Abstract:
:Atrial fibrillation (AF) is a significant etiologic cause of acute ischemic stroke (AIS) that leads to disabling deficits as well as significant morbidity and mortality in this population. Approximately 25 % of AIS is considered to be cryptogenic with no etiology ascertained at the time of the index event. Recent advances from the EMBRACE and CRYSTAL-AF trial have improved detection and treatment of AF and subsequently lead to changes in guidelines. However, with improved detection rates, the duration and frequency cutoffs for treating AF are currently being investigated to ensure optimization of patient selection and subsequent treatment.
journal_name
Curr Atheroscler Repjournal_title
Current atherosclerosis reportsauthors
Sangha RS,Bernstein Rdoi
10.1007/s11883-015-0544-3subject
Has Abstractpub_date
2015-12-01 00:00:00pages
71issue
12eissn
1523-3804issn
1534-6242pii
10.1007/s11883-015-0544-3journal_volume
17pub_type
杂志文章,评审abstract:PURPOSE OF REVIEW:High-intensity exercise may beneficially impact on insulin sensitivity. However, there is still uncertainty on the actual impact of high-intensity interval training (HIIT) on chronic physiologic adaptations among patients with type 2 diabetes mellitus (T2DM). We aimed to systematically search and appr...
journal_title:Current atherosclerosis reports
pub_type: 杂志文章
doi:10.1007/s11883-019-0767-9
更新日期:2019-02-02 00:00:00
abstract::Approximately one third of ischemic strokes are labeled cryptogenic because the etiology is unknown despite a thorough evaluation. Paroxysmal atrial fibrillation carries the same risk of ischemic stroke as persistent atrial fibrillation and has increasingly gained attention as a potential source of cryptogenic stroke....
journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11883-015-0547-0
更新日期:2015-12-01 00:00:00
abstract::The acute evaluation of stroke patients has undergone dramatic advances in the recent past. The increasing availability of novel magnetic resonance imaging (MRI) techniques, such as diffusion and perfusion MRI, provides a plethora of information to clinicians evaluating patients suspected of having an acute stroke. Th...
journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11883-004-0057-y
更新日期:2004-07-01 00:00:00
abstract::Atherothrombosis remains a major cause of morbidity and mortality in the western world. The underlying processes associated with clinical expression of atherothrombosis include oxidative stress and proteolysis in relation to neovascularisation and intraplaque hemorrhages, leading to immuno-inflammatory response, cell ...
journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11883-010-0102-y
更新日期:2010-05-01 00:00:00
abstract::Lipodystrophies are a group of heterogeneous diseases characterized by the loss of adipose tissue and by abnormalities of carbohydrate and lipid metabolism, including insulin resistance, diabetes, and hyperlipidemia. In this review, we describe several mouse models that recapitulate various aspects of the lipodystroph...
journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11883-000-0077-1
更新日期:2000-09-01 00:00:00
abstract::The effects of cis-monounsaturated fatty acids (cis-MUFAs) on the risk of coronary heart disease (CHD) and on CHD mortality are not clear. Also, dietary recommendations for cis-MUFA as derived by various organizations are not in agreement. Earlier studies have mainly focused on the effects of cis-MUFA on serum lipids ...
journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11883-016-0597-y
更新日期:2016-07-01 00:00:00
abstract::Stroke is a common and disabling condition. Intravenous tissue plasminogen activator (tPA) administered within 3 h of symptom onset is the standard therapy for eligible patients with acute ischemic stroke. Unfortunately, because of the time limitation, very few patients with ischemic stroke actually receive this treat...
journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11883-010-0121-8
更新日期:2010-09-01 00:00:00
abstract:PURPOSE OF REVIEW:In this review, we describe the mechanism behind coronary artery calcification formation and detection, as well as its implication in cardiovascular disease (CVD) risk stratification, intervention, and prognosis in asymptomatic individuals. RECENT FINDINGS:Multiple cohort and population studies have ...
journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11883-019-0812-8
更新日期:2019-11-21 00:00:00
abstract::Abdominal aortic aneurysms (AAA) are permanent dilations in the infra-renal area in which the arterial tissue is characterized by inflammation and medial degeneration. AAAs are a common vascular disorder and cause significant mortality in the aged population. Despite the high prevalence of this disease, there is limit...
journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11883-002-0023-5
更新日期:2002-05-01 00:00:00
abstract::The High-Risk Plaque (HRP) Initiative is a research and development effort to advance the understanding, recognition, and management of asymptomatic individuals at risk for a near-term atherothrombotic event such as myocardial infarction or stroke. Clinical studies using the newest technologies have been initiated, in...
journal_title:Current atherosclerosis reports
pub_type: 杂志文章,随机对照试验
doi:10.1007/s11883-011-0193-0
更新日期:2011-10-01 00:00:00
abstract::We briefly and comprehensively present some of the novel findings in the field of revascularization therapy and management of ST-segment-elevation myocardial infarction (STEMI). We highlight the latest evidence-based advancements in the pharmacological and mechanical treatment of patients who presented with STEMI. Sin...
journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11883-014-0412-6
更新日期:2014-06-01 00:00:00
abstract::Atherothrombotic cardiovascular events are a leading cause of morbidity and mortality in patients with type 2 diabetes (T2D). A number of factors beyond hyperglycemia contribute to this increased risk of cardiovascular events in T2D, including elevated blood pressure, dyslipidemia, inflammation, endothelial dysfunctio...
journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11883-014-0408-2
更新日期:2014-05-01 00:00:00
abstract::Most clinical trials on antioxidants using vitamin E or beta-carotene have failed to note any significant change in cardiovascular endpoints. The results of these studies have been interpreted as a setback for the oxidation hypothesis. An analysis of the hypothesis and the trials, however, points out major misconcepti...
journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11883-001-0077-9
更新日期:2001-09-01 00:00:00
abstract::ᅟ: Chronic total occlusions (CTOs) are an important and increasingly recognized subgroup of coronary lesions, documented in at least 30%, but up to 52% of patients with coronary artery disease (CAD) undergoing coronary angiography. Percutaneous coronary intervention (PCI) of these lesions is increasingly pursued, with...
journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11883-018-0760-8
更新日期:2018-11-07 00:00:00
abstract:PURPOSE OF REVIEW:Thoracic radiation therapy is an effective treatment for several malignancies, such as Hodgkin's lymphoma and breast cancer. Over the years, however, the incidence of cardiovascular events has increased in these patients, notably in younger survivors who do not have traditional risk factors. This revi...
journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11883-017-0658-x
更新日期:2017-05-01 00:00:00
abstract::Daily lifestyle practices and habits profoundly affect the likelihood of developing cardiovascular disease (CVD). Abundant research and multiple recent consensus documents support the role of regular physical activity, not smoking cigarettes, maintaining a healthy body weight, controlling cholesterol levels, and contr...
journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11883-014-0444-y
更新日期:2014-10-01 00:00:00
abstract::Effective prevention of the current annual $400 billion losses from atherosclerosis and cardiovascular disease (CVD) will require preventing primary causes rather than just decreasing signs and symptoms (risk factors) produced by those causes. All CVD risk factors predict a likelihood of CVD, but not all are causes of...
journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11883-009-0042-6
更新日期:2009-07-01 00:00:00
abstract::More than half of the men and women in the United States are overweight or obese. Obesity is associated with an increased risk for various diseases, most notably, hypertension, diabetes mellitus, dyslipidemia, and coronary heart disease (CHD). The location of excessive body fat, particularly in the visceral area, has ...
journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11883-000-0065-5
更新日期:2000-07-01 00:00:00
abstract::Since initial reports of its association with ischemic stroke appeared in 1988, there has been continued controversy regarding the existence and strength of the association between patent foramen ovale (PFO) and ischemic stroke. Many case-control studies have reported an association between incident cryptogenic ischem...
journal_title:Current atherosclerosis reports
pub_type: 杂志文章
doi:10.1007/s11883-010-0114-7
更新日期:2010-07-01 00:00:00
abstract::Atherosclerosis remains the major cause of morbidity and mortality in Western countries. Atherothrombotic complications, including vascular occlusions and severe narrowing of nutrient blood vessels in the cerebral, coronary, or peripheral circulation, usually require invasive revascularization strategies. As molecular...
journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11883-003-0022-1
更新日期:2003-05-01 00:00:00
abstract::Angioplasty and stenting for intracranial atherosclerotic stenosis (ICAS) are a last resort for patients with high-grade intracranial stenosis with multiple ischemic events unresponsive to medical therapy. Medical management, consisting of aggressive risk factor control and dual antiplatelet therapy, is superior to an...
journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11883-015-0527-4
更新日期:2015-08-01 00:00:00
abstract::Calcification of atherosclerotic lesions was long thought to be an age - related, passive process, but increasingly data has revealed that atherosclerotic calcification is a more active process, involving complex signaling pathways and bone-like genetic programs. Initially, imaging of atherosclerotic calcification was...
journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11883-016-0601-6
更新日期:2016-08-01 00:00:00
abstract::The original version of this article contains errors in Table 3. "At least 1 project/publication in the year" and "> 1 publication per year" have been switched under the titles of "Clinical Track" and "Physician-Scientist track". ...
journal_title:Current atherosclerosis reports
pub_type: 杂志文章,已发布勘误
doi:10.1007/s11883-018-0743-9
更新日期:2018-06-19 00:00:00
abstract:PURPOSE OF REVIEW:Coronary artery no-reflow phenomenon is an incidental outcome of percutaneous coronary intervention in patients presenting with acute myocardial infarction. Despite advances in pharmacologic and non-pharmacologic therapies, coronary no-reflow phenomenon occurs more commonly than desired. It often resu...
journal_title:Current atherosclerosis reports
pub_type: 杂志文章
doi:10.1007/s11883-018-0747-5
更新日期:2018-07-05 00:00:00
abstract::Inflammation and oxidative processes are key components of atherosclerosis, from fatty streak formation to plaque rupture and thrombosis. Recent basic and clinical studies have identified a number of inflammatory and oxidative processes that appear to play a direct role in atherothrombosis and identify potentially cli...
journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11883-004-0038-1
更新日期:2004-05-01 00:00:00
abstract::Atherosclerotic carotid artery stenosis is a major cause of disabling stroke or death. Although carotid endarterectomy (CEA) is currently considered to be the standard of care for patients with a severe symptomatic stenosis and selected patients with an asymptomatic carotid stenosis, carotid angioplasty and stenting (...
journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11883-008-0061-8
更新日期:2008-10-01 00:00:00
abstract::Light to moderate alcohol intake is known to have cardioprotective properties; however, the magnitude of protection depends on other factors and may be confined to some subsets of the population. This review focuses on factors that modify the relationship between alcohol and coronary heart disease (CHD). The cardiopro...
journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11883-007-0007-6
更新日期:2007-08-01 00:00:00
abstract::Clinically, aspirin resistance is defined as the failure of aspirin therapy to prevent an acute vascular thrombotic event despite regular intake of appropriate doses. In the laboratory, aspirin resistance encompasses the drug's failure to attain a particular level of platelet inhibition. From a clinical standpoint, th...
journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11883-008-0022-2
更新日期:2008-04-01 00:00:00
abstract:PURPOSE OF REVIEW:Perivascular adipose tissue (PVAT) has a complex, bidirectional relationship with the vascular wall. In disease states, PVAT secretes pro-inflammatory adipocytokines which may contribute to atherosclerosis. Recent evidence demonstrates that pericoronary adipose tissue (PCAT) may also function as a sen...
journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11883-019-0817-3
更新日期:2019-11-19 00:00:00
abstract:PURPOSE OF REVIEW:Non-alcoholic fatty liver disease (NAFLD) is frequently associated with obesity and overweight. It has a broad spectrum of clinical and histological presentations, such as steatosis, inflammation (known as non-alcoholic steatohepatitis or NASH), fibrosis, and cirrhosis. There is increasing evidence th...
journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11883-017-0681-y
更新日期:2017-10-07 00:00:00