The effect of gastrointestinal surgery on insulin resistance and insulin secretion.

Abstract:

:Diabesity is a term often used to indicate the association of type-2 diabetes mellitus (T2DM) with obesity; the prevalence of both conditions is rapidly increasing worldwide and has reached epidemic proportions. Insulin resistance represents the major determinant of T2DM, which becomes manifest once relative β-cell failure ensues and insulin secretion is no longer sufficient to compensate for insulin resistance. In recent years, gastrointestinal surgery has emerged as the most effective option for the treatment of obesity and diabetes, with level-1 evidence of diabetes remission. Restrictive gastric operations such as gastric banding can improve insulin resistance in proportion to weight loss, while gastrointestinal bypass procedures, such as roux-en-y gastric-bypass (RYGB) and biliopancreatic diversion (BPD), can improve glucose homeostasis even before a significant weight loss is reached, suggesting weight-independent mechanisms of action. Studies comparing RYGB to BPD show that RYGB primarily enhances insulin secretion and reduces hepatic glucose output, whereas BPD rapidly improves glycemia primarily through the normalization of insulin sensitivity. Given the fact that BPD involves a significantly longer bypass of the proximal intestine than RYGB, these data suggest that the exclusion of a greater length of small bowel from the transit of food may cause broader and more profound influence on insulin sensitivity.

journal_name

Curr Atheroscler Rep

authors

Castagneto M,Mingrone G

doi

10.1007/s11883-012-0284-6

subject

Has Abstract

pub_date

2012-12-01 00:00:00

pages

624-30

issue

6

eissn

1523-3804

issn

1534-6242

journal_volume

14

pub_type

杂志文章,评审
  • Blood lipids and stroke: what more can we do besides reducing low-density lipoprotein cholesterol?

    abstract::Statin therapy has became the most important advance in stroke prevention since the introduction of aspirin and blood pressure-lowering therapies. Other lipid-modifying drugs have been less successful in reducing the incidence of stroke, but because of evidence for the use of triglyceride-lowering drugs and treatments...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-011-0186-z

    authors: Deplanque D,Amarenco P

    更新日期:2011-08-01 00:00:00

  • Screening for hypercoagulable syndromes following stroke.

    abstract::Patients with ischemic stroke of unclear etiology are often screened for hypercoagulable syndromes or thrombophilias. These have been recognized to cause venous thrombosis, and include hereditary deficiencies of coagulation factors, genetic mutations, or acquired disorders. However, the majority of coagulation disorde...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-003-0052-8

    authors: Bushnell C,Goldstein LB

    更新日期:2003-07-01 00:00:00

  • Evolving concepts regarding transient ischemic attacks.

    abstract::Transient ischemic attack (TIA) represents one end of the spectrum of focal brain ischemia, the other being completed infarction or ischemic stroke. The evolving technologic advancements in neuroimaging continue to change and sharpen the definition, epidemiology, and management of TIA. As a powerful risk factor for is...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-005-0019-z

    authors: Liberato B,Prabhakaran S,Sacco RL

    更新日期:2005-07-01 00:00:00

  • The role of fibrates in managing hyperlipidemia: mechanisms of action and clinical efficacy.

    abstract::At a time when the lipid management guidelines give more and more emphasis to the identification and treatment of high-risk patients with the metabolic syndrome and diabetes, there is an obvious need to balance the known effects of low-density lipoprotein (LDL) lowering with the new evidence of clinical efficacy deriv...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-004-0104-8

    authors: Fazio S,Linton MF

    更新日期:2004-03-01 00:00:00

  • Correction to: Cardiovascular Disease Prevention: Training Opportunities, the Challenges, and Future Directions.

    abstract::The original version of this article contains errors in Table 3. "At least 1 project/publication in the year" and "> 1 publication per year" have been switched under the titles of "Clinical Track" and "Physician-Scientist track". ...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,已发布勘误

    doi:10.1007/s11883-018-0743-9

    authors: Saeed A,Dabhadkar K,Virani SS,Jones PH,Ballantyne CM,Nambi V

    更新日期:2018-06-19 00:00:00

  • Structural Basis for Vital Function and Malfunction of Serum Amyloid A: an Acute-Phase Protein that Wears Hydrophobicity on Its Sleeve.

    abstract:PURPOSE OF REVIEW:This review addresses normal and pathologic functions of serum amyloid A (SAA), an enigmatic biomarker of inflammation and protein precursor of AA amyloidosis, a life-threatening complication of chronic inflammation. SAA is a small, highly evolutionarily conserved acute-phase protein whose plasma leve...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-020-00888-y

    authors: Gursky O

    更新日期:2020-09-24 00:00:00

  • Lifestyle factors and stroke risk: exercise, alcohol, diet, obesity, smoking, drug use, and stress.

    abstract::Various lifestyle factors have been associated with increasing the risk of stroke. These include lack of exercise, alcohol, diet, obesity, smoking, drug use, and stress. Guidelines endorsed by the Centers for Disease Control and Prevention and the National Institutes of Health recommend that Americans should exercise ...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-000-0111-3

    authors: Boden-Albala B,Sacco RL

    更新日期:2000-03-01 00:00:00

  • A review of trials evaluating nonstatin lipid-lowering therapies.

    abstract::Recently reported clinical trials raise doubts on the effectiveness of nonstatin lipid-lowering therapies in reducing the residual risk of cardiovascular events after statin monotherapy. Addition of -torcetrapib to statin therapy increased overall mortality in coronary patients despite a marked increase in high-densit...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-009-0010-1

    authors: Ansell BJ

    更新日期:2009-01-01 00:00:00

  • Aspirin resistance in atherosclerosis.

    abstract::Clinically, aspirin resistance is defined as the failure of aspirin therapy to prevent an acute vascular thrombotic event despite regular intake of appropriate doses. In the laboratory, aspirin resistance encompasses the drug's failure to attain a particular level of platelet inhibition. From a clinical standpoint, th...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-008-0022-2

    authors: Blair P,Freedman JE

    更新日期:2008-04-01 00:00:00

  • Obesity and Cardiovascular Disease: a Risk Factor or a Risk Marker?

    abstract::In the USA, 69 % of adults are either overweight or obese and 35 % are obese. Obesity is associated with an increased incidence of various cardiovascular disorders. Obesity is a risk marker for cardiovascular disease, in that it is associated with a much higher prevalence of comorbidities such as diabetes, hypertensio...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-016-0575-4

    authors: Mandviwala T,Khalid U,Deswal A

    更新日期:2016-05-01 00:00:00

  • Dietary fiber prevents carbohydrate-induced hypertriglyceridemia.

    abstract::Plant foods rich in carbohydrate and dietary fiber have many health benefits. One concern often expressed about higher carbohydrate, lower fat diets is that they may increase fasting serum triglycerides. Recently the importance of hypertriglyceridemia as an independent risk factor for coronary heart disease has been r...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-000-0055-7

    authors: Anderson JW

    更新日期:2000-11-01 00:00:00

  • Low-density lipoprotein reduction: is the risk worth the benefit?

    abstract::Outcomes from recent lipid-lowering trials have led to an update of the third Report of the National Cholesterol Education Program (NCEP) Adult Treatment Panel's guidelines for treatment of hypercholesterolemia in adults. The updated NCEP guidelines now offer an optional goal of low-density lipoprotein (LDL) cholester...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-006-0060-6

    authors: Sabharwal AK,Boord JB

    更新日期:2006-01-01 00:00:00

  • Clinical trials of vitamin E in coronary artery disease: is it time to reconsider the low-density lipoprotein oxidation hypothesis?

    abstract::A wide range of structurally unrelated antioxidants inhibit atherosclerosis in animal models of hypercholesterolemia, implicating oxidation of low-density lipoprotein (LDL) in the pathogenesis of atherosclerosis. However, most prospective, randomized trials of one proposed antioxidant, vitamin E, have failed to demons...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-003-0075-1

    authors: Heinecke JW

    更新日期:2003-03-01 00:00:00

  • Genetic predictors of plasma lipid response to diet intervention.

    abstract::There is a growing interest in determining the genetic predictors of plasma lipid response to diet intervention. Several candidate gene loci, namely, apolipoprotein (APO) A1, APOA4, APOC3, APOB, APOE, CETP, LPL, and FABP2, have been shown to explain a significant, but still rather small, proportion of the interindivid...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-999-0032-8

    authors: Ordovas JM,Galluzzi JR

    更新日期:1999-11-01 00:00:00

  • Emerging Evidence that ApoC-III Inhibitors Provide Novel Options to Reduce the Residual CVD.

    abstract:PURPOSE OF REVIEW:Apolipoprotein C-III (apoC-III) is known to inhibit lipoprotein lipase (LPL) and function as an important regulator of triglyceride metabolism. In addition, apoC-III has also more recently been identified as an important risk factor for cardiovascular disease. This review summarizes the mechanisms by ...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-019-0791-9

    authors: Taskinen MR,Packard CJ,Borén J

    更新日期:2019-05-20 00:00:00

  • Cannabis and Cardiovascular Disease.

    abstract:PURPOSE OF REVIEW:The use of recreational drugs has increased globally, with the most commonly used recreational drug being cannabis. As of 2019, 10 states and the District of Columbia have legalized cannabis for recreational use, with more states potentially joining this movement. With the increased legalization of ca...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-019-0783-9

    authors: Ghosh M,Naderi S

    更新日期:2019-04-12 00:00:00

  • Soy, garlic, and ginkgo biloba: their potential role in cardiovascular disease prevention and treatment.

    abstract::There are hundreds of foods, nutrients, herbs, and botanicals that have "bioactive" constituents with potential human health benefits. Three of these are discussed in this review: soy, garlic, and ginkgo biloba. Each of these three choices involves an ingestible item composed of a complex mixture of bioactive agents. ...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-003-0037-7

    authors: Gardner CD,Messina M,Lawson LD,Farquhar JW

    更新日期:2003-11-01 00:00:00

  • Carotid Atherosclerosis in Patients with Atrial Fibrillation.

    abstract:PURPOSE OF REVIEW:This review aims to explore the relationship between AF and carotid atherosclerosis, and the impact on the outcomes of cardiovascular and cerebrovascular events. Also, our aim is to critically review current knowledge and delineate future directions for effective treatment or prevention as well as str...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-019-0808-4

    authors: Wang Z,Korantzopoulos P,Liu T

    更新日期:2019-11-29 00:00:00

  • Low-density lipoprotein apheresis in the treatment of atherosclerosis and other potential uses.

    abstract::This review concerns the clinical impact of low-density lipoprotein (LDL) apheresis for patients with refractory hypercholesterolemia. We examine and provide examples of investigations that have demonstrated the clinical benefits of LDL apheresis. In addition to benefits derived from the stabilization or regression of...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-001-0052-5

    authors: Moriarty PM,Gibson CA

    更新日期:2001-03-01 00:00:00

  • Lipid management: considerations in acute coronary syndrome.

    abstract::Managing dyslipidemia is an important part of the primary and secondary prevention of coronary heart disease. Low-density lipoprotein cholesterol reduction remains the primary lipid goal. Patients who have experienced an acute coronary syndrome (ACS) are at very high risk of recurrent adverse cardiovascular events. A ...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章

    doi:10.1007/s11883-009-0024-8

    authors: Polsani VR,Virani SS,Nambi V

    更新日期:2009-03-01 00:00:00

  • Hormone replacement therapy trials: an update.

    abstract::Recent randomized trials of hormone replacement therapy (HRT) in postmenopausal women are not consistent with the decrease in cardiovascular risk seen in observational studies of hormone therapy users compared with nonusers. Emerging evidence indicates that HRT use in some women with established coronary heart disease...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章

    doi:10.1007/s11883-002-0040-4

    authors: Duvernoy CS,Mosca L

    更新日期:2002-03-01 00:00:00

  • Are omega-3 fatty acids the most important nutritional modulators of coronary heart disease risk?

    abstract::With each passing year, the evidence linking an increased risk for coronary heart disease (CHD) death with a chronic dietary deficiency in long-chain omega-3 (n-3) fatty acids (FAs) grows stronger. Recently, a federally mandated evidence-based review in the United States concluded that n-3 FAs, especially eicosapentae...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-004-0085-7

    authors: Harris WS

    更新日期:2004-11-01 00:00:00

  • FXR agonists as therapeutic agents for non-alcoholic fatty liver disease.

    abstract::Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the metabolic syndrome and a risk factor for both cardiovascular and hepatic related morbidity and mortality. The increasing prevalence of this disease requires novel therapeutic approaches to prevent disease progression. Farnesoid X receptors a...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-015-0500-2

    authors: Carr RM,Reid AE

    更新日期:2015-04-01 00:00:00

  • Pharmacogenetics of Lipid-Lowering Agents: Precision or Indecision Medicine?

    abstract::Lipid-lowering medications, particularly statins, have been a popular target for pharmacogenetic studies. A handful of genes have shown promise for predicting response to therapy from the perspective of lipid lowering, as well as myopathy. A number of genes have been implicated and have biological plausibility based o...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-016-0573-6

    authors: Alfonsi JE,Hegele RA,Gryn SE

    更新日期:2016-05-01 00:00:00

  • Remnant lipoproteins and atherosclerosis.

    abstract::A recently developed assay for quantification of remnant-like particle cholesterol has provided considerable evidence that reinforces the concept that elevated levels of plasma remnants are associated with increased cardiovascular disease in different populations and distinct patient groups. In this review, we provide...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-005-0037-x

    authors: Twickler T,Dallinga-Thie GM,Chapman MJ,Cohn JS

    更新日期:2005-03-01 00:00:00

  • Mechanisms of abdominal aortic aneurysm formation.

    abstract::Abdominal aortic aneurysms (AAA) are permanent dilations in the infra-renal area in which the arterial tissue is characterized by inflammation and medial degeneration. AAAs are a common vascular disorder and cause significant mortality in the aged population. Despite the high prevalence of this disease, there is limit...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-002-0023-5

    authors: Daugherty A,Cassis LA

    更新日期:2002-05-01 00:00:00

  • Postprandial hypertriglyceridemia and cardiovascular disease: current and future therapies.

    abstract::Exaggerated postprandial hypertriglyceridemia is a risk factor for cardiovascular disease. This metabolic abnormality is principally due to overproduction and/or decreased catabolism of triglyceride-rich lipoproteins (TRLs) and is a consequence of pathogenic genetic variations and other coexistent medical conditions, ...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-013-0309-9

    authors: Chan DC,Pang J,Romic G,Watts GF

    更新日期:2013-03-01 00:00:00

  • Degenerative Severe Aortic Stenosis and Concomitant Coronary Artery Disease: What Is Changing in the Era of the "Transcatheter Revolution"?

    abstract:PURPOSE OF REVIEW:To summarize epidemiology, pathophysiology, prognostic relevance, and treatment options of coronary artery disease (CAD) when coupled with severe aortic stenosis (SAS). In regard to treatment options, we focused on the most recently adopted therapeutic approaches and on the future perspectives in ligh...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-020-0835-1

    authors: Pepe M,Larosa C,Rosa I,Biondi-Zoccai G,Nestola PL,Di Cillo O,Bortone AS,Giordano A,Favale S

    更新日期:2020-05-26 00:00:00

  • Correction to: Does 24-h Activity Cycle Influence Plasma PCSK9 Concentration? A Systematic Review and Meta-Analysis.

    abstract::Due to typesetting mistake, an unknown image was accidentally captured as graphical abstract. This should be removed. ...

    journal_title:Current atherosclerosis reports

    pub_type: 已发布勘误

    doi:10.1007/s11883-020-00868-2

    authors: Kuo WC,Stevens JM,Ersig AL,Johnson HM,Tung TH,Bratzke LC

    更新日期:2020-07-07 00:00:00

  • Potential contributions of intimal and plaque hypoxia to atherosclerosis.

    abstract::Injury of arterial endothelium by abnormal shear stress and other insults induces migration and proliferation of vascular smooth muscle cells (VSMCs), which in turn leads to intimal thickening, hypoxia, and vasa vasorum angiogenesis. The resultant new blood vessels extend from the tunica media into the outer intima, a...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-015-0510-0

    authors: Fong GH

    更新日期:2015-06-01 00:00:00