High-Intensity Interval Training in Patients with Type 2 Diabetes Mellitus: a Systematic Review.

Abstract:

PURPOSE OF REVIEW:High-intensity exercise may beneficially impact on insulin sensitivity. However, there is still uncertainty on the actual impact of high-intensity interval training (HIIT) on chronic physiologic adaptations among patients with type 2 diabetes mellitus (T2DM). We aimed to systematically search and appraise the evidence base on the effects of HIIT in comparison to mild- or moderate-intensity interval training (MMIIT) on glycemic control inT2DM. RECENT FINDINGS:A total of 5 RCT met the inclusion criteria. Most studies presented significant differences for weight and BMI with HIIT, and with both interventions for total body fat. For the other health-related variables (systolic and diastolic BP, fasting cholesterol, LDL and HDL, triglycerides, fasting glucose, and HbAc1), only 1 study provided detailed results for HIIT, showing significant differences for systolic BP and HDL cholesterol in 2 studies, total cholesterol, LDL, and triglycerides, whereas for MIIT, only 1 study brought significant differences for LDL cholesterol. For glucose levels, significant differences were reported in 4 studies for both HIIT and MMIT, but only two studies used the percentage delta assessment tool, whereas 1 study only showed significant improvements for HIIT. The number of studies for the analysis is not precise as to the statements regarding the results of the intervention proposed for this public, since they do not allow identifying a consistency of the findings, not presenting diversity between the training methods and the different methods of volume control and intensity of training.

journal_name

Curr Atheroscler Rep

authors

da Silva DE,Grande AJ,Roever L,Tse G,Liu T,Biondi-Zoccai G,de Farias JM

doi

10.1007/s11883-019-0767-9

subject

Has Abstract

pub_date

2019-02-02 00:00:00

pages

8

issue

2

eissn

1523-3804

issn

1534-6242

pii

10.1007/s11883-019-0767-9

journal_volume

21

pub_type

杂志文章
  • Vitamin D, Calcium, and Cardiovascular Disease: A"D"vantageous or "D"etrimental? An Era of Uncertainty.

    abstract::While the function of vitamin D in regulating calcium homeostasis is well established, there has been growing interest in its role in the prevention of numerous chronic diseases, including cardiovascular disease (CVD). There is mounting epidemiological evidence suggesting that vitamin D deficiency is linked to increas...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-017-0637-2

    authors: Chin K,Appel LJ,Michos ED

    更新日期:2017-01-01 00:00:00

  • The high-risk plaque initiative: primary prevention of atherothrombotic events in the asymptomatic population.

    abstract::The High-Risk Plaque (HRP) Initiative is a research and development effort to advance the understanding, recognition, and management of asymptomatic individuals at risk for a near-term atherothrombotic event such as myocardial infarction or stroke. Clinical studies using the newest technologies have been initiated, in...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s11883-011-0193-0

    authors: Falk E,Sillesen H,Muntendam P,Fuster V

    更新日期:2011-10-01 00:00:00

  • Novel mechanisms of abdominal aortic aneurysms.

    abstract::Abdominal aortic aneurysms (AAAs) are a common but asymptomatic disease that has high susceptibility to rupture. Current therapeutic options are limited to surgical procedures because no pharmacological approaches have been proven to decrease either expansion or rupture of human AAAs. The current dearth of effective m...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-012-0271-y

    authors: Lu H,Rateri DL,Bruemmer D,Cassis LA,Daugherty A

    更新日期:2012-10-01 00:00:00

  • Should hyperhomocysteinemia be treated in patients with atherosclerotic disease?

    abstract::Numerous retrospective and prospective observational studies support an association between elevated homocysteine and increased risk for myocardial infarction, stroke, and peripheral vascular disease. Although folic acid therapy substantially reduces homocysteine levels, recent large, randomized controlled trials fail...

    journal_title:Current atherosclerosis reports

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/s11883-007-0048-x

    authors: Maron BA,Loscalzo J

    更新日期:2007-11-01 00:00:00

  • Blood lipids and stroke: what more can we do besides reducing low-density lipoprotein cholesterol?

    abstract::Statin therapy has became the most important advance in stroke prevention since the introduction of aspirin and blood pressure-lowering therapies. Other lipid-modifying drugs have been less successful in reducing the incidence of stroke, but because of evidence for the use of triglyceride-lowering drugs and treatments...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-011-0186-z

    authors: Deplanque D,Amarenco P

    更新日期:2011-08-01 00:00:00

  • Mouse models of lipodystrophy.

    abstract::Lipodystrophies are a group of heterogeneous diseases characterized by the loss of adipose tissue and by abnormalities of carbohydrate and lipid metabolism, including insulin resistance, diabetes, and hyperlipidemia. In this review, we describe several mouse models that recapitulate various aspects of the lipodystroph...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-000-0077-1

    authors: Reue K,Péterfy M

    更新日期:2000-09-01 00:00:00

  • Genome-wide association studies in atherosclerosis.

    abstract::Cardiovascular disease remains the major cause of worldwide morbidity and mortality. Its pathophysiology is complex and multifactorial. Because the phenotype of cardiovascular disease often shows a marked heritable pattern, it is likely that genetic factors play an important role. In recent years, large genome-wide as...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-011-0173-4

    authors: Sivapalaratnam S,Motazacker MM,Maiwald S,Hovingh GK,Kastelein JJ,Levi M,Trip MD,Dallinga-Thie GM

    更新日期:2011-06-01 00:00:00

  • Sex-Based Differences in Chronic Total Occlusion Management.

    abstract::ᅟ: Chronic total occlusions (CTOs) are an important and increasingly recognized subgroup of coronary lesions, documented in at least 30%, but up to 52% of patients with coronary artery disease (CAD) undergoing coronary angiography. Percutaneous coronary intervention (PCI) of these lesions is increasingly pursued, with...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-018-0760-8

    authors: Cheney A,Kearney KE,Lombardi W

    更新日期:2018-11-07 00:00:00

  • The effect of gastrointestinal surgery on insulin resistance and insulin secretion.

    abstract::Diabesity is a term often used to indicate the association of type-2 diabetes mellitus (T2DM) with obesity; the prevalence of both conditions is rapidly increasing worldwide and has reached epidemic proportions. Insulin resistance represents the major determinant of T2DM, which becomes manifest once relative β-cell fa...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-012-0284-6

    authors: Castagneto M,Mingrone G

    更新日期:2012-12-01 00:00:00

  • Postprandial hypertriglyceridemia and cardiovascular disease: current and future therapies.

    abstract::Exaggerated postprandial hypertriglyceridemia is a risk factor for cardiovascular disease. This metabolic abnormality is principally due to overproduction and/or decreased catabolism of triglyceride-rich lipoproteins (TRLs) and is a consequence of pathogenic genetic variations and other coexistent medical conditions, ...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-013-0309-9

    authors: Chan DC,Pang J,Romic G,Watts GF

    更新日期:2013-03-01 00:00:00

  • Pleiotropic effects of statins: moving beyond cholesterol control.

    abstract::3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors or "statin" medications are the most commonly prescribed therapy for lowering cholesterol. In use for over a decade, they have demonstrated both safety and tolerability across a broad range of patients. The ability to inhibit the biosynthesis of cholesterol an...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-005-0073-6

    authors: Garcia PJ

    更新日期:2005-02-01 00:00:00

  • A general assessment of the safety of HMG CoA reductase inhibitors (statins).

    abstract::Few principles in medicine today are as well accepted as the benefits of using statins to reduce cardiovascular risk factors and to prevent cardiovascular disease. The recent withdrawal of a statin (cerivastatin) has lead to a re-examination of all statins, and an attempt to better assess the risk-benefit ratio of thi...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-002-0060-0

    authors: Black DM

    更新日期:2002-01-01 00:00:00

  • Perivascular Adipose Tissue and Coronary Atherosclerosis: from Biology to Imaging Phenotyping.

    abstract:PURPOSE OF REVIEW:Perivascular adipose tissue (PVAT) has a complex, bidirectional relationship with the vascular wall. In disease states, PVAT secretes pro-inflammatory adipocytokines which may contribute to atherosclerosis. Recent evidence demonstrates that pericoronary adipose tissue (PCAT) may also function as a sen...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-019-0817-3

    authors: Lin A,Dey D,Wong DTL,Nerlekar N

    更新日期:2019-11-19 00:00:00

  • The Role of Nutraceuticals in the Optimization of Lipid-Lowering Therapy in High-Risk Patients with Dyslipidaemia.

    abstract:PURPOSE OF REVIEW:We aimed to summarize recent guidelines, position papers, and high-quality clinical research relating the use of nutraceuticals in the management of individuals at high risk of atherosclerotic cardiovascular disease. RECENT FINDINGS:It is essential that individuals at high risk of cardiovascular dise...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-020-00887-z

    authors: Penson PE,Banach M

    更新日期:2020-09-18 00:00:00

  • HDL as a Causal Factor in Atherosclerosis: Insights from Human Genetics.

    abstract::High-density lipoprotein cholesterol (HDL-C) levels are inversely related to risk of atherosclerotic cardiovascular disease (ASCVD). However, the simplistic assumption that HDL-C levels directly and causally impact atherogenesis has been challenged in recent years. The purpose of this article is to review the current ...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-016-0623-0

    authors: Brunham LR

    更新日期:2016-12-01 00:00:00

  • Evolving concepts regarding transient ischemic attacks.

    abstract::Transient ischemic attack (TIA) represents one end of the spectrum of focal brain ischemia, the other being completed infarction or ischemic stroke. The evolving technologic advancements in neuroimaging continue to change and sharpen the definition, epidemiology, and management of TIA. As a powerful risk factor for is...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-005-0019-z

    authors: Liberato B,Prabhakaran S,Sacco RL

    更新日期:2005-07-01 00:00:00

  • The Air Force/Texas Coronary Atherosclerosis Prevention Study: implications for preventive cardiology in the general adult US population.

    abstract::Atherosclerotic cardiovascular diseases are the most common causes of death in the United States. Fibrous plaques develop in 77% to 78% of men before age 30. The mean low-density lipoprotein-cholesterol (LDL-C) level in men aged 25 to 30 years is 117 mg/dL. In the Air Force/Texas Coronary Atherosclerosis Prevention St...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章

    doi:10.1007/s11883-999-0048-0

    authors: Whitney E

    更新日期:1999-07-01 00:00:00

  • Pharmacology of antiplatelet agents.

    abstract::Pharmacotherapies with agents that inhibit platelet function have proven to be effective in the treatment of acute coronary syndromes, and in the prevention of complications during and after percutaneous coronary intervention. Because of multiple synergetic pathways of platelet activation and their close interplay wit...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-013-0371-3

    authors: Kalra K,Franzese CJ,Gesheff MG,Lev EI,Pandya S,Bliden KP,Tantry US,Gurbel PA

    更新日期:2013-12-01 00:00:00

  • Inflammatory and oxidative markers in atherosclerosis: relationship to outcome.

    abstract::Inflammation and oxidative processes are key components of atherosclerosis, from fatty streak formation to plaque rupture and thrombosis. Recent basic and clinical studies have identified a number of inflammatory and oxidative processes that appear to play a direct role in atherothrombosis and identify potentially cli...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-004-0038-1

    authors: Shishehbor MH,Hazen SL

    更新日期:2004-05-01 00:00:00

  • Paroxysmal Atrial Fibrillation in Cryptogenic Stroke: an Overlooked Explanation?

    abstract::Approximately one third of ischemic strokes are labeled cryptogenic because the etiology is unknown despite a thorough evaluation. Paroxysmal atrial fibrillation carries the same risk of ischemic stroke as persistent atrial fibrillation and has increasingly gained attention as a potential source of cryptogenic stroke....

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-015-0547-0

    authors: Zhang C,Kasner SE

    更新日期:2015-12-01 00:00:00

  • A Clinical Guide to Combination Lipid-Lowering Therapy.

    abstract:PURPOSE OF REVIEW:We provide an overview of our current understanding of combination lipid-lowering therapies intended for dyslipidemia treatment and cardiovascular disease prevention. First, we analyze recent statin and non-statin combination therapy guidelines and clinical studies since the publication of 2013 Americ...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-018-0721-2

    authors: Russell C,Sheth S,Jacoby D

    更新日期:2018-03-07 00:00:00

  • Potential contributions of intimal and plaque hypoxia to atherosclerosis.

    abstract::Injury of arterial endothelium by abnormal shear stress and other insults induces migration and proliferation of vascular smooth muscle cells (VSMCs), which in turn leads to intimal thickening, hypoxia, and vasa vasorum angiogenesis. The resultant new blood vessels extend from the tunica media into the outer intima, a...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-015-0510-0

    authors: Fong GH

    更新日期:2015-06-01 00:00:00

  • Did the antioxidant trials fail to validate the oxidation hypothesis?

    abstract::Most clinical trials on antioxidants using vitamin E or beta-carotene have failed to note any significant change in cardiovascular endpoints. The results of these studies have been interpreted as a setback for the oxidation hypothesis. An analysis of the hypothesis and the trials, however, points out major misconcepti...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-001-0077-9

    authors: Parthasarathy S,Khan-Merchant N,Penumetcha M,Khan BV,Santanam N

    更新日期:2001-09-01 00:00:00

  • Cardiovascular prevention in the cancer survivor.

    abstract::Cancer survivorship should be defined starting not from completion of treatment, but from the time of diagnosis. Assessing and controlling the cancer patient's cardiovascular risk before, during, and after treatment is crucial to improving their overall outcome. There are many cancer therapies, including but not limit...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-014-0484-3

    authors: Chen CL

    更新日期:2015-03-01 00:00:00

  • The Role of Metabolic Surgery in Non-alcoholic Steatohepatitis Improvement.

    abstract:PURPOSE OF REVIEW:Non-alcoholic fatty liver disease (NAFLD) is frequently associated with obesity and overweight. It has a broad spectrum of clinical and histological presentations, such as steatosis, inflammation (known as non-alcoholic steatohepatitis or NASH), fibrosis, and cirrhosis. There is increasing evidence th...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-017-0681-y

    authors: Caravatto PP,Cohen R

    更新日期:2017-10-07 00:00:00

  • Antiatherothrombotic effects of dipeptidyl peptidase inhibitors.

    abstract::Atherothrombotic cardiovascular events are a leading cause of morbidity and mortality in patients with type 2 diabetes (T2D). A number of factors beyond hyperglycemia contribute to this increased risk of cardiovascular events in T2D, including elevated blood pressure, dyslipidemia, inflammation, endothelial dysfunctio...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-014-0408-2

    authors: Cameron-Vendrig A,Mundil D,Husain M

    更新日期:2014-05-01 00:00:00

  • Genetics of Arterial-Wall-Specific Mechanisms in Atherosclerosis: Focus on Mitochondrial Mutations.

    abstract:PURPOSE OF REVIEW:Mutations in both nuclear and mitochondrial genes are associated with the development of atherosclerotic lesions in arteries and may provide a partial explanation to the focal nature of lesion distribution in the arterial wall. This review is aimed to discuss the genetic aspects of atherogenesis with ...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-020-00873-5

    authors: Orekhov AN,Ivanova EA,Markin AM,Nikiforov NG,Sobenin IA

    更新日期:2020-08-09 00:00:00

  • Does differing metabolism by cytochrome p450 have clinical importance?

    abstract::The cytochrome P450 (CYP) is a group of enzymes that oxidatively modify drugs to a more water-soluble form for renal excretion. Nearly 50% of all clinically used medications and endogenous steroids are metabolized by the CYP enzyme 3A4, which explains why many of the important potential drug interactions involved this...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-000-0090-4

    authors: Davidson MH

    更新日期:2000-01-01 00:00:00

  • The plaque "micro" environment: microRNAs control the risk and the development of atherosclerosis.

    abstract::While the discovery of microRNAs has exponentially expanded our understanding of the regulatory mechanisms governing gene networks in many biological processes, the study of these tiny RNA powerhouses in cardiovascular disease is in its infancy. To date, there have been over 1200 human microRNAs identified, and they a...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-012-0272-x

    authors: Rayner KJ,Moore KJ

    更新日期:2012-10-01 00:00:00

  • Genetic determinants of plasma triglycerides: impact of rare and common mutations.

    abstract::Raised plasma triglyceride (TG) levels are an independent risk factor for coronary artery disease (CAD), and thus understanding the genetic and environmental determinants of TG levels are of major importance. TG metabolism is a process for delivering free fatty acids for energy storage or b-oxidation, and involves a n...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-001-0061-4

    authors: Talmud PJ

    更新日期:2001-05-01 00:00:00