Abstract:
PURPOSE OF REVIEW:This review focuses on recent evidence examining the role gut microbiota play in coronary heart disease. It also provides a succinct overview of current and future therapies targeting the gut microbiota for coronary heart disease risk reduction. RECENT FINDINGS:A consensus has been reached that differences exist in the gut microbiotas of patients with coronary heart disease. Studies have shown that the gut microbiota is associated with obesity, diabetes, dyslipidemia, and hypertension, which are risk factors for coronary heart disease. The gut microbiota is involved in mediating basic metabolic processes, such as cholesterol metabolism, uric acid metabolism, oxidative stress, and inflammatory reactions, through its metabolites, which can induce the development of atherosclerosis and coronary heart disease. Interfering with the composition of gut microbiota, supplementing probiotics, and fecal donation are active areas of research to potentially prevent and treat coronary heart disease. Gut microbiota are causally associated with coronary heart disease. We analyzed the gut microbiota's effects on risk factors for coronary heart disease and studied the effects of gut microbiota metabolites on coronary heart disease. Gut microbiota is a potential target for preventing and treating coronary heart disease.
journal_name
Curr Atheroscler Repjournal_title
Current atherosclerosis reportsauthors
Liu H,Zhuang J,Tang P,Li J,Xiong X,Deng Hdoi
10.1007/s11883-020-00892-2subject
Has Abstractpub_date
2020-10-16 00:00:00pages
77issue
12eissn
1523-3804issn
1534-6242pii
10.1007/s11883-020-00892-2journal_volume
22pub_type
杂志文章,评审abstract::Atherothrombotic cardiovascular events are a leading cause of morbidity and mortality in patients with type 2 diabetes (T2D). A number of factors beyond hyperglycemia contribute to this increased risk of cardiovascular events in T2D, including elevated blood pressure, dyslipidemia, inflammation, endothelial dysfunctio...
journal_title:Current atherosclerosis reports
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journal_title:Current atherosclerosis reports
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journal_title:Current atherosclerosis reports
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journal_title:Current atherosclerosis reports
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journal_title:Current atherosclerosis reports
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s11883-020-0829-z
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journal_title:Current atherosclerosis reports
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journal_title:Current atherosclerosis reports
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journal_title:Current atherosclerosis reports
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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更新日期:2019-04-12 00:00:00
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journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
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更新日期:2013-02-01 00:00:00
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journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
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更新日期:2009-09-01 00:00:00
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journal_title:Current atherosclerosis reports
pub_type: 杂志文章
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更新日期:1999-07-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2011-06-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1007/s11883-013-0391-z
更新日期:2014-03-01 00:00:00
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journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
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更新日期:2007-10-01 00:00:00
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更新日期:2014-04-01 00:00:00
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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更新日期:2011-12-01 00:00:00
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journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
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更新日期:2001-11-01 00:00:00
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journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
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更新日期:2019-05-20 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2000-03-01 00:00:00
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journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
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更新日期:2013-12-01 00:00:00
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journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
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更新日期:2014-04-01 00:00:00
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journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
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更新日期:2011-04-01 00:00:00