Abstract：
:Diabetes and its micro- and macrovascular complications represent a worldwide epidemic that will place an enormous financial burden on poorer countries in the years to come. In patients with diabetes and hypertension, the main determinant of the cardiovascular and renal benefits of antihypertensive drugs is the blood pressure (BP) level achieved under treatment. Quite recently, the paradigm of a BP target < 130/80 mm Hg in these patients has been questioned by a number of trials, including data from the Action to Control Cardiovascular Risk in Diabetes (ACCORD) blood pressure-lowering arm and from the diabetic cohort of International Verapamil SR-Trandolapril Study (INVEST). At the same time, even if the key role of BP control is unquestionable, a growing number of published trials suggest that different antihypertensive combinations may offer specific cardio-, vasculo-, and renoprotective advantages that go beyond BP reduction per se. The present review focuses on the most recent and important literature that explored the "optimal" antihypertensive therapy in patients with type 2 diabetes and concomitant hypertension, and it discusses in detail the various areas of uncertainty, including the specific renoprotective effects of renin-angiotensin system blocking agents and the long-term effects of angiotensin-converting enzyme/angiotensin receptor blocker combinations on the progression of diabetic nephropathy.
journal_name
Curr Atheroscler Repjournal_title
Current atherosclerosis reportsauthors
Reboldi G,Gentile G,Angeli F,Verdecchia Pdoi
10.1007/s11883-011-0160-9subject
Has Abstractpub_date
2011-04-01 00:00:00pages
176-85issue
2eissn
1523-3804issn
1534-6242journal_volume
13pub_type
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pub_type： 杂志文章,已发布勘误
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pub_type： 杂志文章,评审
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更新日期：2014-05-01 00:00:00
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pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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更新日期：2009-01-01 00:00:00
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journal_title：Current atherosclerosis reports
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pub_type： 杂志文章,评审
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更新日期：2018-01-30 00:00:00
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更新日期：2003-01-01 00:00:00
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pub_type： 已发布勘误
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更新日期：2020-07-07 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2015-04-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2005-09-01 00:00:00
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journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
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更新日期：2014-03-01 00:00:00
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pub_type： 杂志文章
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更新日期：2010-07-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2016-12-01 00:00:00
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journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
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更新日期：2005-02-01 00:00:00
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journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
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更新日期：2000-05-01 00:00:00
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pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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更新日期：2016-12-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2008-12-01 00:00:00
abstract：:Understanding of the pathophysiology of atherosclerosis can provide new strategies for the prevention and treatment of patients with this common disease. Clinical, epidemiologic, and basic molecular science studies have identified oxidative stress as a factor contributing to the development and progression of atherosc...
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pub_type： 杂志文章,评审
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更新日期：2005-05-01 00:00:00
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journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
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更新日期：2019-11-19 00:00:00
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journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
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更新日期：2002-11-01 00:00:00
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journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
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更新日期：2019-05-20 00:00:00
abstract：:Overwhelming evidence now shows that 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (ie, statins) are safe and effective in primary and secondary prevention of cardiovascular disease. Atherosclerosis, the primary cause of heart disease, is directly and independently related to hypercholesterolemia and infl...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
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更新日期：2008-02-01 00:00:00
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journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-020-0821-7
更新日期：2020-01-07 00:00:00
abstract：:Atherothrombosis remains a major cause of morbidity and mortality in the western world. The underlying processes associated with clinical expression of atherothrombosis include oxidative stress and proteolysis in relation to neovascularisation and intraplaque hemorrhages, leading to immuno-inflammatory response, cell ...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-010-0102-y
更新日期：2010-05-01 00:00:00
