Imaging Atherosclerotic Plaque Calcification: Translating Biology.

Abstract:

:Calcification of atherosclerotic lesions was long thought to be an age - related, passive process, but increasingly data has revealed that atherosclerotic calcification is a more active process, involving complex signaling pathways and bone-like genetic programs. Initially, imaging of atherosclerotic calcification was limited to gross assessment of calcium burden, which is associated with total atherosclerotic burden and risk of cardiovascular mortality and of all cause mortality. More recently, sophisticated molecular imaging studies of the various processes involved in calcification have begun to elucidate information about plaque calcium composition and consequent vulnerability to rupture, leading to hard cardiovascular events like myocardial infarction. As such, there has been renewed interest in imaging calcification to advance risk assessment accuracy in an evolving era of precision medicine. Here we summarize recent advances in our understanding of the biologic process of atherosclerotic calcification as well as some of the molecular imaging tools used to assess it.

journal_name

Curr Atheroscler Rep

authors

Bailey G,Meadows J,Morrison AR

doi

10.1007/s11883-016-0601-6

subject

Has Abstract

pub_date

2016-08-01 00:00:00

pages

51

issue

8

eissn

1523-3804

issn

1534-6242

pii

10.1007/s11883-016-0601-6

journal_volume

18

pub_type

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