The Role of Metabolic Surgery in Non-alcoholic Steatohepatitis Improvement.

Abstract:

PURPOSE OF REVIEW:Non-alcoholic fatty liver disease (NAFLD) is frequently associated with obesity and overweight. It has a broad spectrum of clinical and histological presentations, such as steatosis, inflammation (known as non-alcoholic steatohepatitis or NASH), fibrosis, and cirrhosis. There is increasing evidence that marked weight loss following bariatric surgery is associated with NASH resolution; however, little is known about the mechanisms that may lead to this beneficial condition and if it is due to weight loss alone. In this review, the authors present the latest data regarding NASH resolution following metabolic surgery and try to answer the following questions: is NASH resolution due to weight loss alone or is it related to weight-independent effects similarly to T2D? In such case, can NASH be considered as a sole criterion for metabolic surgery? RECENT FINDINGS:Most data evaluating NAFLD and bariatric and metabolic surgery are derived from cohort studies. Available data are extremely variable, but in general show a dramatic regression of steatosis, inflammatory changes, and in some cases even fibrosis that is probably linked to major weight loss following surgery. There are no randomized controlled trials evaluating the effects of metabolic surgery over NASH vs. lifestyle modifications. To consider NASH a sole indication for metabolic surgery regardless of BMI, such studies are desperately needed and should be the primary focus of future research in metabolic surgery.

journal_name

Curr Atheroscler Rep

authors

Caravatto PP,Cohen R

doi

10.1007/s11883-017-0681-y

subject

Has Abstract

pub_date

2017-10-07 00:00:00

pages

45

issue

11

eissn

1523-3804

issn

1534-6242

pii

10.1007/s11883-017-0681-y

journal_volume

19

pub_type

杂志文章,评审
  • Diet and pharmacologic therapy of obesity to modify atherosclerosis.

    abstract::More than half of the men and women in the United States are overweight or obese. Obesity is associated with an increased risk for various diseases, most notably, hypertension, diabetes mellitus, dyslipidemia, and coronary heart disease (CHD). The location of excessive body fat, particularly in the visceral area, has ...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-000-0065-5

    authors: Jones PH

    更新日期:2000-07-01 00:00:00

  • Impact of circulating esterified eicosanoids and other oxylipins on endothelial function.

    abstract::Eicosanoids, including epoxyeicosatrienoic acids, hydroxyeicosatetraenoic acids, and other oxylipins derived from polyunsaturated fatty acids, have emerging roles in endothelial inflammation and subsequent atherosclerosis. Unlike eicosanoids in the prostanoid series, they are known to be esterified in cell lipids such...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-009-0061-3

    authors: Shearer GC,Newman JW

    更新日期:2009-11-01 00:00:00

  • An Update on Gender Disparities in Coronary Heart Disease Care.

    abstract::Coronary heart disease (CHD), traditionally considered a male disease, causes far more deaths in women than cancer. The prevalence of CHD is lower in women at any age, but with advancing age, this differential decreases. The clinical outcomes including myocardial infarction mortality, all-cause mortality, and reinfarc...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-016-0574-5

    authors: Shah T,Palaskas N,Ahmed A

    更新日期:2016-05-01 00:00:00

  • Delayed Cerebral Ischemia after Subarachnoid Hemorrhage: Beyond Vasospasm and Towards a Multifactorial Pathophysiology.

    abstract:PURPOSE OF REVIEW:Delayed cerebral ischemia (DCI) is common after subarachnoid hemorrhage (SAH) and represents a significant cause of poor functional outcome. DCI was mainly thought to be caused by cerebral vasospasm; however, recent clinical trials have been unable to confirm this hypothesis. Studies in humans and ani...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-017-0690-x

    authors: Geraghty JR,Testai FD

    更新日期:2017-10-23 00:00:00

  • Mechanisms of abdominal aortic aneurysm formation.

    abstract::Abdominal aortic aneurysms (AAA) are permanent dilations in the infra-renal area in which the arterial tissue is characterized by inflammation and medial degeneration. AAAs are a common vascular disorder and cause significant mortality in the aged population. Despite the high prevalence of this disease, there is limit...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-002-0023-5

    authors: Daugherty A,Cassis LA

    更新日期:2002-05-01 00:00:00

  • The plaque "micro" environment: microRNAs control the risk and the development of atherosclerosis.

    abstract::While the discovery of microRNAs has exponentially expanded our understanding of the regulatory mechanisms governing gene networks in many biological processes, the study of these tiny RNA powerhouses in cardiovascular disease is in its infancy. To date, there have been over 1200 human microRNAs identified, and they a...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-012-0272-x

    authors: Rayner KJ,Moore KJ

    更新日期:2012-10-01 00:00:00

  • Aspirin for the Primary Prevention of Cardiovascular Disease: In Need of Clarity.

    abstract::Aspirin remains one of the most extensively studied cardiovascular medications in the history of medicine. However, despite multiple, well-designed, large randomized controlled trials evaluating the potential of aspirin to prevent cardiovascular events in individuals without known cardiovascular disease (CVD), the rol...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-015-0555-0

    authors: Miedema MD,Huguelet J,Virani SS

    更新日期:2016-01-01 00:00:00

  • Cardiovascular prevention in the cancer survivor.

    abstract::Cancer survivorship should be defined starting not from completion of treatment, but from the time of diagnosis. Assessing and controlling the cancer patient's cardiovascular risk before, during, and after treatment is crucial to improving their overall outcome. There are many cancer therapies, including but not limit...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-014-0484-3

    authors: Chen CL

    更新日期:2015-03-01 00:00:00

  • Applied gene therapy in preclinical models of vascular injury.

    abstract::Atherosclerosis remains the major cause of morbidity and mortality in Western countries. Atherothrombotic complications, including vascular occlusions and severe narrowing of nutrient blood vessels in the cerebral, coronary, or peripheral circulation, usually require invasive revascularization strategies. As molecular...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-003-0022-1

    authors: Janssens SP

    更新日期:2003-05-01 00:00:00

  • Proteomics of acute coronary syndromes.

    abstract::Acute coronary syndromes (ACS), such as unstable angina, acute myocardial infarction, and sudden cardiac death, are commonly associated with the presence of vulnerable plaques in coronary arteries. Rupture or erosion of vulnerable plaques results in the formation of luminal thrombi due to the physical contact between ...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-009-0030-x

    authors: Didangelos A,Simper D,Monaco C,Mayr M

    更新日期:2009-05-01 00:00:00

  • A Latin American perspective on the new ACC/AHA clinical guidelines for managing atherosclerotic cardiovascular disease.

    abstract::Atherosclerotic heart disease and stroke are leading causes of disability and death worldwide, affecting not only developed countries, but also low- and middle-income regions. Different strategies for handling dyslipidemia as a critical pathogenic risk factor for atherosclerosis have been proposed. However, these reco...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-014-0400-x

    authors: Cuevas A,Arteaga A,Rigotti A

    更新日期:2014-04-01 00:00:00

  • Radiation-Induced Cardiovascular Disease.

    abstract:PURPOSE OF REVIEW:Thoracic radiation therapy is an effective treatment for several malignancies, such as Hodgkin's lymphoma and breast cancer. Over the years, however, the incidence of cardiovascular events has increased in these patients, notably in younger survivors who do not have traditional risk factors. This revi...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-017-0658-x

    authors: Raghunathan D,Khilji MI,Hassan SA,Yusuf SW

    更新日期:2017-05-01 00:00:00

  • Genetic determinants of plasma triglycerides: impact of rare and common mutations.

    abstract::Raised plasma triglyceride (TG) levels are an independent risk factor for coronary artery disease (CAD), and thus understanding the genetic and environmental determinants of TG levels are of major importance. TG metabolism is a process for delivering free fatty acids for energy storage or b-oxidation, and involves a n...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-001-0061-4

    authors: Talmud PJ

    更新日期:2001-05-01 00:00:00

  • Lp-PLA(2) as a marker of cardiovascular diseases.

    abstract::Inflammation lies at the base of endothelial dysfunction, eventually leading to plaque formation. The degree of inflammation defines the "vulnerability" of plaque to rupture. Numerous strategies have been adopted to identify and eventually treat high-risk vulnerable plaque. Lipoprotein-associated phospholipase A(2) (L...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-010-0095-6

    authors: Bhatti S,Hakeem A,Cilingiroglu M

    更新日期:2010-03-01 00:00:00

  • Advances in Coronary No-Reflow Phenomenon-a Contemporary Review.

    abstract:PURPOSE OF REVIEW:Coronary artery no-reflow phenomenon is an incidental outcome of percutaneous coronary intervention in patients presenting with acute myocardial infarction. Despite advances in pharmacologic and non-pharmacologic therapies, coronary no-reflow phenomenon occurs more commonly than desired. It often resu...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章

    doi:10.1007/s11883-018-0747-5

    authors: Karimianpour A,Maran A

    更新日期:2018-07-05 00:00:00

  • The low-density lipoprotein receptor family: genetics, function, and evolution.

    abstract::With ever increasing sophistication in molecular biological approaches, the low-density lipoprotein receptor supergene family continues to grow rapidly. From the well-defined key role of these receptors in lipoprotein metabolism, the new members move the field into many different and diverse physiologic and developmen...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章

    doi:10.1007/s11883-999-0007-9

    authors: Schneider WJ,Nimpf J,Brandes C,Drexler M

    更新日期:1999-09-01 00:00:00

  • Lifestyle strategies for cardiovascular risk reduction.

    abstract::Daily lifestyle practices and habits profoundly affect the likelihood of developing cardiovascular disease (CVD). Abundant research and multiple recent consensus documents support the role of regular physical activity, not smoking cigarettes, maintaining a healthy body weight, controlling cholesterol levels, and contr...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-014-0444-y

    authors: Rippe JM,Angelopoulos TJ

    更新日期:2014-10-01 00:00:00

  • Genetics of Arterial-Wall-Specific Mechanisms in Atherosclerosis: Focus on Mitochondrial Mutations.

    abstract:PURPOSE OF REVIEW:Mutations in both nuclear and mitochondrial genes are associated with the development of atherosclerotic lesions in arteries and may provide a partial explanation to the focal nature of lesion distribution in the arterial wall. This review is aimed to discuss the genetic aspects of atherogenesis with ...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-020-00873-5

    authors: Orekhov AN,Ivanova EA,Markin AM,Nikiforov NG,Sobenin IA

    更新日期:2020-08-09 00:00:00

  • Vitamin D, Calcium, and Cardiovascular Disease: A"D"vantageous or "D"etrimental? An Era of Uncertainty.

    abstract::While the function of vitamin D in regulating calcium homeostasis is well established, there has been growing interest in its role in the prevention of numerous chronic diseases, including cardiovascular disease (CVD). There is mounting epidemiological evidence suggesting that vitamin D deficiency is linked to increas...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-017-0637-2

    authors: Chin K,Appel LJ,Michos ED

    更新日期:2017-01-01 00:00:00

  • Biologic therapies for dyslipidemia.

    abstract::Biologic therapies involve the utilization of proteins, DNA, antibodies, or other substances derived or synthesized from living tissue for therapeutic effects. There are several biologic therapies in clinical development for the prevention and treatment of atherosclerosis. The most advanced in human trials are apolipo...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-004-0118-2

    authors: Davidson MH

    更新日期:2004-01-01 00:00:00

  • Omega-3 fatty acids: a growing ocean of choices.

    abstract::There has been increasing interest in the health benefits of supplemental and/or dietary omega-3 polyunsaturated fatty acids (PUFAs), particularly in their role in disease prevention. This interest escalated once their effects on cardiovascular health were observed from numerous observational studies in populations wh...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-013-0389-6

    authors: Fares H,Lavie CJ,DiNicolantonio JJ,O'Keefe JH,Milani RV

    更新日期:2014-02-01 00:00:00

  • Role of cis-Monounsaturated Fatty Acids in the Prevention of Coronary Heart Disease.

    abstract::The effects of cis-monounsaturated fatty acids (cis-MUFAs) on the risk of coronary heart disease (CHD) and on CHD mortality are not clear. Also, dietary recommendations for cis-MUFA as derived by various organizations are not in agreement. Earlier studies have mainly focused on the effects of cis-MUFA on serum lipids ...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-016-0597-y

    authors: Joris PJ,Mensink RP

    更新日期:2016-07-01 00:00:00

  • Lifestyle factors and stroke risk: exercise, alcohol, diet, obesity, smoking, drug use, and stress.

    abstract::Various lifestyle factors have been associated with increasing the risk of stroke. These include lack of exercise, alcohol, diet, obesity, smoking, drug use, and stress. Guidelines endorsed by the Centers for Disease Control and Prevention and the National Institutes of Health recommend that Americans should exercise ...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-000-0111-3

    authors: Boden-Albala B,Sacco RL

    更新日期:2000-03-01 00:00:00

  • Did the antioxidant trials fail to validate the oxidation hypothesis?

    abstract::Most clinical trials on antioxidants using vitamin E or beta-carotene have failed to note any significant change in cardiovascular endpoints. The results of these studies have been interpreted as a setback for the oxidation hypothesis. An analysis of the hypothesis and the trials, however, points out major misconcepti...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-001-0077-9

    authors: Parthasarathy S,Khan-Merchant N,Penumetcha M,Khan BV,Santanam N

    更新日期:2001-09-01 00:00:00

  • Nicotinic acid: a new look at an old drug.

    abstract::Dyslipidemia is central to the process of atherosclerosis. Modification of the lipid profile by diet, exercise, or pharmacologic therapy has been demonstrated to reduce the risk from atherosclerosis in clinical studies in primary and secondary prevention. Nicotinic acid has been in clinical use for over 50 years. The ...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-009-0014-x

    authors: Farmer JA

    更新日期:2009-03-01 00:00:00

  • Liver X receptors as therapeutic targets in metabolism and atherosclerosis.

    abstract::The liver X receptors (LXRs) are ligand-activated transcription factors belonging to the nuclear hormone receptor superfamily. Since their initial identification more than a decade ago, LXRs have been characterized as key transcriptional regulators of lipid and carbohydrate homeostasis. LXRs are activated by the intra...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-008-0013-3

    authors: Nomiyama T,Bruemmer D

    更新日期:2008-02-01 00:00:00

  • Alcohol and atherosclerosis: recent insights.

    abstract::Light to moderate alcohol intake is known to have cardioprotective properties; however, the magnitude of protection depends on other factors and may be confined to some subsets of the population. This review focuses on factors that modify the relationship between alcohol and coronary heart disease (CHD). The cardiopro...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-007-0007-6

    authors: Tolstrup J,Grønbaek M

    更新日期:2007-08-01 00:00:00

  • Mobile Stroke Units - Cost-Effective or Just an Expensive Hype?

    abstract:PURPOSE OF REVIEW:Acute stroke is a treatable disease. Nevertheless, only a minority of patients obtain guideline-adjusted therapy. One major reason is the small time window in which therapies have to be administered in order to reverse or mitigate brain injury and prevent disability. The Mobile Stroke Unit (MSU) conce...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-018-0751-9

    authors: Walter S,Grunwald IQ,Helwig SA,Ragoschke-Schumm A,Kettner M,Fousse M,Lesmeister M,Fassbender K

    更新日期:2018-08-29 00:00:00

  • Approach to dyslipidemia, lipodystrophy, and cardiovascular risk in patients with HIV infection.

    abstract::There is a significant prevalence (20%-80% depending on the population and the study) of lipid disorders and other cardiovascular risk factors in people living with HIV infection. This review focuses on HIV and HIV treatment-associated metabolic and cardiovascular concerns, including dyslipidemias, lipodystrophy syndr...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-010-0152-1

    authors: Troll JG

    更新日期:2011-02-01 00:00:00

  • Oxidative stress and atherosclerosis.

    abstract::Understanding of the pathophysiology of atherosclerosis can provide new strategies for the prevention and treatment of patients with this common disease. Clinical, epidemiologic, and basic molecular science studies have identified oxidative stress as a factor contributing to the development and progression of atherosc...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-005-0013-5

    authors: Schulze PC,Lee RT

    更新日期:2005-05-01 00:00:00