FXR agonists as therapeutic agents for non-alcoholic fatty liver disease.

Abstract:

:Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the metabolic syndrome and a risk factor for both cardiovascular and hepatic related morbidity and mortality. The increasing prevalence of this disease requires novel therapeutic approaches to prevent disease progression. Farnesoid X receptors are bile acid receptors with roles in lipid, glucose, and energy homeostasis. Synthetic farnesoid X receptor (FXR) agonists have been developed to specifically target these receptors for therapeutic use in NAFLD patients. Here, we present a review of bile acid physiology and how agonism of FXR receptors has been examined in pre-clinical and clinical NAFLD. Early evidence suggests a potential role for synthetic FXR agonists in the management of NAFLD; however, additional studies are needed to clarify their effects on lipid and glucose parameters in humans.

journal_name

Curr Atheroscler Rep

authors

Carr RM,Reid AE

doi

10.1007/s11883-015-0500-2

subject

Has Abstract

pub_date

2015-04-01 00:00:00

pages

500

issue

4

eissn

1523-3804

issn

1534-6242

journal_volume

17

pub_type

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