Abstract：
:Diabesity is a term often used to indicate the association of type-2 diabetes mellitus (T2DM) with obesity; the prevalence of both conditions is rapidly increasing worldwide and has reached epidemic proportions. Insulin resistance represents the major determinant of T2DM, which becomes manifest once relative β-cell failure ensues and insulin secretion is no longer sufficient to compensate for insulin resistance. In recent years, gastrointestinal surgery has emerged as the most effective option for the treatment of obesity and diabetes, with level-1 evidence of diabetes remission. Restrictive gastric operations such as gastric banding can improve insulin resistance in proportion to weight loss, while gastrointestinal bypass procedures, such as roux-en-y gastric-bypass (RYGB) and biliopancreatic diversion (BPD), can improve glucose homeostasis even before a significant weight loss is reached, suggesting weight-independent mechanisms of action. Studies comparing RYGB to BPD show that RYGB primarily enhances insulin secretion and reduces hepatic glucose output, whereas BPD rapidly improves glycemia primarily through the normalization of insulin sensitivity. Given the fact that BPD involves a significantly longer bypass of the proximal intestine than RYGB, these data suggest that the exclusion of a greater length of small bowel from the transit of food may cause broader and more profound influence on insulin sensitivity.
journal_name
Curr Atheroscler Repjournal_title
Current atherosclerosis reportsauthors
Castagneto M,Mingrone Gdoi
10.1007/s11883-012-0284-6subject
Has Abstractpub_date
2012-12-01 00:00:00pages
624-30issue
6eissn
1523-3804issn
1534-6242journal_volume
14pub_type
杂志文章,评审abstract：:In the USA, 69 % of adults are either overweight or obese and 35 % are obese. Obesity is associated with an increased incidence of various cardiovascular disorders. Obesity is a risk marker for cardiovascular disease, in that it is associated with a much higher prevalence of comorbidities such as diabetes, hypertensio...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
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更新日期：2016-05-01 00:00:00
abstract：PURPOSE OF REVIEW:To summarize epidemiology, pathophysiology, prognostic relevance, and treatment options of coronary artery disease (CAD) when coupled with severe aortic stenosis (SAS). In regard to treatment options, we focused on the most recently adopted therapeutic approaches and on the future perspectives in ligh...
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更新日期：2020-05-26 00:00:00
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journal_title：Current atherosclerosis reports
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doi：10.1007/BF02693931
更新日期：2007-01-01 00:00:00
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pub_type： 杂志文章,评审
doi：10.1007/s11883-000-0065-5
更新日期：2000-07-01 00:00:00
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journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-001-0040-9
更新日期：2001-11-01 00:00:00
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更新日期：2011-08-01 00:00:00
abstract：:The ability for statins to reduce major cardiovascular events and mortality has lead to this drug class being the most commonly prescribed in the world. In particular, the benefit of these drugs in type 2 diabetes (T2D) is well established. In February 2012, the Food and Drug Administration released changes to statin ...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
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更新日期：2013-02-01 00:00:00
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journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
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更新日期：2010-01-01 00:00:00
abstract：PURPOSE OF REVIEW:Acute stroke is a treatable disease. Nevertheless, only a minority of patients obtain guideline-adjusted therapy. One major reason is the small time window in which therapies have to be administered in order to reverse or mitigate brain injury and prevent disability. The Mobile Stroke Unit (MSU) conce...
journal_title：Current atherosclerosis reports
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更新日期：2018-08-29 00:00:00
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更新日期：2012-08-01 00:00:00
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journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
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更新日期：2013-03-01 00:00:00
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journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
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更新日期：2013-01-01 00:00:00
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journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
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更新日期：2020-06-23 00:00:00
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journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
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更新日期：2017-05-01 00:00:00
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journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-004-0057-y
更新日期：2004-07-01 00:00:00
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journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-017-0690-x
更新日期：2017-10-23 00:00:00
abstract：:Diabetes and its micro- and macrovascular complications represent a worldwide epidemic that will place an enormous financial burden on poorer countries in the years to come. In patients with diabetes and hypertension, the main determinant of the cardiovascular and renal benefits of antihypertensive drugs is the blood ...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-011-0160-9
更新日期：2011-04-01 00:00:00
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journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-008-0061-8
更新日期：2008-10-01 00:00:00
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journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-014-0444-y
更新日期：2014-10-01 00:00:00
abstract：:Calcification of atherosclerotic lesions was long thought to be an age - related, passive process, but increasingly data has revealed that atherosclerotic calcification is a more active process, involving complex signaling pathways and bone-like genetic programs. Initially, imaging of atherosclerotic calcification was...
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pub_type： 杂志文章,评审
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更新日期：2016-08-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2015-12-01 00:00:00
abstract：:Raised plasma triglyceride (TG) levels are an independent risk factor for coronary artery disease (CAD), and thus understanding the genetic and environmental determinants of TG levels are of major importance. TG metabolism is a process for delivering free fatty acids for energy storage or b-oxidation, and involves a n...
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更新日期：2001-05-01 00:00:00
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journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
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更新日期：2019-04-12 00:00:00
abstract：:Atherosclerotic heart disease and stroke are leading causes of disability and death worldwide, affecting not only developed countries, but also low- and middle-income regions. Different strategies for handling dyslipidemia as a critical pathogenic risk factor for atherosclerosis have been proposed. However, these reco...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-014-0400-x
更新日期：2014-04-01 00:00:00
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journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-011-0173-4
更新日期：2011-06-01 00:00:00
abstract：PURPOSE OF REVIEW:We aimed to summarize recent guidelines, position papers, and high-quality clinical research relating the use of nutraceuticals in the management of individuals at high risk of atherosclerotic cardiovascular disease. RECENT FINDINGS:It is essential that individuals at high risk of cardiovascular dise...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
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更新日期：2020-09-18 00:00:00
abstract：PURPOSE OF REVIEW:The goal of this manuscript is to summarize the current understanding of the secreted APOA1 binding protein (AIBP), encoded by NAXE, in angiogenesis, hematopoiesis, and inflammation. The studies on AIBP illustrate a critical connection between lipid metabolism and the aforementioned endothelial and im...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-020-00899-9
更新日期：2020-11-24 00:00:00
abstract：:With each passing year, the evidence linking an increased risk for coronary heart disease (CHD) death with a chronic dietary deficiency in long-chain omega-3 (n-3) fatty acids (FAs) grows stronger. Recently, a federally mandated evidence-based review in the United States concluded that n-3 FAs, especially eicosapentae...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-004-0085-7
更新日期：2004-11-01 00:00:00
abstract：:Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is an enzyme which binds to oxidized LDL and has a pro-inflammatory role in the pathogenesis of atherosclerosis. The Lp-PLA(2) Studies Collaboration showed the relationship between Lp-PLA(2) levels and activity with coronary heart disease and ischemic stroke. Level...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-011-0201-4
更新日期：2011-12-01 00:00:00
abstract：PURPOSE OF REVIEW:Coronary artery no-reflow phenomenon is an incidental outcome of percutaneous coronary intervention in patients presenting with acute myocardial infarction. Despite advances in pharmacologic and non-pharmacologic therapies, coronary no-reflow phenomenon occurs more commonly than desired. It often resu...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章
doi：10.1007/s11883-018-0747-5
更新日期：2018-07-05 00:00:00
