PPAR delta agonists and metabolic diseases.

Abstract:

:Peroxisome proliferator-activated receptors (PPARs) are the key transcription factors regulating lipid metabolism and energy homeostasis. PPARalpha and PPARgamma are known therapeutic targets for hypertriglyceridemia and type 2 diabetes, respectively. The physiologic function of the third member, PPARdelta, has been difficult to define due to its broad tissue distribution. Through the creation of transgenic mouse models and identification of high-affinity synthetic ligands, the diverse activities of PPARdelta in several metabolically active tissues, including skeletal muscle, adipose tissue, liver, and macrophages, have recently been revealed. These metabolic activities of PPARdelta implicate the potential use of PPARdelta agonists to treat metabolic diseases, including atherosclerosis and insulin resistance.

journal_name

Curr Atheroscler Rep

authors

Kang K,Hatano B,Lee CH

doi

10.1007/BF02693931

subject

Has Abstract

pub_date

2007-01-01 00:00:00

pages

72-7

issue

1

eissn

1523-3804

issn

1534-6242

journal_volume

9

pub_type

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