Sex-Based Considerations in the Evaluation of Chest Pain and Management of Obstructive Coronary Artery Disease.

Abstract:

PURPOSE OF REVIEW:Coronary artery disease (CAD) is a major cause of morbidity and mortality globally and poses a threat to both men and women across their lifespans. There is accumulating evidence to support that CAD may present differently in women and men, ranging from the clinical presentation, diagnosis, and management of the disease to underlying differences in the biological and pathophysiological mechanisms. This has called for an expansion of our conventional tools used in the diagnosis and management of obstructive CAD. Understanding these key sex differences will potentially help tailor our diagnostic and treatment strategies and provide equitable and optimal care to both men and women. RECENT FINDINGS:Numerous studies have consistently shown that women with CAD tend to be older, have a higher burden of co-morbidities, and experience worse outcomes compared to their male counterparts. Women tend to wait longer to seek medical care for cardiovascular symptoms and when they do, they are usually referred late in the disease process and treated less aggressively. Women are significantly underrepresented in most cardiovascular clinical trials, thereby creating an important limitation in the evidence base used for treating cardiovascular disease in women. In this review, we sought to describe the sex-based considerations in evaluation and management of obstructive CAD, underscore the mechanisms behind these considerations, and help develop a more personalized approach according to current paradigms.

journal_name

Curr Atheroscler Rep

authors

Madan N,Gajo E,Sanghani RM,Volgman AS

doi

10.1007/s11883-020-00855-7

subject

Has Abstract

pub_date

2020-06-23 00:00:00

pages

39

issue

8

eissn

1523-3804

issn

1534-6242

pii

10.1007/s11883-020-00855-7

journal_volume

22

pub_type

杂志文章,评审
  • Innovative approaches to comprehensive cardiovascular disease risk reduction in clinical and community-based settings.

    abstract::We have developed, tested, and successfully implemented an affordable, evidence-based, comprehensive cardiovascular disease risk-reduction program for use in primary and secondary prevention settings. The program is administered at hospitals, physician practices, cardiac rehabilitation programs, work sites, shopping m...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-001-0040-9

    authors: Gordon NF,Salmon RD,Mitchell BS,Faircloth GC,Levinrad LI,Salmon S,Saxon WE,Reid KS

    更新日期:2001-11-01 00:00:00

  • Rheumatoid Arthritis: Atherosclerosis Imaging and Cardiovascular Risk Assessment Using Machine and Deep Learning-Based Tissue Characterization.

    abstract:PURPOSE OF THE REVIEW:Rheumatoid arthritis (RA) is a chronic, autoimmune disease which may result in a higher risk of cardiovascular (CV) events and stroke. Tissue characterization and risk stratification of patients with rheumatoid arthritis are a challenging problem. Risk stratification of RA patients using tradition...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-019-0766-x

    authors: Khanna NN,Jamthikar AD,Gupta D,Piga M,Saba L,Carcassi C,Giannopoulos AA,Nicolaides A,Laird JR,Suri HS,Mavrogeni S,Protogerou AD,Sfikakis P,Kitas GD,Suri JS

    更新日期:2019-01-25 00:00:00

  • Lifestyle factors and stroke risk: exercise, alcohol, diet, obesity, smoking, drug use, and stress.

    abstract::Various lifestyle factors have been associated with increasing the risk of stroke. These include lack of exercise, alcohol, diet, obesity, smoking, drug use, and stress. Guidelines endorsed by the Centers for Disease Control and Prevention and the National Institutes of Health recommend that Americans should exercise ...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-000-0111-3

    authors: Boden-Albala B,Sacco RL

    更新日期:2000-03-01 00:00:00

  • Modulation of the renin-angiotensin-aldosterone system in heart failure.

    abstract::The renin-angiotensin-aldosterone system (RAAS) is well-established and continues to be pursued as a therapeutic target in the treatment of heart failure, predominantly due to the success of agents that block RAAS in clinical trials of systolic heart failure. The optimal treatment of heart failure patients with preser...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-014-0403-7

    authors: George J,Struthers AD,Lang CC

    更新日期:2014-04-01 00:00:00

  • Cardiovascular disease in women.

    abstract::The rates of cardiovascular disease (CVD) have decreased significantly for men over the past few decades, but similar reductions have not occurred in women. Consequently, CVD remains the leading killer of women in the United States. Men usually develop heart disease earlier than women, but women develop heart disease ...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-008-0046-7

    authors: Lee LV,Foody JM

    更新日期:2008-08-01 00:00:00

  • Proteomic and metabolomic profiles in atherothrombotic vascular disease.

    abstract::Atherothrombosis remains a major cause of morbidity and mortality in the western world. The underlying processes associated with clinical expression of atherothrombosis include oxidative stress and proteolysis in relation to neovascularisation and intraplaque hemorrhages, leading to immuno-inflammatory response, cell ...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-010-0102-y

    authors: Martinez-Pinna R,Barbas C,Blanco-Colio LM,Tunon J,Ramos-Mozo P,Lopez JA,Meilhac O,Michel JB,Egido J,Martin-Ventura JL

    更新日期:2010-05-01 00:00:00

  • Soy, garlic, and ginkgo biloba: their potential role in cardiovascular disease prevention and treatment.

    abstract::There are hundreds of foods, nutrients, herbs, and botanicals that have "bioactive" constituents with potential human health benefits. Three of these are discussed in this review: soy, garlic, and ginkgo biloba. Each of these three choices involves an ingestible item composed of a complex mixture of bioactive agents. ...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-003-0037-7

    authors: Gardner CD,Messina M,Lawson LD,Farquhar JW

    更新日期:2003-11-01 00:00:00

  • Hormone replacement therapy trials: an update.

    abstract::Recent randomized trials of hormone replacement therapy (HRT) in postmenopausal women are not consistent with the decrease in cardiovascular risk seen in observational studies of hormone therapy users compared with nonusers. Emerging evidence indicates that HRT use in some women with established coronary heart disease...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章

    doi:10.1007/s11883-002-0040-4

    authors: Duvernoy CS,Mosca L

    更新日期:2002-03-01 00:00:00

  • Omega-3 fatty acids: a growing ocean of choices.

    abstract::There has been increasing interest in the health benefits of supplemental and/or dietary omega-3 polyunsaturated fatty acids (PUFAs), particularly in their role in disease prevention. This interest escalated once their effects on cardiovascular health were observed from numerous observational studies in populations wh...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-013-0389-6

    authors: Fares H,Lavie CJ,DiNicolantonio JJ,O'Keefe JH,Milani RV

    更新日期:2014-02-01 00:00:00

  • Postprandial hypertriglyceridemia and cardiovascular disease: current and future therapies.

    abstract::Exaggerated postprandial hypertriglyceridemia is a risk factor for cardiovascular disease. This metabolic abnormality is principally due to overproduction and/or decreased catabolism of triglyceride-rich lipoproteins (TRLs) and is a consequence of pathogenic genetic variations and other coexistent medical conditions, ...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-013-0309-9

    authors: Chan DC,Pang J,Romic G,Watts GF

    更新日期:2013-03-01 00:00:00

  • Impact of circulating esterified eicosanoids and other oxylipins on endothelial function.

    abstract::Eicosanoids, including epoxyeicosatrienoic acids, hydroxyeicosatetraenoic acids, and other oxylipins derived from polyunsaturated fatty acids, have emerging roles in endothelial inflammation and subsequent atherosclerosis. Unlike eicosanoids in the prostanoid series, they are known to be esterified in cell lipids such...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-009-0061-3

    authors: Shearer GC,Newman JW

    更新日期:2009-11-01 00:00:00

  • Optimal therapy in hypertensive subjects with diabetes mellitus.

    abstract::Diabetes and its micro- and macrovascular complications represent a worldwide epidemic that will place an enormous financial burden on poorer countries in the years to come. In patients with diabetes and hypertension, the main determinant of the cardiovascular and renal benefits of antihypertensive drugs is the blood ...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-011-0160-9

    authors: Reboldi G,Gentile G,Angeli F,Verdecchia P

    更新日期:2011-04-01 00:00:00

  • HDL hypothesis: where do we stand now?

    abstract::There is robust epidemiological evidence dating back to the original Framingham Heart Study from 1977 that indicates an important inverse relationship between high-density lipoprotein cholesterol (HDL-C) and risk of incident coronary artery disease (CAD). Despite this body of scientific information demonstrating that ...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-014-0398-0

    authors: Tariq SM,Sidhu MS,Toth PP,Boden WE

    更新日期:2014-04-01 00:00:00

  • Lipoprotein apheresis.

    abstract::Lipoprotein apheresis is an extracorporeal therapy whereby apo B-containing lipoproteins (LDL, vLDL, and Lp(a)) are selectively removed from the plasma of a patient. It is a variation of plasma exchange, which non-selectively removes all plasma proteins. Lipoprotein apheresis is most commonly used to treat patients wi...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-015-0516-7

    authors: Bhoj VG,Sachais BS

    更新日期:2015-07-01 00:00:00

  • Genetics of Arterial-Wall-Specific Mechanisms in Atherosclerosis: Focus on Mitochondrial Mutations.

    abstract:PURPOSE OF REVIEW:Mutations in both nuclear and mitochondrial genes are associated with the development of atherosclerotic lesions in arteries and may provide a partial explanation to the focal nature of lesion distribution in the arterial wall. This review is aimed to discuss the genetic aspects of atherogenesis with ...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-020-00873-5

    authors: Orekhov AN,Ivanova EA,Markin AM,Nikiforov NG,Sobenin IA

    更新日期:2020-08-09 00:00:00

  • Current Role of Lipoprotein Apheresis.

    abstract:PURPOSE OF REVIEW:Lipoprotein apheresis is a very efficient but time-consuming and expensive method of lowering levels of low-density lipoprotein cholesterol, lipoprotein(a)) and other apoB containing lipoproteins, including triglyceride-rich lipoproteins. First introduced almost 45 years ago, it has long been a therap...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-019-0787-5

    authors: Thompson G,Parhofer KG

    更新日期:2019-05-01 00:00:00

  • Degenerative Severe Aortic Stenosis and Concomitant Coronary Artery Disease: What Is Changing in the Era of the "Transcatheter Revolution"?

    abstract:PURPOSE OF REVIEW:To summarize epidemiology, pathophysiology, prognostic relevance, and treatment options of coronary artery disease (CAD) when coupled with severe aortic stenosis (SAS). In regard to treatment options, we focused on the most recently adopted therapeutic approaches and on the future perspectives in ligh...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-020-0835-1

    authors: Pepe M,Larosa C,Rosa I,Biondi-Zoccai G,Nestola PL,Di Cillo O,Bortone AS,Giordano A,Favale S

    更新日期:2020-05-26 00:00:00

  • Is atherosclerosis regression a realistic goal of statin therapy and what does that mean?

    abstract::Atherosclerosis is a complex disease associated with aberrant lipoprotein metabolism and leukocyte infiltration into arterial tissue that leads to cardiovascular diseases. Statins have emerged as among the most effective means of reducing the risk of cardiovascular disease in both primary and secondary prevention sett...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-012-0294-4

    authors: Singh M,Bedi US

    更新日期:2013-01-01 00:00:00

  • Screening for hypercoagulable syndromes following stroke.

    abstract::Patients with ischemic stroke of unclear etiology are often screened for hypercoagulable syndromes or thrombophilias. These have been recognized to cause venous thrombosis, and include hereditary deficiencies of coagulation factors, genetic mutations, or acquired disorders. However, the majority of coagulation disorde...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-003-0052-8

    authors: Bushnell C,Goldstein LB

    更新日期:2003-07-01 00:00:00

  • Early Cardioversion in Atrial Fibrillation: Earlier Is Better, but Not Always and (Maybe) Not Immediately.

    abstract::Atrial fibrillation (AF) is the most common cardiac arrhythmia in humans. One of its important features is the tendency to become more persistent over time, even in the absence of underlying progressive heart disease. Conversion and maintenance of sinus rhythm by pharmacological or electrical methods become increasing...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-017-0638-1

    authors: Piña PG,Chicos AB

    更新日期:2017-01-01 00:00:00

  • Computerized approaches to communication retraining after stroke.

    abstract::Augmentative and alternative communication (AAC) strategies traditionally have been designed for individuals for whom oral speech is not a viable option. Common clinical practice has expanded AAC use to a tool for cognitive retraining or remediation. Although technologic developments offer the potential for vastly imp...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-002-0008-4

    authors: Ansel BM,Weinrich M

    更新日期:2002-07-01 00:00:00

  • Recent developments with lipoprotein-associated phospholipase A2 inhibitors.

    abstract::Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is a calcium-independent phospholipase A(2) enzyme secreted by leukocytes and associated with circulating low-density lipoprotein and macrophages in atherosclerotic plaques. Until recently, the biological role of Lp-PLA(2) in atherosclerosis was controversial, but ...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-009-0076-9

    authors: Chauffe RJ,Wilensky RL,Mohler ER 3rd

    更新日期:2010-01-01 00:00:00

  • Even "WISE-R?"-an Update on the NHLBI-Sponsored Women's Ischemia Syndrome Evaluation.

    abstract:PURPOSE OF REVIEW:For over 20 years, the Women's Ischemia Syndrome Evaluation (WISE), a program sponsored by the National Heart, Lung, and Blood Institute, has explored diverse and important aspects of ischemic heart disease in women. RECENT FINDINGS:Women with symptoms and signs of ischemia but no significant epicard...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-020-00852-w

    authors: Barsky L,Merz CNB,Wei J,Shufelt C,Handberg E,Pepine C,Rutledge T,Reis S,Doyle M,Rogers W,Shaw L,Sopko G

    更新日期:2020-06-18 00:00:00

  • High-Intensity Interval Training in Patients with Type 2 Diabetes Mellitus: a Systematic Review.

    abstract:PURPOSE OF REVIEW:High-intensity exercise may beneficially impact on insulin sensitivity. However, there is still uncertainty on the actual impact of high-intensity interval training (HIIT) on chronic physiologic adaptations among patients with type 2 diabetes mellitus (T2DM). We aimed to systematically search and appr...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章

    doi:10.1007/s11883-019-0767-9

    authors: da Silva DE,Grande AJ,Roever L,Tse G,Liu T,Biondi-Zoccai G,de Farias JM

    更新日期:2019-02-02 00:00:00

  • Aspirin resistance in atherosclerosis.

    abstract::Clinically, aspirin resistance is defined as the failure of aspirin therapy to prevent an acute vascular thrombotic event despite regular intake of appropriate doses. In the laboratory, aspirin resistance encompasses the drug's failure to attain a particular level of platelet inhibition. From a clinical standpoint, th...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-008-0022-2

    authors: Blair P,Freedman JE

    更新日期:2008-04-01 00:00:00

  • Low-density lipoprotein apheresis in the treatment of atherosclerosis and other potential uses.

    abstract::This review concerns the clinical impact of low-density lipoprotein (LDL) apheresis for patients with refractory hypercholesterolemia. We examine and provide examples of investigations that have demonstrated the clinical benefits of LDL apheresis. In addition to benefits derived from the stabilization or regression of...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-001-0052-5

    authors: Moriarty PM,Gibson CA

    更新日期:2001-03-01 00:00:00

  • Cryptogenic stroke in patients with patent foramen ovale.

    abstract::Paradoxical embolism through a patent foramen ovale (PFO) is a commonly identified potential mechanism of ischemic stroke, especially in young patients. The recurrent stroke rate among young cryptogenic stroke patients with a PFO is modest, but higher than normal for their age. Co-existing atrial septal aneurysm is a ...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-007-0039-y

    authors: Saver JL

    更新日期:2007-10-01 00:00:00

  • A general assessment of the safety of HMG CoA reductase inhibitors (statins).

    abstract::Few principles in medicine today are as well accepted as the benefits of using statins to reduce cardiovascular risk factors and to prevent cardiovascular disease. The recent withdrawal of a statin (cerivastatin) has lead to a re-examination of all statins, and an attempt to better assess the risk-benefit ratio of thi...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-002-0060-0

    authors: Black DM

    更新日期:2002-01-01 00:00:00

  • Low-density lipoprotein reduction in high-risk patients: how low do you go?

    abstract::Cardiovascular disease and its clinical sequelae remain the leading causes of morbidity and mortality in many regions of the world. Dyslipidemia is a critical risk factor to intercept in both the primary and secondary prevention of acute cardiovascular events. The prospective, placebo-controlled clinical trials conduc...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-004-0045-2

    authors: Toth PP

    更新日期:2004-09-01 00:00:00

  • Delayed Cerebral Ischemia after Subarachnoid Hemorrhage: Beyond Vasospasm and Towards a Multifactorial Pathophysiology.

    abstract:PURPOSE OF REVIEW:Delayed cerebral ischemia (DCI) is common after subarachnoid hemorrhage (SAH) and represents a significant cause of poor functional outcome. DCI was mainly thought to be caused by cerebral vasospasm; however, recent clinical trials have been unable to confirm this hypothesis. Studies in humans and ani...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-017-0690-x

    authors: Geraghty JR,Testai FD

    更新日期:2017-10-23 00:00:00