A review of trials evaluating nonstatin lipid-lowering therapies.

abstract：:Despite the recent decline in mortality from coronary heart disease (CHD), this disease remains the leading killer of US adults of all ages. CHD in young adults is not as well characterized as CHD in older individuals because it occurs less frequently, but this disease can have devastating consequences for young patie...

journal_title：Current atherosclerosis reports

authors： Rubin JB,Borden WB

更新日期：2012-04-01 00:00:00

abstract：:There has been increasing interest in the health benefits of supplemental and/or dietary omega-3 polyunsaturated fatty acids (PUFAs), particularly in their role in disease prevention. This interest escalated once their effects on cardiovascular health were observed from numerous observational studies in populations wh...

journal_title：Current atherosclerosis reports

authors： Fares H,Lavie CJ,DiNicolantonio JJ,O'Keefe JH,Milani RV

更新日期：2014-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Perivascular adipose tissue (PVAT) has a complex, bidirectional relationship with the vascular wall. In disease states, PVAT secretes pro-inflammatory adipocytokines which may contribute to atherosclerosis. Recent evidence demonstrates that pericoronary adipose tissue (PCAT) may also function as a sen...

journal_title：Current atherosclerosis reports

authors： Lin A,Dey D,Wong DTL,Nerlekar N

更新日期：2019-11-19 00:00:00

abstract：:We have developed, tested, and successfully implemented an affordable, evidence-based, comprehensive cardiovascular disease risk-reduction program for use in primary and secondary prevention settings. The program is administered at hospitals, physician practices, cardiac rehabilitation programs, work sites, shopping m...

journal_title：Current atherosclerosis reports

authors： Gordon NF,Salmon RD,Mitchell BS,Faircloth GC,Levinrad LI,Salmon S,Saxon WE,Reid KS

更新日期：2001-11-01 00:00:00

abstract：:The rates of cardiovascular disease (CVD) have decreased significantly for men over the past few decades, but similar reductions have not occurred in women. Consequently, CVD remains the leading killer of women in the United States. Men usually develop heart disease earlier than women, but women develop heart disease ...

journal_title：Current atherosclerosis reports

authors： Lee LV,Foody JM

更新日期：2008-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Studies have revealed a relation between birth weight (BW) and later risk of cardiovascular diseases (CVDs). This meta-analysis aimed to report the dose-response relationship between BW and risk of CVDs. RECENT FINDINGS:The relation of BW to CVD subtypes was found to be U-shaped as BW below ~ 2500 g ...

journal_title：Current atherosclerosis reports

authors： Mohseni R,Mohammed SH,Safabakhsh M,Mohseni F,Monfared ZS,Seyyedi J,Mejareh ZN,Alizadeh S

更新日期：2020-04-23 00:00:00

abstract：:Daily lifestyle practices and habits profoundly affect the likelihood of developing cardiovascular disease (CVD). Abundant research and multiple recent consensus documents support the role of regular physical activity, not smoking cigarettes, maintaining a healthy body weight, controlling cholesterol levels, and contr...

journal_title：Current atherosclerosis reports

authors： Rippe JM,Angelopoulos TJ

更新日期：2014-10-01 00:00:00

abstract：:Cancer survivorship should be defined starting not from completion of treatment, but from the time of diagnosis. Assessing and controlling the cancer patient's cardiovascular risk before, during, and after treatment is crucial to improving their overall outcome. There are many cancer therapies, including but not limit...

journal_title：Current atherosclerosis reports

authors： Chen CL

更新日期：2015-03-01 00:00:00

abstract：PURPOSE OF REVIEW:We provide an overview of our current understanding of combination lipid-lowering therapies intended for dyslipidemia treatment and cardiovascular disease prevention. First, we analyze recent statin and non-statin combination therapy guidelines and clinical studies since the publication of 2013 Americ...

journal_title：Current atherosclerosis reports

authors： Russell C,Sheth S,Jacoby D

更新日期：2018-03-07 00:00:00

abstract：:Cardiovascular disease remains the major cause of worldwide morbidity and mortality. Its pathophysiology is complex and multifactorial. Because the phenotype of cardiovascular disease often shows a marked heritable pattern, it is likely that genetic factors play an important role. In recent years, large genome-wide as...

journal_title：Current atherosclerosis reports

authors： Sivapalaratnam S,Motazacker MM,Maiwald S,Hovingh GK,Kastelein JJ,Levi M,Trip MD,Dallinga-Thie GM

更新日期：2011-06-01 00:00:00

abstract：:Peroxisome proliferator-activated receptors (PPARs) are the key transcription factors regulating lipid metabolism and energy homeostasis. PPARalpha and PPARgamma are known therapeutic targets for hypertriglyceridemia and type 2 diabetes, respectively. The physiologic function of the third member, PPARdelta, has been d...

journal_title：Current atherosclerosis reports

authors： Kang K,Hatano B,Lee CH

更新日期：2007-01-01 00:00:00

abstract：:Atherosclerotic heart disease and stroke are leading causes of disability and death worldwide, affecting not only developed countries, but also low- and middle-income regions. Different strategies for handling dyslipidemia as a critical pathogenic risk factor for atherosclerosis have been proposed. However, these reco...

journal_title：Current atherosclerosis reports

authors： Cuevas A,Arteaga A,Rigotti A

更新日期：2014-04-01 00:00:00

abstract：:3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors or "statin" medications are the most commonly prescribed therapy for lowering cholesterol. In use for over a decade, they have demonstrated both safety and tolerability across a broad range of patients. The ability to inhibit the biosynthesis of cholesterol an...

journal_title：Current atherosclerosis reports

authors： Garcia PJ

更新日期：2005-02-01 00:00:00

abstract：:Abdominal aortic aneurysms (AAA) are permanent dilations in the infra-renal area in which the arterial tissue is characterized by inflammation and medial degeneration. AAAs are a common vascular disorder and cause significant mortality in the aged population. Despite the high prevalence of this disease, there is limit...

journal_title：Current atherosclerosis reports

authors： Daugherty A,Cassis LA

更新日期：2002-05-01 00:00:00

abstract：PURPOSE OF REVIEW:We will review the available data on the epidemiology, pathophysiology, diagnosis, and management of microvascular coronary dysfunction (MCD). RECENT FINDINGS:The study of MCD was pioneered by the Women's Ischemia Syndrome Evaluation (WISE) cohort. New techniques in the diagnosis of this condition, u...

journal_title：Current atherosclerosis reports

authors： Naderi S

更新日期：2018-01-30 00:00:00

abstract：:Dietary interventions have been consistently proposed as a part of a comprehensive strategy to lower the incidence and severity of coronary heart disease (CHD), in the process providing long-term cardioprotection. Replacement of dietary saturated fatty acids (SFA) with higher intakes of monounsaturated fatty acids (MU...

journal_title：Current atherosclerosis reports

authors： Degirolamo C,Rudel LL

更新日期：2010-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The goal of this manuscript is to summarize the current understanding of the secreted APOA1 binding protein (AIBP), encoded by NAXE, in angiogenesis, hematopoiesis, and inflammation. The studies on AIBP illustrate a critical connection between lipid metabolism and the aforementioned endothelial and im...

journal_title：Current atherosclerosis reports

authors： Qiu X,Luo J,Fang L

更新日期：2020-11-24 00:00:00

abstract：:Stroke is the second leading cause of mortality world-wide and is well suited for prevention because it has a high prevalence, high burden of economic cost, well-defined modifiable risk factors, and effective prevention measures. Atherosclerosis is one of the major mechanisms of ischemic stroke, but the apparent diffe...

journal_title：Current atherosclerosis reports

authors： Bang OY

更新日期：2006-07-01 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the metabolic syndrome and a risk factor for both cardiovascular and hepatic related morbidity and mortality. The increasing prevalence of this disease requires novel therapeutic approaches to prevent disease progression. Farnesoid X receptors a...

journal_title：Current atherosclerosis reports

authors： Carr RM,Reid AE

更新日期：2015-04-01 00:00:00

abstract：:The ability for statins to reduce major cardiovascular events and mortality has lead to this drug class being the most commonly prescribed in the world. In particular, the benefit of these drugs in type 2 diabetes (T2D) is well established. In February 2012, the Food and Drug Administration released changes to statin ...

journal_title：Current atherosclerosis reports

authors： Axsom K,Berger JS,Schwartzbard AZ

更新日期：2013-02-01 00:00:00

abstract：PURPOSE OF REVIEW:This review summarizes the pathophysiology of calcific aortic valve stenosis (CAVS) and surveys relevant clinical data and basic research that explain how CAVS arises. RECENT FINDINGS:Lipoprotein(a) [Lp(a)], lipoprotein-associated phospholipase A2 (Lp-PLA2), oxidized phospholipids (OxPL), autotaxin, ...

journal_title：Current atherosclerosis reports

authors： de Oliveira Sá MPB,Cavalcanti LRP,Perazzo ÁM,Gomes RAF,Clavel MA,Pibarot P,Biondi-Zoccai G,Zhigalov K,Weymann A,Ruhparwar A,Lima RC

更新日期：2020-01-07 00:00:00

abstract：:The acute evaluation of stroke patients has undergone dramatic advances in the recent past. The increasing availability of novel magnetic resonance imaging (MRI) techniques, such as diffusion and perfusion MRI, provides a plethora of information to clinicians evaluating patients suspected of having an acute stroke. Th...

journal_title：Current atherosclerosis reports

authors： Duong TQ,Fisher M

更新日期：2004-07-01 00:00:00

abstract：:Cardiovascular disease and its clinical sequelae remain the leading causes of morbidity and mortality in many regions of the world. Dyslipidemia is a critical risk factor to intercept in both the primary and secondary prevention of acute cardiovascular events. The prospective, placebo-controlled clinical trials conduc...

journal_title：Current atherosclerosis reports

authors： Toth PP

更新日期：2004-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Coronary artery no-reflow phenomenon is an incidental outcome of percutaneous coronary intervention in patients presenting with acute myocardial infarction. Despite advances in pharmacologic and non-pharmacologic therapies, coronary no-reflow phenomenon occurs more commonly than desired. It often resu...

journal_title：Current atherosclerosis reports

authors： Karimianpour A,Maran A

更新日期：2018-07-05 00:00:00

abstract：:Since initial reports of its association with ischemic stroke appeared in 1988, there has been continued controversy regarding the existence and strength of the association between patent foramen ovale (PFO) and ischemic stroke. Many case-control studies have reported an association between incident cryptogenic ischem...

journal_title：Current atherosclerosis reports

authors： Carpenter DA,Ford AL,Lee JM

更新日期：2010-07-01 00:00:00

abstract：:The matrix metalloproteinase (MMP) family of enzymes is involved in arterial wall extracellular matrix degradation and remodeling. The latter activities have been implicated in a number of normal and pathologic processes, such as atherosclerotic lesion formation and progression, plaque destabilization and rupture, but...

journal_title：Current atherosclerosis reports

authors： Ketelhuth DF,Bäck M

更新日期：2011-04-01 00:00:00

abstract：:The cardioprotective effects of omega-3 fatty acids (n-3 FAs) are well known, but the role that the n-6 FAs play in coronary heart disease is unclear. These two classes of essential FAs compete for a number of enzyme systems, and their metabolites can powerfully influence (often in different directions) inflammatory r...

journal_title：Current atherosclerosis reports

authors： Harris WS

更新日期：2006-11-01 00:00:00

abstract：:Serum cholesterol traditionally has been considered a poor predictor of total stroke risk; however, it is associated positively with ischemic stroke risk and associated negatively with hemorrhagic stroke risk. Although studies failed to demonstrate stroke reduction using older cholesterol-lowering medications, recent ...

journal_title：Current atherosclerosis reports

authors： Ansell BJ

更新日期：2000-03-01 00:00:00

abstract：:At a time when the lipid management guidelines give more and more emphasis to the identification and treatment of high-risk patients with the metabolic syndrome and diabetes, there is an obvious need to balance the known effects of low-density lipoprotein (LDL) lowering with the new evidence of clinical efficacy deriv...

journal_title：Current atherosclerosis reports

authors： Fazio S,Linton MF

更新日期：2004-03-01 00:00:00

abstract：PURPOSE OF REVIEW:This review addresses normal and pathologic functions of serum amyloid A (SAA), an enigmatic biomarker of inflammation and protein precursor of AA amyloidosis, a life-threatening complication of chronic inflammation. SAA is a small, highly evolutionarily conserved acute-phase protein whose plasma leve...

journal_title：Current atherosclerosis reports

authors： Gursky O

更新日期：2020-09-24 00:00:00