Proteomic and metabolomic profiles in atherothrombotic vascular disease.

abstract：:Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the metabolic syndrome and a risk factor for both cardiovascular and hepatic related morbidity and mortality. The increasing prevalence of this disease requires novel therapeutic approaches to prevent disease progression. Farnesoid X receptors a...

journal_title：Current atherosclerosis reports

authors： Carr RM,Reid AE

更新日期：2015-04-01 00:00:00

abstract：:Atherosclerotic heart disease and stroke are leading causes of disability and death worldwide, affecting not only developed countries, but also low- and middle-income regions. Different strategies for handling dyslipidemia as a critical pathogenic risk factor for atherosclerosis have been proposed. However, these reco...

journal_title：Current atherosclerosis reports

authors： Cuevas A,Arteaga A,Rigotti A

更新日期：2014-04-01 00:00:00

abstract：PURPOSE OF REVIEW:We summarize recent advances in the understanding of genetic testing in familial hypercholesterolemia (FH), the use of expanded FH next-generation sequencing panels, and directions for future research. RECENT FINDINGS:The uptake of massively parallel sequencing in research and diagnostic laboratories...

journal_title：Current atherosclerosis reports

authors： Hooper AJ,Burnett JR,Bell DA,Watts GF

更新日期：2018-05-19 00:00:00

abstract：PURPOSE OF REVIEW:Perivascular adipose tissue (PVAT) has a complex, bidirectional relationship with the vascular wall. In disease states, PVAT secretes pro-inflammatory adipocytokines which may contribute to atherosclerosis. Recent evidence demonstrates that pericoronary adipose tissue (PCAT) may also function as a sen...

journal_title：Current atherosclerosis reports

authors： Lin A,Dey D,Wong DTL,Nerlekar N

更新日期：2019-11-19 00:00:00

abstract：PURPOSE OF REVIEW:Delayed cerebral ischemia (DCI) is common after subarachnoid hemorrhage (SAH) and represents a significant cause of poor functional outcome. DCI was mainly thought to be caused by cerebral vasospasm; however, recent clinical trials have been unable to confirm this hypothesis. Studies in humans and ani...

journal_title：Current atherosclerosis reports

authors： Geraghty JR,Testai FD

更新日期：2017-10-23 00:00:00

abstract：:Atherosclerotic cardiovascular diseases are the most common causes of death in the United States. Fibrous plaques develop in 77% to 78% of men before age 30. The mean low-density lipoprotein-cholesterol (LDL-C) level in men aged 25 to 30 years is 117 mg/dL. In the Air Force/Texas Coronary Atherosclerosis Prevention St...

journal_title：Current atherosclerosis reports

authors： Whitney E

更新日期：1999-07-01 00:00:00

abstract：:Since initial reports of its association with ischemic stroke appeared in 1988, there has been continued controversy regarding the existence and strength of the association between patent foramen ovale (PFO) and ischemic stroke. Many case-control studies have reported an association between incident cryptogenic ischem...

journal_title：Current atherosclerosis reports

authors： Carpenter DA,Ford AL,Lee JM

更新日期：2010-07-01 00:00:00

abstract：:Despite the recent decline in mortality from coronary heart disease (CHD), this disease remains the leading killer of US adults of all ages. CHD in young adults is not as well characterized as CHD in older individuals because it occurs less frequently, but this disease can have devastating consequences for young patie...

journal_title：Current atherosclerosis reports

authors： Rubin JB,Borden WB

更新日期：2012-04-01 00:00:00

abstract：:With each passing year, the evidence linking an increased risk for coronary heart disease (CHD) death with a chronic dietary deficiency in long-chain omega-3 (n-3) fatty acids (FAs) grows stronger. Recently, a federally mandated evidence-based review in the United States concluded that n-3 FAs, especially eicosapentae...

journal_title：Current atherosclerosis reports

authors： Harris WS

更新日期：2004-11-01 00:00:00

abstract：:Abdominal aortic aneurysms (AAA) are permanent dilations in the infra-renal area in which the arterial tissue is characterized by inflammation and medial degeneration. AAAs are a common vascular disorder and cause significant mortality in the aged population. Despite the high prevalence of this disease, there is limit...

journal_title：Current atherosclerosis reports

authors： Daugherty A,Cassis LA

更新日期：2002-05-01 00:00:00

abstract：:The effects of cis-monounsaturated fatty acids (cis-MUFAs) on the risk of coronary heart disease (CHD) and on CHD mortality are not clear. Also, dietary recommendations for cis-MUFA as derived by various organizations are not in agreement. Earlier studies have mainly focused on the effects of cis-MUFA on serum lipids ...

journal_title：Current atherosclerosis reports

authors： Joris PJ,Mensink RP

更新日期：2016-07-01 00:00:00

abstract：:Injury of arterial endothelium by abnormal shear stress and other insults induces migration and proliferation of vascular smooth muscle cells (VSMCs), which in turn leads to intimal thickening, hypoxia, and vasa vasorum angiogenesis. The resultant new blood vessels extend from the tunica media into the outer intima, a...

journal_title：Current atherosclerosis reports

authors： Fong GH

更新日期：2015-06-01 00:00:00

abstract：:There is a significant prevalence (20%-80% depending on the population and the study) of lipid disorders and other cardiovascular risk factors in people living with HIV infection. This review focuses on HIV and HIV treatment-associated metabolic and cardiovascular concerns, including dyslipidemias, lipodystrophy syndr...

journal_title：Current atherosclerosis reports

authors： Troll JG

更新日期：2011-02-01 00:00:00

abstract：:Preliminary evidence demonstrating that adding 0.5 mg of colchicine per day to statin and antiplatelet therapy reduced the risk of acute coronary events in patients with stable coronary artery disease has raised the hope that it may prove effective for the long-term secondary prevention of cardiovascular disease. The ...

journal_title：Current atherosclerosis reports

authors： Nidorf SM,Eikelboom JW,Thompson PL

更新日期：2014-03-01 00:00:00

abstract：:The ability of high-density lipoprotein (HDL) to promote cholesterol efflux is an important component of its ability to protect against cardiovascular disease. In addition, the anti-inflammatory properties of HDL are important as well. As part of the innate immune system, HDL appears to have evolved to increase inflam...

journal_title：Current atherosclerosis reports

authors： Navab M,Yu R,Gharavi N,Huang W,Ezra N,Lotfizadeh A,Anantharamaiah GM,Alipour N,Van Lenten BJ,Reddy ST,Marelli D

更新日期：2007-09-01 00:00:00

abstract：:Inflammation and oxidative processes are key components of atherosclerosis, from fatty streak formation to plaque rupture and thrombosis. Recent basic and clinical studies have identified a number of inflammatory and oxidative processes that appear to play a direct role in atherothrombosis and identify potentially cli...

journal_title：Current atherosclerosis reports

authors： Shishehbor MH,Hazen SL

更新日期：2004-05-01 00:00:00

abstract：:Spontaneous intracerebral hemorrhage (ICH) is a devastating disease with high morbidity and mortality. Acutely, ICH is associated with a sudden surge in intracranial pressure (ICP), as the volume of hematoma increases the pressure in the closed head, leading to non-specific symptoms of ICP: headache, nausea, vomiting,...

journal_title：Current atherosclerosis reports

authors： Ko SB,Choi HA,Lee K

更新日期：2012-08-01 00:00:00

abstract：PURPOSE OF REVIEW:This review summarizes the pathophysiology of calcific aortic valve stenosis (CAVS) and surveys relevant clinical data and basic research that explain how CAVS arises. RECENT FINDINGS:Lipoprotein(a) [Lp(a)], lipoprotein-associated phospholipase A2 (Lp-PLA2), oxidized phospholipids (OxPL), autotaxin, ...

journal_title：Current atherosclerosis reports

authors： de Oliveira Sá MPB,Cavalcanti LRP,Perazzo ÁM,Gomes RAF,Clavel MA,Pibarot P,Biondi-Zoccai G,Zhigalov K,Weymann A,Ruhparwar A,Lima RC

更新日期：2020-01-07 00:00:00

abstract：:The acute evaluation of stroke patients has undergone dramatic advances in the recent past. The increasing availability of novel magnetic resonance imaging (MRI) techniques, such as diffusion and perfusion MRI, provides a plethora of information to clinicians evaluating patients suspected of having an acute stroke. Th...

journal_title：Current atherosclerosis reports

authors： Duong TQ,Fisher M

更新日期：2004-07-01 00:00:00

abstract：:Stroke is the second leading cause of mortality world-wide and is well suited for prevention because it has a high prevalence, high burden of economic cost, well-defined modifiable risk factors, and effective prevention measures. Atherosclerosis is one of the major mechanisms of ischemic stroke, but the apparent diffe...

journal_title：Current atherosclerosis reports

authors： Bang OY

更新日期：2006-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Coronary artery no-reflow phenomenon is an incidental outcome of percutaneous coronary intervention in patients presenting with acute myocardial infarction. Despite advances in pharmacologic and non-pharmacologic therapies, coronary no-reflow phenomenon occurs more commonly than desired. It often resu...

journal_title：Current atherosclerosis reports

authors： Karimianpour A,Maran A

更新日期：2018-07-05 00:00:00

abstract：:There has been increasing interest in the health benefits of supplemental and/or dietary omega-3 polyunsaturated fatty acids (PUFAs), particularly in their role in disease prevention. This interest escalated once their effects on cardiovascular health were observed from numerous observational studies in populations wh...

journal_title：Current atherosclerosis reports

authors： Fares H,Lavie CJ,DiNicolantonio JJ,O'Keefe JH,Milani RV

更新日期：2014-02-01 00:00:00

abstract：:The liver X receptors (LXRs) are ligand-activated transcription factors belonging to the nuclear hormone receptor superfamily. Since their initial identification more than a decade ago, LXRs have been characterized as key transcriptional regulators of lipid and carbohydrate homeostasis. LXRs are activated by the intra...

journal_title：Current atherosclerosis reports

authors： Nomiyama T,Bruemmer D

更新日期：2008-02-01 00:00:00

abstract：:Recently reported clinical trials raise doubts on the effectiveness of nonstatin lipid-lowering therapies in reducing the residual risk of cardiovascular events after statin monotherapy. Addition of -torcetrapib to statin therapy increased overall mortality in coronary patients despite a marked increase in high-densit...

journal_title：Current atherosclerosis reports

authors： Ansell BJ

更新日期：2009-01-01 00:00:00

abstract：:Platelets are critical modulators of atherothrombotic events. In the acute setting, platelets are activated and aggregate on the surface of atherosclerotic plaque that has ruptured, fissured, or developed erosions. The overlying thrombus leads to sudden development of arterial luminal obstruction, inducing ischemia an...

journal_title：Current atherosclerosis reports

authors： Toth PP,Armani A

更新日期：2009-09-01 00:00:00

abstract：:Lipodystrophies are a group of heterogeneous diseases characterized by the loss of adipose tissue and by abnormalities of carbohydrate and lipid metabolism, including insulin resistance, diabetes, and hyperlipidemia. In this review, we describe several mouse models that recapitulate various aspects of the lipodystroph...

journal_title：Current atherosclerosis reports

authors： Reue K,Péterfy M

更新日期：2000-09-01 00:00:00

abstract：:Lipoprotein apheresis is an extracorporeal therapy whereby apo B-containing lipoproteins (LDL, vLDL, and Lp(a)) are selectively removed from the plasma of a patient. It is a variation of plasma exchange, which non-selectively removes all plasma proteins. Lipoprotein apheresis is most commonly used to treat patients wi...

journal_title：Current atherosclerosis reports

authors： Bhoj VG,Sachais BS

更新日期：2015-07-01 00:00:00

abstract：:Atrial fibrillation (AF) is a significant etiologic cause of acute ischemic stroke (AIS) that leads to disabling deficits as well as significant morbidity and mortality in this population. Approximately 25 % of AIS is considered to be cryptogenic with no etiology ascertained at the time of the index event. Recent adva...

journal_title：Current atherosclerosis reports

authors： Sangha RS,Bernstein R

更新日期：2015-12-01 00:00:00

abstract：:Light to moderate alcohol intake is known to have cardioprotective properties; however, the magnitude of protection depends on other factors and may be confined to some subsets of the population. This review focuses on factors that modify the relationship between alcohol and coronary heart disease (CHD). The cardiopro...

journal_title：Current atherosclerosis reports

authors： Tolstrup J,Grønbaek M

更新日期：2007-08-01 00:00:00

abstract：:The thiazolidinediones, acting through peroxisome proliferator-activated receptor chi (PPARchi), affect multiple areas of metabolism. Of increasing importance is the recognition that these agents affect lipoprotein metabolism and cause changes in serum lipid and lipoprotein levels. All three thiazolidinediones, includ...

journal_title：Current atherosclerosis reports

authors： Goldberg RB

更新日期：2006-09-01 00:00:00