Abstract：
:Lipoprotein apheresis is an extracorporeal therapy whereby apo B-containing lipoproteins (LDL, vLDL, and Lp(a)) are selectively removed from the plasma of a patient. It is a variation of plasma exchange, which non-selectively removes all plasma proteins. Lipoprotein apheresis is most commonly used to treat patients with familial hypercholesterolemia, but is also often used for other hyperlipidemic patients, including those with elevated Lp(a), to limit and/or reverse the atherosclerotic complications of high cholesterol. Herein, we provide an overview of lipoprotein apheresis including indications, techniques, efficacy, and adverse events, as well as guidelines and other considerations important for selection of patients for this therapy.
journal_name
Curr Atheroscler Repjournal_title
Current atherosclerosis reportsauthors
Bhoj VG,Sachais BSdoi
10.1007/s11883-015-0516-7subject
Has Abstractpub_date
2015-07-01 00:00:00pages
39issue
7eissn
1523-3804issn
1534-6242journal_volume
17pub_type
杂志文章,评审abstract：:Plant-derived alpha-linolenic acid has been studied in a limited number of investigations. So far, some epidemiologic and a few mechanistic studies suggest a potential of protection from cardiovascular disease, but this potential remains to be proven in intervention studies. In contrast, eicosapentaenoic acid (EPA) an...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-003-0086-y
更新日期：2003-03-01 00:00:00
abstract：:Abdominal aortic aneurysms (AAA) are permanent dilations in the infra-renal area in which the arterial tissue is characterized by inflammation and medial degeneration. AAAs are a common vascular disorder and cause significant mortality in the aged population. Despite the high prevalence of this disease, there is limit...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-002-0023-5
更新日期：2002-05-01 00:00:00
abstract：PURPOSE OF REVIEW:The goal of this manuscript is to summarize the current understanding of the secreted APOA1 binding protein (AIBP), encoded by NAXE, in angiogenesis, hematopoiesis, and inflammation. The studies on AIBP illustrate a critical connection between lipid metabolism and the aforementioned endothelial and im...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-020-00899-9
更新日期：2020-11-24 00:00:00
abstract：:Biologic therapies involve the utilization of proteins, DNA, antibodies, or other substances derived or synthesized from living tissue for therapeutic effects. There are several biologic therapies in clinical development for the prevention and treatment of atherosclerosis. The most advanced in human trials are apolipo...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-004-0118-2
更新日期：2004-01-01 00:00:00
abstract：:Various lifestyle factors have been associated with increasing the risk of stroke. These include lack of exercise, alcohol, diet, obesity, smoking, drug use, and stress. Guidelines endorsed by the Centers for Disease Control and Prevention and the National Institutes of Health recommend that Americans should exercise ...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-000-0111-3
更新日期：2000-03-01 00:00:00
abstract：:Inflammation lies at the base of endothelial dysfunction, eventually leading to plaque formation. The degree of inflammation defines the "vulnerability" of plaque to rupture. Numerous strategies have been adopted to identify and eventually treat high-risk vulnerable plaque. Lipoprotein-associated phospholipase A(2) (L...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-010-0095-6
更新日期：2010-03-01 00:00:00
abstract：:The ability of statins to lower serum cholesterol and reduce coronary heart disease endpoints has confirmed portions of the lipid hypothesis. However, the time to benefit and increased benefit in overlapping populations have suggested that nonlipid or pleiotropic effects of statins may be present. The apparent benefit...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-003-0066-2
更新日期：2003-01-01 00:00:00
abstract：:Plant foods rich in carbohydrate and dietary fiber have many health benefits. One concern often expressed about higher carbohydrate, lower fat diets is that they may increase fasting serum triglycerides. Recently the importance of hypertriglyceridemia as an independent risk factor for coronary heart disease has been r...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-000-0055-7
更新日期：2000-11-01 00:00:00
abstract：:There are hundreds of foods, nutrients, herbs, and botanicals that have "bioactive" constituents with potential human health benefits. Three of these are discussed in this review: soy, garlic, and ginkgo biloba. Each of these three choices involves an ingestible item composed of a complex mixture of bioactive agents. ...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-003-0037-7
更新日期：2003-11-01 00:00:00
abstract：PURPOSE OF REVIEW:In this review, we describe the mechanism behind coronary artery calcification formation and detection, as well as its implication in cardiovascular disease (CVD) risk stratification, intervention, and prognosis in asymptomatic individuals. RECENT FINDINGS:Multiple cohort and population studies have ...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-019-0812-8
更新日期：2019-11-21 00:00:00
abstract：PURPOSE OF REVIEW:We provide an overview of our current understanding of combination lipid-lowering therapies intended for dyslipidemia treatment and cardiovascular disease prevention. First, we analyze recent statin and non-statin combination therapy guidelines and clinical studies since the publication of 2013 Americ...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-018-0721-2
更新日期：2018-03-07 00:00:00
abstract：:The acute evaluation of stroke patients has undergone dramatic advances in the recent past. The increasing availability of novel magnetic resonance imaging (MRI) techniques, such as diffusion and perfusion MRI, provides a plethora of information to clinicians evaluating patients suspected of having an acute stroke. Th...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-004-0057-y
更新日期：2004-07-01 00:00:00
abstract：PURPOSE OF REVIEW:Despite the important progress in identifying high-risk atherosclerotic plaques, many key elements are elusive. Advanced imaging modalities provide valuable information about the anatomic and functional plaque characteristics and underscore the presence of multiple plaque morphologies. However, how th...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-016-0626-x
更新日期：2016-12-01 00:00:00
abstract：:Despite the recent decline in mortality from coronary heart disease (CHD), this disease remains the leading killer of US adults of all ages. CHD in young adults is not as well characterized as CHD in older individuals because it occurs less frequently, but this disease can have devastating consequences for young patie...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-012-0226-3
更新日期：2012-04-01 00:00:00
abstract：:Stroke is the second leading cause of mortality world-wide and is well suited for prevention because it has a high prevalence, high burden of economic cost, well-defined modifiable risk factors, and effective prevention measures. Atherosclerosis is one of the major mechanisms of ischemic stroke, but the apparent diffe...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-006-0012-1
更新日期：2006-07-01 00:00:00
abstract：PURPOSE OF REVIEW:Delayed cerebral ischemia (DCI) is common after subarachnoid hemorrhage (SAH) and represents a significant cause of poor functional outcome. DCI was mainly thought to be caused by cerebral vasospasm; however, recent clinical trials have been unable to confirm this hypothesis. Studies in humans and ani...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-017-0690-x
更新日期：2017-10-23 00:00:00
abstract：PURPOSE OF REVIEW:High lipoprotein(a) levels are observationally and causally, from human genetics, associated with increased risk of cardiovascular disease including myocardial infarction and aortic valve stenosis. The European Atherosclerosis Society recommends screening for elevated lipoprotein(a) levels in high-ris...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-019-0792-8
更新日期：2019-05-20 00:00:00
abstract：:Lipid-lowering medications, particularly statins, have been a popular target for pharmacogenetic studies. A handful of genes have shown promise for predicting response to therapy from the perspective of lipid lowering, as well as myopathy. A number of genes have been implicated and have biological plausibility based o...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-016-0573-6
更新日期：2016-05-01 00:00:00
abstract：PURPOSE OF REVIEW:Perivascular adipose tissue (PVAT) has a complex, bidirectional relationship with the vascular wall. In disease states, PVAT secretes pro-inflammatory adipocytokines which may contribute to atherosclerosis. Recent evidence demonstrates that pericoronary adipose tissue (PCAT) may also function as a sen...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-019-0817-3
更新日期：2019-11-19 00:00:00
abstract：:Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is a calcium-independent phospholipase A(2) enzyme secreted by leukocytes and associated with circulating low-density lipoprotein and macrophages in atherosclerotic plaques. Until recently, the biological role of Lp-PLA(2) in atherosclerosis was controversial, but ...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-009-0076-9
更新日期：2010-01-01 00:00:00
abstract：PURPOSE OF REVIEW:We aimed to summarize recent guidelines, position papers, and high-quality clinical research relating the use of nutraceuticals in the management of individuals at high risk of atherosclerotic cardiovascular disease. RECENT FINDINGS:It is essential that individuals at high risk of cardiovascular dise...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-020-00887-z
更新日期：2020-09-18 00:00:00
abstract：:Lipodystrophies are a group of heterogeneous diseases characterized by the loss of adipose tissue and by abnormalities of carbohydrate and lipid metabolism, including insulin resistance, diabetes, and hyperlipidemia. In this review, we describe several mouse models that recapitulate various aspects of the lipodystroph...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-000-0077-1
更新日期：2000-09-01 00:00:00
abstract：:Diabetes and its micro- and macrovascular complications represent a worldwide epidemic that will place an enormous financial burden on poorer countries in the years to come. In patients with diabetes and hypertension, the main determinant of the cardiovascular and renal benefits of antihypertensive drugs is the blood ...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-011-0160-9
更新日期：2011-04-01 00:00:00
abstract：:Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is an enzyme which binds to oxidized LDL and has a pro-inflammatory role in the pathogenesis of atherosclerosis. The Lp-PLA(2) Studies Collaboration showed the relationship between Lp-PLA(2) levels and activity with coronary heart disease and ischemic stroke. Level...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-011-0201-4
更新日期：2011-12-01 00:00:00
abstract：PURPOSE OF REVIEW:To summarize epidemiology, pathophysiology, prognostic relevance, and treatment options of coronary artery disease (CAD) when coupled with severe aortic stenosis (SAS). In regard to treatment options, we focused on the most recently adopted therapeutic approaches and on the future perspectives in ligh...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-020-0835-1
更新日期：2020-05-26 00:00:00
abstract：PURPOSE OF REVIEW:Coronary artery no-reflow phenomenon is an incidental outcome of percutaneous coronary intervention in patients presenting with acute myocardial infarction. Despite advances in pharmacologic and non-pharmacologic therapies, coronary no-reflow phenomenon occurs more commonly than desired. It often resu...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章
doi：10.1007/s11883-018-0747-5
更新日期：2018-07-05 00:00:00
abstract：:Serum cholesterol traditionally has been considered a poor predictor of total stroke risk; however, it is associated positively with ischemic stroke risk and associated negatively with hemorrhagic stroke risk. Although studies failed to demonstrate stroke reduction using older cholesterol-lowering medications, recent ...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-000-0101-5
更新日期：2000-03-01 00:00:00
abstract：:Dyslipidemia is central to the process of atherosclerosis. Modification of the lipid profile by diet, exercise, or pharmacologic therapy has been demonstrated to reduce the risk from atherosclerosis in clinical studies in primary and secondary prevention. Nicotinic acid has been in clinical use for over 50 years. The ...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-009-0014-x
更新日期：2009-03-01 00:00:00
abstract：PURPOSE OF THE REVIEW:Rheumatoid arthritis (RA) is a chronic, autoimmune disease which may result in a higher risk of cardiovascular (CV) events and stroke. Tissue characterization and risk stratification of patients with rheumatoid arthritis are a challenging problem. Risk stratification of RA patients using tradition...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-019-0766-x
更新日期：2019-01-25 00:00:00
abstract：:Although the role of implantable cardioverter defibrillator (ICD) and cardiac resynchronization therapy (CRT) in improving outcomes in ischemic cardiomyopathy (ICM) has been described, the data regarding gender-based survival outcomes are limited. There is a higher preponderance of non-ischemic cardiomyopathy (NICM) i...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-015-0512-y
更新日期：2015-06-01 00:00:00
