Abstract：
:Serum cholesterol traditionally has been considered a poor predictor of total stroke risk; however, it is associated positively with ischemic stroke risk and associated negatively with hemorrhagic stroke risk. Although studies failed to demonstrate stroke reduction using older cholesterol-lowering medications, recent study of the statin class of medications shows both consistent stroke and other cardiovascular benefits. Ischemic stroke and coronary heart disease share similar underlying mechanisms, likely explaining much of the therapeutic benefit from statins. Current research is directed at further determining groups of patients most likely to benefit from lipid reduction in stroke prevention. In the interim, patients with established atherosclerosis should be treated with a statin to achieve a low-density lipoprotein cholesterol level less than 100 mg/dL.
journal_name
Curr Atheroscler Repjournal_title
Current atherosclerosis reportsauthors
Ansell BJdoi
10.1007/s11883-000-0101-5keywords:
subject
Has Abstractpub_date
2000-03-01 00:00:00pages
92-6issue
2eissn
1523-3804issn
1534-6242journal_volume
2pub_type
杂志文章,评审abstract：:Cardiovascular disease remains the major cause of worldwide morbidity and mortality. Its pathophysiology is complex and multifactorial. Because the phenotype of cardiovascular disease often shows a marked heritable pattern, it is likely that genetic factors play an important role. In recent years, large genome-wide as...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-011-0173-4
更新日期：2011-06-01 00:00:00
abstract：:A substantial body of epidemiologic data has shed light on the potential protective effects of the Mediterranean diet against atherosclerosis in humans. Many believe the reason the Mediterranean diet is atheroprotective is the elevated consumption of olive oil, an oil poor in saturated fatty acids (SFA) and highly enr...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章
doi：10.1007/s11883-007-0066-8
更新日期：2007-12-01 00:00:00
abstract：:There is a growing interest in determining the genetic predictors of plasma lipid response to diet intervention. Several candidate gene loci, namely, apolipoprotein (APO) A1, APOA4, APOC3, APOB, APOE, CETP, LPL, and FABP2, have been shown to explain a significant, but still rather small, proportion of the interindivid...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-999-0032-8
更新日期：1999-11-01 00:00:00
abstract：PURPOSE OF REVIEW:In this review, we describe the mechanism behind coronary artery calcification formation and detection, as well as its implication in cardiovascular disease (CVD) risk stratification, intervention, and prognosis in asymptomatic individuals. RECENT FINDINGS:Multiple cohort and population studies have ...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-019-0812-8
更新日期：2019-11-21 00:00:00
abstract：:The ability for statins to reduce major cardiovascular events and mortality has lead to this drug class being the most commonly prescribed in the world. In particular, the benefit of these drugs in type 2 diabetes (T2D) is well established. In February 2012, the Food and Drug Administration released changes to statin ...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-012-0299-z
更新日期：2013-02-01 00:00:00
abstract：:Dietary interventions have been consistently proposed as a part of a comprehensive strategy to lower the incidence and severity of coronary heart disease (CHD), in the process providing long-term cardioprotection. Replacement of dietary saturated fatty acids (SFA) with higher intakes of monounsaturated fatty acids (MU...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-010-0133-4
更新日期：2010-11-01 00:00:00
abstract：:Approximately one third of ischemic strokes are labeled cryptogenic because the etiology is unknown despite a thorough evaluation. Paroxysmal atrial fibrillation carries the same risk of ischemic stroke as persistent atrial fibrillation and has increasingly gained attention as a potential source of cryptogenic stroke....
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-015-0547-0
更新日期：2015-12-01 00:00:00
abstract：:Plant foods rich in carbohydrate and dietary fiber have many health benefits. One concern often expressed about higher carbohydrate, lower fat diets is that they may increase fasting serum triglycerides. Recently the importance of hypertriglyceridemia as an independent risk factor for coronary heart disease has been r...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-000-0055-7
更新日期：2000-11-01 00:00:00
abstract：:Lipodystrophies are a group of heterogeneous diseases characterized by the loss of adipose tissue and by abnormalities of carbohydrate and lipid metabolism, including insulin resistance, diabetes, and hyperlipidemia. In this review, we describe several mouse models that recapitulate various aspects of the lipodystroph...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-000-0077-1
更新日期：2000-09-01 00:00:00
abstract：PURPOSE OF REVIEW:Despite the important progress in identifying high-risk atherosclerotic plaques, many key elements are elusive. Advanced imaging modalities provide valuable information about the anatomic and functional plaque characteristics and underscore the presence of multiple plaque morphologies. However, how th...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-016-0626-x
更新日期：2016-12-01 00:00:00
abstract：:The cytochrome P450 (CYP) is a group of enzymes that oxidatively modify drugs to a more water-soluble form for renal excretion. Nearly 50% of all clinically used medications and endogenous steroids are metabolized by the CYP enzyme 3A4, which explains why many of the important potential drug interactions involved this...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-000-0090-4
更新日期：2000-01-01 00:00:00
abstract：PURPOSE OF REVIEW:This review addresses normal and pathologic functions of serum amyloid A (SAA), an enigmatic biomarker of inflammation and protein precursor of AA amyloidosis, a life-threatening complication of chronic inflammation. SAA is a small, highly evolutionarily conserved acute-phase protein whose plasma leve...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-020-00888-y
更新日期：2020-09-24 00:00:00
abstract：:In the USA, 69 % of adults are either overweight or obese and 35 % are obese. Obesity is associated with an increased incidence of various cardiovascular disorders. Obesity is a risk marker for cardiovascular disease, in that it is associated with a much higher prevalence of comorbidities such as diabetes, hypertensio...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-016-0575-4
更新日期：2016-05-01 00:00:00
abstract：PURPOSE OF REVIEW:Apolipoprotein C-III (apoC-III) is known to inhibit lipoprotein lipase (LPL) and function as an important regulator of triglyceride metabolism. In addition, apoC-III has also more recently been identified as an important risk factor for cardiovascular disease. This review summarizes the mechanisms by ...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-019-0791-9
更新日期：2019-05-20 00:00:00
abstract：:The cardioprotective effects of omega-3 fatty acids (n-3 FAs) are well known, but the role that the n-6 FAs play in coronary heart disease is unclear. These two classes of essential FAs compete for a number of enzyme systems, and their metabolites can powerfully influence (often in different directions) inflammatory r...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-006-0019-7
更新日期：2006-11-01 00:00:00
abstract：:Clinically, aspirin resistance is defined as the failure of aspirin therapy to prevent an acute vascular thrombotic event despite regular intake of appropriate doses. In the laboratory, aspirin resistance encompasses the drug's failure to attain a particular level of platelet inhibition. From a clinical standpoint, th...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-008-0022-2
更新日期：2008-04-01 00:00:00
abstract：:Cancer survivorship should be defined starting not from completion of treatment, but from the time of diagnosis. Assessing and controlling the cancer patient's cardiovascular risk before, during, and after treatment is crucial to improving their overall outcome. There are many cancer therapies, including but not limit...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-014-0484-3
更新日期：2015-03-01 00:00:00
abstract：:Injury of arterial endothelium by abnormal shear stress and other insults induces migration and proliferation of vascular smooth muscle cells (VSMCs), which in turn leads to intimal thickening, hypoxia, and vasa vasorum angiogenesis. The resultant new blood vessels extend from the tunica media into the outer intima, a...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-015-0510-0
更新日期：2015-06-01 00:00:00
abstract：PURPOSE OF REVIEW:The review aims to describe the differences between men and women in those factors that can influence a worse prognosis in women after an acute cardiovascular event. RECENT FINDINGS:Women adequately treated with current evidence-based medications for acute myocardial infarction and for conventional c...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-020-00882-4
更新日期：2020-09-03 00:00:00
abstract：:Diabetes and its micro- and macrovascular complications represent a worldwide epidemic that will place an enormous financial burden on poorer countries in the years to come. In patients with diabetes and hypertension, the main determinant of the cardiovascular and renal benefits of antihypertensive drugs is the blood ...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-011-0160-9
更新日期：2011-04-01 00:00:00
abstract：:A wide range of structurally unrelated antioxidants inhibit atherosclerosis in animal models of hypercholesterolemia, implicating oxidation of low-density lipoprotein (LDL) in the pathogenesis of atherosclerosis. However, most prospective, randomized trials of one proposed antioxidant, vitamin E, have failed to demons...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-003-0075-1
更新日期：2003-03-01 00:00:00
abstract：:Stroke is a common and disabling condition. Intravenous tissue plasminogen activator (tPA) administered within 3 h of symptom onset is the standard therapy for eligible patients with acute ischemic stroke. Unfortunately, because of the time limitation, very few patients with ischemic stroke actually receive this treat...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-010-0121-8
更新日期：2010-09-01 00:00:00
abstract：:At a time when the lipid management guidelines give more and more emphasis to the identification and treatment of high-risk patients with the metabolic syndrome and diabetes, there is an obvious need to balance the known effects of low-density lipoprotein (LDL) lowering with the new evidence of clinical efficacy deriv...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-004-0104-8
更新日期：2004-03-01 00:00:00
abstract：:While the discovery of microRNAs has exponentially expanded our understanding of the regulatory mechanisms governing gene networks in many biological processes, the study of these tiny RNA powerhouses in cardiovascular disease is in its infancy. To date, there have been over 1200 human microRNAs identified, and they a...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-012-0272-x
更新日期：2012-10-01 00:00:00
abstract：:Recent studies confirm and extend previous evidence that lipoprotein (Lp) plays a significant role in atherosclerosis and is one of the top five or six risk factors for cardiovascular disease. In Japanese patients, Lp levels and apo phenotypes are significant predictors for myocardial infarction. Lp levels are signifi...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-000-0026-z
更新日期：2000-05-01 00:00:00
abstract：:Atherothrombosis remains a major cause of morbidity and mortality in the western world. The underlying processes associated with clinical expression of atherothrombosis include oxidative stress and proteolysis in relation to neovascularisation and intraplaque hemorrhages, leading to immuno-inflammatory response, cell ...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-010-0102-y
更新日期：2010-05-01 00:00:00
abstract：PURPOSE OF REVIEW:This review summarizes the pathophysiology of calcific aortic valve stenosis (CAVS) and surveys relevant clinical data and basic research that explain how CAVS arises. RECENT FINDINGS:Lipoprotein(a) [Lp(a)], lipoprotein-associated phospholipase A2 (Lp-PLA2), oxidized phospholipids (OxPL), autotaxin, ...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-020-0821-7
更新日期：2020-01-07 00:00:00
abstract：:Overwhelming evidence now shows that 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (ie, statins) are safe and effective in primary and secondary prevention of cardiovascular disease. Atherosclerosis, the primary cause of heart disease, is directly and independently related to hypercholesterolemia and infl...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-008-0003-5
更新日期：2008-02-01 00:00:00
abstract：PURPOSE OF REVIEW:High-intensity exercise may beneficially impact on insulin sensitivity. However, there is still uncertainty on the actual impact of high-intensity interval training (HIIT) on chronic physiologic adaptations among patients with type 2 diabetes mellitus (T2DM). We aimed to systematically search and appr...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章
doi：10.1007/s11883-019-0767-9
更新日期：2019-02-02 00:00:00
abstract：:The effects of cis-monounsaturated fatty acids (cis-MUFAs) on the risk of coronary heart disease (CHD) and on CHD mortality are not clear. Also, dietary recommendations for cis-MUFA as derived by various organizations are not in agreement. Earlier studies have mainly focused on the effects of cis-MUFA on serum lipids ...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-016-0597-y
更新日期：2016-07-01 00:00:00
