Abstract：
:Atherothrombosis remains a major cause of morbidity and mortality in the western world. The underlying processes associated with clinical expression of atherothrombosis include oxidative stress and proteolysis in relation to neovascularisation and intraplaque hemorrhages, leading to immuno-inflammatory response, cell death, and extracellular matrix breakdown. The complex biological multifactorial nature of atherothrombosis requires the development of novel technologies that allow the analysis of cellular and molecular processes responsible for the transition to disease phenotypes and the discovery of new diagnostic and prognostic biomarkers. In the present article, we have reviewed recent advances in the application of proteomic and metabolomic techniques to the study of atherothrombosis. We have focused on recent studies analyzing cells involved in hemo-thrombus formation (platelets, red blood cells, and polymorphonuclear cells), as well as tissues, tissue-conditioned media, and plasma of atherothrombotic patients. In the future, the application of these high-throughput technologies, along with imaging techniques, in systems biology approaches will help to individualize medicine.
journal_name
Curr Atheroscler Repjournal_title
Current atherosclerosis reportsauthors
Martinez-Pinna R,Barbas C,Blanco-Colio LM,Tunon J,Ramos-Mozo P,Lopez JA,Meilhac O,Michel JB,Egido J,Martin-Ventura JLdoi
10.1007/s11883-010-0102-ysubject
Has Abstractpub_date
2010-05-01 00:00:00pages
202-8issue
3eissn
1523-3804issn
1534-6242journal_volume
12pub_type
杂志文章,评审abstract：:There has been increasing interest in the health benefits of supplemental and/or dietary omega-3 polyunsaturated fatty acids (PUFAs), particularly in their role in disease prevention. This interest escalated once their effects on cardiovascular health were observed from numerous observational studies in populations wh...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-013-0389-6
更新日期：2014-02-01 00:00:00
abstract：:This review concerns the clinical impact of low-density lipoprotein (LDL) apheresis for patients with refractory hypercholesterolemia. We examine and provide examples of investigations that have demonstrated the clinical benefits of LDL apheresis. In addition to benefits derived from the stabilization or regression of...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-001-0052-5
更新日期：2001-03-01 00:00:00
abstract：:Thiazolidinediones (TZDs), which are synthetic ligands for peroxisome proliferator activated receptor g (PPARg) activation, have been introduced in clinical medicine to improve insulin resistance and glycemic control in patients with type 2 diabetes. The metabolic effects of TZDs are mediated by receptor-dependent act...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-005-0049-6
更新日期：2005-09-01 00:00:00
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journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-020-00873-5
更新日期：2020-08-09 00:00:00
abstract：:More than half of the men and women in the United States are overweight or obese. Obesity is associated with an increased risk for various diseases, most notably, hypertension, diabetes mellitus, dyslipidemia, and coronary heart disease (CHD). The location of excessive body fat, particularly in the visceral area, has ...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-000-0065-5
更新日期：2000-07-01 00:00:00
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journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-017-0638-1
更新日期：2017-01-01 00:00:00
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journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-009-0014-x
更新日期：2009-03-01 00:00:00
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journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-019-0791-9
更新日期：2019-05-20 00:00:00
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journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-019-0808-4
更新日期：2019-11-29 00:00:00
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journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
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更新日期：2008-12-01 00:00:00
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journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-003-0086-y
更新日期：2003-03-01 00:00:00
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pub_type： 杂志文章,评审
doi：10.1007/s11883-012-0299-z
更新日期：2013-02-01 00:00:00
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journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
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更新日期：2015-03-01 00:00:00
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journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
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更新日期：2014-03-01 00:00:00
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journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-005-0037-x
更新日期：2005-03-01 00:00:00
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journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
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更新日期：2015-07-01 00:00:00
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journal_title：Current atherosclerosis reports
pub_type： 杂志文章,随机对照试验
doi：10.1007/s11883-011-0193-0
更新日期：2011-10-01 00:00:00
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journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-001-0012-0
更新日期：2001-01-01 00:00:00
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journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-007-0039-y
更新日期：2007-10-01 00:00:00
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journal_title：Current atherosclerosis reports
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更新日期：2015-06-01 00:00:00
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更新日期：2020-09-03 00:00:00
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journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
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更新日期：2012-08-01 00:00:00
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journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
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更新日期：2009-05-01 00:00:00
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journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
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更新日期：2016-12-01 00:00:00
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journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/BF02693931
更新日期：2007-01-01 00:00:00
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journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-000-0055-7
更新日期：2000-11-01 00:00:00
abstract：:Since initial reports of its association with ischemic stroke appeared in 1988, there has been continued controversy regarding the existence and strength of the association between patent foramen ovale (PFO) and ischemic stroke. Many case-control studies have reported an association between incident cryptogenic ischem...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章
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更新日期：2010-07-01 00:00:00
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journal_title：Current atherosclerosis reports
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更新日期：2018-07-17 00:00:00
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journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-003-0066-2
更新日期：2003-01-01 00:00:00
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journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
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更新日期：2001-07-01 00:00:00
