Abstract:
:There is now a consensus about recommending the Mediterranean diet pattern for the prevention of coronary heart disease (CHD) and cancer. The most important aspect of this treatment decision, in contrast with the pharmacologic prevention of CHD (including cholesterol lowering), is that the Mediterranean diet has a striking effect on survival. The main explanation for this is that the Mediterranean diet is protective not only against CHD and cancers but also against other various chronic diseases. Furthermore, the Mediterranean diet appears to be effective at reducing atherosclerosis and the risk of fatal complications (ie, sudden cardiac death and heart failure) of atherosclerosis. Finally, unlike drug therapies, no harmful side effect has been reported following the adoption of this dietary pattern. Many micro- and macronutrients characteristic of the Mediterranean diet interact in a synergistic way to induce states of resistance to chronic diseases. More research is required to understand these complex interplays.
journal_name
Curr Atheroscler Repjournal_title
Current atherosclerosis reportsauthors
de Lorgeril M,Salen Pdoi
10.1007/s11883-008-0080-5subject
Has Abstractpub_date
2008-12-01 00:00:00pages
518-22issue
6eissn
1523-3804issn
1534-6242journal_volume
10pub_type
杂志文章,评审abstract:PURPOSE OF REVIEW:We will review the available data on the epidemiology, pathophysiology, diagnosis, and management of microvascular coronary dysfunction (MCD). RECENT FINDINGS:The study of MCD was pioneered by the Women's Ischemia Syndrome Evaluation (WISE) cohort. New techniques in the diagnosis of this condition, u...
journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11883-018-0710-5
更新日期:2018-01-30 00:00:00
abstract::A wide range of structurally unrelated antioxidants inhibit atherosclerosis in animal models of hypercholesterolemia, implicating oxidation of low-density lipoprotein (LDL) in the pathogenesis of atherosclerosis. However, most prospective, randomized trials of one proposed antioxidant, vitamin E, have failed to demons...
journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11883-003-0075-1
更新日期:2003-03-01 00:00:00
abstract::Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is a calcium-independent phospholipase A(2) enzyme secreted by leukocytes and associated with circulating low-density lipoprotein and macrophages in atherosclerotic plaques. Until recently, the biological role of Lp-PLA(2) in atherosclerosis was controversial, but ...
journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11883-009-0076-9
更新日期:2010-01-01 00:00:00
abstract::Atherosclerotic heart disease and stroke are leading causes of disability and death worldwide, affecting not only developed countries, but also low- and middle-income regions. Different strategies for handling dyslipidemia as a critical pathogenic risk factor for atherosclerosis have been proposed. However, these reco...
journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11883-014-0400-x
更新日期:2014-04-01 00:00:00
abstract::The effects of cis-monounsaturated fatty acids (cis-MUFAs) on the risk of coronary heart disease (CHD) and on CHD mortality are not clear. Also, dietary recommendations for cis-MUFA as derived by various organizations are not in agreement. Earlier studies have mainly focused on the effects of cis-MUFA on serum lipids ...
journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11883-016-0597-y
更新日期:2016-07-01 00:00:00
abstract::A substantial body of epidemiologic data has shed light on the potential protective effects of the Mediterranean diet against atherosclerosis in humans. Many believe the reason the Mediterranean diet is atheroprotective is the elevated consumption of olive oil, an oil poor in saturated fatty acids (SFA) and highly enr...
journal_title:Current atherosclerosis reports
pub_type: 杂志文章
doi:10.1007/s11883-007-0066-8
更新日期:2007-12-01 00:00:00
abstract:PURPOSE OF REVIEW:In this review, we describe the mechanism behind coronary artery calcification formation and detection, as well as its implication in cardiovascular disease (CVD) risk stratification, intervention, and prognosis in asymptomatic individuals. RECENT FINDINGS:Multiple cohort and population studies have ...
journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11883-019-0812-8
更新日期:2019-11-21 00:00:00
abstract:PURPOSE OF REVIEW:High lipoprotein(a) levels are observationally and causally, from human genetics, associated with increased risk of cardiovascular disease including myocardial infarction and aortic valve stenosis. The European Atherosclerosis Society recommends screening for elevated lipoprotein(a) levels in high-ris...
journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11883-019-0792-8
更新日期:2019-05-20 00:00:00
abstract::Inflammation lies at the base of endothelial dysfunction, eventually leading to plaque formation. The degree of inflammation defines the "vulnerability" of plaque to rupture. Numerous strategies have been adopted to identify and eventually treat high-risk vulnerable plaque. Lipoprotein-associated phospholipase A(2) (L...
journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11883-010-0095-6
更新日期:2010-03-01 00:00:00
abstract::More than half of the men and women in the United States are overweight or obese. Obesity is associated with an increased risk for various diseases, most notably, hypertension, diabetes mellitus, dyslipidemia, and coronary heart disease (CHD). The location of excessive body fat, particularly in the visceral area, has ...
journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11883-000-0065-5
更新日期:2000-07-01 00:00:00
abstract::Cancer survivorship should be defined starting not from completion of treatment, but from the time of diagnosis. Assessing and controlling the cancer patient's cardiovascular risk before, during, and after treatment is crucial to improving their overall outcome. There are many cancer therapies, including but not limit...
journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11883-014-0484-3
更新日期:2015-03-01 00:00:00
abstract::Abdominal aortic aneurysms (AAA) are permanent dilations in the infra-renal area in which the arterial tissue is characterized by inflammation and medial degeneration. AAAs are a common vascular disorder and cause significant mortality in the aged population. Despite the high prevalence of this disease, there is limit...
journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11883-002-0023-5
更新日期:2002-05-01 00:00:00
abstract::Spontaneous intracerebral hemorrhage (ICH) is a devastating disease with high morbidity and mortality. Acutely, ICH is associated with a sudden surge in intracranial pressure (ICP), as the volume of hematoma increases the pressure in the closed head, leading to non-specific symptoms of ICP: headache, nausea, vomiting,...
journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11883-012-0251-2
更新日期:2012-08-01 00:00:00
abstract::Pharmacotherapies with agents that inhibit platelet function have proven to be effective in the treatment of acute coronary syndromes, and in the prevention of complications during and after percutaneous coronary intervention. Because of multiple synergetic pathways of platelet activation and their close interplay wit...
journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11883-013-0371-3
更新日期:2013-12-01 00:00:00
abstract::Recent randomized trials of hormone replacement therapy (HRT) in postmenopausal women are not consistent with the decrease in cardiovascular risk seen in observational studies of hormone therapy users compared with nonusers. Emerging evidence indicates that HRT use in some women with established coronary heart disease...
journal_title:Current atherosclerosis reports
pub_type: 杂志文章
doi:10.1007/s11883-002-0040-4
更新日期:2002-03-01 00:00:00
abstract::Augmentative and alternative communication (AAC) strategies traditionally have been designed for individuals for whom oral speech is not a viable option. Common clinical practice has expanded AAC use to a tool for cognitive retraining or remediation. Although technologic developments offer the potential for vastly imp...
journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11883-002-0008-4
更新日期:2002-07-01 00:00:00
abstract::Vascular inflammation contributes critically to the initiation and progression of atherosclerosis. These processes are accelerated in hyperglycemia and play key roles in the increased incidence and severity of myocardial infarction and stroke observed in diabetes. Evidence suggests that the ligands of the receptor for...
journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11883-006-0078-9
更新日期:2006-05-01 00:00:00
abstract::Atherosclerosis is a complex disease associated with aberrant lipoprotein metabolism and leukocyte infiltration into arterial tissue that leads to cardiovascular diseases. Statins have emerged as among the most effective means of reducing the risk of cardiovascular disease in both primary and secondary prevention sett...
journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11883-012-0294-4
更新日期:2013-01-01 00:00:00
abstract::Biologic therapies involve the utilization of proteins, DNA, antibodies, or other substances derived or synthesized from living tissue for therapeutic effects. There are several biologic therapies in clinical development for the prevention and treatment of atherosclerosis. The most advanced in human trials are apolipo...
journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11883-004-0118-2
更新日期:2004-01-01 00:00:00
abstract::Few principles in medicine today are as well accepted as the benefits of using statins to reduce cardiovascular risk factors and to prevent cardiovascular disease. The recent withdrawal of a statin (cerivastatin) has lead to a re-examination of all statins, and an attempt to better assess the risk-benefit ratio of thi...
journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11883-002-0060-0
更新日期:2002-01-01 00:00:00
abstract::The ability for statins to reduce major cardiovascular events and mortality has lead to this drug class being the most commonly prescribed in the world. In particular, the benefit of these drugs in type 2 diabetes (T2D) is well established. In February 2012, the Food and Drug Administration released changes to statin ...
journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11883-012-0299-z
更新日期:2013-02-01 00:00:00
abstract::Effective prevention of the current annual $400 billion losses from atherosclerosis and cardiovascular disease (CVD) will require preventing primary causes rather than just decreasing signs and symptoms (risk factors) produced by those causes. All CVD risk factors predict a likelihood of CVD, but not all are causes of...
journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11883-009-0042-6
更新日期:2009-07-01 00:00:00
abstract::Although the role of implantable cardioverter defibrillator (ICD) and cardiac resynchronization therapy (CRT) in improving outcomes in ischemic cardiomyopathy (ICM) has been described, the data regarding gender-based survival outcomes are limited. There is a higher preponderance of non-ischemic cardiomyopathy (NICM) i...
journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11883-015-0512-y
更新日期:2015-06-01 00:00:00
abstract::Diabesity is a term often used to indicate the association of type-2 diabetes mellitus (T2DM) with obesity; the prevalence of both conditions is rapidly increasing worldwide and has reached epidemic proportions. Insulin resistance represents the major determinant of T2DM, which becomes manifest once relative β-cell fa...
journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11883-012-0284-6
更新日期:2012-12-01 00:00:00
abstract::The Third Report of the National Cholesterol Education Program's Adult Treatment Panel (ATP III) has an extensive section on nonpharmacologic therapy for those with abnormal blood lipids. ATP III focused on the high-saturated fat atherogenic diet, obesity, and sedentary lifestyle and recommended a program of therapeut...
journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11883-002-0047-x
更新日期:2002-11-01 00:00:00
abstract:PURPOSE OF REVIEW:Perivascular adipose tissue (PVAT) has a complex, bidirectional relationship with the vascular wall. In disease states, PVAT secretes pro-inflammatory adipocytokines which may contribute to atherosclerosis. Recent evidence demonstrates that pericoronary adipose tissue (PCAT) may also function as a sen...
journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11883-019-0817-3
更新日期:2019-11-19 00:00:00
abstract::Plant foods rich in carbohydrate and dietary fiber have many health benefits. One concern often expressed about higher carbohydrate, lower fat diets is that they may increase fasting serum triglycerides. Recently the importance of hypertriglyceridemia as an independent risk factor for coronary heart disease has been r...
journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11883-000-0055-7
更新日期:2000-11-01 00:00:00
abstract:PURPOSE OF REVIEW:Mutations in both nuclear and mitochondrial genes are associated with the development of atherosclerotic lesions in arteries and may provide a partial explanation to the focal nature of lesion distribution in the arterial wall. This review is aimed to discuss the genetic aspects of atherogenesis with ...
journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11883-020-00873-5
更新日期:2020-08-09 00:00:00
abstract::Since initial reports of its association with ischemic stroke appeared in 1988, there has been continued controversy regarding the existence and strength of the association between patent foramen ovale (PFO) and ischemic stroke. Many case-control studies have reported an association between incident cryptogenic ischem...
journal_title:Current atherosclerosis reports
pub_type: 杂志文章
doi:10.1007/s11883-010-0114-7
更新日期:2010-07-01 00:00:00
abstract::The renin-angiotensin-aldosterone system (RAAS) is well-established and continues to be pursued as a therapeutic target in the treatment of heart failure, predominantly due to the success of agents that block RAAS in clinical trials of systolic heart failure. The optimal treatment of heart failure patients with preser...
journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11883-014-0403-7
更新日期:2014-04-01 00:00:00