Abstract：
:Diabesity is a term often used to indicate the association of type-2 diabetes mellitus (T2DM) with obesity; the prevalence of both conditions is rapidly increasing worldwide and has reached epidemic proportions. Insulin resistance represents the major determinant of T2DM, which becomes manifest once relative β-cell failure ensues and insulin secretion is no longer sufficient to compensate for insulin resistance. In recent years, gastrointestinal surgery has emerged as the most effective option for the treatment of obesity and diabetes, with level-1 evidence of diabetes remission. Restrictive gastric operations such as gastric banding can improve insulin resistance in proportion to weight loss, while gastrointestinal bypass procedures, such as roux-en-y gastric-bypass (RYGB) and biliopancreatic diversion (BPD), can improve glucose homeostasis even before a significant weight loss is reached, suggesting weight-independent mechanisms of action. Studies comparing RYGB to BPD show that RYGB primarily enhances insulin secretion and reduces hepatic glucose output, whereas BPD rapidly improves glycemia primarily through the normalization of insulin sensitivity. Given the fact that BPD involves a significantly longer bypass of the proximal intestine than RYGB, these data suggest that the exclusion of a greater length of small bowel from the transit of food may cause broader and more profound influence on insulin sensitivity.
journal_name
Curr Atheroscler Repjournal_title
Current atherosclerosis reportsauthors
Castagneto M,Mingrone Gdoi
10.1007/s11883-012-0284-6subject
Has Abstractpub_date
2012-12-01 00:00:00pages
624-30issue
6eissn
1523-3804issn
1534-6242journal_volume
14pub_type
杂志文章,评审abstract：:Coronary heart disease (CHD), traditionally considered a male disease, causes far more deaths in women than cancer. The prevalence of CHD is lower in women at any age, but with advancing age, this differential decreases. The clinical outcomes including myocardial infarction mortality, all-cause mortality, and reinfarc...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-016-0574-5
更新日期：2016-05-01 00:00:00
abstract：:This review concerns the clinical impact of low-density lipoprotein (LDL) apheresis for patients with refractory hypercholesterolemia. We examine and provide examples of investigations that have demonstrated the clinical benefits of LDL apheresis. In addition to benefits derived from the stabilization or regression of...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-001-0052-5
更新日期：2001-03-01 00:00:00
abstract：PURPOSE OF REVIEW:In this review, we describe the mechanism behind coronary artery calcification formation and detection, as well as its implication in cardiovascular disease (CVD) risk stratification, intervention, and prognosis in asymptomatic individuals. RECENT FINDINGS:Multiple cohort and population studies have ...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-019-0812-8
更新日期：2019-11-21 00:00:00
abstract：:Spontaneous intracerebral hemorrhage (ICH) is a devastating disease with high morbidity and mortality. Acutely, ICH is associated with a sudden surge in intracranial pressure (ICP), as the volume of hematoma increases the pressure in the closed head, leading to non-specific symptoms of ICP: headache, nausea, vomiting,...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-012-0251-2
更新日期：2012-08-01 00:00:00
abstract：:Lipodystrophies are a group of heterogeneous diseases characterized by the loss of adipose tissue and by abnormalities of carbohydrate and lipid metabolism, including insulin resistance, diabetes, and hyperlipidemia. In this review, we describe several mouse models that recapitulate various aspects of the lipodystroph...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-000-0077-1
更新日期：2000-09-01 00:00:00
abstract：:Patients with ischemic stroke of unclear etiology are often screened for hypercoagulable syndromes or thrombophilias. These have been recognized to cause venous thrombosis, and include hereditary deficiencies of coagulation factors, genetic mutations, or acquired disorders. However, the majority of coagulation disorde...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-003-0052-8
更新日期：2003-07-01 00:00:00
abstract：:Augmentative and alternative communication (AAC) strategies traditionally have been designed for individuals for whom oral speech is not a viable option. Common clinical practice has expanded AAC use to a tool for cognitive retraining or remediation. Although technologic developments offer the potential for vastly imp...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-002-0008-4
更新日期：2002-07-01 00:00:00
abstract：:Despite the recent decline in mortality from coronary heart disease (CHD), this disease remains the leading killer of US adults of all ages. CHD in young adults is not as well characterized as CHD in older individuals because it occurs less frequently, but this disease can have devastating consequences for young patie...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-012-0226-3
更新日期：2012-04-01 00:00:00
abstract：:Atherothrombotic cardiovascular events are a leading cause of morbidity and mortality in patients with type 2 diabetes (T2D). A number of factors beyond hyperglycemia contribute to this increased risk of cardiovascular events in T2D, including elevated blood pressure, dyslipidemia, inflammation, endothelial dysfunctio...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-014-0408-2
更新日期：2014-05-01 00:00:00
abstract：:The acute evaluation of stroke patients has undergone dramatic advances in the recent past. The increasing availability of novel magnetic resonance imaging (MRI) techniques, such as diffusion and perfusion MRI, provides a plethora of information to clinicians evaluating patients suspected of having an acute stroke. Th...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-004-0057-y
更新日期：2004-07-01 00:00:00
abstract：PURPOSE OF REVIEW:The review aims to describe the differences between men and women in those factors that can influence a worse prognosis in women after an acute cardiovascular event. RECENT FINDINGS:Women adequately treated with current evidence-based medications for acute myocardial infarction and for conventional c...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-020-00882-4
更新日期：2020-09-03 00:00:00
abstract：:Stroke is a common and disabling condition. Intravenous tissue plasminogen activator (tPA) administered within 3 h of symptom onset is the standard therapy for eligible patients with acute ischemic stroke. Unfortunately, because of the time limitation, very few patients with ischemic stroke actually receive this treat...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-010-0121-8
更新日期：2010-09-01 00:00:00
abstract：:Biologic therapies involve the utilization of proteins, DNA, antibodies, or other substances derived or synthesized from living tissue for therapeutic effects. There are several biologic therapies in clinical development for the prevention and treatment of atherosclerosis. The most advanced in human trials are apolipo...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-004-0118-2
更新日期：2004-01-01 00:00:00
abstract：:The original version of this article contains errors in Table 3. "At least 1 project/publication in the year" and "> 1 publication per year" have been switched under the titles of "Clinical Track" and "Physician-Scientist track". ...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,已发布勘误
doi：10.1007/s11883-018-0743-9
更新日期：2018-06-19 00:00:00
abstract：:Lipid-lowering medications, particularly statins, have been a popular target for pharmacogenetic studies. A handful of genes have shown promise for predicting response to therapy from the perspective of lipid lowering, as well as myopathy. A number of genes have been implicated and have biological plausibility based o...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-016-0573-6
更新日期：2016-05-01 00:00:00
abstract：:The High-Risk Plaque (HRP) Initiative is a research and development effort to advance the understanding, recognition, and management of asymptomatic individuals at risk for a near-term atherothrombotic event such as myocardial infarction or stroke. Clinical studies using the newest technologies have been initiated, in...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,随机对照试验
doi：10.1007/s11883-011-0193-0
更新日期：2011-10-01 00:00:00
abstract：PURPOSE OF REVIEW:Lipoprotein apheresis is a very efficient but time-consuming and expensive method of lowering levels of low-density lipoprotein cholesterol, lipoprotein(a)) and other apoB containing lipoproteins, including triglyceride-rich lipoproteins. First introduced almost 45 years ago, it has long been a therap...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-019-0787-5
更新日期：2019-05-01 00:00:00
abstract：:The rates of cardiovascular disease (CVD) have decreased significantly for men over the past few decades, but similar reductions have not occurred in women. Consequently, CVD remains the leading killer of women in the United States. Men usually develop heart disease earlier than women, but women develop heart disease ...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-008-0046-7
更新日期：2008-08-01 00:00:00
abstract：PURPOSE OF REVIEW:This review aims to explore the relationship between AF and carotid atherosclerosis, and the impact on the outcomes of cardiovascular and cerebrovascular events. Also, our aim is to critically review current knowledge and delineate future directions for effective treatment or prevention as well as str...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-019-0808-4
更新日期：2019-11-29 00:00:00
abstract：:Injury of arterial endothelium by abnormal shear stress and other insults induces migration and proliferation of vascular smooth muscle cells (VSMCs), which in turn leads to intimal thickening, hypoxia, and vasa vasorum angiogenesis. The resultant new blood vessels extend from the tunica media into the outer intima, a...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-015-0510-0
更新日期：2015-06-01 00:00:00
abstract：:Due to typesetting mistake, an unknown image was accidentally captured as graphical abstract. This should be removed. ...
journal_title：Current atherosclerosis reports
pub_type： 已发布勘误
doi：10.1007/s11883-020-00868-2
更新日期：2020-07-07 00:00:00
abstract：:There is a significant prevalence (20%-80% depending on the population and the study) of lipid disorders and other cardiovascular risk factors in people living with HIV infection. This review focuses on HIV and HIV treatment-associated metabolic and cardiovascular concerns, including dyslipidemias, lipodystrophy syndr...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-010-0152-1
更新日期：2011-02-01 00:00:00
abstract：:A wide range of structurally unrelated antioxidants inhibit atherosclerosis in animal models of hypercholesterolemia, implicating oxidation of low-density lipoprotein (LDL) in the pathogenesis of atherosclerosis. However, most prospective, randomized trials of one proposed antioxidant, vitamin E, have failed to demons...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-003-0075-1
更新日期：2003-03-01 00:00:00
abstract：:Atherosclerosis remains the major cause of morbidity and mortality in Western countries. Atherothrombotic complications, including vascular occlusions and severe narrowing of nutrient blood vessels in the cerebral, coronary, or peripheral circulation, usually require invasive revascularization strategies. As molecular...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-003-0022-1
更新日期：2003-05-01 00:00:00
abstract：PURPOSE OF REVIEW:Non-alcoholic fatty liver disease (NAFLD) is frequently associated with obesity and overweight. It has a broad spectrum of clinical and histological presentations, such as steatosis, inflammation (known as non-alcoholic steatohepatitis or NASH), fibrosis, and cirrhosis. There is increasing evidence th...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-017-0681-y
更新日期：2017-10-07 00:00:00
abstract：:Atherosclerotic cardiovascular diseases are the most common causes of death in the United States. Fibrous plaques develop in 77% to 78% of men before age 30. The mean low-density lipoprotein-cholesterol (LDL-C) level in men aged 25 to 30 years is 117 mg/dL. In the Air Force/Texas Coronary Atherosclerosis Prevention St...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章
doi：10.1007/s11883-999-0048-0
更新日期：1999-07-01 00:00:00
abstract：:The cytochrome P450 (CYP) is a group of enzymes that oxidatively modify drugs to a more water-soluble form for renal excretion. Nearly 50% of all clinically used medications and endogenous steroids are metabolized by the CYP enzyme 3A4, which explains why many of the important potential drug interactions involved this...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-000-0090-4
更新日期：2000-01-01 00:00:00
abstract：PURPOSE OF REVIEW:This review focuses on recent evidence examining the role gut microbiota play in coronary heart disease. It also provides a succinct overview of current and future therapies targeting the gut microbiota for coronary heart disease risk reduction. RECENT FINDINGS:A consensus has been reached that diffe...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-020-00892-2
更新日期：2020-10-16 00:00:00
abstract：:We briefly and comprehensively present some of the novel findings in the field of revascularization therapy and management of ST-segment-elevation myocardial infarction (STEMI). We highlight the latest evidence-based advancements in the pharmacological and mechanical treatment of patients who presented with STEMI. Sin...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-014-0412-6
更新日期：2014-06-01 00:00:00
abstract：:Outcomes from recent lipid-lowering trials have led to an update of the third Report of the National Cholesterol Education Program (NCEP) Adult Treatment Panel's guidelines for treatment of hypercholesterolemia in adults. The updated NCEP guidelines now offer an optional goal of low-density lipoprotein (LDL) cholester...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-006-0060-6
更新日期：2006-01-01 00:00:00
