The Role of the Gut Microbiota in Coronary Heart Disease.

Abstract:

PURPOSE OF REVIEW:This review focuses on recent evidence examining the role gut microbiota play in coronary heart disease. It also provides a succinct overview of current and future therapies targeting the gut microbiota for coronary heart disease risk reduction. RECENT FINDINGS:A consensus has been reached that differences exist in the gut microbiotas of patients with coronary heart disease. Studies have shown that the gut microbiota is associated with obesity, diabetes, dyslipidemia, and hypertension, which are risk factors for coronary heart disease. The gut microbiota is involved in mediating basic metabolic processes, such as cholesterol metabolism, uric acid metabolism, oxidative stress, and inflammatory reactions, through its metabolites, which can induce the development of atherosclerosis and coronary heart disease. Interfering with the composition of gut microbiota, supplementing probiotics, and fecal donation are active areas of research to potentially prevent and treat coronary heart disease. Gut microbiota are causally associated with coronary heart disease. We analyzed the gut microbiota's effects on risk factors for coronary heart disease and studied the effects of gut microbiota metabolites on coronary heart disease. Gut microbiota is a potential target for preventing and treating coronary heart disease.

journal_name

Curr Atheroscler Rep

authors

Liu H,Zhuang J,Tang P,Li J,Xiong X,Deng H

doi

10.1007/s11883-020-00892-2

subject

Has Abstract

pub_date

2020-10-16 00:00:00

pages

77

issue

12

eissn

1523-3804

issn

1534-6242

pii

10.1007/s11883-020-00892-2

journal_volume

22

pub_type

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