Abstract:
:With each passing year, the evidence linking an increased risk for coronary heart disease (CHD) death with a chronic dietary deficiency in long-chain omega-3 (n-3) fatty acids (FAs) grows stronger. Recently, a federally mandated evidence-based review in the United States concluded that n-3 FAs, especially eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have clear cardioprotective effects, and national and international expert panels and health organizations have begun to call for increased EPA and DHA intakes. Consumption of between 450 and 1000 mg/d is recommended for those without and with known CHD, respectively. Based on animal and isolated cell studies, these FAs were presumed to have antiarrhythmic effects. The first direct evidence for this in humans was recently published, as were new data linking low n-3 FA intakes with risk for developing atrial fibrillation. The strength of the n-3 story has now led to a proposal that blood levels of EPA plus DHA be considered a new, modifiable, and clinically relevant risk factor for death from CHD.
journal_name
Curr Atheroscler Repjournal_title
Current atherosclerosis reportsauthors
Harris WSdoi
10.1007/s11883-004-0085-7keywords:
subject
Has Abstractpub_date
2004-11-01 00:00:00pages
447-52issue
6eissn
1523-3804issn
1534-6242journal_volume
6pub_type
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更新日期:2014-04-01 00:00:00
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更新日期:2005-09-01 00:00:00
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更新日期:2016-05-01 00:00:00
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更新日期:2020-11-24 00:00:00