Even "WISE-R?"-an Update on the NHLBI-Sponsored Women's Ischemia Syndrome Evaluation.

Abstract:

PURPOSE OF REVIEW:For over 20 years, the Women's Ischemia Syndrome Evaluation (WISE), a program sponsored by the National Heart, Lung, and Blood Institute, has explored diverse and important aspects of ischemic heart disease in women. RECENT FINDINGS:Women with symptoms and signs of ischemia but no significant epicardial obstructive coronary artery disease (INOCA) were documented to be at elevated risk for recurrent angina hospitalization, major adverse cardiac events, death, and health resource consumption rivaling those with obstructive coronary disease. WISE investigators have advanced our understanding of cardiovascular outcomes, systemic manifestations, psychological variables, socioeconomic factors, genetic contributions, hormonal status, advanced imaging, coronary functional findings, biomarkers, patient-reported outcomes, and treatments pertaining to women with this disease entity. This review delves into the WISE findings subsequent to a prior review1, postulates directions for future research, and asks are we "Even 'WISE-R?'".

journal_name

Curr Atheroscler Rep

authors

Barsky L,Merz CNB,Wei J,Shufelt C,Handberg E,Pepine C,Rutledge T,Reis S,Doyle M,Rogers W,Shaw L,Sopko G

doi

10.1007/s11883-020-00852-w

subject

Has Abstract

pub_date

2020-06-18 00:00:00

pages

35

issue

8

eissn

1523-3804

issn

1534-6242

pii

10.1007/s11883-020-00852-w

journal_volume

22

pub_type

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