Sex-Based Considerations in the Evaluation of Chest Pain and Management of Obstructive Coronary Artery Disease.

Abstract:

PURPOSE OF REVIEW:Coronary artery disease (CAD) is a major cause of morbidity and mortality globally and poses a threat to both men and women across their lifespans. There is accumulating evidence to support that CAD may present differently in women and men, ranging from the clinical presentation, diagnosis, and management of the disease to underlying differences in the biological and pathophysiological mechanisms. This has called for an expansion of our conventional tools used in the diagnosis and management of obstructive CAD. Understanding these key sex differences will potentially help tailor our diagnostic and treatment strategies and provide equitable and optimal care to both men and women. RECENT FINDINGS:Numerous studies have consistently shown that women with CAD tend to be older, have a higher burden of co-morbidities, and experience worse outcomes compared to their male counterparts. Women tend to wait longer to seek medical care for cardiovascular symptoms and when they do, they are usually referred late in the disease process and treated less aggressively. Women are significantly underrepresented in most cardiovascular clinical trials, thereby creating an important limitation in the evidence base used for treating cardiovascular disease in women. In this review, we sought to describe the sex-based considerations in evaluation and management of obstructive CAD, underscore the mechanisms behind these considerations, and help develop a more personalized approach according to current paradigms.

journal_name

Curr Atheroscler Rep

authors

Madan N,Gajo E,Sanghani RM,Volgman AS

doi

10.1007/s11883-020-00855-7

subject

Has Abstract

pub_date

2020-06-23 00:00:00

pages

39

issue

8

eissn

1523-3804

issn

1534-6242

pii

10.1007/s11883-020-00855-7

journal_volume

22

pub_type

杂志文章,评审
  • Cryptogenic stroke in patients with patent foramen ovale.

    abstract::Paradoxical embolism through a patent foramen ovale (PFO) is a commonly identified potential mechanism of ischemic stroke, especially in young patients. The recurrent stroke rate among young cryptogenic stroke patients with a PFO is modest, but higher than normal for their age. Co-existing atrial septal aneurysm is a ...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-007-0039-y

    authors: Saver JL

    更新日期:2007-10-01 00:00:00

  • Role of Coronary Calcium Score to Identify Candidates for ASCVD Prevention.

    abstract:PURPOSE OF REVIEW:In this review, we describe the mechanism behind coronary artery calcification formation and detection, as well as its implication in cardiovascular disease (CVD) risk stratification, intervention, and prognosis in asymptomatic individuals. RECENT FINDINGS:Multiple cohort and population studies have ...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-019-0812-8

    authors: Nguyen HL,Liu J,Del Castillo M,Shah T

    更新日期:2019-11-21 00:00:00

  • An Update on Gender Disparities in Coronary Heart Disease Care.

    abstract::Coronary heart disease (CHD), traditionally considered a male disease, causes far more deaths in women than cancer. The prevalence of CHD is lower in women at any age, but with advancing age, this differential decreases. The clinical outcomes including myocardial infarction mortality, all-cause mortality, and reinfarc...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-016-0574-5

    authors: Shah T,Palaskas N,Ahmed A

    更新日期:2016-05-01 00:00:00

  • Sex-Based Differences in Chronic Total Occlusion Management.

    abstract::ᅟ: Chronic total occlusions (CTOs) are an important and increasingly recognized subgroup of coronary lesions, documented in at least 30%, but up to 52% of patients with coronary artery disease (CAD) undergoing coronary angiography. Percutaneous coronary intervention (PCI) of these lesions is increasingly pursued, with...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-018-0760-8

    authors: Cheney A,Kearney KE,Lombardi W

    更新日期:2018-11-07 00:00:00

  • Imaging Atherosclerotic Plaque Calcification: Translating Biology.

    abstract::Calcification of atherosclerotic lesions was long thought to be an age - related, passive process, but increasingly data has revealed that atherosclerotic calcification is a more active process, involving complex signaling pathways and bone-like genetic programs. Initially, imaging of atherosclerotic calcification was...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-016-0601-6

    authors: Bailey G,Meadows J,Morrison AR

    更新日期:2016-08-01 00:00:00

  • Acute revascularization in ST-segment-elevation myocardial infarction.

    abstract::We briefly and comprehensively present some of the novel findings in the field of revascularization therapy and management of ST-segment-elevation myocardial infarction (STEMI). We highlight the latest evidence-based advancements in the pharmacological and mechanical treatment of patients who presented with STEMI. Sin...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-014-0412-6

    authors: Prodanov P,Widimsky P

    更新日期:2014-06-01 00:00:00

  • High-Intensity Interval Training in Patients with Type 2 Diabetes Mellitus: a Systematic Review.

    abstract:PURPOSE OF REVIEW:High-intensity exercise may beneficially impact on insulin sensitivity. However, there is still uncertainty on the actual impact of high-intensity interval training (HIIT) on chronic physiologic adaptations among patients with type 2 diabetes mellitus (T2DM). We aimed to systematically search and appr...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章

    doi:10.1007/s11883-019-0767-9

    authors: da Silva DE,Grande AJ,Roever L,Tse G,Liu T,Biondi-Zoccai G,de Farias JM

    更新日期:2019-02-02 00:00:00

  • PPAR delta agonists and metabolic diseases.

    abstract::Peroxisome proliferator-activated receptors (PPARs) are the key transcription factors regulating lipid metabolism and energy homeostasis. PPARalpha and PPARgamma are known therapeutic targets for hypertriglyceridemia and type 2 diabetes, respectively. The physiologic function of the third member, PPARdelta, has been d...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/BF02693931

    authors: Kang K,Hatano B,Lee CH

    更新日期:2007-01-01 00:00:00

  • Heterogeneity of Coronary Plaque Morphology and Natural History: Current Understanding and Clinical Significance.

    abstract:PURPOSE OF REVIEW:Despite the important progress in identifying high-risk atherosclerotic plaques, many key elements are elusive. Advanced imaging modalities provide valuable information about the anatomic and functional plaque characteristics and underscore the presence of multiple plaque morphologies. However, how th...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-016-0626-x

    authors: Zaromytidou M,Antoniadis AP,Siasos G,Coskun AU,Andreou I,Papafaklis MI,Lucier M,Feldman CL,Stone PH

    更新日期:2016-12-01 00:00:00

  • Intracranial atherosclerotic stroke: specific focus on the metabolic syndrome and inflammation.

    abstract::Stroke is the second leading cause of mortality world-wide and is well suited for prevention because it has a high prevalence, high burden of economic cost, well-defined modifiable risk factors, and effective prevention measures. Atherosclerosis is one of the major mechanisms of ischemic stroke, but the apparent diffe...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-006-0012-1

    authors: Bang OY

    更新日期:2006-07-01 00:00:00

  • Impact of thiazolidinedione therapy on atherogenesis.

    abstract::Thiazolidinediones (TZDs), which are synthetic ligands for peroxisome proliferator activated receptor g (PPARg) activation, have been introduced in clinical medicine to improve insulin resistance and glycemic control in patients with type 2 diabetes. The metabolic effects of TZDs are mediated by receptor-dependent act...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-005-0049-6

    authors: van Wijk JP,Rabelink TJ

    更新日期:2005-09-01 00:00:00

  • Proteomics of acute coronary syndromes.

    abstract::Acute coronary syndromes (ACS), such as unstable angina, acute myocardial infarction, and sudden cardiac death, are commonly associated with the presence of vulnerable plaques in coronary arteries. Rupture or erosion of vulnerable plaques results in the formation of luminal thrombi due to the physical contact between ...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-009-0030-x

    authors: Didangelos A,Simper D,Monaco C,Mayr M

    更新日期:2009-05-01 00:00:00

  • The ligand/RAGE axis: lighting the fuse and igniting vascular stress.

    abstract::Vascular inflammation contributes critically to the initiation and progression of atherosclerosis. These processes are accelerated in hyperglycemia and play key roles in the increased incidence and severity of myocardial infarction and stroke observed in diabetes. Evidence suggests that the ligands of the receptor for...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-006-0078-9

    authors: Yan SF,Naka Y,Hudson BI,Herold K,Yan SD,Ramasamy R,Schmidt AM

    更新日期:2006-05-01 00:00:00

  • Gender Differences in Residual Risk Factors for Major Adverse Cardiovascular Events Following ACS and How to Bridge the Gap.

    abstract:PURPOSE OF REVIEW:The review aims to describe the differences between men and women in those factors that can influence a worse prognosis in women after an acute cardiovascular event. RECENT FINDINGS:Women adequately treated with current evidence-based medications for acute myocardial infarction and for conventional c...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-020-00882-4

    authors: Manfrini O,Cenko E,Bugiardini R

    更新日期:2020-09-03 00:00:00

  • Alcohol and atherosclerosis: recent insights.

    abstract::Light to moderate alcohol intake is known to have cardioprotective properties; however, the magnitude of protection depends on other factors and may be confined to some subsets of the population. This review focuses on factors that modify the relationship between alcohol and coronary heart disease (CHD). The cardiopro...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-007-0007-6

    authors: Tolstrup J,Grønbaek M

    更新日期:2007-08-01 00:00:00

  • ICD and CRT use in ischemic heart disease in women.

    abstract::Although the role of implantable cardioverter defibrillator (ICD) and cardiac resynchronization therapy (CRT) in improving outcomes in ischemic cardiomyopathy (ICM) has been described, the data regarding gender-based survival outcomes are limited. There is a higher preponderance of non-ischemic cardiomyopathy (NICM) i...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-015-0512-y

    authors: Mehta NK,Abraham WT,Maytin M

    更新日期:2015-06-01 00:00:00

  • Soy, garlic, and ginkgo biloba: their potential role in cardiovascular disease prevention and treatment.

    abstract::There are hundreds of foods, nutrients, herbs, and botanicals that have "bioactive" constituents with potential human health benefits. Three of these are discussed in this review: soy, garlic, and ginkgo biloba. Each of these three choices involves an ingestible item composed of a complex mixture of bioactive agents. ...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-003-0037-7

    authors: Gardner CD,Messina M,Lawson LD,Farquhar JW

    更新日期:2003-11-01 00:00:00

  • The role of lipoprotein[a] in atherosclerosis.

    abstract::Recent studies confirm and extend previous evidence that lipoprotein (Lp) plays a significant role in atherosclerosis and is one of the top five or six risk factors for cardiovascular disease. In Japanese patients, Lp levels and apo phenotypes are significant predictors for myocardial infarction. Lp levels are signifi...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-000-0026-z

    authors: Morrisett JD

    更新日期:2000-05-01 00:00:00

  • The Air Force/Texas Coronary Atherosclerosis Prevention Study: implications for preventive cardiology in the general adult US population.

    abstract::Atherosclerotic cardiovascular diseases are the most common causes of death in the United States. Fibrous plaques develop in 77% to 78% of men before age 30. The mean low-density lipoprotein-cholesterol (LDL-C) level in men aged 25 to 30 years is 117 mg/dL. In the Air Force/Texas Coronary Atherosclerosis Prevention St...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章

    doi:10.1007/s11883-999-0048-0

    authors: Whitney E

    更新日期:1999-07-01 00:00:00

  • Screening for hypercoagulable syndromes following stroke.

    abstract::Patients with ischemic stroke of unclear etiology are often screened for hypercoagulable syndromes or thrombophilias. These have been recognized to cause venous thrombosis, and include hereditary deficiencies of coagulation factors, genetic mutations, or acquired disorders. However, the majority of coagulation disorde...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-003-0052-8

    authors: Bushnell C,Goldstein LB

    更新日期:2003-07-01 00:00:00

  • Dietary fiber prevents carbohydrate-induced hypertriglyceridemia.

    abstract::Plant foods rich in carbohydrate and dietary fiber have many health benefits. One concern often expressed about higher carbohydrate, lower fat diets is that they may increase fasting serum triglycerides. Recently the importance of hypertriglyceridemia as an independent risk factor for coronary heart disease has been r...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-000-0055-7

    authors: Anderson JW

    更新日期:2000-11-01 00:00:00

  • The Role of the Gut Microbiota in Coronary Heart Disease.

    abstract:PURPOSE OF REVIEW:This review focuses on recent evidence examining the role gut microbiota play in coronary heart disease. It also provides a succinct overview of current and future therapies targeting the gut microbiota for coronary heart disease risk reduction. RECENT FINDINGS:A consensus has been reached that diffe...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-020-00892-2

    authors: Liu H,Zhuang J,Tang P,Li J,Xiong X,Deng H

    更新日期:2020-10-16 00:00:00

  • AIBP, Angiogenesis, Hematopoiesis, and Atherogenesis.

    abstract:PURPOSE OF REVIEW:The goal of this manuscript is to summarize the current understanding of the secreted APOA1 binding protein (AIBP), encoded by NAXE, in angiogenesis, hematopoiesis, and inflammation. The studies on AIBP illustrate a critical connection between lipid metabolism and the aforementioned endothelial and im...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-020-00899-9

    authors: Qiu X,Luo J,Fang L

    更新日期:2020-11-24 00:00:00

  • Genetic predictors of plasma lipid response to diet intervention.

    abstract::There is a growing interest in determining the genetic predictors of plasma lipid response to diet intervention. Several candidate gene loci, namely, apolipoprotein (APO) A1, APOA4, APOC3, APOB, APOE, CETP, LPL, and FABP2, have been shown to explain a significant, but still rather small, proportion of the interindivid...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-999-0032-8

    authors: Ordovas JM,Galluzzi JR

    更新日期:1999-11-01 00:00:00

  • A Clinical Guide to Combination Lipid-Lowering Therapy.

    abstract:PURPOSE OF REVIEW:We provide an overview of our current understanding of combination lipid-lowering therapies intended for dyslipidemia treatment and cardiovascular disease prevention. First, we analyze recent statin and non-statin combination therapy guidelines and clinical studies since the publication of 2013 Americ...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-018-0721-2

    authors: Russell C,Sheth S,Jacoby D

    更新日期:2018-03-07 00:00:00

  • Pleiotropic effects of statins: moving beyond cholesterol control.

    abstract::3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors or "statin" medications are the most commonly prescribed therapy for lowering cholesterol. In use for over a decade, they have demonstrated both safety and tolerability across a broad range of patients. The ability to inhibit the biosynthesis of cholesterol an...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-005-0073-6

    authors: Garcia PJ

    更新日期:2005-02-01 00:00:00

  • Impact of thiazolidenediones on serum lipoprotein levels.

    abstract::The thiazolidinediones, acting through peroxisome proliferator-activated receptor chi (PPARchi), affect multiple areas of metabolism. Of increasing importance is the recognition that these agents affect lipoprotein metabolism and cause changes in serum lipid and lipoprotein levels. All three thiazolidinediones, includ...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,meta分析,评审

    doi:10.1007/s11883-006-0037-5

    authors: Goldberg RB

    更新日期:2006-09-01 00:00:00

  • Applied gene therapy in preclinical models of vascular injury.

    abstract::Atherosclerosis remains the major cause of morbidity and mortality in Western countries. Atherothrombotic complications, including vascular occlusions and severe narrowing of nutrient blood vessels in the cerebral, coronary, or peripheral circulation, usually require invasive revascularization strategies. As molecular...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-003-0022-1

    authors: Janssens SP

    更新日期:2003-05-01 00:00:00

  • Therapeutic lifestyle change and Adult Treatment Panel III: evidence then and now.

    abstract::The Third Report of the National Cholesterol Education Program's Adult Treatment Panel (ATP III) has an extensive section on nonpharmacologic therapy for those with abnormal blood lipids. ATP III focused on the high-saturated fat atherogenic diet, obesity, and sedentary lifestyle and recommended a program of therapeut...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-002-0047-x

    authors: Stone NJ,Van Horn L

    更新日期:2002-11-01 00:00:00

  • Emerging Evidence that ApoC-III Inhibitors Provide Novel Options to Reduce the Residual CVD.

    abstract:PURPOSE OF REVIEW:Apolipoprotein C-III (apoC-III) is known to inhibit lipoprotein lipase (LPL) and function as an important regulator of triglyceride metabolism. In addition, apoC-III has also more recently been identified as an important risk factor for cardiovascular disease. This review summarizes the mechanisms by ...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-019-0791-9

    authors: Taskinen MR,Packard CJ,Borén J

    更新日期:2019-05-20 00:00:00