Obesity and Cardiovascular Disease: a Risk Factor or a Risk Marker?

abstract：:Atherosclerosis remains the major cause of morbidity and mortality in Western countries. Atherothrombotic complications, including vascular occlusions and severe narrowing of nutrient blood vessels in the cerebral, coronary, or peripheral circulation, usually require invasive revascularization strategies. As molecular...

journal_title：Current atherosclerosis reports

authors： Janssens SP

更新日期：2003-05-01 00:00:00

abstract：:There is robust epidemiological evidence dating back to the original Framingham Heart Study from 1977 that indicates an important inverse relationship between high-density lipoprotein cholesterol (HDL-C) and risk of incident coronary artery disease (CAD). Despite this body of scientific information demonstrating that ...

journal_title：Current atherosclerosis reports

authors： Tariq SM,Sidhu MS,Toth PP,Boden WE

更新日期：2014-04-01 00:00:00

abstract：:A wide range of structurally unrelated antioxidants inhibit atherosclerosis in animal models of hypercholesterolemia, implicating oxidation of low-density lipoprotein (LDL) in the pathogenesis of atherosclerosis. However, most prospective, randomized trials of one proposed antioxidant, vitamin E, have failed to demons...

journal_title：Current atherosclerosis reports

authors： Heinecke JW

更新日期：2003-03-01 00:00:00

abstract：:There are hundreds of foods, nutrients, herbs, and botanicals that have "bioactive" constituents with potential human health benefits. Three of these are discussed in this review: soy, garlic, and ginkgo biloba. Each of these three choices involves an ingestible item composed of a complex mixture of bioactive agents. ...

journal_title：Current atherosclerosis reports

authors： Gardner CD,Messina M,Lawson LD,Farquhar JW

更新日期：2003-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose is to review evidence on cardiovascular risks and benefits of new treatments for type 2 diabetes mellitus. RECENT FINDINGS:In response to guidance issued by the Food and Drug Administration, thousands of patients have been enrolled in large randomized trials evaluating the cardiovascular ...

journal_title：Current atherosclerosis reports

authors： Flory JH,Ukena JK,Floyd JS

更新日期：2016-12-01 00:00:00

abstract：:The development of multiple diagnostic intracoronary imaging modalities has increased our understanding of coronary atherosclerotic disease. These imaging modalities, intravascular ultrasound (IVUS), optical coherence tomography (OCT), and near-infrared spectroscopy (NIRS), have provided a method to study plaques and ...

journal_title：Current atherosclerosis reports

authors： Hoang V,Grounds J,Pham D,Virani S,Hamzeh I,Qureshi AM,Lakkis N,Alam M

更新日期：2016-09-01 00:00:00

abstract：:Understanding of the pathophysiology of atherosclerosis can provide new strategies for the prevention and treatment of patients with this common disease. Clinical, epidemiologic, and basic molecular science studies have identified oxidative stress as a factor contributing to the development and progression of atherosc...

journal_title：Current atherosclerosis reports

authors： Schulze PC,Lee RT

更新日期：2005-05-01 00:00:00

abstract：:Spontaneous intracerebral hemorrhage (ICH) is a devastating disease with high morbidity and mortality. Acutely, ICH is associated with a sudden surge in intracranial pressure (ICP), as the volume of hematoma increases the pressure in the closed head, leading to non-specific symptoms of ICP: headache, nausea, vomiting,...

journal_title：Current atherosclerosis reports

authors： Ko SB,Choi HA,Lee K

更新日期：2012-08-01 00:00:00

abstract：:The matrix metalloproteinase (MMP) family of enzymes is involved in arterial wall extracellular matrix degradation and remodeling. The latter activities have been implicated in a number of normal and pathologic processes, such as atherosclerotic lesion formation and progression, plaque destabilization and rupture, but...

journal_title：Current atherosclerosis reports

authors： Ketelhuth DF,Bäck M

更新日期：2011-04-01 00:00:00

abstract：:Aspirin remains one of the most extensively studied cardiovascular medications in the history of medicine. However, despite multiple, well-designed, large randomized controlled trials evaluating the potential of aspirin to prevent cardiovascular events in individuals without known cardiovascular disease (CVD), the rol...

journal_title：Current atherosclerosis reports

authors： Miedema MD,Huguelet J,Virani SS

更新日期：2016-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Mutations in both nuclear and mitochondrial genes are associated with the development of atherosclerotic lesions in arteries and may provide a partial explanation to the focal nature of lesion distribution in the arterial wall. This review is aimed to discuss the genetic aspects of atherogenesis with ...

journal_title：Current atherosclerosis reports

authors： Orekhov AN,Ivanova EA,Markin AM,Nikiforov NG,Sobenin IA

更新日期：2020-08-09 00:00:00

abstract：PURPOSE OF REVIEW:Lipoprotein apheresis is a very efficient but time-consuming and expensive method of lowering levels of low-density lipoprotein cholesterol, lipoprotein(a)) and other apoB containing lipoproteins, including triglyceride-rich lipoproteins. First introduced almost 45 years ago, it has long been a therap...

journal_title：Current atherosclerosis reports

authors： Thompson G,Parhofer KG

更新日期：2019-05-01 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the metabolic syndrome and a risk factor for both cardiovascular and hepatic related morbidity and mortality. The increasing prevalence of this disease requires novel therapeutic approaches to prevent disease progression. Farnesoid X receptors a...

journal_title：Current atherosclerosis reports

authors： Carr RM,Reid AE

更新日期：2015-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Perivascular adipose tissue (PVAT) has a complex, bidirectional relationship with the vascular wall. In disease states, PVAT secretes pro-inflammatory adipocytokines which may contribute to atherosclerosis. Recent evidence demonstrates that pericoronary adipose tissue (PCAT) may also function as a sen...

journal_title：Current atherosclerosis reports

authors： Lin A,Dey D,Wong DTL,Nerlekar N

更新日期：2019-11-19 00:00:00

abstract：:The original version of this article contains errors in Table 3. "At least 1 project/publication in the year" and "> 1 publication per year" have been switched under the titles of "Clinical Track" and "Physician-Scientist track". ...

journal_title：Current atherosclerosis reports

authors： Saeed A,Dabhadkar K,Virani SS,Jones PH,Ballantyne CM,Nambi V

更新日期：2018-06-19 00:00:00

abstract：PURPOSE OF REVIEW:Acute stroke is a treatable disease. Nevertheless, only a minority of patients obtain guideline-adjusted therapy. One major reason is the small time window in which therapies have to be administered in order to reverse or mitigate brain injury and prevent disability. The Mobile Stroke Unit (MSU) conce...

journal_title：Current atherosclerosis reports

authors： Walter S,Grunwald IQ,Helwig SA,Ragoschke-Schumm A,Kettner M,Fousse M,Lesmeister M,Fassbender K

更新日期：2018-08-29 00:00:00

abstract：PURPOSE OF REVIEW:Thoracic radiation therapy is an effective treatment for several malignancies, such as Hodgkin's lymphoma and breast cancer. Over the years, however, the incidence of cardiovascular events has increased in these patients, notably in younger survivors who do not have traditional risk factors. This revi...

journal_title：Current atherosclerosis reports

authors： Raghunathan D,Khilji MI,Hassan SA,Yusuf SW

更新日期：2017-05-01 00:00:00

abstract：:With ever increasing sophistication in molecular biological approaches, the low-density lipoprotein receptor supergene family continues to grow rapidly. From the well-defined key role of these receptors in lipoprotein metabolism, the new members move the field into many different and diverse physiologic and developmen...

journal_title：Current atherosclerosis reports

authors： Schneider WJ,Nimpf J,Brandes C,Drexler M

更新日期：1999-09-01 00:00:00

abstract：:Atherosclerotic heart disease and stroke are leading causes of disability and death worldwide, affecting not only developed countries, but also low- and middle-income regions. Different strategies for handling dyslipidemia as a critical pathogenic risk factor for atherosclerosis have been proposed. However, these reco...

journal_title：Current atherosclerosis reports

authors： Cuevas A,Arteaga A,Rigotti A

更新日期：2014-04-01 00:00:00

abstract：:Exaggerated postprandial hypertriglyceridemia is a risk factor for cardiovascular disease. This metabolic abnormality is principally due to overproduction and/or decreased catabolism of triglyceride-rich lipoproteins (TRLs) and is a consequence of pathogenic genetic variations and other coexistent medical conditions, ...

journal_title：Current atherosclerosis reports

authors： Chan DC,Pang J,Romic G,Watts GF

更新日期：2013-03-01 00:00:00

abstract：:The cardioprotective effects of omega-3 fatty acids (n-3 FAs) are well known, but the role that the n-6 FAs play in coronary heart disease is unclear. These two classes of essential FAs compete for a number of enzyme systems, and their metabolites can powerfully influence (often in different directions) inflammatory r...

journal_title：Current atherosclerosis reports

authors： Harris WS

更新日期：2006-11-01 00:00:00

abstract：:The ability of statins to lower serum cholesterol and reduce coronary heart disease endpoints has confirmed portions of the lipid hypothesis. However, the time to benefit and increased benefit in overlapping populations have suggested that nonlipid or pleiotropic effects of statins may be present. The apparent benefit...

journal_title：Current atherosclerosis reports

authors： Callahan AS 3rd

更新日期：2003-01-01 00:00:00

abstract：PURPOSE OF REVIEW:For over 20 years, the Women's Ischemia Syndrome Evaluation (WISE), a program sponsored by the National Heart, Lung, and Blood Institute, has explored diverse and important aspects of ischemic heart disease in women. RECENT FINDINGS:Women with symptoms and signs of ischemia but no significant epicard...

journal_title：Current atherosclerosis reports

authors： Barsky L,Merz CNB,Wei J,Shufelt C,Handberg E,Pepine C,Rutledge T,Reis S,Doyle M,Rogers W,Shaw L,Sopko G

更新日期：2020-06-18 00:00:00

abstract：:Diabetes and its micro- and macrovascular complications represent a worldwide epidemic that will place an enormous financial burden on poorer countries in the years to come. In patients with diabetes and hypertension, the main determinant of the cardiovascular and renal benefits of antihypertensive drugs is the blood ...

journal_title：Current atherosclerosis reports

authors： Reboldi G,Gentile G,Angeli F,Verdecchia P

更新日期：2011-04-01 00:00:00

abstract：PURPOSE OF REVIEW:We summarize recent advances in the understanding of genetic testing in familial hypercholesterolemia (FH), the use of expanded FH next-generation sequencing panels, and directions for future research. RECENT FINDINGS:The uptake of massively parallel sequencing in research and diagnostic laboratories...

journal_title：Current atherosclerosis reports

authors： Hooper AJ,Burnett JR,Bell DA,Watts GF

更新日期：2018-05-19 00:00:00

abstract：PURPOSE OF REVIEW:The goal of this manuscript is to summarize the current understanding of the secreted APOA1 binding protein (AIBP), encoded by NAXE, in angiogenesis, hematopoiesis, and inflammation. The studies on AIBP illustrate a critical connection between lipid metabolism and the aforementioned endothelial and im...

journal_title：Current atherosclerosis reports

authors： Qiu X,Luo J,Fang L

更新日期：2020-11-24 00:00:00

abstract：:Overwhelming evidence now shows that 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (ie, statins) are safe and effective in primary and secondary prevention of cardiovascular disease. Atherosclerosis, the primary cause of heart disease, is directly and independently related to hypercholesterolemia and infl...

journal_title：Current atherosclerosis reports

authors： Orr JD

更新日期：2008-02-01 00:00:00

abstract：:At a time when the lipid management guidelines give more and more emphasis to the identification and treatment of high-risk patients with the metabolic syndrome and diabetes, there is an obvious need to balance the known effects of low-density lipoprotein (LDL) lowering with the new evidence of clinical efficacy deriv...

journal_title：Current atherosclerosis reports

authors： Fazio S,Linton MF

更新日期：2004-03-01 00:00:00

abstract：:Patients with ischemic stroke of unclear etiology are often screened for hypercoagulable syndromes or thrombophilias. These have been recognized to cause venous thrombosis, and include hereditary deficiencies of coagulation factors, genetic mutations, or acquired disorders. However, the majority of coagulation disorde...

journal_title：Current atherosclerosis reports

authors： Bushnell C,Goldstein LB

更新日期：2003-07-01 00:00:00

abstract：:Transient ischemic attack (TIA) represents one end of the spectrum of focal brain ischemia, the other being completed infarction or ischemic stroke. The evolving technologic advancements in neuroimaging continue to change and sharpen the definition, epidemiology, and management of TIA. As a powerful risk factor for is...

journal_title：Current atherosclerosis reports

authors： Liberato B,Prabhakaran S,Sacco RL

更新日期：2005-07-01 00:00:00