Abstract:
:Calcification of atherosclerotic lesions was long thought to be an age - related, passive process, but increasingly data has revealed that atherosclerotic calcification is a more active process, involving complex signaling pathways and bone-like genetic programs. Initially, imaging of atherosclerotic calcification was limited to gross assessment of calcium burden, which is associated with total atherosclerotic burden and risk of cardiovascular mortality and of all cause mortality. More recently, sophisticated molecular imaging studies of the various processes involved in calcification have begun to elucidate information about plaque calcium composition and consequent vulnerability to rupture, leading to hard cardiovascular events like myocardial infarction. As such, there has been renewed interest in imaging calcification to advance risk assessment accuracy in an evolving era of precision medicine. Here we summarize recent advances in our understanding of the biologic process of atherosclerotic calcification as well as some of the molecular imaging tools used to assess it.
journal_name
Curr Atheroscler Repjournal_title
Current atherosclerosis reportsauthors
Bailey G,Meadows J,Morrison ARdoi
10.1007/s11883-016-0601-6subject
Has Abstractpub_date
2016-08-01 00:00:00pages
51issue
8eissn
1523-3804issn
1534-6242pii
10.1007/s11883-016-0601-6journal_volume
18pub_type
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