journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-008-0013-3
更新日期：2008-02-01 00:00:00
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journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
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更新日期：2008-08-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2004-11-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2012-08-01 00:00:00
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journal_title：Current atherosclerosis reports
pub_type： 杂志文章
doi：10.1007/s11883-007-0066-8
更新日期：2007-12-01 00:00:00
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更新日期：2018-07-17 00:00:00
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journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
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更新日期：2002-05-01 00:00:00
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journal_title：Current atherosclerosis reports
pub_type： 杂志文章
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更新日期：2009-03-01 00:00:00
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更新日期：2019-05-01 00:00:00
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更新日期：2018-05-19 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2004-09-01 00:00:00
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journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
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更新日期：2006-05-01 00:00:00
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journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
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更新日期：2009-03-01 00:00:00
abstract：:The matrix metalloproteinase (MMP) family of enzymes is involved in arterial wall extracellular matrix degradation and remodeling. The latter activities have been implicated in a number of normal and pathologic processes, such as atherosclerotic lesion formation and progression, plaque destabilization and rupture, but...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
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更新日期：2011-04-01 00:00:00
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journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-009-0030-x
更新日期：2009-05-01 00:00:00
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journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-011-0201-4
更新日期：2011-12-01 00:00:00
abstract：:Raised plasma triglyceride (TG) levels are an independent risk factor for coronary artery disease (CAD), and thus understanding the genetic and environmental determinants of TG levels are of major importance. TG metabolism is a process for delivering free fatty acids for energy storage or b-oxidation, and involves a n...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-001-0061-4
更新日期：2001-05-01 00:00:00
