Antiatherogenic components of olive oil.

abstract：:High-density lipoprotein cholesterol (HDL-C) levels are inversely related to risk of atherosclerotic cardiovascular disease (ASCVD). However, the simplistic assumption that HDL-C levels directly and causally impact atherogenesis has been challenged in recent years. The purpose of this article is to review the current ...

journal_title：Current atherosclerosis reports

authors： Brunham LR

更新日期：2016-12-01 00:00:00

abstract：:Biologic therapies involve the utilization of proteins, DNA, antibodies, or other substances derived or synthesized from living tissue for therapeutic effects. There are several biologic therapies in clinical development for the prevention and treatment of atherosclerosis. The most advanced in human trials are apolipo...

journal_title：Current atherosclerosis reports

authors： Davidson MH

更新日期：2004-01-01 00:00:00

abstract：PURPOSE OF REVIEW:In this review, we describe the mechanism behind coronary artery calcification formation and detection, as well as its implication in cardiovascular disease (CVD) risk stratification, intervention, and prognosis in asymptomatic individuals. RECENT FINDINGS:Multiple cohort and population studies have ...

journal_title：Current atherosclerosis reports

authors： Nguyen HL,Liu J,Del Castillo M,Shah T

更新日期：2019-11-21 00:00:00

abstract：:Coronary heart disease (CHD), traditionally considered a male disease, causes far more deaths in women than cancer. The prevalence of CHD is lower in women at any age, but with advancing age, this differential decreases. The clinical outcomes including myocardial infarction mortality, all-cause mortality, and reinfarc...

journal_title：Current atherosclerosis reports

authors： Shah T,Palaskas N,Ahmed A

更新日期：2016-05-01 00:00:00

abstract：:Abdominal aortic aneurysms (AAAs) are a common but asymptomatic disease that has high susceptibility to rupture. Current therapeutic options are limited to surgical procedures because no pharmacological approaches have been proven to decrease either expansion or rupture of human AAAs. The current dearth of effective m...

journal_title：Current atherosclerosis reports

authors： Lu H,Rateri DL,Bruemmer D,Cassis LA,Daugherty A

更新日期：2012-10-01 00:00:00

abstract：:At a time when the lipid management guidelines give more and more emphasis to the identification and treatment of high-risk patients with the metabolic syndrome and diabetes, there is an obvious need to balance the known effects of low-density lipoprotein (LDL) lowering with the new evidence of clinical efficacy deriv...

journal_title：Current atherosclerosis reports

authors： Fazio S,Linton MF

更新日期：2004-03-01 00:00:00

abstract：:More than half of the men and women in the United States are overweight or obese. Obesity is associated with an increased risk for various diseases, most notably, hypertension, diabetes mellitus, dyslipidemia, and coronary heart disease (CHD). The location of excessive body fat, particularly in the visceral area, has ...

journal_title：Current atherosclerosis reports

authors： Jones PH

更新日期：2000-07-01 00:00:00

abstract：:The High-Risk Plaque (HRP) Initiative is a research and development effort to advance the understanding, recognition, and management of asymptomatic individuals at risk for a near-term atherothrombotic event such as myocardial infarction or stroke. Clinical studies using the newest technologies have been initiated, in...

journal_title：Current atherosclerosis reports

authors： Falk E,Sillesen H,Muntendam P,Fuster V

更新日期：2011-10-01 00:00:00

abstract：:Statin therapy has became the most important advance in stroke prevention since the introduction of aspirin and blood pressure-lowering therapies. Other lipid-modifying drugs have been less successful in reducing the incidence of stroke, but because of evidence for the use of triglyceride-lowering drugs and treatments...

journal_title：Current atherosclerosis reports

authors： Deplanque D,Amarenco P

更新日期：2011-08-01 00:00:00

abstract：:Preliminary evidence demonstrating that adding 0.5 mg of colchicine per day to statin and antiplatelet therapy reduced the risk of acute coronary events in patients with stable coronary artery disease has raised the hope that it may prove effective for the long-term secondary prevention of cardiovascular disease. The ...

journal_title：Current atherosclerosis reports

authors： Nidorf SM,Eikelboom JW,Thompson PL

更新日期：2014-03-01 00:00:00

abstract：:Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is an enzyme which binds to oxidized LDL and has a pro-inflammatory role in the pathogenesis of atherosclerosis. The Lp-PLA(2) Studies Collaboration showed the relationship between Lp-PLA(2) levels and activity with coronary heart disease and ischemic stroke. Level...

journal_title：Current atherosclerosis reports

authors： Wong CK,White HD

更新日期：2011-12-01 00:00:00

abstract：:Lipodystrophies are a group of heterogeneous diseases characterized by the loss of adipose tissue and by abnormalities of carbohydrate and lipid metabolism, including insulin resistance, diabetes, and hyperlipidemia. In this review, we describe several mouse models that recapitulate various aspects of the lipodystroph...

journal_title：Current atherosclerosis reports

authors： Reue K,Péterfy M

更新日期：2000-09-01 00:00:00

abstract：:Injury of arterial endothelium by abnormal shear stress and other insults induces migration and proliferation of vascular smooth muscle cells (VSMCs), which in turn leads to intimal thickening, hypoxia, and vasa vasorum angiogenesis. The resultant new blood vessels extend from the tunica media into the outer intima, a...

journal_title：Current atherosclerosis reports

authors： Fong GH

更新日期：2015-06-01 00:00:00

abstract：:The liver X receptors (LXRs) are ligand-activated transcription factors belonging to the nuclear hormone receptor superfamily. Since their initial identification more than a decade ago, LXRs have been characterized as key transcriptional regulators of lipid and carbohydrate homeostasis. LXRs are activated by the intra...

journal_title：Current atherosclerosis reports

authors： Nomiyama T,Bruemmer D

更新日期：2008-02-01 00:00:00

abstract：:The cytochrome P450 (CYP) is a group of enzymes that oxidatively modify drugs to a more water-soluble form for renal excretion. Nearly 50% of all clinically used medications and endogenous steroids are metabolized by the CYP enzyme 3A4, which explains why many of the important potential drug interactions involved this...

journal_title：Current atherosclerosis reports

authors： Davidson MH

更新日期：2000-01-01 00:00:00

abstract：:3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors or "statin" medications are the most commonly prescribed therapy for lowering cholesterol. In use for over a decade, they have demonstrated both safety and tolerability across a broad range of patients. The ability to inhibit the biosynthesis of cholesterol an...

journal_title：Current atherosclerosis reports

authors： Garcia PJ

更新日期：2005-02-01 00:00:00

abstract：:Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is a calcium-independent phospholipase A(2) enzyme secreted by leukocytes and associated with circulating low-density lipoprotein and macrophages in atherosclerotic plaques. Until recently, the biological role of Lp-PLA(2) in atherosclerosis was controversial, but ...

journal_title：Current atherosclerosis reports

authors： Chauffe RJ,Wilensky RL,Mohler ER 3rd

更新日期：2010-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Lipoprotein apheresis is a very efficient but time-consuming and expensive method of lowering levels of low-density lipoprotein cholesterol, lipoprotein(a)) and other apoB containing lipoproteins, including triglyceride-rich lipoproteins. First introduced almost 45 years ago, it has long been a therap...

journal_title：Current atherosclerosis reports

authors： Thompson G,Parhofer KG

更新日期：2019-05-01 00:00:00

abstract：:Aggressive lipid lowering was initially controversial due to evidence from epidemiologic studies that implied an increase in total mortality with low cholesterol levels combined with equivocal results from early trials utilizing bile acid resins or fibric acid derivatives. The advent of statin therapy allowed signific...

journal_title：Current atherosclerosis reports

authors： Todd J,Farmer JA

更新日期：2006-03-01 00:00:00

abstract：:Dyslipidemia is central to the process of atherosclerosis. Modification of the lipid profile by diet, exercise, or pharmacologic therapy has been demonstrated to reduce the risk from atherosclerosis in clinical studies in primary and secondary prevention. Nicotinic acid has been in clinical use for over 50 years. The ...

journal_title：Current atherosclerosis reports

authors： Farmer JA

更新日期：2009-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Delayed cerebral ischemia (DCI) is common after subarachnoid hemorrhage (SAH) and represents a significant cause of poor functional outcome. DCI was mainly thought to be caused by cerebral vasospasm; however, recent clinical trials have been unable to confirm this hypothesis. Studies in humans and ani...

journal_title：Current atherosclerosis reports

authors： Geraghty JR,Testai FD

更新日期：2017-10-23 00:00:00

abstract：:Patients with ischemic stroke of unclear etiology are often screened for hypercoagulable syndromes or thrombophilias. These have been recognized to cause venous thrombosis, and include hereditary deficiencies of coagulation factors, genetic mutations, or acquired disorders. However, the majority of coagulation disorde...

journal_title：Current atherosclerosis reports

authors： Bushnell C,Goldstein LB

更新日期：2003-07-01 00:00:00

abstract：:Light to moderate alcohol intake is known to have cardioprotective properties; however, the magnitude of protection depends on other factors and may be confined to some subsets of the population. This review focuses on factors that modify the relationship between alcohol and coronary heart disease (CHD). The cardiopro...

journal_title：Current atherosclerosis reports

authors： Tolstrup J,Grønbaek M

更新日期：2007-08-01 00:00:00

abstract：:Most clinical trials on antioxidants using vitamin E or beta-carotene have failed to note any significant change in cardiovascular endpoints. The results of these studies have been interpreted as a setback for the oxidation hypothesis. An analysis of the hypothesis and the trials, however, points out major misconcepti...

journal_title：Current atherosclerosis reports

authors： Parthasarathy S,Khan-Merchant N,Penumetcha M,Khan BV,Santanam N

更新日期：2001-09-01 00:00:00

abstract：:Approximately one third of ischemic strokes are labeled cryptogenic because the etiology is unknown despite a thorough evaluation. Paroxysmal atrial fibrillation carries the same risk of ischemic stroke as persistent atrial fibrillation and has increasingly gained attention as a potential source of cryptogenic stroke....

journal_title：Current atherosclerosis reports

authors： Zhang C,Kasner SE

更新日期：2015-12-01 00:00:00

abstract：:Inflammation and oxidative processes are key components of atherosclerosis, from fatty streak formation to plaque rupture and thrombosis. Recent basic and clinical studies have identified a number of inflammatory and oxidative processes that appear to play a direct role in atherothrombosis and identify potentially cli...

journal_title：Current atherosclerosis reports

authors： Shishehbor MH,Hazen SL

更新日期：2004-05-01 00:00:00

abstract：:There is a significant prevalence (20%-80% depending on the population and the study) of lipid disorders and other cardiovascular risk factors in people living with HIV infection. This review focuses on HIV and HIV treatment-associated metabolic and cardiovascular concerns, including dyslipidemias, lipodystrophy syndr...

journal_title：Current atherosclerosis reports

authors： Troll JG

更新日期：2011-02-01 00:00:00

abstract：:Atherosclerotic cardiovascular diseases are the most common causes of death in the United States. Fibrous plaques develop in 77% to 78% of men before age 30. The mean low-density lipoprotein-cholesterol (LDL-C) level in men aged 25 to 30 years is 117 mg/dL. In the Air Force/Texas Coronary Atherosclerosis Prevention St...

journal_title：Current atherosclerosis reports

authors： Whitney E

更新日期：1999-07-01 00:00:00

abstract：:A wide range of structurally unrelated antioxidants inhibit atherosclerosis in animal models of hypercholesterolemia, implicating oxidation of low-density lipoprotein (LDL) in the pathogenesis of atherosclerosis. However, most prospective, randomized trials of one proposed antioxidant, vitamin E, have failed to demons...

journal_title：Current atherosclerosis reports

authors： Heinecke JW

更新日期：2003-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Perivascular adipose tissue (PVAT) has a complex, bidirectional relationship with the vascular wall. In disease states, PVAT secretes pro-inflammatory adipocytokines which may contribute to atherosclerosis. Recent evidence demonstrates that pericoronary adipose tissue (PCAT) may also function as a sen...

journal_title：Current atherosclerosis reports

authors： Lin A,Dey D,Wong DTL,Nerlekar N

更新日期：2019-11-19 00:00:00