Impact of circulating esterified eicosanoids and other oxylipins on endothelial function.

abstract：:The development of multiple diagnostic intracoronary imaging modalities has increased our understanding of coronary atherosclerotic disease. These imaging modalities, intravascular ultrasound (IVUS), optical coherence tomography (OCT), and near-infrared spectroscopy (NIRS), have provided a method to study plaques and ...

journal_title：Current atherosclerosis reports

authors： Hoang V,Grounds J,Pham D,Virani S,Hamzeh I,Qureshi AM,Lakkis N,Alam M

更新日期：2016-09-01 00:00:00

abstract：:Lipid-lowering medications, particularly statins, have been a popular target for pharmacogenetic studies. A handful of genes have shown promise for predicting response to therapy from the perspective of lipid lowering, as well as myopathy. A number of genes have been implicated and have biological plausibility based o...

journal_title：Current atherosclerosis reports

authors： Alfonsi JE,Hegele RA,Gryn SE

更新日期：2016-05-01 00:00:00

abstract：:There are hundreds of foods, nutrients, herbs, and botanicals that have "bioactive" constituents with potential human health benefits. Three of these are discussed in this review: soy, garlic, and ginkgo biloba. Each of these three choices involves an ingestible item composed of a complex mixture of bioactive agents. ...

journal_title：Current atherosclerosis reports

authors： Gardner CD,Messina M,Lawson LD,Farquhar JW

更新日期：2003-11-01 00:00:00

abstract：:A recently developed assay for quantification of remnant-like particle cholesterol has provided considerable evidence that reinforces the concept that elevated levels of plasma remnants are associated with increased cardiovascular disease in different populations and distinct patient groups. In this review, we provide...

journal_title：Current atherosclerosis reports

authors： Twickler T,Dallinga-Thie GM,Chapman MJ,Cohn JS

更新日期：2005-03-01 00:00:00

abstract：:The renin-angiotensin-aldosterone system (RAAS) is well-established and continues to be pursued as a therapeutic target in the treatment of heart failure, predominantly due to the success of agents that block RAAS in clinical trials of systolic heart failure. The optimal treatment of heart failure patients with preser...

journal_title：Current atherosclerosis reports

authors： George J,Struthers AD,Lang CC

更新日期：2014-04-01 00:00:00

abstract：:Due to typesetting mistake, an unknown image was accidentally captured as graphical abstract. This should be removed. ...

journal_title：Current atherosclerosis reports

authors： Kuo WC,Stevens JM,Ersig AL,Johnson HM,Tung TH,Bratzke LC

更新日期：2020-07-07 00:00:00

abstract：:The liver X receptors (LXRs) are ligand-activated transcription factors belonging to the nuclear hormone receptor superfamily. Since their initial identification more than a decade ago, LXRs have been characterized as key transcriptional regulators of lipid and carbohydrate homeostasis. LXRs are activated by the intra...

journal_title：Current atherosclerosis reports

authors： Nomiyama T,Bruemmer D

更新日期：2008-02-01 00:00:00

abstract：PURPOSE OF REVIEW:This review specifically summarises and reports terrestrial mammals of the gerbil subfamily, known as Israeli sand rats or Psammomys obesus (P. obesus) as a diet-controlled, unique, polygenic rodent model for research in the areas of obesity, type 2 diabetes, and cardiovascular diseases. The animal mo...

journal_title：Current atherosclerosis reports

authors： Chaudhary R,Walder KR,Hagemeyer CE,Kanwar JR

更新日期：2018-07-17 00:00:00

abstract：:Despite the recent decline in mortality from coronary heart disease (CHD), this disease remains the leading killer of US adults of all ages. CHD in young adults is not as well characterized as CHD in older individuals because it occurs less frequently, but this disease can have devastating consequences for young patie...

journal_title：Current atherosclerosis reports

authors： Rubin JB,Borden WB

更新日期：2012-04-01 00:00:00

abstract：:Recently reported clinical trials raise doubts on the effectiveness of nonstatin lipid-lowering therapies in reducing the residual risk of cardiovascular events after statin monotherapy. Addition of -torcetrapib to statin therapy increased overall mortality in coronary patients despite a marked increase in high-densit...

journal_title：Current atherosclerosis reports

authors： Ansell BJ

更新日期：2009-01-01 00:00:00

abstract：:Plant-derived alpha-linolenic acid has been studied in a limited number of investigations. So far, some epidemiologic and a few mechanistic studies suggest a potential of protection from cardiovascular disease, but this potential remains to be proven in intervention studies. In contrast, eicosapentaenoic acid (EPA) an...

journal_title：Current atherosclerosis reports

authors： von Schacky C

更新日期：2003-03-01 00:00:00

abstract：:Serum cholesterol traditionally has been considered a poor predictor of total stroke risk; however, it is associated positively with ischemic stroke risk and associated negatively with hemorrhagic stroke risk. Although studies failed to demonstrate stroke reduction using older cholesterol-lowering medications, recent ...

journal_title：Current atherosclerosis reports

authors： Ansell BJ

更新日期：2000-03-01 00:00:00

abstract：:Aspirin remains one of the most extensively studied cardiovascular medications in the history of medicine. However, despite multiple, well-designed, large randomized controlled trials evaluating the potential of aspirin to prevent cardiovascular events in individuals without known cardiovascular disease (CVD), the rol...

journal_title：Current atherosclerosis reports

authors： Miedema MD,Huguelet J,Virani SS

更新日期：2016-01-01 00:00:00

abstract：:More than half of the men and women in the United States are overweight or obese. Obesity is associated with an increased risk for various diseases, most notably, hypertension, diabetes mellitus, dyslipidemia, and coronary heart disease (CHD). The location of excessive body fat, particularly in the visceral area, has ...

journal_title：Current atherosclerosis reports

authors： Jones PH

更新日期：2000-07-01 00:00:00

abstract：:The ability of high-density lipoprotein (HDL) to promote cholesterol efflux is an important component of its ability to protect against cardiovascular disease. In addition, the anti-inflammatory properties of HDL are important as well. As part of the innate immune system, HDL appears to have evolved to increase inflam...

journal_title：Current atherosclerosis reports

authors： Navab M,Yu R,Gharavi N,Huang W,Ezra N,Lotfizadeh A,Anantharamaiah GM,Alipour N,Van Lenten BJ,Reddy ST,Marelli D

更新日期：2007-09-01 00:00:00

abstract：:Several studies confirm cognitive impairment and dementia to be increased after stroke in the elderly. Although not necessarily involving memory deficits, the frequency of cognitive impairments may occur in up to 30% of stroke survivors at 3 months. This impairment may be confounded by preexisting cognitive decline or...

journal_title：Current atherosclerosis reports

authors： Kalaria RN,Ballard C

更新日期：2001-07-01 00:00:00

abstract：:Preliminary evidence demonstrating that adding 0.5 mg of colchicine per day to statin and antiplatelet therapy reduced the risk of acute coronary events in patients with stable coronary artery disease has raised the hope that it may prove effective for the long-term secondary prevention of cardiovascular disease. The ...

journal_title：Current atherosclerosis reports

authors： Nidorf SM,Eikelboom JW,Thompson PL

更新日期：2014-03-01 00:00:00

abstract：:There has been increasing interest in the health benefits of supplemental and/or dietary omega-3 polyunsaturated fatty acids (PUFAs), particularly in their role in disease prevention. This interest escalated once their effects on cardiovascular health were observed from numerous observational studies in populations wh...

journal_title：Current atherosclerosis reports

authors： Fares H,Lavie CJ,DiNicolantonio JJ,O'Keefe JH,Milani RV

更新日期：2014-02-01 00:00:00

abstract：PURPOSE OF REVIEW:We summarize recent advances in the understanding of genetic testing in familial hypercholesterolemia (FH), the use of expanded FH next-generation sequencing panels, and directions for future research. RECENT FINDINGS:The uptake of massively parallel sequencing in research and diagnostic laboratories...

journal_title：Current atherosclerosis reports

authors： Hooper AJ,Burnett JR,Bell DA,Watts GF

更新日期：2018-05-19 00:00:00

abstract：PURPOSE OF REVIEW:We will review the available data on the epidemiology, pathophysiology, diagnosis, and management of microvascular coronary dysfunction (MCD). RECENT FINDINGS:The study of MCD was pioneered by the Women's Ischemia Syndrome Evaluation (WISE) cohort. New techniques in the diagnosis of this condition, u...

journal_title：Current atherosclerosis reports

authors： Naderi S

更新日期：2018-01-30 00:00:00

abstract：PURPOSE OF REVIEW:Acute stroke is a treatable disease. Nevertheless, only a minority of patients obtain guideline-adjusted therapy. One major reason is the small time window in which therapies have to be administered in order to reverse or mitigate brain injury and prevent disability. The Mobile Stroke Unit (MSU) conce...

journal_title：Current atherosclerosis reports

authors： Walter S,Grunwald IQ,Helwig SA,Ragoschke-Schumm A,Kettner M,Fousse M,Lesmeister M,Fassbender K

更新日期：2018-08-29 00:00:00

abstract：:Raised plasma triglyceride (TG) levels are an independent risk factor for coronary artery disease (CAD), and thus understanding the genetic and environmental determinants of TG levels are of major importance. TG metabolism is a process for delivering free fatty acids for energy storage or b-oxidation, and involves a n...

journal_title：Current atherosclerosis reports

authors： Talmud PJ

更新日期：2001-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Despite the important progress in identifying high-risk atherosclerotic plaques, many key elements are elusive. Advanced imaging modalities provide valuable information about the anatomic and functional plaque characteristics and underscore the presence of multiple plaque morphologies. However, how th...

journal_title：Current atherosclerosis reports

authors： Zaromytidou M,Antoniadis AP,Siasos G,Coskun AU,Andreou I,Papafaklis MI,Lucier M,Feldman CL,Stone PH

更新日期：2016-12-01 00:00:00

abstract：:Most clinical trials on antioxidants using vitamin E or beta-carotene have failed to note any significant change in cardiovascular endpoints. The results of these studies have been interpreted as a setback for the oxidation hypothesis. An analysis of the hypothesis and the trials, however, points out major misconcepti...

journal_title：Current atherosclerosis reports

authors： Parthasarathy S,Khan-Merchant N,Penumetcha M,Khan BV,Santanam N

更新日期：2001-09-01 00:00:00

abstract：PURPOSE OF REVIEW:High-intensity exercise may beneficially impact on insulin sensitivity. However, there is still uncertainty on the actual impact of high-intensity interval training (HIIT) on chronic physiologic adaptations among patients with type 2 diabetes mellitus (T2DM). We aimed to systematically search and appr...

journal_title：Current atherosclerosis reports

authors： da Silva DE,Grande AJ,Roever L,Tse G,Liu T,Biondi-Zoccai G,de Farias JM

更新日期：2019-02-02 00:00:00

abstract：:Few principles in medicine today are as well accepted as the benefits of using statins to reduce cardiovascular risk factors and to prevent cardiovascular disease. The recent withdrawal of a statin (cerivastatin) has lead to a re-examination of all statins, and an attempt to better assess the risk-benefit ratio of thi...

journal_title：Current atherosclerosis reports

authors： Black DM

更新日期：2002-01-01 00:00:00

abstract：:Erectile dysfunction (ED) is a common problem in the United States, with estimates that 30 million men suffer with some degree of ED. Although causes include psychogenic, organic, and mixed forms, in middle-aged and older men one of the most common causes is vascular disease. Endothelial dysfunction, even without defi...

journal_title：Current atherosclerosis reports

authors： Kloner RA,Speakman M

更新日期：2002-09-01 00:00:00

abstract：:The original version of this article contains errors in Table 3. "At least 1 project/publication in the year" and "> 1 publication per year" have been switched under the titles of "Clinical Track" and "Physician-Scientist track". ...

journal_title：Current atherosclerosis reports

authors： Saeed A,Dabhadkar K,Virani SS,Jones PH,Ballantyne CM,Nambi V

更新日期：2018-06-19 00:00:00

abstract：:With each passing year, the evidence linking an increased risk for coronary heart disease (CHD) death with a chronic dietary deficiency in long-chain omega-3 (n-3) fatty acids (FAs) grows stronger. Recently, a federally mandated evidence-based review in the United States concluded that n-3 FAs, especially eicosapentae...

journal_title：Current atherosclerosis reports

authors： Harris WS

更新日期：2004-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The use of recreational drugs has increased globally, with the most commonly used recreational drug being cannabis. As of 2019, 10 states and the District of Columbia have legalized cannabis for recreational use, with more states potentially joining this movement. With the increased legalization of ca...

journal_title：Current atherosclerosis reports

authors： Ghosh M,Naderi S

更新日期：2019-04-12 00:00:00