Abstract:
PURPOSE OF REVIEW:We aimed to summarize recent guidelines, position papers, and high-quality clinical research relating the use of nutraceuticals in the management of individuals at high risk of atherosclerotic cardiovascular disease. RECENT FINDINGS:It is essential that individuals at high risk of cardiovascular disease receive guideline-directed evidence-based therapies to reduce their risk of morbidity and mortality from cardiovascular events. Compared with conventional therapeutics, nutraceuticals have undergone relatively little investigation in randomized controlled trials. Thus, recommendations for nutraceuticals in international guidelines are rare, and nutraceuticals should not be used preferentially in place of statins. Nevertheless, recent position papers from the International Lipid Expert Panel and clinical evidence from studies of triglyceride reduction by polyunsaturated fatty acid administration demonstrate that nutraceuticals do have an important role in optimizing therapy in individuals at high risk of cardiovascular disease. Roles for nutraceuticals include as follows: (1) managing residual risk associated with lipids other than low-density lipoprotein cholesterol (LDL-C); (2) managing non-lipid-mediated residual risk; (3) optimizing LDL-C treatment in statin intolerance; (4) optimizing LCL-C treatment when add-on therapies for statins are not available; (5) as adjuncts to lifestyle for individuals at high lifetime risk of atherosclerotic cardiovascular disease (ASCVD). The strength of evidence for each of these applications is variable. In addition to guideline-directed therapeutics, nutraceuticals may have roles in optimizing preventative therapy and targeting residual risk in individuals at high risk of ASCVD. Application of Good Manufacturing Practice and randomized controlled trials when producing and evaluating nutraceuticals will expand the armoury of evidence-based agents for the prevention of ASCVD.
journal_name
Curr Atheroscler Repjournal_title
Current atherosclerosis reportsauthors
Penson PE,Banach Mdoi
10.1007/s11883-020-00887-zsubject
Has Abstractpub_date
2020-09-18 00:00:00pages
67issue
11eissn
1523-3804issn
1534-6242pii
10.1007/s11883-020-00887-zjournal_volume
22pub_type
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journal_title:Current atherosclerosis reports
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doi:10.1007/s11883-999-0048-0
更新日期:1999-07-01 00:00:00
abstract::Plant foods rich in carbohydrate and dietary fiber have many health benefits. One concern often expressed about higher carbohydrate, lower fat diets is that they may increase fasting serum triglycerides. Recently the importance of hypertriglyceridemia as an independent risk factor for coronary heart disease has been r...
journal_title:Current atherosclerosis reports
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journal_title:Current atherosclerosis reports
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doi:10.1007/s11883-016-0607-0
更新日期:2016-09-01 00:00:00
abstract:PURPOSE OF REVIEW:The purpose is to review evidence on cardiovascular risks and benefits of new treatments for type 2 diabetes mellitus. RECENT FINDINGS:In response to guidance issued by the Food and Drug Administration, thousands of patients have been enrolled in large randomized trials evaluating the cardiovascular ...
journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11883-016-0633-y
更新日期:2016-12-01 00:00:00
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journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11883-007-0039-y
更新日期:2007-10-01 00:00:00
abstract:PURPOSE OF REVIEW:Apolipoprotein C-III (apoC-III) is known to inhibit lipoprotein lipase (LPL) and function as an important regulator of triglyceride metabolism. In addition, apoC-III has also more recently been identified as an important risk factor for cardiovascular disease. This review summarizes the mechanisms by ...
journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11883-019-0791-9
更新日期:2019-05-20 00:00:00
abstract::Erectile dysfunction (ED) is a common problem in the United States, with estimates that 30 million men suffer with some degree of ED. Although causes include psychogenic, organic, and mixed forms, in middle-aged and older men one of the most common causes is vascular disease. Endothelial dysfunction, even without defi...
journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11883-002-0078-3
更新日期:2002-09-01 00:00:00
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journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11883-015-0547-0
更新日期:2015-12-01 00:00:00
abstract:PURPOSE OF REVIEW:We will review the available data on the epidemiology, pathophysiology, diagnosis, and management of microvascular coronary dysfunction (MCD). RECENT FINDINGS:The study of MCD was pioneered by the Women's Ischemia Syndrome Evaluation (WISE) cohort. New techniques in the diagnosis of this condition, u...
journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11883-018-0710-5
更新日期:2018-01-30 00:00:00
abstract::In the USA, 69 % of adults are either overweight or obese and 35 % are obese. Obesity is associated with an increased incidence of various cardiovascular disorders. Obesity is a risk marker for cardiovascular disease, in that it is associated with a much higher prevalence of comorbidities such as diabetes, hypertensio...
journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11883-016-0575-4
更新日期:2016-05-01 00:00:00
abstract::Cancer survivorship should be defined starting not from completion of treatment, but from the time of diagnosis. Assessing and controlling the cancer patient's cardiovascular risk before, during, and after treatment is crucial to improving their overall outcome. There are many cancer therapies, including but not limit...
journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11883-014-0484-3
更新日期:2015-03-01 00:00:00
abstract:PURPOSE OF REVIEW:This review specifically summarises and reports terrestrial mammals of the gerbil subfamily, known as Israeli sand rats or Psammomys obesus (P. obesus) as a diet-controlled, unique, polygenic rodent model for research in the areas of obesity, type 2 diabetes, and cardiovascular diseases. The animal mo...
journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11883-018-0746-6
更新日期:2018-07-17 00:00:00
abstract::Plant-derived alpha-linolenic acid has been studied in a limited number of investigations. So far, some epidemiologic and a few mechanistic studies suggest a potential of protection from cardiovascular disease, but this potential remains to be proven in intervention studies. In contrast, eicosapentaenoic acid (EPA) an...
journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11883-003-0086-y
更新日期:2003-03-01 00:00:00
abstract::Functional foods are foods that, by virtue of physiologically active food components, provide health benefits beyond basic nutrition. Many functional foods have been found to be potentially beneficial in the prevention and treatment of cardiovascular disease, the leading cause of mortality in the United States. These ...
journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11883-000-0045-9
更新日期:2000-11-01 00:00:00
abstract::There is a growing interest in determining the genetic predictors of plasma lipid response to diet intervention. Several candidate gene loci, namely, apolipoprotein (APO) A1, APOA4, APOC3, APOB, APOE, CETP, LPL, and FABP2, have been shown to explain a significant, but still rather small, proportion of the interindivid...
journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11883-999-0032-8
更新日期:1999-11-01 00:00:00
abstract::The thiazolidinediones, acting through peroxisome proliferator-activated receptor chi (PPARchi), affect multiple areas of metabolism. Of increasing importance is the recognition that these agents affect lipoprotein metabolism and cause changes in serum lipid and lipoprotein levels. All three thiazolidinediones, includ...
journal_title:Current atherosclerosis reports
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s11883-006-0037-5
更新日期:2006-09-01 00:00:00
abstract::Atherothrombotic cardiovascular events are a leading cause of morbidity and mortality in patients with type 2 diabetes (T2D). A number of factors beyond hyperglycemia contribute to this increased risk of cardiovascular events in T2D, including elevated blood pressure, dyslipidemia, inflammation, endothelial dysfunctio...
journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11883-014-0408-2
更新日期:2014-05-01 00:00:00
abstract::Aspirin remains one of the most extensively studied cardiovascular medications in the history of medicine. However, despite multiple, well-designed, large randomized controlled trials evaluating the potential of aspirin to prevent cardiovascular events in individuals without known cardiovascular disease (CVD), the rol...
journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11883-015-0555-0
更新日期:2016-01-01 00:00:00
abstract::There has been increasing interest in the health benefits of supplemental and/or dietary omega-3 polyunsaturated fatty acids (PUFAs), particularly in their role in disease prevention. This interest escalated once their effects on cardiovascular health were observed from numerous observational studies in populations wh...
journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11883-013-0389-6
更新日期:2014-02-01 00:00:00
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journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11883-015-0527-4
更新日期:2015-08-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1007/s11883-012-0251-2
更新日期:2012-08-01 00:00:00
abstract::Diabetes and its micro- and macrovascular complications represent a worldwide epidemic that will place an enormous financial burden on poorer countries in the years to come. In patients with diabetes and hypertension, the main determinant of the cardiovascular and renal benefits of antihypertensive drugs is the blood ...
journal_title:Current atherosclerosis reports
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更新日期:2006-05-01 00:00:00
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更新日期:2012-06-01 00:00:00
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更新日期:2002-07-01 00:00:00
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journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
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更新日期:2000-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Perivascular adipose tissue (PVAT) has a complex, bidirectional relationship with the vascular wall. In disease states, PVAT secretes pro-inflammatory adipocytokines which may contribute to atherosclerosis. Recent evidence demonstrates that pericoronary adipose tissue (PCAT) may also function as a sen...
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更新日期:2019-11-19 00:00:00
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pub_type: 杂志文章
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更新日期:2018-07-05 00:00:00
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更新日期:2020-09-24 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2011-04-01 00:00:00