Low-density lipoprotein reduction: is the risk worth the benefit?

abstract：:While the function of vitamin D in regulating calcium homeostasis is well established, there has been growing interest in its role in the prevention of numerous chronic diseases, including cardiovascular disease (CVD). There is mounting epidemiological evidence suggesting that vitamin D deficiency is linked to increas...

journal_title：Current atherosclerosis reports

authors： Chin K,Appel LJ,Michos ED

更新日期：2017-01-01 00:00:00

abstract：:There is now a consensus about recommending the Mediterranean diet pattern for the prevention of coronary heart disease (CHD) and cancer. The most important aspect of this treatment decision, in contrast with the pharmacologic prevention of CHD (including cholesterol lowering), is that the Mediterranean diet has a str...

journal_title：Current atherosclerosis reports

authors： de Lorgeril M,Salen P

更新日期：2008-12-01 00:00:00

abstract：:There is a growing interest in determining the genetic predictors of plasma lipid response to diet intervention. Several candidate gene loci, namely, apolipoprotein (APO) A1, APOA4, APOC3, APOB, APOE, CETP, LPL, and FABP2, have been shown to explain a significant, but still rather small, proportion of the interindivid...

journal_title：Current atherosclerosis reports

authors： Ordovas JM,Galluzzi JR

更新日期：1999-11-01 00:00:00

abstract：:Platelets are critical modulators of atherothrombotic events. In the acute setting, platelets are activated and aggregate on the surface of atherosclerotic plaque that has ruptured, fissured, or developed erosions. The overlying thrombus leads to sudden development of arterial luminal obstruction, inducing ischemia an...

journal_title：Current atherosclerosis reports

authors： Toth PP,Armani A

更新日期：2009-09-01 00:00:00

abstract：:Cardiovascular disease remains the major cause of worldwide morbidity and mortality. Its pathophysiology is complex and multifactorial. Because the phenotype of cardiovascular disease often shows a marked heritable pattern, it is likely that genetic factors play an important role. In recent years, large genome-wide as...

journal_title：Current atherosclerosis reports

authors： Sivapalaratnam S,Motazacker MM,Maiwald S,Hovingh GK,Kastelein JJ,Levi M,Trip MD,Dallinga-Thie GM

更新日期：2011-06-01 00:00:00

abstract：:Light to moderate alcohol intake is known to have cardioprotective properties; however, the magnitude of protection depends on other factors and may be confined to some subsets of the population. This review focuses on factors that modify the relationship between alcohol and coronary heart disease (CHD). The cardiopro...

journal_title：Current atherosclerosis reports

authors： Tolstrup J,Grønbaek M

更新日期：2007-08-01 00:00:00

abstract：PURPOSE OF REVIEW:We provide an overview of our current understanding of combination lipid-lowering therapies intended for dyslipidemia treatment and cardiovascular disease prevention. First, we analyze recent statin and non-statin combination therapy guidelines and clinical studies since the publication of 2013 Americ...

journal_title：Current atherosclerosis reports

authors： Russell C,Sheth S,Jacoby D

更新日期：2018-03-07 00:00:00

abstract：:Effective prevention of the current annual $400 billion losses from atherosclerosis and cardiovascular disease (CVD) will require preventing primary causes rather than just decreasing signs and symptoms (risk factors) produced by those causes. All CVD risk factors predict a likelihood of CVD, but not all are causes of...

journal_title：Current atherosclerosis reports

authors： Lands B

更新日期：2009-07-01 00:00:00

abstract：PURPOSE OF REVIEW:We aimed to summarize recent guidelines, position papers, and high-quality clinical research relating the use of nutraceuticals in the management of individuals at high risk of atherosclerotic cardiovascular disease. RECENT FINDINGS:It is essential that individuals at high risk of cardiovascular dise...

journal_title：Current atherosclerosis reports

authors： Penson PE,Banach M

更新日期：2020-09-18 00:00:00

abstract：:Recent randomized trials of hormone replacement therapy (HRT) in postmenopausal women are not consistent with the decrease in cardiovascular risk seen in observational studies of hormone therapy users compared with nonusers. Emerging evidence indicates that HRT use in some women with established coronary heart disease...

journal_title：Current atherosclerosis reports

authors： Duvernoy CS,Mosca L

更新日期：2002-03-01 00:00:00

abstract：:Coronary heart disease (CHD), traditionally considered a male disease, causes far more deaths in women than cancer. The prevalence of CHD is lower in women at any age, but with advancing age, this differential decreases. The clinical outcomes including myocardial infarction mortality, all-cause mortality, and reinfarc...

journal_title：Current atherosclerosis reports

authors： Shah T,Palaskas N,Ahmed A

更新日期：2016-05-01 00:00:00

abstract：:There are hundreds of foods, nutrients, herbs, and botanicals that have "bioactive" constituents with potential human health benefits. Three of these are discussed in this review: soy, garlic, and ginkgo biloba. Each of these three choices involves an ingestible item composed of a complex mixture of bioactive agents. ...

journal_title：Current atherosclerosis reports

authors： Gardner CD,Messina M,Lawson LD,Farquhar JW

更新日期：2003-11-01 00:00:00

abstract：:Few principles in medicine today are as well accepted as the benefits of using statins to reduce cardiovascular risk factors and to prevent cardiovascular disease. The recent withdrawal of a statin (cerivastatin) has lead to a re-examination of all statins, and an attempt to better assess the risk-benefit ratio of thi...

journal_title：Current atherosclerosis reports

authors： Black DM

更新日期：2002-01-01 00:00:00

abstract：:Acute coronary syndromes (ACS), such as unstable angina, acute myocardial infarction, and sudden cardiac death, are commonly associated with the presence of vulnerable plaques in coronary arteries. Rupture or erosion of vulnerable plaques results in the formation of luminal thrombi due to the physical contact between ...

journal_title：Current atherosclerosis reports

authors： Didangelos A,Simper D,Monaco C,Mayr M

更新日期：2009-05-01 00:00:00

abstract：:Abdominal aortic aneurysms (AAA) are permanent dilations in the infra-renal area in which the arterial tissue is characterized by inflammation and medial degeneration. AAAs are a common vascular disorder and cause significant mortality in the aged population. Despite the high prevalence of this disease, there is limit...

journal_title：Current atherosclerosis reports

authors： Daugherty A,Cassis LA

更新日期：2002-05-01 00:00:00

abstract：:Diabesity is a term often used to indicate the association of type-2 diabetes mellitus (T2DM) with obesity; the prevalence of both conditions is rapidly increasing worldwide and has reached epidemic proportions. Insulin resistance represents the major determinant of T2DM, which becomes manifest once relative β-cell fa...

journal_title：Current atherosclerosis reports

authors： Castagneto M,Mingrone G

更新日期：2012-12-01 00:00:00

abstract：:3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors or "statin" medications are the most commonly prescribed therapy for lowering cholesterol. In use for over a decade, they have demonstrated both safety and tolerability across a broad range of patients. The ability to inhibit the biosynthesis of cholesterol an...

journal_title：Current atherosclerosis reports

authors： Garcia PJ

更新日期：2005-02-01 00:00:00

abstract：:The Third Report of the National Cholesterol Education Program's Adult Treatment Panel (ATP III) has an extensive section on nonpharmacologic therapy for those with abnormal blood lipids. ATP III focused on the high-saturated fat atherogenic diet, obesity, and sedentary lifestyle and recommended a program of therapeut...

journal_title：Current atherosclerosis reports

authors： Stone NJ,Van Horn L

更新日期：2002-11-01 00:00:00

abstract：:There is a significant prevalence (20%-80% depending on the population and the study) of lipid disorders and other cardiovascular risk factors in people living with HIV infection. This review focuses on HIV and HIV treatment-associated metabolic and cardiovascular concerns, including dyslipidemias, lipodystrophy syndr...

journal_title：Current atherosclerosis reports

authors： Troll JG

更新日期：2011-02-01 00:00:00

abstract：PURPOSE OF REVIEW:The use of recreational drugs has increased globally, with the most commonly used recreational drug being cannabis. As of 2019, 10 states and the District of Columbia have legalized cannabis for recreational use, with more states potentially joining this movement. With the increased legalization of ca...

journal_title：Current atherosclerosis reports

authors： Ghosh M,Naderi S

更新日期：2019-04-12 00:00:00

abstract：:Spontaneous intracerebral hemorrhage (ICH) is a devastating disease with high morbidity and mortality. Acutely, ICH is associated with a sudden surge in intracranial pressure (ICP), as the volume of hematoma increases the pressure in the closed head, leading to non-specific symptoms of ICP: headache, nausea, vomiting,...

journal_title：Current atherosclerosis reports

authors： Ko SB,Choi HA,Lee K

更新日期：2012-08-01 00:00:00

abstract：:The matrix metalloproteinase (MMP) family of enzymes is involved in arterial wall extracellular matrix degradation and remodeling. The latter activities have been implicated in a number of normal and pathologic processes, such as atherosclerotic lesion formation and progression, plaque destabilization and rupture, but...

journal_title：Current atherosclerosis reports

authors： Ketelhuth DF,Bäck M

更新日期：2011-04-01 00:00:00

abstract：:Atherothrombotic cardiovascular events are a leading cause of morbidity and mortality in patients with type 2 diabetes (T2D). A number of factors beyond hyperglycemia contribute to this increased risk of cardiovascular events in T2D, including elevated blood pressure, dyslipidemia, inflammation, endothelial dysfunctio...

journal_title：Current atherosclerosis reports

authors： Cameron-Vendrig A,Mundil D,Husain M

更新日期：2014-05-01 00:00:00

abstract：:Cancer survivorship should be defined starting not from completion of treatment, but from the time of diagnosis. Assessing and controlling the cancer patient's cardiovascular risk before, during, and after treatment is crucial to improving their overall outcome. There are many cancer therapies, including but not limit...

journal_title：Current atherosclerosis reports

authors： Chen CL

更新日期：2015-03-01 00:00:00

abstract：:Pharmacotherapies with agents that inhibit platelet function have proven to be effective in the treatment of acute coronary syndromes, and in the prevention of complications during and after percutaneous coronary intervention. Because of multiple synergetic pathways of platelet activation and their close interplay wit...

journal_title：Current atherosclerosis reports

authors： Kalra K,Franzese CJ,Gesheff MG,Lev EI,Pandya S,Bliden KP,Tantry US,Gurbel PA

更新日期：2013-12-01 00:00:00

abstract：:Daily lifestyle practices and habits profoundly affect the likelihood of developing cardiovascular disease (CVD). Abundant research and multiple recent consensus documents support the role of regular physical activity, not smoking cigarettes, maintaining a healthy body weight, controlling cholesterol levels, and contr...

journal_title：Current atherosclerosis reports

authors： Rippe JM,Angelopoulos TJ

更新日期：2014-10-01 00:00:00

abstract：:Erectile dysfunction (ED) is a common problem in the United States, with estimates that 30 million men suffer with some degree of ED. Although causes include psychogenic, organic, and mixed forms, in middle-aged and older men one of the most common causes is vascular disease. Endothelial dysfunction, even without defi...

journal_title：Current atherosclerosis reports

authors： Kloner RA,Speakman M

更新日期：2002-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Lipoprotein apheresis is a very efficient but time-consuming and expensive method of lowering levels of low-density lipoprotein cholesterol, lipoprotein(a)) and other apoB containing lipoproteins, including triglyceride-rich lipoproteins. First introduced almost 45 years ago, it has long been a therap...

journal_title：Current atherosclerosis reports

authors： Thompson G,Parhofer KG

更新日期：2019-05-01 00:00:00

abstract：PURPOSE OF REVIEW:For over 20 years, the Women's Ischemia Syndrome Evaluation (WISE), a program sponsored by the National Heart, Lung, and Blood Institute, has explored diverse and important aspects of ischemic heart disease in women. RECENT FINDINGS:Women with symptoms and signs of ischemia but no significant epicard...

journal_title：Current atherosclerosis reports

authors： Barsky L,Merz CNB,Wei J,Shufelt C,Handberg E,Pepine C,Rutledge T,Reis S,Doyle M,Rogers W,Shaw L,Sopko G

更新日期：2020-06-18 00:00:00

abstract：PURPOSE OF REVIEW:We will review the available data on the epidemiology, pathophysiology, diagnosis, and management of microvascular coronary dysfunction (MCD). RECENT FINDINGS:The study of MCD was pioneered by the Women's Ischemia Syndrome Evaluation (WISE) cohort. New techniques in the diagnosis of this condition, u...

journal_title：Current atherosclerosis reports

authors： Naderi S

更新日期：2018-01-30 00:00:00