Low-density lipoprotein apheresis in the treatment of atherosclerosis and other potential uses.

abstract：PURPOSE OF REVIEW:The goal of this manuscript is to summarize the current understanding of the secreted APOA1 binding protein (AIBP), encoded by NAXE, in angiogenesis, hematopoiesis, and inflammation. The studies on AIBP illustrate a critical connection between lipid metabolism and the aforementioned endothelial and im...

journal_title：Current atherosclerosis reports

authors： Qiu X,Luo J,Fang L

更新日期：2020-11-24 00:00:00

abstract：PURPOSE OF REVIEW:Lipoprotein apheresis is a very efficient but time-consuming and expensive method of lowering levels of low-density lipoprotein cholesterol, lipoprotein(a)) and other apoB containing lipoproteins, including triglyceride-rich lipoproteins. First introduced almost 45 years ago, it has long been a therap...

journal_title：Current atherosclerosis reports

authors： Thompson G,Parhofer KG

更新日期：2019-05-01 00:00:00

abstract：:The renin-angiotensin-aldosterone system (RAAS) is well-established and continues to be pursued as a therapeutic target in the treatment of heart failure, predominantly due to the success of agents that block RAAS in clinical trials of systolic heart failure. The optimal treatment of heart failure patients with preser...

journal_title：Current atherosclerosis reports

authors： George J,Struthers AD,Lang CC

更新日期：2014-04-01 00:00:00

abstract：:Cardiovascular disease and its clinical sequelae remain the leading causes of morbidity and mortality in many regions of the world. Dyslipidemia is a critical risk factor to intercept in both the primary and secondary prevention of acute cardiovascular events. The prospective, placebo-controlled clinical trials conduc...

journal_title：Current atherosclerosis reports

authors： Toth PP

更新日期：2004-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Delayed cerebral ischemia (DCI) is common after subarachnoid hemorrhage (SAH) and represents a significant cause of poor functional outcome. DCI was mainly thought to be caused by cerebral vasospasm; however, recent clinical trials have been unable to confirm this hypothesis. Studies in humans and ani...

journal_title：Current atherosclerosis reports

authors： Geraghty JR,Testai FD

更新日期：2017-10-23 00:00:00

abstract：:Acute coronary syndromes (ACS), such as unstable angina, acute myocardial infarction, and sudden cardiac death, are commonly associated with the presence of vulnerable plaques in coronary arteries. Rupture or erosion of vulnerable plaques results in the formation of luminal thrombi due to the physical contact between ...

journal_title：Current atherosclerosis reports

authors： Didangelos A,Simper D,Monaco C,Mayr M

更新日期：2009-05-01 00:00:00

abstract：:Understanding of the pathophysiology of atherosclerosis can provide new strategies for the prevention and treatment of patients with this common disease. Clinical, epidemiologic, and basic molecular science studies have identified oxidative stress as a factor contributing to the development and progression of atherosc...

journal_title：Current atherosclerosis reports

authors： Schulze PC,Lee RT

更新日期：2005-05-01 00:00:00

abstract：:Statin therapy has became the most important advance in stroke prevention since the introduction of aspirin and blood pressure-lowering therapies. Other lipid-modifying drugs have been less successful in reducing the incidence of stroke, but because of evidence for the use of triglyceride-lowering drugs and treatments...

journal_title：Current atherosclerosis reports

authors： Deplanque D,Amarenco P

更新日期：2011-08-01 00:00:00

abstract：:The matrix metalloproteinase (MMP) family of enzymes is involved in arterial wall extracellular matrix degradation and remodeling. The latter activities have been implicated in a number of normal and pathologic processes, such as atherosclerotic lesion formation and progression, plaque destabilization and rupture, but...

journal_title：Current atherosclerosis reports

authors： Ketelhuth DF,Bäck M

更新日期：2011-04-01 00:00:00

abstract：PURPOSE OF REVIEW:This review addresses normal and pathologic functions of serum amyloid A (SAA), an enigmatic biomarker of inflammation and protein precursor of AA amyloidosis, a life-threatening complication of chronic inflammation. SAA is a small, highly evolutionarily conserved acute-phase protein whose plasma leve...

journal_title：Current atherosclerosis reports

authors： Gursky O

更新日期：2020-09-24 00:00:00

abstract：PURPOSE OF REVIEW:This review specifically summarises and reports terrestrial mammals of the gerbil subfamily, known as Israeli sand rats or Psammomys obesus (P. obesus) as a diet-controlled, unique, polygenic rodent model for research in the areas of obesity, type 2 diabetes, and cardiovascular diseases. The animal mo...

journal_title：Current atherosclerosis reports

authors： Chaudhary R,Walder KR,Hagemeyer CE,Kanwar JR

更新日期：2018-07-17 00:00:00

abstract：:Inflammation lies at the base of endothelial dysfunction, eventually leading to plaque formation. The degree of inflammation defines the "vulnerability" of plaque to rupture. Numerous strategies have been adopted to identify and eventually treat high-risk vulnerable plaque. Lipoprotein-associated phospholipase A(2) (L...

journal_title：Current atherosclerosis reports

authors： Bhatti S,Hakeem A,Cilingiroglu M

更新日期：2010-03-01 00:00:00

abstract：:Atrial fibrillation (AF) is the most common cardiac arrhythmia in humans. One of its important features is the tendency to become more persistent over time, even in the absence of underlying progressive heart disease. Conversion and maintenance of sinus rhythm by pharmacological or electrical methods become increasing...

journal_title：Current atherosclerosis reports

authors： Piña PG,Chicos AB

更新日期：2017-01-01 00:00:00

abstract：:The rates of cardiovascular disease (CVD) have decreased significantly for men over the past few decades, but similar reductions have not occurred in women. Consequently, CVD remains the leading killer of women in the United States. Men usually develop heart disease earlier than women, but women develop heart disease ...

journal_title：Current atherosclerosis reports

authors： Lee LV,Foody JM

更新日期：2008-08-01 00:00:00

abstract：:Demonstration of a direct relationship between plasma triglyceride (TG) concentration and atherosclerosis has proven difficult due to confounding variables that accompany elevated plasma TG, such as other dyslipidemias, obesity, and type 2 diabetes. However, human genetic studies have provided evidence suggesting a ca...

journal_title：Current atherosclerosis reports

authors： Johansen CT,Hegele RA

更新日期：2012-06-01 00:00:00

abstract：:Atherosclerotic carotid artery stenosis is a major cause of disabling stroke or death. Although carotid endarterectomy (CEA) is currently considered to be the standard of care for patients with a severe symptomatic stenosis and selected patients with an asymptomatic carotid stenosis, carotid angioplasty and stenting (...

journal_title：Current atherosclerosis reports

authors： Kastrup A,Schnaudigel S,Wasser K,Gröschel K

更新日期：2008-10-01 00:00:00

abstract：:Thiazolidinediones (TZDs), which are synthetic ligands for peroxisome proliferator activated receptor g (PPARg) activation, have been introduced in clinical medicine to improve insulin resistance and glycemic control in patients with type 2 diabetes. The metabolic effects of TZDs are mediated by receptor-dependent act...

journal_title：Current atherosclerosis reports

authors： van Wijk JP,Rabelink TJ

更新日期：2005-09-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose is to review evidence on cardiovascular risks and benefits of new treatments for type 2 diabetes mellitus. RECENT FINDINGS:In response to guidance issued by the Food and Drug Administration, thousands of patients have been enrolled in large randomized trials evaluating the cardiovascular ...

journal_title：Current atherosclerosis reports

authors： Flory JH,Ukena JK,Floyd JS

更新日期：2016-12-01 00:00:00

abstract：PURPOSE OF REVIEW:We summarize recent advances in the understanding of genetic testing in familial hypercholesterolemia (FH), the use of expanded FH next-generation sequencing panels, and directions for future research. RECENT FINDINGS:The uptake of massively parallel sequencing in research and diagnostic laboratories...

journal_title：Current atherosclerosis reports

authors： Hooper AJ,Burnett JR,Bell DA,Watts GF

更新日期：2018-05-19 00:00:00

abstract：:Augmentative and alternative communication (AAC) strategies traditionally have been designed for individuals for whom oral speech is not a viable option. Common clinical practice has expanded AAC use to a tool for cognitive retraining or remediation. Although technologic developments offer the potential for vastly imp...

journal_title：Current atherosclerosis reports

authors： Ansel BM,Weinrich M

更新日期：2002-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Studies have revealed a relation between birth weight (BW) and later risk of cardiovascular diseases (CVDs). This meta-analysis aimed to report the dose-response relationship between BW and risk of CVDs. RECENT FINDINGS:The relation of BW to CVD subtypes was found to be U-shaped as BW below ~ 2500 g ...

journal_title：Current atherosclerosis reports

authors： Mohseni R,Mohammed SH,Safabakhsh M,Mohseni F,Monfared ZS,Seyyedi J,Mejareh ZN,Alizadeh S

更新日期：2020-04-23 00:00:00

abstract：PURPOSE OF REVIEW:Coronary artery disease (CAD) is a major cause of morbidity and mortality globally and poses a threat to both men and women across their lifespans. There is accumulating evidence to support that CAD may present differently in women and men, ranging from the clinical presentation, diagnosis, and manage...

journal_title：Current atherosclerosis reports

authors： Madan N,Gajo E,Sanghani RM,Volgman AS

更新日期：2020-06-23 00:00:00

abstract：:Light to moderate alcohol intake is known to have cardioprotective properties; however, the magnitude of protection depends on other factors and may be confined to some subsets of the population. This review focuses on factors that modify the relationship between alcohol and coronary heart disease (CHD). The cardiopro...

journal_title：Current atherosclerosis reports

authors： Tolstrup J,Grønbaek M

更新日期：2007-08-01 00:00:00

abstract：PURPOSE OF REVIEW:This review aims to explore the relationship between AF and carotid atherosclerosis, and the impact on the outcomes of cardiovascular and cerebrovascular events. Also, our aim is to critically review current knowledge and delineate future directions for effective treatment or prevention as well as str...

journal_title：Current atherosclerosis reports

authors： Wang Z,Korantzopoulos P,Liu T

更新日期：2019-11-29 00:00:00

abstract：:Due to typesetting mistake, an unknown image was accidentally captured as graphical abstract. This should be removed. ...

journal_title：Current atherosclerosis reports

authors： Kuo WC,Stevens JM,Ersig AL,Johnson HM,Tung TH,Bratzke LC

更新日期：2020-07-07 00:00:00

abstract：:Cancer survivorship should be defined starting not from completion of treatment, but from the time of diagnosis. Assessing and controlling the cancer patient's cardiovascular risk before, during, and after treatment is crucial to improving their overall outcome. There are many cancer therapies, including but not limit...

journal_title：Current atherosclerosis reports

authors： Chen CL

更新日期：2015-03-01 00:00:00

abstract：:Dyslipidemia is central to the process of atherosclerosis. Modification of the lipid profile by diet, exercise, or pharmacologic therapy has been demonstrated to reduce the risk from atherosclerosis in clinical studies in primary and secondary prevention. Nicotinic acid has been in clinical use for over 50 years. The ...

journal_title：Current atherosclerosis reports

authors： Farmer JA

更新日期：2009-03-01 00:00:00

abstract：PURPOSE OF REVIEW:To summarize epidemiology, pathophysiology, prognostic relevance, and treatment options of coronary artery disease (CAD) when coupled with severe aortic stenosis (SAS). In regard to treatment options, we focused on the most recently adopted therapeutic approaches and on the future perspectives in ligh...

journal_title：Current atherosclerosis reports

authors： Pepe M,Larosa C,Rosa I,Biondi-Zoccai G,Nestola PL,Di Cillo O,Bortone AS,Giordano A,Favale S

更新日期：2020-05-26 00:00:00

abstract：:There is now a consensus about recommending the Mediterranean diet pattern for the prevention of coronary heart disease (CHD) and cancer. The most important aspect of this treatment decision, in contrast with the pharmacologic prevention of CHD (including cholesterol lowering), is that the Mediterranean diet has a str...

journal_title：Current atherosclerosis reports

authors： de Lorgeril M,Salen P

更新日期：2008-12-01 00:00:00

abstract：:Injury of arterial endothelium by abnormal shear stress and other insults induces migration and proliferation of vascular smooth muscle cells (VSMCs), which in turn leads to intimal thickening, hypoxia, and vasa vasorum angiogenesis. The resultant new blood vessels extend from the tunica media into the outer intima, a...

journal_title：Current atherosclerosis reports

authors： Fong GH

更新日期：2015-06-01 00:00:00