Abstract:
:Vascular inflammation contributes critically to the initiation and progression of atherosclerosis. These processes are accelerated in hyperglycemia and play key roles in the increased incidence and severity of myocardial infarction and stroke observed in diabetes. Evidence suggests that the ligands of the receptor for advanced glycation endproducts (RAGE), a multiligand member of the immunoglobulin superfamily, interact with this receptor to play important roles in both early development and progression of atherosclerosis and vascular inflammation. Studies in animal models of vascular injury underscored the potent impact of RAGE blockade; administration of ligand-binding decoys of RAGE or antibodies to the receptor reduced the consequences of diabetes, hyperlipidemia, and physical injury to the vessel wall. This review focuses on the ligand repertoire of RAGE, the impact of ligand-RAGE interaction, and the potent effect of RAGE blockade in rodent models of vascular injury.
journal_name
Curr Atheroscler Repjournal_title
Current atherosclerosis reportsauthors
Yan SF,Naka Y,Hudson BI,Herold K,Yan SD,Ramasamy R,Schmidt AMdoi
10.1007/s11883-006-0078-9subject
Has Abstractpub_date
2006-05-01 00:00:00pages
232-9issue
3eissn
1523-3804issn
1534-6242journal_volume
8pub_type
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journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11883-005-0049-6
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更新日期:2002-11-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2015-12-01 00:00:00
abstract:PURPOSE OF REVIEW:The review aims to describe the differences between men and women in those factors that can influence a worse prognosis in women after an acute cardiovascular event. RECENT FINDINGS:Women adequately treated with current evidence-based medications for acute myocardial infarction and for conventional c...
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pub_type: 杂志文章,评审
doi:10.1007/s11883-020-00882-4
更新日期:2020-09-03 00:00:00
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pub_type: 杂志文章,评审
doi:10.1007/s11883-003-0037-7
更新日期:2003-11-01 00:00:00
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journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
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更新日期:2008-12-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1007/s11883-013-0309-9
更新日期:2013-03-01 00:00:00
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journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
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更新日期:2005-02-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2011-04-01 00:00:00
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pub_type: 杂志文章,meta分析,评审
doi:10.1007/s11883-020-0829-z
更新日期:2020-04-23 00:00:00
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pub_type: 杂志文章,评审
doi:10.1007/s11883-020-0821-7
更新日期:2020-01-07 00:00:00
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journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11883-004-0104-8
更新日期:2004-03-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1007/s11883-010-0102-y
更新日期:2010-05-01 00:00:00
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journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11883-009-0030-x
更新日期:2009-05-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1007/s11883-012-0294-4
更新日期:2013-01-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1007/s11883-016-0597-y
更新日期:2016-07-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2010-03-01 00:00:00
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更新日期:2019-11-29 00:00:00
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更新日期:2004-05-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1007/s11883-005-0059-4
更新日期:2005-11-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2015-08-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2011-08-01 00:00:00
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更新日期:2019-11-21 00:00:00
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更新日期:2015-06-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2014-10-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2004-09-01 00:00:00