Abstract：
:Calcification of atherosclerotic lesions was long thought to be an age - related, passive process, but increasingly data has revealed that atherosclerotic calcification is a more active process, involving complex signaling pathways and bone-like genetic programs. Initially, imaging of atherosclerotic calcification was limited to gross assessment of calcium burden, which is associated with total atherosclerotic burden and risk of cardiovascular mortality and of all cause mortality. More recently, sophisticated molecular imaging studies of the various processes involved in calcification have begun to elucidate information about plaque calcium composition and consequent vulnerability to rupture, leading to hard cardiovascular events like myocardial infarction. As such, there has been renewed interest in imaging calcification to advance risk assessment accuracy in an evolving era of precision medicine. Here we summarize recent advances in our understanding of the biologic process of atherosclerotic calcification as well as some of the molecular imaging tools used to assess it.
journal_name
Curr Atheroscler Repjournal_title
Current atherosclerosis reportsauthors
Bailey G,Meadows J,Morrison ARdoi
10.1007/s11883-016-0601-6subject
Has Abstractpub_date
2016-08-01 00:00:00pages
51issue
8eissn
1523-3804issn
1534-6242pii
10.1007/s11883-016-0601-6journal_volume
18pub_type
杂志文章,评审abstract：:The acute evaluation of stroke patients has undergone dramatic advances in the recent past. The increasing availability of novel magnetic resonance imaging (MRI) techniques, such as diffusion and perfusion MRI, provides a plethora of information to clinicians evaluating patients suspected of having an acute stroke. Th...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-004-0057-y
更新日期：2004-07-01 00:00:00
abstract：:Plant foods rich in carbohydrate and dietary fiber have many health benefits. One concern often expressed about higher carbohydrate, lower fat diets is that they may increase fasting serum triglycerides. Recently the importance of hypertriglyceridemia as an independent risk factor for coronary heart disease has been r...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-000-0055-7
更新日期：2000-11-01 00:00:00
abstract：PURPOSE OF REVIEW:Perivascular adipose tissue (PVAT) has a complex, bidirectional relationship with the vascular wall. In disease states, PVAT secretes pro-inflammatory adipocytokines which may contribute to atherosclerosis. Recent evidence demonstrates that pericoronary adipose tissue (PCAT) may also function as a sen...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-019-0817-3
更新日期：2019-11-19 00:00:00
abstract：:Few principles in medicine today are as well accepted as the benefits of using statins to reduce cardiovascular risk factors and to prevent cardiovascular disease. The recent withdrawal of a statin (cerivastatin) has lead to a re-examination of all statins, and an attempt to better assess the risk-benefit ratio of thi...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-002-0060-0
更新日期：2002-01-01 00:00:00
abstract：:The ability of statins to lower serum cholesterol and reduce coronary heart disease endpoints has confirmed portions of the lipid hypothesis. However, the time to benefit and increased benefit in overlapping populations have suggested that nonlipid or pleiotropic effects of statins may be present. The apparent benefit...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-003-0066-2
更新日期：2003-01-01 00:00:00
abstract：PURPOSE OF REVIEW:In this review, we describe the mechanism behind coronary artery calcification formation and detection, as well as its implication in cardiovascular disease (CVD) risk stratification, intervention, and prognosis in asymptomatic individuals. RECENT FINDINGS:Multiple cohort and population studies have ...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-019-0812-8
更新日期：2019-11-21 00:00:00
abstract：:Transient ischemic attack (TIA) represents one end of the spectrum of focal brain ischemia, the other being completed infarction or ischemic stroke. The evolving technologic advancements in neuroimaging continue to change and sharpen the definition, epidemiology, and management of TIA. As a powerful risk factor for is...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-005-0019-z
更新日期：2005-07-01 00:00:00
abstract：PURPOSE OF REVIEW:Thoracic radiation therapy is an effective treatment for several malignancies, such as Hodgkin's lymphoma and breast cancer. Over the years, however, the incidence of cardiovascular events has increased in these patients, notably in younger survivors who do not have traditional risk factors. This revi...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-017-0658-x
更新日期：2017-05-01 00:00:00
abstract：:Spontaneous intracerebral hemorrhage (ICH) is a devastating disease with high morbidity and mortality. Acutely, ICH is associated with a sudden surge in intracranial pressure (ICP), as the volume of hematoma increases the pressure in the closed head, leading to non-specific symptoms of ICP: headache, nausea, vomiting,...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-012-0251-2
更新日期：2012-08-01 00:00:00
abstract：:Preliminary evidence demonstrating that adding 0.5 mg of colchicine per day to statin and antiplatelet therapy reduced the risk of acute coronary events in patients with stable coronary artery disease has raised the hope that it may prove effective for the long-term secondary prevention of cardiovascular disease. The ...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-013-0391-z
更新日期：2014-03-01 00:00:00
abstract：:Exaggerated postprandial hypertriglyceridemia is a risk factor for cardiovascular disease. This metabolic abnormality is principally due to overproduction and/or decreased catabolism of triglyceride-rich lipoproteins (TRLs) and is a consequence of pathogenic genetic variations and other coexistent medical conditions, ...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-013-0309-9
更新日期：2013-03-01 00:00:00
abstract：PURPOSE OF THE REVIEW:Rheumatoid arthritis (RA) is a chronic, autoimmune disease which may result in a higher risk of cardiovascular (CV) events and stroke. Tissue characterization and risk stratification of patients with rheumatoid arthritis are a challenging problem. Risk stratification of RA patients using tradition...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-019-0766-x
更新日期：2019-01-25 00:00:00
abstract：:The renin-angiotensin-aldosterone system (RAAS) is well-established and continues to be pursued as a therapeutic target in the treatment of heart failure, predominantly due to the success of agents that block RAAS in clinical trials of systolic heart failure. The optimal treatment of heart failure patients with preser...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-014-0403-7
更新日期：2014-04-01 00:00:00
abstract：:Several studies confirm cognitive impairment and dementia to be increased after stroke in the elderly. Although not necessarily involving memory deficits, the frequency of cognitive impairments may occur in up to 30% of stroke survivors at 3 months. This impairment may be confounded by preexisting cognitive decline or...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-001-0028-5
更新日期：2001-07-01 00:00:00
abstract：:Injury of arterial endothelium by abnormal shear stress and other insults induces migration and proliferation of vascular smooth muscle cells (VSMCs), which in turn leads to intimal thickening, hypoxia, and vasa vasorum angiogenesis. The resultant new blood vessels extend from the tunica media into the outer intima, a...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-015-0510-0
更新日期：2015-06-01 00:00:00
abstract：:We briefly and comprehensively present some of the novel findings in the field of revascularization therapy and management of ST-segment-elevation myocardial infarction (STEMI). We highlight the latest evidence-based advancements in the pharmacological and mechanical treatment of patients who presented with STEMI. Sin...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-014-0412-6
更新日期：2014-06-01 00:00:00
abstract：:Abdominal aortic aneurysms (AAAs) are a common but asymptomatic disease that has high susceptibility to rupture. Current therapeutic options are limited to surgical procedures because no pharmacological approaches have been proven to decrease either expansion or rupture of human AAAs. The current dearth of effective m...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-012-0271-y
更新日期：2012-10-01 00:00:00
abstract：:Recent studies confirm and extend previous evidence that lipoprotein (Lp) plays a significant role in atherosclerosis and is one of the top five or six risk factors for cardiovascular disease. In Japanese patients, Lp levels and apo phenotypes are significant predictors for myocardial infarction. Lp levels are signifi...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-000-0026-z
更新日期：2000-05-01 00:00:00
abstract：:Lipoprotein apheresis is an extracorporeal therapy whereby apo B-containing lipoproteins (LDL, vLDL, and Lp(a)) are selectively removed from the plasma of a patient. It is a variation of plasma exchange, which non-selectively removes all plasma proteins. Lipoprotein apheresis is most commonly used to treat patients wi...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-015-0516-7
更新日期：2015-07-01 00:00:00
abstract：PURPOSE OF REVIEW:We aimed to summarize recent guidelines, position papers, and high-quality clinical research relating the use of nutraceuticals in the management of individuals at high risk of atherosclerotic cardiovascular disease. RECENT FINDINGS:It is essential that individuals at high risk of cardiovascular dise...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-020-00887-z
更新日期：2020-09-18 00:00:00
abstract：:Stroke is the second leading cause of mortality world-wide and is well suited for prevention because it has a high prevalence, high burden of economic cost, well-defined modifiable risk factors, and effective prevention measures. Atherosclerosis is one of the major mechanisms of ischemic stroke, but the apparent diffe...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-006-0012-1
更新日期：2006-07-01 00:00:00
abstract：:Atrial fibrillation (AF) is a significant etiologic cause of acute ischemic stroke (AIS) that leads to disabling deficits as well as significant morbidity and mortality in this population. Approximately 25 % of AIS is considered to be cryptogenic with no etiology ascertained at the time of the index event. Recent adva...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-015-0544-3
更新日期：2015-12-01 00:00:00
abstract：:Pharmacotherapies with agents that inhibit platelet function have proven to be effective in the treatment of acute coronary syndromes, and in the prevention of complications during and after percutaneous coronary intervention. Because of multiple synergetic pathways of platelet activation and their close interplay wit...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-013-0371-3
更新日期：2013-12-01 00:00:00
abstract：PURPOSE OF REVIEW:Delayed cerebral ischemia (DCI) is common after subarachnoid hemorrhage (SAH) and represents a significant cause of poor functional outcome. DCI was mainly thought to be caused by cerebral vasospasm; however, recent clinical trials have been unable to confirm this hypothesis. Studies in humans and ani...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-017-0690-x
更新日期：2017-10-23 00:00:00
abstract：:Aspirin remains one of the most extensively studied cardiovascular medications in the history of medicine. However, despite multiple, well-designed, large randomized controlled trials evaluating the potential of aspirin to prevent cardiovascular events in individuals without known cardiovascular disease (CVD), the rol...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-015-0555-0
更新日期：2016-01-01 00:00:00
abstract：:Approximately one third of ischemic strokes are labeled cryptogenic because the etiology is unknown despite a thorough evaluation. Paroxysmal atrial fibrillation carries the same risk of ischemic stroke as persistent atrial fibrillation and has increasingly gained attention as a potential source of cryptogenic stroke....
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-015-0547-0
更新日期：2015-12-01 00:00:00
abstract：:Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is a calcium-independent phospholipase A(2) enzyme secreted by leukocytes and associated with circulating low-density lipoprotein and macrophages in atherosclerotic plaques. Until recently, the biological role of Lp-PLA(2) in atherosclerosis was controversial, but ...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-009-0076-9
更新日期：2010-01-01 00:00:00
abstract：:Diabetes and its micro- and macrovascular complications represent a worldwide epidemic that will place an enormous financial burden on poorer countries in the years to come. In patients with diabetes and hypertension, the main determinant of the cardiovascular and renal benefits of antihypertensive drugs is the blood ...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-011-0160-9
更新日期：2011-04-01 00:00:00
abstract：PURPOSE OF REVIEW:We summarize recent advances in the understanding of genetic testing in familial hypercholesterolemia (FH), the use of expanded FH next-generation sequencing panels, and directions for future research. RECENT FINDINGS:The uptake of massively parallel sequencing in research and diagnostic laboratories...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-018-0731-0
更新日期：2018-05-19 00:00:00
abstract：PURPOSE OF REVIEW:This review aims to explore the relationship between AF and carotid atherosclerosis, and the impact on the outcomes of cardiovascular and cerebrovascular events. Also, our aim is to critically review current knowledge and delineate future directions for effective treatment or prevention as well as str...
journal_title：Current atherosclerosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11883-019-0808-4
更新日期：2019-11-29 00:00:00
