Abstract:
:Most clinical trials on antioxidants using vitamin E or beta-carotene have failed to note any significant change in cardiovascular endpoints. The results of these studies have been interpreted as a setback for the oxidation hypothesis. An analysis of the hypothesis and the trials, however, points out major misconceptions about the hypothesis and unjustified outcome expectations. Wrong selection of patient population, endpoints that are incompatible with the hypothesis, poor choice of antioxidants, and lack of inclusion of biochemical markers of oxidative stress and markers of vascular response are some of the contributors to the "failure" of these trials.
journal_name
Curr Atheroscler Repjournal_title
Current atherosclerosis reportsauthors
Parthasarathy S,Khan-Merchant N,Penumetcha M,Khan BV,Santanam Ndoi
10.1007/s11883-001-0077-9keywords:
subject
Has Abstractpub_date
2001-09-01 00:00:00pages
392-8issue
5eissn
1523-3804issn
1534-6242journal_volume
3pub_type
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更新日期:2014-06-01 00:00:00
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