Benefits and hazards of dietary carbohydrate.

abstract：:The acute evaluation of stroke patients has undergone dramatic advances in the recent past. The increasing availability of novel magnetic resonance imaging (MRI) techniques, such as diffusion and perfusion MRI, provides a plethora of information to clinicians evaluating patients suspected of having an acute stroke. Th...

journal_title：Current atherosclerosis reports

authors： Duong TQ,Fisher M

更新日期：2004-07-01 00:00:00

abstract：PURPOSE OF REVIEW:We will review the available data on the epidemiology, pathophysiology, diagnosis, and management of microvascular coronary dysfunction (MCD). RECENT FINDINGS:The study of MCD was pioneered by the Women's Ischemia Syndrome Evaluation (WISE) cohort. New techniques in the diagnosis of this condition, u...

journal_title：Current atherosclerosis reports

authors： Naderi S

更新日期：2018-01-30 00:00:00

abstract：:Lipodystrophies are a group of heterogeneous diseases characterized by the loss of adipose tissue and by abnormalities of carbohydrate and lipid metabolism, including insulin resistance, diabetes, and hyperlipidemia. In this review, we describe several mouse models that recapitulate various aspects of the lipodystroph...

journal_title：Current atherosclerosis reports

authors： Reue K,Péterfy M

更新日期：2000-09-01 00:00:00

abstract：:Lipid-lowering medications, particularly statins, have been a popular target for pharmacogenetic studies. A handful of genes have shown promise for predicting response to therapy from the perspective of lipid lowering, as well as myopathy. A number of genes have been implicated and have biological plausibility based o...

journal_title：Current atherosclerosis reports

authors： Alfonsi JE,Hegele RA,Gryn SE

更新日期：2016-05-01 00:00:00

abstract：:Outcomes from recent lipid-lowering trials have led to an update of the third Report of the National Cholesterol Education Program (NCEP) Adult Treatment Panel's guidelines for treatment of hypercholesterolemia in adults. The updated NCEP guidelines now offer an optional goal of low-density lipoprotein (LDL) cholester...

journal_title：Current atherosclerosis reports

authors： Sabharwal AK,Boord JB

更新日期：2006-01-01 00:00:00

abstract：:A recently developed assay for quantification of remnant-like particle cholesterol has provided considerable evidence that reinforces the concept that elevated levels of plasma remnants are associated with increased cardiovascular disease in different populations and distinct patient groups. In this review, we provide...

journal_title：Current atherosclerosis reports

authors： Twickler T,Dallinga-Thie GM,Chapman MJ,Cohn JS

更新日期：2005-03-01 00:00:00

abstract：:Clinically, aspirin resistance is defined as the failure of aspirin therapy to prevent an acute vascular thrombotic event despite regular intake of appropriate doses. In the laboratory, aspirin resistance encompasses the drug's failure to attain a particular level of platelet inhibition. From a clinical standpoint, th...

journal_title：Current atherosclerosis reports

authors： Blair P,Freedman JE

更新日期：2008-04-01 00:00:00

abstract：:Peroxisome proliferator-activated receptors (PPARs) are the key transcription factors regulating lipid metabolism and energy homeostasis. PPARalpha and PPARgamma are known therapeutic targets for hypertriglyceridemia and type 2 diabetes, respectively. The physiologic function of the third member, PPARdelta, has been d...

journal_title：Current atherosclerosis reports

authors： Kang K,Hatano B,Lee CH

更新日期：2007-01-01 00:00:00

abstract：:The ability for statins to reduce major cardiovascular events and mortality has lead to this drug class being the most commonly prescribed in the world. In particular, the benefit of these drugs in type 2 diabetes (T2D) is well established. In February 2012, the Food and Drug Administration released changes to statin ...

journal_title：Current atherosclerosis reports

authors： Axsom K,Berger JS,Schwartzbard AZ

更新日期：2013-02-01 00:00:00

abstract：:Atrial fibrillation (AF) is the most common cardiac arrhythmia in humans. One of its important features is the tendency to become more persistent over time, even in the absence of underlying progressive heart disease. Conversion and maintenance of sinus rhythm by pharmacological or electrical methods become increasing...

journal_title：Current atherosclerosis reports

authors： Piña PG,Chicos AB

更新日期：2017-01-01 00:00:00

abstract：:The cytochrome P450 (CYP) is a group of enzymes that oxidatively modify drugs to a more water-soluble form for renal excretion. Nearly 50% of all clinically used medications and endogenous steroids are metabolized by the CYP enzyme 3A4, which explains why many of the important potential drug interactions involved this...

journal_title：Current atherosclerosis reports

authors： Davidson MH

更新日期：2000-01-01 00:00:00

abstract：:There is robust epidemiological evidence dating back to the original Framingham Heart Study from 1977 that indicates an important inverse relationship between high-density lipoprotein cholesterol (HDL-C) and risk of incident coronary artery disease (CAD). Despite this body of scientific information demonstrating that ...

journal_title：Current atherosclerosis reports

authors： Tariq SM,Sidhu MS,Toth PP,Boden WE

更新日期：2014-04-01 00:00:00

abstract：:Diabesity is a term often used to indicate the association of type-2 diabetes mellitus (T2DM) with obesity; the prevalence of both conditions is rapidly increasing worldwide and has reached epidemic proportions. Insulin resistance represents the major determinant of T2DM, which becomes manifest once relative β-cell fa...

journal_title：Current atherosclerosis reports

authors： Castagneto M,Mingrone G

更新日期：2012-12-01 00:00:00

abstract：:The development of multiple diagnostic intracoronary imaging modalities has increased our understanding of coronary atherosclerotic disease. These imaging modalities, intravascular ultrasound (IVUS), optical coherence tomography (OCT), and near-infrared spectroscopy (NIRS), have provided a method to study plaques and ...

journal_title：Current atherosclerosis reports

authors： Hoang V,Grounds J,Pham D,Virani S,Hamzeh I,Qureshi AM,Lakkis N,Alam M

更新日期：2016-09-01 00:00:00

abstract：:The thiazolidinediones, acting through peroxisome proliferator-activated receptor chi (PPARchi), affect multiple areas of metabolism. Of increasing importance is the recognition that these agents affect lipoprotein metabolism and cause changes in serum lipid and lipoprotein levels. All three thiazolidinediones, includ...

journal_title：Current atherosclerosis reports

authors： Goldberg RB

更新日期：2006-09-01 00:00:00

abstract：:The liver X receptors (LXRs) are ligand-activated transcription factors belonging to the nuclear hormone receptor superfamily. Since their initial identification more than a decade ago, LXRs have been characterized as key transcriptional regulators of lipid and carbohydrate homeostasis. LXRs are activated by the intra...

journal_title：Current atherosclerosis reports

authors： Nomiyama T,Bruemmer D

更新日期：2008-02-01 00:00:00

abstract：:Injury of arterial endothelium by abnormal shear stress and other insults induces migration and proliferation of vascular smooth muscle cells (VSMCs), which in turn leads to intimal thickening, hypoxia, and vasa vasorum angiogenesis. The resultant new blood vessels extend from the tunica media into the outer intima, a...

journal_title：Current atherosclerosis reports

authors： Fong GH

更新日期：2015-06-01 00:00:00

abstract：PURPOSE OF REVIEW:This review aims to explore the relationship between AF and carotid atherosclerosis, and the impact on the outcomes of cardiovascular and cerebrovascular events. Also, our aim is to critically review current knowledge and delineate future directions for effective treatment or prevention as well as str...

journal_title：Current atherosclerosis reports

authors： Wang Z,Korantzopoulos P,Liu T

更新日期：2019-11-29 00:00:00

abstract：PURPOSE OF THE REVIEW:Rheumatoid arthritis (RA) is a chronic, autoimmune disease which may result in a higher risk of cardiovascular (CV) events and stroke. Tissue characterization and risk stratification of patients with rheumatoid arthritis are a challenging problem. Risk stratification of RA patients using tradition...

journal_title：Current atherosclerosis reports

authors： Khanna NN,Jamthikar AD,Gupta D,Piga M,Saba L,Carcassi C,Giannopoulos AA,Nicolaides A,Laird JR,Suri HS,Mavrogeni S,Protogerou AD,Sfikakis P,Kitas GD,Suri JS

更新日期：2019-01-25 00:00:00

abstract：:Managing dyslipidemia is an important part of the primary and secondary prevention of coronary heart disease. Low-density lipoprotein cholesterol reduction remains the primary lipid goal. Patients who have experienced an acute coronary syndrome (ACS) are at very high risk of recurrent adverse cardiovascular events. A ...

journal_title：Current atherosclerosis reports

authors： Polsani VR,Virani SS,Nambi V

更新日期：2009-03-01 00:00:00

abstract：:Cardiovascular disease and its clinical sequelae remain the leading causes of morbidity and mortality in many regions of the world. Dyslipidemia is a critical risk factor to intercept in both the primary and secondary prevention of acute cardiovascular events. The prospective, placebo-controlled clinical trials conduc...

journal_title：Current atherosclerosis reports

authors： Toth PP

更新日期：2004-09-01 00:00:00

abstract：:At a time when the lipid management guidelines give more and more emphasis to the identification and treatment of high-risk patients with the metabolic syndrome and diabetes, there is an obvious need to balance the known effects of low-density lipoprotein (LDL) lowering with the new evidence of clinical efficacy deriv...

journal_title：Current atherosclerosis reports

authors： Fazio S,Linton MF

更新日期：2004-03-01 00:00:00

abstract：:More than half of the men and women in the United States are overweight or obese. Obesity is associated with an increased risk for various diseases, most notably, hypertension, diabetes mellitus, dyslipidemia, and coronary heart disease (CHD). The location of excessive body fat, particularly in the visceral area, has ...

journal_title：Current atherosclerosis reports

authors： Jones PH

更新日期：2000-07-01 00:00:00

abstract：:Biologic therapies involve the utilization of proteins, DNA, antibodies, or other substances derived or synthesized from living tissue for therapeutic effects. There are several biologic therapies in clinical development for the prevention and treatment of atherosclerosis. The most advanced in human trials are apolipo...

journal_title：Current atherosclerosis reports

authors： Davidson MH

更新日期：2004-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose is to review evidence on cardiovascular risks and benefits of new treatments for type 2 diabetes mellitus. RECENT FINDINGS:In response to guidance issued by the Food and Drug Administration, thousands of patients have been enrolled in large randomized trials evaluating the cardiovascular ...

journal_title：Current atherosclerosis reports

authors： Flory JH,Ukena JK,Floyd JS

更新日期：2016-12-01 00:00:00

abstract：:Most clinical trials on antioxidants using vitamin E or beta-carotene have failed to note any significant change in cardiovascular endpoints. The results of these studies have been interpreted as a setback for the oxidation hypothesis. An analysis of the hypothesis and the trials, however, points out major misconcepti...

journal_title：Current atherosclerosis reports

authors： Parthasarathy S,Khan-Merchant N,Penumetcha M,Khan BV,Santanam N

更新日期：2001-09-01 00:00:00

abstract：:Daily lifestyle practices and habits profoundly affect the likelihood of developing cardiovascular disease (CVD). Abundant research and multiple recent consensus documents support the role of regular physical activity, not smoking cigarettes, maintaining a healthy body weight, controlling cholesterol levels, and contr...

journal_title：Current atherosclerosis reports

authors： Rippe JM,Angelopoulos TJ

更新日期：2014-10-01 00:00:00

abstract：:Inflammation lies at the base of endothelial dysfunction, eventually leading to plaque formation. The degree of inflammation defines the "vulnerability" of plaque to rupture. Numerous strategies have been adopted to identify and eventually treat high-risk vulnerable plaque. Lipoprotein-associated phospholipase A(2) (L...

journal_title：Current atherosclerosis reports

authors： Bhatti S,Hakeem A,Cilingiroglu M

更新日期：2010-03-01 00:00:00

abstract：:Acute coronary syndromes (ACS), such as unstable angina, acute myocardial infarction, and sudden cardiac death, are commonly associated with the presence of vulnerable plaques in coronary arteries. Rupture or erosion of vulnerable plaques results in the formation of luminal thrombi due to the physical contact between ...

journal_title：Current atherosclerosis reports

authors： Didangelos A,Simper D,Monaco C,Mayr M

更新日期：2009-05-01 00:00:00

abstract：:Atherothrombosis remains a major cause of morbidity and mortality in the western world. The underlying processes associated with clinical expression of atherothrombosis include oxidative stress and proteolysis in relation to neovascularisation and intraplaque hemorrhages, leading to immuno-inflammatory response, cell ...

journal_title：Current atherosclerosis reports

authors： Martinez-Pinna R,Barbas C,Blanco-Colio LM,Tunon J,Ramos-Mozo P,Lopez JA,Meilhac O,Michel JB,Egido J,Martin-Ventura JL

更新日期：2010-05-01 00:00:00