Abstract：
PURPOSE OF REVIEW:Coronary artery disease (CAD) is a major cause of morbidity and mortality globally and poses a threat to both men and women across their lifespans. There is accumulating evidence to support that CAD may present differently in women and men, ranging from the clinical presentation, diagnosis, and management of the disease to underlying differences in the biological and pathophysiological mechanisms. This has called for an expansion of our conventional tools used in the diagnosis and management of obstructive CAD. Understanding these key sex differences will potentially help tailor our diagnostic and treatment strategies and provide equitable and optimal care to both men and women. RECENT FINDINGS:Numerous studies have consistently shown that women with CAD tend to be older, have a higher burden of co-morbidities, and experience worse outcomes compared to their male counterparts. Women tend to wait longer to seek medical care for cardiovascular symptoms and when they do, they are usually referred late in the disease process and treated less aggressively. Women are significantly underrepresented in most cardiovascular clinical trials, thereby creating an important limitation in the evidence base used for treating cardiovascular disease in women. In this review, we sought to describe the sex-based considerations in evaluation and management of obstructive CAD, underscore the mechanisms behind these considerations, and help develop a more personalized approach according to current paradigms.
journal_name
Curr Atheroscler Repjournal_title
Current atherosclerosis reportsauthors
Madan N,Gajo E,Sanghani RM,Volgman ASdoi
10.1007/s11883-020-00855-7subject
Has Abstractpub_date
2020-06-23 00:00:00pages
39issue
8eissn
1523-3804issn
1534-6242pii
10.1007/s11883-020-00855-7journal_volume
22pub_type
杂志文章,评审abstract：:Serum cholesterol traditionally has been considered a poor predictor of total stroke risk; however, it is associated positively with ischemic stroke risk and associated negatively with hemorrhagic stroke risk. Although studies failed to demonstrate stroke reduction using older cholesterol-lowering medications, recent ...
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pub_type： 杂志文章,评审
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更新日期：2000-03-01 00:00:00
abstract：:Coronary heart disease (CHD), traditionally considered a male disease, causes far more deaths in women than cancer. The prevalence of CHD is lower in women at any age, but with advancing age, this differential decreases. The clinical outcomes including myocardial infarction mortality, all-cause mortality, and reinfarc...
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pub_type： 杂志文章,评审
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更新日期：2009-09-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2018-05-19 00:00:00
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journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
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更新日期：2011-04-01 00:00:00
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pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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更新日期：1999-09-01 00:00:00
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更新日期：2001-03-01 00:00:00
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journal_title：Current atherosclerosis reports
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更新日期：2016-12-01 00:00:00
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journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
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更新日期：2005-03-01 00:00:00
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更新日期：2012-12-01 00:00:00
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journal_title：Current atherosclerosis reports
pub_type： 已发布勘误
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更新日期：2020-07-07 00:00:00
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pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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更新日期：2010-05-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2003-03-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2013-03-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2008-04-01 00:00:00
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pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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更新日期：2016-01-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2016-08-01 00:00:00
abstract：:Erectile dysfunction (ED) is a common problem in the United States, with estimates that 30 million men suffer with some degree of ED. Although causes include psychogenic, organic, and mixed forms, in middle-aged and older men one of the most common causes is vascular disease. Endothelial dysfunction, even without defi...
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pub_type： 杂志文章,评审
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更新日期：2002-09-01 00:00:00
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journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
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更新日期：2006-05-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2009-07-01 00:00:00
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journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
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更新日期：2007-09-01 00:00:00
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journal_title：Current atherosclerosis reports
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更新日期：2006-07-01 00:00:00
